Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHO3XL)

• Drug Name: LUF-5981 Drug Info
• Synonyms: LUF-5981; CHEMBL219160; GTPL5607; LUF5981; LUF 5981; BDBM50205283; 2,6-diphenyl-8-cyclohexyl-1-deazapurine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 16109435
  TTD Drug ID: DMHO3XL

Molecule-Related Drug Atlas

Drug(s) Targeting Adenosine A3 receptor (ADORA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IB-MECA	DM9G5XD	Psoriasis vulgaris	EA90	Phase 3	[3]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[4]
NITD609	DMQHBSX	Malaria	1F40-1F45	Phase 2	[5]
CF102	DMP56WJ	Hepatocellular carcinoma	2C12.02	Phase 2	[6]
SCH-442416	DMQ2K1V	N. A.	N. A.	Phase 1	[7]
AST-004	DM5WMG7	Stroke	8B20	Phase 1	[8]
BEMESETRON	DMSPJX9	N. A.	N. A.	Discontinued in Phase 3	[9]
BAY 60-6583	DMTEJV1	Myocardial ischemia	BA6Z	Preclinical	[10]
CF602	DM0ULO2	Inflammation	1A00-CA43.1	Preclinical	[6]
CF502	DMQSJ20	Inflammation	1A00-CA43.1	Preclinical	[6]

Drug(s) Targeting Adenosine A2a receptor (ADORA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[11]
Istradefylline	DM20VSK	Parkinson disease	8A00.0	Approved	[12]
Regadenoson	DM76VHG	Radionuclide imaging	N.A.	Approved	[13]
Tozadenant	DMATC14	Parkinson disease	8A00.0	Phase 3	[14]
Binodenoson	DMVHF8G	Hypertension	BA00-BA04	Phase 3	[15]
Apadenoson	DMD8QTC	Coronary artery disease	BA80	Phase 3	[16]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[4]
Dexefaroxan	DMTY4KN	Parkinson disease	8A00.0	Phase 2	[17]
AMP-579	DMJ4GPR	Hyperlipidaemia	5C80	Phase 2	[18]
BIIB014	DMH7RJ1	Parkinson disease	8A00.0	Phase 2	[19]

Drug(s) Targeting Adenosine A2b receptor (ADORA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[20]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[20]
A295	DM55GO2	Aggressive cancer	2A00-2F9Z	IND submitted	[21]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[4]
YT-146	DM3YVKQ	Hypertension	BA00-BA04	Phase 2	[22]
AB928	DMDOXMN	Metastatic colorectal cancer	2B91	Phase 1/2	[23]
KF-17837	DMQ6DLZ	Parkinson disease	8A00.0	Phase 1	[24]
Xanthine	DMFBOQ7	Apnea	MD11.0	Phase 1	[25]
CVT-6883	DMY84TW	Asthma	CA23	Phase 1	[26]
PBF-1129	DMOPGXM	Non-small-cell lung cancer	2C25.Y	Phase 1	[23]

Drug(s) Targeting Adenosine A1 receptor (ADORA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[11]
Rolofylline	DMSZPR3	Heart failure	BD10-BD13	Phase 3	[27]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[4]
AMP-579	DMJ4GPR	Hyperlipidaemia	5C80	Phase 2	[18]
SELODENOSON	DMQM3IX	Cardiac arrhythmias	BC9Z	Phase 2	[28]
Apaxifylline	DMQMV9F	Cognitive impairment	6D71	Phase 2	[29]
SLV320	DM867BJ	Heart failure	BD10-BD13	Phase 2	[30]
DTI-0009	DMV84OK	Atrial fibrillation	BC81.3	Phase 2	[28]
Capadenoson	DMYWO62	Atrial fibrillation	BC81.3	Phase 2	[31]
BAY 1067197	DM4JGNH	Heart failure	BD10-BD13	Phase 2	[32]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A1 receptor (ADORA1)	TTK25J1	AA1R_HUMAN	Inhibitor	[2]
Adenosine A2a receptor (ADORA2A)	TTM2AOE	AA2AR_HUMAN	Inhibitor	[2]
Adenosine A2b receptor (ADORA2B)	TTNE7KG	AA2BR_HUMAN	Inhibitor	[2]
Adenosine A3 receptor (ADORA3)	TTJFY5U	AA3R_HUMAN	Inhibitor	[2]

References

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• [21] Clinical pipeline report, company report or official report of Klus Pharma
• [22] Identification of adenosine A2 receptor-cAMP system in human aortic endothelial cells. Biochem Biophys Res Commun. 1994 Mar 15;199(2):905-10.
• [23] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [24] Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. J Med Chem. 1993 Nov 12;36(23):3731-3.
• [25] Role of adenosine in asthma. Drug Dev Res. 1996;39:333-6.
• [26] GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse. J Pharmacol Exp Ther. 2012 Dec;343(3):587-95.
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