Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKMBES)

Drug Name

Plazomicin Drug Info

Synonyms

ACHN-490; UNII-LYO9XZ250J; 1154757-24-0; LYO9XZ250J; Plazomicin [USAN:INN]; Plazomicin (USAN); ZINC68150640; DB12615; D10151; D-Streptamine,

Indication

Disease Entry	ICD 11	Status	REF
Bronchitis	CA20	Approved	[1]
Prostate disease	GA91	Approved	[1]
Urinary tract infection	GC08	Approved	[1]
Pancreatic cancer	2C10	Phase 3	[2]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mitochondrial rRNA methyltransferase 2 (MRM2)	TTUQ7WN	MRM2_HUMAN	Inhibitor	[1]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Aminoglycoside O-phosphotransferase (aphA6)	DESGYWE	G9FRK8_PROST	Substrate	[3]
Aminoglycoside acetyltransferase (aac)	DE69QHT	AAC2_PROST	Substrate	[3]

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References

1	In vitro activity of plazomicin against -lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE).J Antimicrob Chemother. 2017 Oct 1;72(10):2792-2795.
2	ClinicalTrials.gov (NCT01970371) A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE). U.S. National Institutes of Health.
3	Plazomicin retains antibiotic activity against most aminoglycoside modifying enzymes. ACS Infect Dis. 2018 Jun 8;4(6):980-987.