Details of the Drug-Related molecule(s) Interaction Atlas

HELENALIN Drug Info

HELENALIN; 6754-13-8; PF 56; Helenalin A; HSDB 3490; NSC85236; UNII-4GUY9L896T; NSC 85236; BRN 0028081; MLS000728512; CHEBI:5635; 4GUY9L896T; 6alpha,8beta-Dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oic acid 12,8-lactone; SMR000445626; Ambrosa-2,11(13)-dien-12-oic acid, 6alpha,8beta-dihydroxy-4-oxo-, 12,8-lactone; (3aR,5R,5aR,8aR,9S,9aS)-9-hydroxy-5,8a-dimethyl-1-methylene-3a,4,5,5a,9,9a-hexahydroazuleno[6,7-b]furan-2,8-dione; Azuleno(6,5-b)furan-2,5-dione, 3,3a,4,4a,7a,8,9,9a-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-, (3

Cross-matching ID

PubChem CID

23205

ChEBI ID

CHEMBL338474

CAS Number

CAS 6754-13-8

TTD Drug ID

DMMCI4H

General Information of Drug (ID: DMMCI4H)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Angiotensin II receptor type-1 (AGTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[5]
Olmesartan medoxomil	DMWBHRY	High blood pressure	BA00	Approved	[6]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[5]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[5]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[7]
Telmisartan	DMS3GX2	Hypertension	BA00-BA04	Approved	[8]
ANGIOTENSIN II	DMLWQ27	Increase blood pressure	BA04	Approved	[9]
SARALASIN	DMKS1DV	Hypertension	BA00-BA04	Approved	[10]
Tasosartan	DMM13DI	Hypertension	BA00-BA04	Approved	[11]
Eprosartan	DM07K2I	Hypertension	BA00-BA04	Approved	[12]
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Drug(s) Targeting Nuclear factor NF-kappa-B (NFKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[13]
Triptolide	DMCMDVR	Autoimmune diabetes	5A10	Phase 3	[14]
Laquinimod	DM3IWS8	Lupus	4A40	Phase 3	[15]
Edasalonexent	DMYVBF6	Duchenne dystrophy	8C70	Phase 3	[16]
MD1003	DMVZ57G	Multiple sclerosis	8A40	Phase 3	[16]
Vadimezan	DMK7CYX	Solid tumour/cancer	2A00-2F9Z	Phase 2	[17]
CAT 1004	DMQBP7R	Duchenne dystrophy	8C70	Phase 2	[18]
Parthenolide	DMCQBFT	N. A.	N. A.	Phase 2	[19]
Recoflavone	DMCSR8I	Inflammatory bowel disease	DD72	Phase 2	[20]
CZEN-002	DMUDMHA	Fungal infection	1F29-1F2F	Phase 2	[21]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Selenium	DM25CGV	N. A.	N. A.	Approved	[25]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[26]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[27]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[28]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[29]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[33]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[23]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[36]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
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Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[41]
Selenium	DM25CGV	N. A.	N. A.	Approved	[25]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[43]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[47]
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Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin II receptor type-1 (AGTR1)	TT8DBY3	AGTR1_HUMAN	Inhibitor	[1]
Nuclear factor NF-kappa-B (NFKB)	TTSXVID	NFKB1_HUMAN; NFKB2_HUMAN; TF65_HUMAN; RELB_HUMAN; REL_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Gene/Protein Processing	[3]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Gene/Protein Processing	[3]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Gene/Protein Processing	[3]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Gene/Protein Processing	[4]

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