Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNA6LF)

Drug Name

3-(tetradecylamino)propylphosphonic acid Drug Info

Synonyms

3-(tetradecylamino)propylphosphonic acid; CHEMBL334213; 725724-60-7; CTK2H2323; DTXSID50658353; BDBM50148403; (3-Tetradecylamino-propyl)-phosphonic acid; [3-(Tetradecylamino)propyl]phosphonic acid; Phosphonic acid, [3-(tetradecylamino)propyl]-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 44344193
CAS Number: CAS 725724-60-7
TTD Drug ID: DMNA6LF

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Sphingosine-1-phosphate receptor 1 (S1PR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Siponimod	DM2R86O	Multiple sclerosis	8A40	Approved	[2]
Fingolimod	DM5JVAN	Multiple sclerosis	8A40	Approved	[3]
Ozanimod	DMT6AM2	Multiple sclerosis	8A40	Approved	[4]
Etrasimod	DMT0A3Y	Ulcerative colitis	DD71	Approved	[5]
Ponesimod	DMEAOYJ	Multiple sclerosis	8A40	Approved	[6]
MT-1303	DMSE9TH	Crohn disease	DD70	Phase 2	[7]
ONO-4641	DMLUM3Y	Rheumatoid arthritis	FA20	Phase 2	[8]
KRP-203	DMOW9X2	Cutaneous lupus erythematosus	EB5Z	Phase 2	[8]
VTX-002	DMZ8Z5A	Ulcerative colitis	DD71	Phase 2	[9]
CBP-307	DM3TH6Y	Ulcerative colitis	DD71	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sphingosine-1-phosphate receptor 1 (S1PR1)	TT9JZCK	S1PR1_HUMAN	Inhibitor	[1]

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References

1	A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 re... J Med Chem. 2004 Dec 30;47(27):6662-5.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
3	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
7	Sphingosine 1-Phosphate Receptor Modulators in Multiple Sclerosis. CNS Drugs. 2015 Jul;29(7):565-75.
8	Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702.
9	Clinical pipeline report, company report or official report of Ventyx Biosciences
10	Clinical pipeline report, company report or official report of Connect Biopharma