Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIOZ29)

Drug Name
Glycine Drug Info
Synonyms
Aciport; Aminoazijnzuur; Aminoessigsaeure; Amitone; Corilin; Glicina; Glicoamin; Gly; Glycin; Glycinum; Glycocoll; Glycolixir; Glycosthene; Glykokoll; Glyzin; Hgly; Leimzucker; Padil; Polyglycine; Acide aminoacetique; Acido aminoacetico; Acidum aminoaceticum; Aminoacetic acid; Aminoethanoic acid; An alpha amino acid ester; Glycine [INN]; Hampshire glycine; Polyglycine II; Sucre de gelatine; Acide aminoacetique [INN-French]; Acido aminoacetico [INN-Spanish]; Acidum aminoaceticum [INN-Latin]; GLY (IUPAC abbrev); GLYCINE, ACS; Glicina [INN-Spanish]; Glycinum [INN-Latin]; Gyn-hydralin; L-Glycine; S04-0135; AB-131/40217813; AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER; GLYCINE 1.5% IN PLASTIC CONTAINER; Glycine (JP15/USP); Glycine iron sulphate (1:1); Glycine, homopolymer (VAN); Glycine, labeled with carbon-14; Glycine, non-medical; Glycine-UL-14C hydrochloride; H-Gly-OH; H2N-CH2-COOH; L-alpha-amino acids; (1-13c)glycinato; (15N)Glycine; 2,2-dialkylglycines; 2-Aminoacetic acid
Indication
Disease Entry ICD 11 Status REF
Allergic rhinitis CA08.0 Approved [1]
Common cold CA00 Approved [1]
Cough MD12 Approved [1]
Cystic fibrosis CA25 Approved [1]
Malnutrition 5B50-5B71 Approved [2]
Rhinitis FA20 Approved [1]
Therapeutic Class
Dietary supplement
Cross-matching ID
PubChem CID
750
ChEBI ID
CHEBI:15428
CAS Number
CAS 56-40-6
TTD Drug ID
DMIOZ29
VARIDT Drug ID
DR00242
INTEDE Drug ID
DR2025

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glutamate receptor ionotropic NMDA 2A (NMDAR2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NBQX DMPHZI5 Neurological disorder 6B60 Phase 1 [14]
YM-90K DMWRT4L Convulsion 8A68.Z Discontinued in Phase 2 [15]
SPERMINE DMD4BFY N. A. N. A. Terminated [16]
L-689560 DMCVY4U Neurodegenerative disorder 8A20-8A23 Terminated [17]
L-698544 DMLRBN1 Alzheimer disease 8A20 Terminated [18]
DIZOCILPINE DMMGYXR Cerebrovascular ischaemia 8B1Z Terminated [19]
RPR-104632 DM9L50N N. A. N. A. Terminated [20]
L-698532 DMO9HM7 Neurological disorder 6B60 Terminated [21]
L-695902 DMT1DNS N. A. N. A. Terminated [18]
L-701324 DMAIJSX Cerebrovascular ischaemia 8B1Z Terminated [21]
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Drug(s) Transported By Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [22]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [22]
Levacecarnine hci DMJBOCR Cognitive impairment 6D71 Approved [23]
L-glutamine DM69G8X Short bowel syndrome KB89.1 Approved [24]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [25]
Valganciclovir DMS2IUH Virus infection 1A24-1D9Z Approved [26]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [27]
D-Serine DM3YH4I N. A. N. A. Phase 4 [28]
L-threonine DMFHTBX Discovery agent N.A. Investigative [28]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Transported By Proton-coupled amino acid transporter 1 (SLC36A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Proline DMKSTWR Malnutrition 5B50-5B71 Approved [29]
Cycloserine DMT1I52 Bacterial infection 1A00-1C4Z Approved [30]
Aminolevulinic acid hci DMS4BLQ Acne vulgaris ED80 Approved [31]
Gaboxadol DMI53FU Insomnia 7A00-7A0Z Approved [32]
Vigabatrin DMYT0OG Alcohol dependence 6C40.2 Approved [33]
Drug(s) Transported By Na(+)/Cl(-) betaine/GABA transporter (SLC6A12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [34]
L-Proline DMKSTWR Malnutrition 5B50-5B71 Approved [6]
Betaine DMGRZW2 Cystitis GC00 Approved [35]
CHOLINE DM5D9YK Insomnia 7A00-7A0Z Investigative [6]
Drug(s) Transported By Sodium- and chloride-dependent glycine transporter 2 (SLC6A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Norepinephrine DMOUC09 Alopecia ED70 Approved [36]
Methylphenidate DM7SJD6 Attention deficit hyperactivity disorder 6A05.Z Approved [37]
Drug(s) Transported By Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
sarcosine DMIVGOR Discovery agent N.A. Investigative [38]
Drug(s) Transported By L-type amino acid transporter 2 (SLC7A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [7]
L-Alanine DMZDN4W Dietary shortage 5B5K Approved [7]
L-Proline DMKSTWR Malnutrition 5B50-5B71 Approved [7]
L-Phenylalanine DMQXI9F Malnutrition 5B50-5B71 Approved [39]
L-Tyrosine DM9O8DT Malnutrition 5B50-5B71 Approved [7]
Drug(s) Metabolized By Bile acid-CoA thioesterase (BAAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [40]
taurine DMVW7N3 Discovery agent N.A. Investigative [10]
ZX-AP000068 DM4Y0NI N. A. N. A. Investigative [10]
NSC-39851 DMMXZBK N. A. N. A. Investigative [10]
Drug(s) Affected By Claudin-5 (CLDN5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Guanfacine extended release DMB1CZ8 Attention deficit hyperactivity disorder 6A05.Z Approved [42]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [43]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [44]
