Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHRVUY)

• Drug Name: PF-07275315 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Atopic dermatitis	EA80	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMHRVUY

Molecule-Related Drug Atlas

Drug(s) Targeting Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexpramipexole	DM6KXAU	Eosinophilic asthma	CB02.0	Phase 3	[3]
SAR-156597	DMUICJD	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[4]
PEGylated pitrakinra	DMBPJ9U	Asthma	CA23	Phase 2	[5]
Tepoxalin	DMVS61L	Asthma	CA23	Phase 2	[6]
Romilkimab	DMYEZ5J	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[7]
IL-4R	DMYEGRH	N. A.	N. A.	Phase 2	[8]
Pascolizumab	DMU3XJP	Asthma	CA23	Phase 2	[5]
PF-07264660	DM0GI2H	Atopic dermatitis	EA80	Phase 1	[2]

Drug(s) Targeting Interleukin-13 (IL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tralokinumab	DM6ENSJ	Atopic dermatitis	EA80	Approved	[9]
Lebrikizumab	DMQP0X5	Severe asthma	CA23	Phase 3	[5]
Dexpramipexole	DM6KXAU	Eosinophilic asthma	CB02.0	Phase 3	[3]
Cendakimab	DM9LSBJ	Eosinophilic esophagitis	DA24.1	Phase 3	[10]
SAR-156597	DMUICJD	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[4]
PEGylated pitrakinra	DMBPJ9U	Asthma	CA23	Phase 2	[5]
Romilkimab	DMYEZ5J	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[7]
QAX-576	DMUWFI7	Allergic rhinitis	CA08.0	Phase 2	[11]
Anrukinzumab	DMTG2O0	Asthma	CA23	Phase 2	[12]
Dectrekumab	DM1H7UK	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[11]

Drug(s) Targeting Thymic stromal lymphopoietin (TSLP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tezepelumab	DM9R5J6	Severe asthma	CA23	Approved	[13]
A378	DMUWRTB	Asthma	CA23	IND submitted	[14]
MEDI9929	DMGD1YP	Asthma	CA23	Phase 2	[15]
CSJ117	DMZJUV6	Asthma	CA23	Phase 2	[16]
AMG 104	DM3XC31	Asthma	CA23	Phase 1	[17]
AZD8630	DMMUF0O	Asthma	CA23	Phase 1	[18]
SAR443765	DMLYI4Z	Asthma	CA23	Phase 1	[19]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-13 (IL13)	TT0GVCH	IL13_HUMAN	Not Available	[2]
Interleukin-4 (IL4)	TTLGTKB	IL4_HUMAN	Not Available	[2]
Thymic stromal lymphopoietin (TSLP)	TTHMW3T	TSLP_HUMAN	Not Available	[2]

References

• [1] ClinicalTrials.gov (NCT05411588) A PHASE 1, RANDOMIZED, DOUBLE-BLIND, SPONSOR OPEN, PLACEBO-CONTROLLED, DOSE ESCALATING STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SINGLE AND MULTIPLE INTRAVENOUS AND SUBCUTANEOUS DOSES OF PF-07275315 IN HEALTHY PARTICIPANTS. U.S.National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of Pfizer
• [3] Therapeutic strategies for eosinophilic dermatoses. Curr Opin Pharmacol. 2019 Jun;46:29-33.
• [4] Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801.
• [5] The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72.
• [6] Therapeutic interference with interferon-gamma (IFN-gamma) and soluble IL-4 receptor (sIL-4R) in allergic diseases. Behring Inst Mitt. 1995 Jun;(96):118-30.
• [7] A randomised, double-blind, placebo-controlled, 24-week, phase II, proof-of-concept study of romilkimab (SAR156597) in early diffuse cutaneous systemic sclerosis. Ann Rheum Dis. 2020 Dec;79(12):1600-1607.
• [8] Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol. 2001 Jun;107(6):963-70.
• [9] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [10] Biologics in eosinophilic gastrointestinal diseases. Ann Allergy Asthma Immunol. 2023 Jan;130(1):21-27.
• [11] Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. J Allergy Clin Immunol. 2015 Feb;135(2):500-7.
• [12] Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study.Gut.2015 Jun;64(6):894-900.
• [13] Tezepelumab in Adults with Uncontrolled Asthma. N Engl J Med. 2017 Sep 7;377(10):936-946.
• [14] Clinical pipeline report, company report or official report of Klus Pharma
• [15] Human immunoglobulin G2Lambda monoclonal antibody directed against thymic stromal lymphopoietin (MEDI9929). European medicines agency science medicines health (EMEA-001613-PIP01-14). European Union. 2015.
• [16] TSLP Inhibitors for Asthma: Current Status and Future Prospects. Drugs. 2020 Apr;80(5):449-458.
• [17] Clinical pipeline report, company report or official report of Amgen
• [18] Clinical pipeline report, company report or official report of AstraZeneca
• [19] Clinical pipeline report, company report or official report of Sanofi