Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHQDLX)

Drug Name

EPO-derived peptide Drug Info

Synonyms

EPO-derived peptide (diabetic retinopathy); EPO helix-B domain peptide (diabetic retinopathy), Araim Pharmaceuticals; EPO-derived peptide (diabetic retinopathy), Araim Pharmaceuticals; Erythropoietin-derived peptide (diabetic retinopathy), Araim Pharmaceuticals

Indication

Disease Entry	ICD 11	Status	REF
Diabetic retinopathy	9B71.0	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMHQDLX

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Erythropoietin Receptor (EPOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Darbepoetin alfa	DMMJTYW	Anemia	3A00-3A9Z	Approved	[2]
Epoetin alfa	DMKWB73	Anemia	3A00-3A9Z	Approved	[3]
Methoxy polyethylene glycol-epoetin beta	DMK1LZD	Kidney transplant rejection	NE84	Approved	[4]
RHuEPO	DMALNG0	Solid tumour/cancer	2A00-2F9Z	Approved	[1]
ErepoXen	DM9YI2C	Anemia	3A00-3A9Z	Phase 3	[5]
Epoetin zeta	DM9QPOU	Anemia	3A00-3A9Z	Phase 3	[6]
Hematide	DMUE843	Anemia	3A00-3A9Z	Phase 3	[7]
Cibinetide	DMCFLRH	Depression	6A70-6A7Z	Phase 2	[8]
GlycoPEGylated erythropoietin	DM5JKCL	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[9]
Albupoietin	DMXK4CI	Anemia	3A00-3A9Z	Terminated	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Erythropoietin Receptor (EPOR)	TTAUX24	EPOR_HUMAN	Modulator	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1718).
2	A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradation. Eur J Biochem. 1999 Jul;263(2):410-9.
3	2007 Standards, Options, and Recommendations: use of erythropoiesis-stimulating agents (ESA: epoetin alfa, epoetin beta, and darbepoetin) for the management of anemia in children with cancer. PediatrBlood Cancer. 2009 Jul;53(1):7-12.
4	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
5	Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review. Haematologica. 2006 Aug;91(8):1076-83.
6	Long-term safety and tolerability of epoetin zeta, administered intravenously, for maintenance treatment of renal anemia. Adv Ther. 2008 Nov;25(11):1215-28.
7	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
8	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9	Design of Homogeneous, MonoPEGylated Erythropoietin Analogs With Preserved In Vitro Bioactivity. Exp Hematol. 2006 June; 34(6): 697-704.
10	Clinical pipeline report, company report or official report of cogenesys.