Urethane DM7NSI0 N. A. N. A. Phase 4 [45]
CS-600G DM1PV4Y N. A. N. A. Phase 3 [46]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [47]
LY294002 DMY1AFS Neuroblastoma 2D11.2 Phase 1 [48]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [12]
JWH-133 DM1DEYU Discovery agent N.A. Investigative [49]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [50]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
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Drug(s) Affected By Glycine receptor subunit alpha-1 (GLRA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Leflunomide DMR8ONJ Arthritis FA20 Approved [61]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [60]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [65]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [66]
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Drug(s) Affected By Occludin (OCLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Testosterone DM7HUNW Hot flushes GA30 Approved [72]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [73]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ethanol DMDRQZU Chronic pain MG30 Approved [76]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor ionotropic NMDA 2A (NMDAR2A) TTKJEMQ NMDE1_HUMAN Antagonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) DT2CFQ5 SC6A9_HUMAN Substrate [4]
Sodium- and chloride-dependent glycine transporter 2 (SLC6A5) DTE8R17 SC6A5_HUMAN Substrate [5]
Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DTBPTJF S6A12_HUMAN Substrate [6]
L-type amino acid transporter 2 (SLC7A8) DTJF3DX LAT2_HUMAN Substrate [7]
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DTW7AE3 AAAT_HUMAN Substrate [8]
Proton-coupled amino acid transporter 1 (SLC36A1) DT48WEM S36A1_HUMAN Substrate [9]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Bile acid-CoA thioesterase (BAAT) DERA3OF BAAT_HUMAN Substrate [10]
Delta-aminolevulinate synthase 2 (ALAS2) DE437BY HEM0_HUMAN Substrate [11]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Claudin-5 (CLDN5) OTUX60YO CLD5_HUMAN Gene/Protein Processing [12]
Glycine receptor subunit alpha-1 (GLRA1) OT05Y9ZR GLRA1_HUMAN Gene/Protein Processing [13]
Occludin (OCLN) OTSUTVWL OCLN_HUMAN Gene/Protein Processing [12]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Gene/Protein Processing [12]

References

1 Glycine FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 727).
3 Glycine transport inhibitors for the treatment of schizophrenia: Symptom and disease modification. Curr Opin Drug Discov Devel. 2009 Jul;12(4):468-78.
4 Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans. Hum Genet. 2016 Nov;135(11):1263-1268.
5 Mutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease. J Biol Chem. 2012 Aug 17;287(34):28975-85.
6 Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol. 2010 Feb 26;6(2):e1000692.
7 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20)
8 Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1046-53.
9 Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells. Eur J Pharm Sci. 2008 Sep 2;35(1-2):86-95.
10 Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids. Methods Enzymol. 2005;400:374-94.
11 Molecular expression and characterization of erythroid-specific 5-aminolevulinate synthase gain-of-function mutations causing X-linked protoporphyria. Mol Med. 2013 Mar 5;19:18-25.
12 Effects of glyphosate and aminomethylphosphonic acid on an isogeneic model of the human blood-brain barrier. Toxicol Lett. 2019 Apr;304:39-49. doi: 10.1016/j.toxlet.2018.12.013. Epub 2018 Dec 31.
13 Sarcophine and (7S, 8R)-dihydroxydeepoxysarcophine from the Red Sea soft coral Sarcophyton glaucum as in vitro and in vivo modulators of glycine receptors. Neurotoxicology. 2020 Sep;80:105-111. doi: 10.1016/j.neuro.2020.07.002. Epub 2020 Jul 20.
14 Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,... J Med Chem. 2001 Sep 13;44(19):3157-65.
15 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with... Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7.
16 Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7.
17 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456).
18 Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993).
19 Synthesis and evaluation of 6,11-ethanohexahydrobenzo[b]quinolizidines: a new class of noncompetitive N-methyl-D-aspartate antagonists. J Med Chem. 1995 Jun 23;38(13):2483-9.
20 Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81.
21 Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71.
22 Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):357-64.
23 A polarized localization of amino acid/carnitine transporter B(0,+) (ATB(0,+)) in the blood-brain barrier. Biochem Biophys Res Commun. 2008 Nov 14;376(2):267-70.
