Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIJSDO)

Drug Name

AVI-6003 Drug Info

Synonyms

NeuGene Plus; NeuGene (Marburg virus, TSO), AVI BioPharma

Indication

Disease Entry	ICD 11	Status	REF
Marburg virus infection	1D60.1	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Ebola virus VP35 messenger RNA (EV VP35 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AVI-6002	DMVUW8A	Ebola virus infection	1D60.0	Phase 1	[2]
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Drug(s) Targeting Ebola virus VP24 messenger RNA (EV VP24 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AVI-6002	DMVUW8A	Ebola virus infection	1D60.0	Phase 1	[2]
AVI-7537	DMLI9U6	Ebola virus infection	1D60.0	Phase 1	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ebola virus VP24 messenger RNA (EV VP24 mRNA)	TTDJLWQ	VP24_EBOSU	Modulator	[2]
Ebola virus VP35 messenger RNA (EV VP35 mRNA)	TT3Z102	VP35_EBOSU	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01353040) Safety Study of Single Administration Post-exposure Prophylaxis Treatment for Marburg Virus. U.S. National Institutes of Health.
2	Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections. Viruses. 2012 November; 4(11): 2806-2830.