Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJBDL0)

Drug Name

BIIB104 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Cognitive impairment	6D71	Phase 2a	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Glutamate receptor AMPA (GRIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[2]
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[3]
Zopiclone	DMPI6Z0	Insomnia	7A00-7A0Z	Approved	[4]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[5]
Enflurane	DM0YJSB	Anaesthesia	9A78.6	Approved	[6]
Isoflurane	DMY6T31	Anaesthesia	9A78.6	Approved	[7]
Bromazepam	DMY9TCW	Anxiety disorder	6B00-6B0Z	Approved	[8]
Artemisinin SP	DMFETDK	Malaria	1F40-1F45	Approved	[9]
Dihydroergotoxine	DM5D6WZ	Alzheimer disease	8A20	Approved	[10]
Barbiturate	DMJIA6T	Anaesthesia	9A78.6	Approved	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Activator	[1]

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References

1	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
2	Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1. Br J Pharmacol. 2007 Nov;152(6):939-45.
3	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
4	Eszopiclone: its use in the treatment of insomnia. Neuropsychiatr Dis Treat. 2007 Aug;3(4):441-453.
5	Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats. Can J Anaesth. 2009 Feb;56(2):126-35.
6	Enflurane directly depresses glutamate AMPA and NMDA currents in mouse spinal cord motor neurons independent of actions on GABAA or glycine receptors. Anesthesiology. 2000 Oct;93(4):1075-84.
7	Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit. Brain Res. 2005 Jan 25;1032(1-2):30-5.
8	Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups. Psychopharmacology (Berl). 2009 May;204(1):61-71.
9	GABA(A) receptor ligands and their therapeutic potentials. Curr Top Med Chem. 2002 Aug;2(8):817-32.
10	Pharmacologic management of Alzheimer disease, Part II: Antioxidants, antihypertensives, and ergoloid derivatives. Ann Pharmacother. 1999 Feb;33(2):188-97.
11	Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79.