Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH97XA)

Drug Name

Igmesine Drug Info

Synonyms

Igmesine hydrochloride; JO-1784; UNII-JV6M14TY35; Igmesine Hydrochloride [USAN]; 130152-35-1; Cinnamyl-1-phenyl-1-N-methyl-N-cyclopropylene; JO 1784; CI 1019; CI-1019; JV6M14TY35; (+)-alpha-(E)-Cinnamyl)-N-(cyclopropylmethyl)-alpha-ethyl-N-methylbenzylamine; (+)-Igmesine hydrochloride; (+)-(E)-N-(Cyclopropylmethyl)-alpha-ethyl-N-methyl-alpha-(3-phenyl-2-propenyl)benzenemethanamine hydrochloride; Igmesine hydrochloride (USAN); (+)-alpha-((E)-Cinnamyl)-N-(cyclopropylmethyl)-alpha-ethyl-N-methylbenzylamine; Alphagen

Indication

Disease Entry	ICD 11	Status	REF
Major depressive disorder	6A70.3	Phase 2	[1]
Chronic obstructive pulmonary disease	CA22	Phase 1	[2]
Cystic fibrosis	CA25	Phase 1	[2]

Cross-matching ID

PubChem CID: 6438340
CAS Number: CAS 140850-73-3
TTD Drug ID: DMH97XA

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Alpha-1-antitrypsin (SERPINA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glassia	DM83MOK	Emphysema	CA21	Approved	[4]
Zemaira	DMA5QPM	Emphysema	CA21	Approved	[5]
AGTC-0106	DMMKASG	Alpha-1 antitrypsin deficiency	5C5A	Phase 2	[6]
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[7]
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Drug(s) Targeting Opioid receptor sigma 1 (OPRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[8]
Dextromethorphan Polistirex	DMEHCY5	Dry cough	MD12	Approved	[9]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[10]
AVP-786	DMV1SOR	Alzheimer disease	8A20	Phase 3	[11]
ADX N05	DMLBYRA	Mood disorder	6A60-6E23	Phase 3	[12]
OPC-14523	DMB1WF3	Bulimia nervosa	6B81	Phase 2	[13]
ANAVEX 2-73	DM67OU4	Alzheimer disease	8A20	Phase 1	[14]
SSR-125047	DMSUFW6	Schizophrenia	6A20	Phase 1	[15]
SA-5845	DM6XZRL	Central nervous system disease	8A04-8D87	Phase 1	[16]
SSR-125329A	DMG6NI8	Immune System disease	4A01-4B41	Phase 1	[17]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Alpha-1-antitrypsin (SERPINA1)	TTA7UJC	A1AT_HUMAN	Modulator	[2]
Opioid receptor sigma 1 (OPRS1)	TT5TPI6	SGMR1_HUMAN	Agonist	[3]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001429)
2	Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
3	Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J Pharmacol Exp Ther. 2006 Jun;317(3):1307-19.
4	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
6	First gene therapy nears landmark European market authorization. Nat Biotechnol. 2012 Sep;30(9):807-9.
7	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
8	Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs R D. 2005;6(3):174-7.
9	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
10	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)
11	Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
12	Clinical pipeline report, company report or official report of SK BioPhamaceuticals.
13	Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001 Dec;41(8):976-88.
14	2011 Pipeline of Anavex.
15	The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
16	Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. J Nucl Med. 2004 Nov;45(11):1939-45.
17	SSR125329A, a high affinity sigma receptor ligand with potent anti-inflammatory properties. Eur J Pharmacol. 2002 Dec 5;456(1-3):123-31.