24 High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes. Neurochem Int. 2006 May-Jun;48(6-7):611-5.
25 Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther. 2004 Mar;308(3):1138-47.
26 Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB(0,+). Pharm Res. 2004 Jul;21(7):1303-10.
27 Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells. FEBS Lett. 2005 Apr 25;579(11):2499-506.
28 D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551.
29 PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats. Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E65-74.
30 Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1). J Cell Physiol. 2005 Aug;204(2):604-13.
31 Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1). Br J Pharmacol. 2010 Mar;159(6):1339-53.
32 Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan. Br J Pharmacol. 2009 Aug;157(8):1380-9.
33 Rectal absorption of vigabatrin, a substrate of the proton coupled amino acid transporter (PAT1, Slc36a1), in rats. Pharm Res. 2012 Apr;29(4):1134-42.
34 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.22.3.1)
35 Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. Epilepsy Res. 2011 Jun;95(1-2):70-81.
36 SLC6A2 Gene (Protein Coding).
37 SLC6 transporters: structure, function, regulation, disease association and therapeutics. Mol Aspects Med. 2013 Apr-Jun;34(2-3):197-219.
38 Glycine is taken up through GLYT1 and GLYT2 transporters into mouse spinal cord axon terminals and causes vesicular and carrier-mediated release of its proposed co-transmitter GABA. J Neurochem. 2001 Mar;76(6):1823-32.
39 Quantifying the relative contributions of different solute carriers to aggregate substrate transport. Sci Rep. 2017 Jan 16;7:40628.
40 Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. J Biol Chem. 1994 Jul 29;269(30):19375-9.
41 Arsenic downregulates tight junction claudin proteins through p38 and NF-B in intestinal epithelial cell line, HT-29. Toxicology. 2017 Mar 15;379:31-39. doi: 10.1016/j.tox.2017.01.011. Epub 2017 Jan 20.
42 Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial. Inflamm Bowel Dis. 2019 May 4;25(6):1006-1018. doi: 10.1093/ibd/izz017.
43 Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells. Chem Biol Interact. 2009 May 15;179(2-3):185-91. doi: 10.1016/j.cbi.2008.11.009. Epub 2008 Nov 21.
44 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
45 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
46 Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2?cells. Chem Biol Interact. 2021 Oct 1;348:109634. doi: 10.1016/j.cbi.2021.109634. Epub 2021 Sep 8.
47 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
48 Involvement of claudin-5 in H(2)S-induced acute lung injury. J Toxicol Sci. 2020;45(5):293-304. doi: 10.2131/jts.45.293.
49 Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions. J Neurosci. 2012 Mar 21;32(12):4004-16. doi: 10.1523/JNEUROSCI.4628-11.2012.
50 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
51 Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter. J Biol Chem. 1990 Nov 25;265(33):20106-16.
52 Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem Biophys Res Commun. 2001 Jan 26;280(3):664-74. doi: 10.1006/bbrc.2000.4216.
53 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
54 Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1. Toxicol Lett. 2009 Jan 30;184(2):81-4. doi: 10.1016/j.toxlet.2008.10.017. Epub 2008 Oct 28.
55 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
56 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
57 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
58 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
59 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
60 Synergistic inhibition of glycinergic transmission in vitro and in vivo by flavonoids and strychnine. Toxicol Sci. 2010 Nov;118(1):171-82. doi: 10.1093/toxsci/kfq245. Epub 2010 Aug 18.
61 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
62 Mechanism of action of the insecticides, lindane and fipronil, on glycine receptor chloride channels. Br J Pharmacol. 2012 Apr;165(8):2707-20. doi: 10.1111/j.1476-5381.2011.01722.x.
63 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
64 A mouse line for inducible and reversible silencing of specific neurons. Mol Brain. 2014 Sep 18;7:68. doi: 10.1186/s13041-014-0068-8.
65 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
66 Does acetaldehyde mediate ethanol action in the central nervous system?. Alcohol Clin Exp Res. 2001 Nov;25(11):1570-5.
67 Protective effect of quercetin on hydrogen peroxide-induced tight junction disruption. Int J Toxicol. 2010 Jul;29(4):418-24. doi: 10.1177/1091581810366487. Epub 2010 May 5.
68 Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
69 Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. J Nutr. 2009 May;139(5):965-74. doi: 10.3945/jn.108.100867. Epub 2009 Mar 18.
70 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
71 Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways. Toxicol Lett. 2020 Oct 10;332:146-154. doi: 10.1016/j.toxlet.2020.07.010. Epub 2020 Jul 16.
72 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
73 The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia. Clin Pharmacol Ther. 2006 Oct;80(4):375-83. doi: 10.1016/j.clpt.2006.07.002.
74 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
75 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
76 Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach. PLoS One. 2014 Sep 16;9(9):e107421. doi: 10.1371/journal.pone.0107421. eCollection 2014.