Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGMXQC)

• Drug Name: STEPHOLIDINE Drug Info
• Synonyms: l-Stepholidine; 16562-13-3; (-)-Stepholidine; stepholidine; (S)-3,9-Dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,10-diol; S-Stepholidine; UNII-0UPX3E69W8; 0UPX3E69W8; Q-100198; (13aS)-3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol; 3,9-Dimethoxy-13a-alpha-berbine-2,10-diol; l-2,10-Dihydroxy-3,9-dimethyloxytetrahydropseudoberberine; L-(S)-Stepholidine; l-SPD; AC1OCEV4; 13a-alpha-BERBINE-2,10-DIOL, 3,9-DIMETHOXY-; GTPL8370; DIB014; CHEMBL487387; SCHEMBL10001966

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6917970
  CAS Number: CAS 16562-13-3
  TTD Drug ID: DMGMXQC

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D3 receptor (D3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cariprazine	DMJYDVK	Bipolar disorder	6A60	Approved	[3]
Pramipexole	DMNMW9R	Parkinson disease	8A00.0	Approved	[4]
Ropinirole	DMA6S1D	Parkinson disease	8A00.0	Approved	[4]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[5]
P2B-001	DM9PVHX	Parkinson disease	8A00.0	Phase 3	[6]
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[7]
ONC201	DMM5SCF	Endometrial cancer	2C76	Phase 2	[8]
TAK-906	DMBQD9H	Diabetic gastroparesis	DA41.00	Phase 2	[9]
GSK598809	DMGU05N	Drug abuse	6C4G.1Z	Phase 2	[10]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[10]

Drug(s) Targeting Dopamine D1 receptor (D1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenyltoloxamine	DMKAEQW	Allergy	4A80-4A85	Approved	[11]
Pergolide	DM14MAE	Parkinson disease	8A00.0	Approved	[4]
Methylergonovine	DMBEX4O	Spontaneous abortion	JA00.0	Approved	[12]
Fenoldopam	DMFAOKP	Hypertension	BA00-BA04	Approved	[13]
Zicronapine	DMP8ESD	Schizophrenia	6A20	Phase 3	[14]
Ecopipam	DMS9R43	Cocaine addiction	6C45.2	Phase 3	[15]
DAS-431	DMM3BPL	Dementia	6D80-6D86	Phase 2	[16]
Dihydrexidine	DMACPQO	Psychotic disorder	6A20-6A25	Phase 1/2	[17]
Lu AF28996	DMY572G	Parkinson disease	8A00.0	Phase 1	[18]
BAM-1110	DMPMKUF	Parkinson disease	8A00.0	Discontinued in Phase 2	[19]

Drug(s) Targeting Dopamine D4 receptor (D4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Phenyltoloxamine	DMKAEQW	Allergy	4A80-4A85	Approved	[11]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[5]
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[7]
L-745,870	DMTGR25	Psychotic disorder	6A20-6A25	Phase 2	[20]
NGD 94-1	DMM1Y8F	Schizophrenia	6A20	Phase 1	[21]
ABT-724	DMDQVY4	Erectile dysfunction	HA01.1	Discontinued in Phase 2	[22]
Lu-35138	DMQ7A35	Psychotic disorder	6A20-6A25	Discontinued in Phase 2	[23]
NGD-94-4	DMZ9WLO	Schizophrenia	6A20	Discontinued in Phase 1	[24]
PD-165167	DMD0GB4	Schizophrenia	6A20	Preclinical	[21]

Drug(s) Targeting Dopamine D5 receptor (D5R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenyltoloxamine	DMKAEQW	Allergy	4A80-4A85	Approved	[11]
LE-300	DMGJL16	Schizophrenia	6A20	Preclinical	[21]
ZD-3638	DM6M9GC	Schizophrenia	6A20	Terminated	[21]
GMC-283	DMT1RH6	Schizophrenia	6A20	Terminated	[21]
(+/-)-nantenine	DM0L3GE	Discovery agent	N.A.	Investigative	[25]
ISOCLOZAPINE	DM52CPU	Discovery agent	N.A.	Investigative	[26]
FLUMEZAPINE	DMW0HOG	Discovery agent	N.A.	Investigative	[27]
ISOLOXAPINE	DMH1BN4	Discovery agent	N.A.	Investigative	[28]
1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine	DMOL2Y0	Discovery agent	N.A.	Investigative	[26]
1-[3-(2-Benzyl-phenoxy)-propyl]-pyrrolidine	DMD2NXL	Discovery agent	N.A.	Investigative	[11]

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[29]
Haloperidol	DM96SE0	Delirium		Approved	[30]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[31]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[32]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[33]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[34]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[35]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[36]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[37]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[38]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D1 receptor (D1R)	TTZFYLI	DRD1_HUMAN	Inhibitor	[2]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Inhibitor	[2]
Dopamine D3 receptor (D3R)	TT4C8EA	DRD3_HUMAN	Inhibitor	[2]
Dopamine D4 receptor (D4R)	TTE0A2F	DRD4_HUMAN	Inhibitor	[2]
Dopamine D5 receptor (D5R)	TTS2PH3	DRD5_HUMAN	Inhibitor	[2]

References

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