Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJB87Q)

Drug Name

Halisulfate 1 Drug Info

Synonyms

CHEBI:69280; CHEMBL387584; halisulfate 1, (rel)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Patented Agent(s)

Discontinued Drug(s)

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Drug(s) Targeting Mycobacterium Isocitrate lyase (MycB icl)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrohalisulfate 1	DM0HQF6	Discovery agent	N.A.	Investigative	[2]
2,2',3-Tribromo-4,4',5,5'-tetrahydroxybibenzyl	DMG7EPF	Discovery agent	N.A.	Investigative	[3]
Bis(2,3-dibromo-4,5-dihydroxyphenyl)ether	DMQ7KR1	Discovery agent	N.A.	Investigative	[3]
3-bromopyruvate	DMYL3ST	Discovery agent	N.A.	Investigative	[4]
Bis(3-bromo-4,5-dihydroxyphenyl)methanone	DMUN50H	Discovery agent	N.A.	Investigative	[3]
5,5'-methylenebis(3,4-dibromobenzene-1,2-diol)	DMZ693W	Discovery agent	N.A.	Investigative	[3]
Glyoxalate, Glyoxylate	DMQUP7O	Discovery agent	N.A.	Investigative	[5]
3-nitropropionate	DMH798G	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Targeting Arachidonate 15-lipoxygenase (15-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indolizine derivative 1	DM4GZBI	N. A.	N. A.	Patented	[6]
Imidazole derivative 10	DMI7W3K	N. A.	N. A.	Patented	[7]
Indole and benzimidazole derivative 1	DMS0169	N. A.	N. A.	Patented	[7]
Triazole derivative 3	DMZR0TH	N. A.	N. A.	Patented	[7]
Isothiazolone derivative 1	DMHAJCM	N. A.	N. A.	Patented	[7]
PMID26560362-Compound-90	DM9V13U	N. A.	N. A.	Patented	[7]
Imidazole derivative 11	DMTJ0DP	N. A.	N. A.	Patented	[7]
Tri-substituted benzene derivative 1	DMEQ3RD	N. A.	N. A.	Patented	[7]
NSC-661755	DMDJT7U	N. A.	N. A.	Terminated	[8]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 15-lipoxygenase (15-LOX)	TTN9T81	LOX15_HUMAN	Inhibitor	[1]
Mycobacterium Isocitrate lyase (MycB icl)	TT58ZYW	ACEA_MYCTU	Inhibitor	[2]

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References

1	Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5.
2	Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. Bioorg Med Chem Lett. 2007 May 1;17(9):2483-6.
3	Bromophenols as Candida albicans isocitrate lyase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8.
4	Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nat Struct Biol. 2000 Aug;7(8):663-8.
5	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6	Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225.
7	15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88.
8	Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
9	Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.