Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML0D1P)

• Drug Name: Reteplase Drug Info
• Synonyms: Retevase; Rapilysin (TN); Retavase (TN); Retevase (TN); Reteplase (USAN/INN)

Indication

Disease Entry	ICD 11	Status	REF
Heart attack	BA41	Approved	[1]

• Therapeutic Class: Thrombolytic Agents
• Cross-matching ID: TTD Drug ID: DML0D1P

Molecule-Related Drug Atlas

Drug(s) Targeting Plasminogen (PLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranolazine	DM0C9IL	Acute coronary syndrome	BA41	Approved	[4]
Aminocaproic Acid	DMFGND4	Bleeding disorder	GA20-GA21	Approved	[5]
Streptokinase	DM5JQ0D	Pulmonary embolism	BB00	Approved	[6]
Tranexamic Acid	DMFI8A7	Excessive bleeding	GA30.02	Approved	[7]
Alteplase	DMRJ3YX	Acute myocardial infarction	BA41	Approved	[8]
Tenecteplase	DMJYN25	Acute myocardial infarction	BA41	Approved	[8]
Anistreplase	DM6Q4B0	Acute coronary syndrome	BA41	Approved	[9]
MELAGATRAN	DM4W8RE	N. A.	N. A.	Phase 3	[10]
Desmoteplase	DMDLU4Z	Ischemic stroke	8B11.5Z	Phase 3	[11]
Plasminogen	DM0EFQS	Alzheimer disease	8A20	Phase 2/3	[12]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[13]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[14]
Fructose	DM43AN2	Vomiting	MD90	Approved	[3]
Ketoprofen	DMRKXPT	Bursitis		Approved	[3]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[17]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[18]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[21]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[22]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasminogen (PLG)	TTP86E2	PLMN_HUMAN	Activator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Drug Response	[3]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Drug Response	[3]

References

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• [19] Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
• [20] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [21] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
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