Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIJGT9)

Drug Name

INCB24360 Drug Info

Synonyms

Epacadostat

Indication

Disease Entry	ICD 11	Status	REF
Urothelial carcinoma	2C92.0	Phase 3	[1]
Melanoma	2C30	Phase 2	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
B-cell lymphoma	2A86	Phase 1	[2]
Colorectal cancer	2B91.Z	Phase 1	[2]
Head and neck cancer	2D42	Phase 1	[2]
Lung cancer	2C25.0	Phase 1	[2]
Lymphoma	2A80-2A86	Phase 1	[2]
Merkel cell carcinoma	2C34	Phase 1	[2]
Ovarian cancer	2C73	Phase 1	[2]
Recurrent glioblastoma	2A00.00	Phase 1	[4]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Indoleamine 2,3-dioxygenase 1 (IDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[6]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[7]
BMS-986205	DM3MAYQ	Melanoma	2C30	Phase 3	[2]
NLG8189	DM0798Z	Melanoma	2C30	Phase 2/3	[2]
DN1406131	DMQFX8R	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
HTI-1090	DMI4TEC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
KHK2455	DMLSUQ8	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
LY3381916	DMONZ1L	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
PF-06840003	DMOX6EJ	Glioma	2A00.0	Phase 1	[4]
NLG802	DMP9J5V	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Indoleamine 2,3-dioxygenase 1 (IDO1)	TTZJYKH	I23O1_HUMAN	Inhibitor	[5]

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References

1	ClinicalTrials.gov (NCT03361865) Pembrolizumab in Combination With Epacadostat or Placebo in Cisplatin-ineligible Urothelial Carcinoma (KEYNOTE-672/ECHO-307). U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8221).
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Incyte. Product Development Pipeline.
6	Interactions between nitric oxide and indoleamine 2,3-dioxygenase. Biochemistry. 2006 Jul 18;45(28):8527-38.
7	Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18.
8	ClinicalTrials.gov (NCT03641794) Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Healthy Volunteers. U.S. National Institutes of Health.
9	Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation. J Enzyme Inhib Med Chem. 2019 Dec;34(1):250-263.