Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKXO9V)

Drug Name

A278 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Non-alcoholic steatohepatitis	DB92.1	IND submitted	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Peroxisome proliferator-activated receptor (PPAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IVA337	DMJV3AX	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[2]
ABTL0812	DMM1W9R	Pancreatic cancer	2C10	Phase 1/2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Peroxisome proliferator-activated receptor (PPAR)	TTRMIZ7	PPARA_HUMAN; PPARD_HUMAN; PPARG_HUMAN	Not Available	[1]

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References

1	Clinical pipeline report, company report or official report of Klus Pharma
2	Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension. Ann Rheum Dis. 2017 Nov;76(11):1931-1940.
3	The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells. Autophagy. 2021 Jun;17(6):1349-1366.