Details of the Drug

General Information of Drug (ID: DM5JVAN)

Drug Name
Fingolimod
Synonyms 2-Amino-2-(4-octylphenethyl)propane-1,3-diol
Indication
Disease Entry ICD 11 Status REF
Multiple sclerosis 8A40 Approved [1]
Primary progressive multiple sclerosis 8A40.1 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [3]
Affected Organisms
Humans and other mammals
ATC Code
L04AA27: Fingolimod
L04AA: Selective immunosuppressants
L04A: IMMUNOSUPPRESSANTS
L04: IMMUNOSUPPRESSANTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 307.5
Logarithm of the Partition Coefficient (xlogp) 4.2
Rotatable Bond Count (rotbonds) 12
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
Clearance
The drug present in the plasma can be removed from the body at the rate of 1.53 mL/min/kg [4]
Half-life
The concentration or amount of drug in body reduced by one-half in 144 hours [4]
Unbound Fraction
The unbound fraction of drug in plasma is 0.002% [4]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 17.3 L/kg [4]
Chemical Identifiers
Formula
C19H33NO2
IUPAC Name
2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol
Canonical SMILES
CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N
InChI
InChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3
InChIKey
KKGQTZUTZRNORY-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
107970
ChEBI ID
CHEBI:63115
CAS Number
162359-55-9
UNII
3QN8BYN5QF
DrugBank ID
DB08868
TTD ID
D07UHS
INTEDE ID
DR0696
ACDINA ID
D00276
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sphingosine-1-phosphate receptor 1 (S1PR1) TT9JZCK S1PR1_HUMAN Modulator [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 4F12 (CYP4F12) DED26GV CP4FC_HUMAN Substrate [6]
Cytochrome P450 4F2 (CYP4F2) DE3GT9C CP4F2_HUMAN Substrate [6]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

ICD Disease Classification 08 Nervous system disease
Disease Class ICD-11: 8A40 Multiple sclerosis
The Studied Tissue Plasmacytoid dendritic cells
The Studied Disease Multiple sclerosis [ICD-11:8A40]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cytochrome P450 4F12 (CYP4F12) DME CYP4F12 4.68E-01 -5.96E-03 -2.58E-02
Cytochrome P450 4F2 (CYP4F2) DME CYP4F2 2.36E-01 -6.45E-02 -1.81E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 145 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 1.0073 3.8025 0.9597 33.7145
MEC1 CTRP2 2.3238 3.0252 2.3238 24.7872
JM1 CTRP2 2.1109 3.4552 2.1089 26.2122
Ki-JK CTRP2 0.4956 3.5452 0.4456 37.1249
NCO2 CTRP2 0.9046 3.466 0.8766 34.3343
SUP-HD1 CTRP2 0.9057 2.7526 0.902 34.2468
SUP-T11 CTRP2 1.0143 4.7511 0.8463 34.0527
NU-DHL-1 CTRP2 1.4429 2.6942 1.4425 30.6572
AML-193 CTRP2 1.5342 2.0233 1.5342 30.0475
Ri-1 CTRP2 1.5358 4.7047 1.4144 30.4432
GA-10 CTRP2 1.5476 2.8436 1.5471 29.96
ST486 CTRP2 1.5656 2.3914 1.5656 29.8382
KMS-11 CTRP2 1.5668 3.8406 1.5398 29.9209
TALL-1 [Human adult T-ALL] CTRP2 1.6537 3.9199 1.6248 29.3482
Mono-Mac-1 CTRP2 1.7105 5.0627 1.542 29.4408
697 CTRP2 1.7279 2.4542 1.7279 28.757
KMS-12-BM CTRP2 1.7294 2.7727 1.7293 28.7474
KMS-21-BM CTRP2 1.7339 4.5851 1.6435 29.0214
SU-DHL-6 CTRP2 1.762 5.2874 1.5537 29.2331
Daudi CTRP2 1.7759 2.6322 1.7758 28.4377
MHH-CALL-4 CTRP2 1.7863 7.1297 1.0615 30.7682
Kasumi-2 CTRP2 1.8016 3.5841 1.7929 28.2953
OCI-AML-3 CTRP2 1.8087 2.4832 1.8087 28.219
MOTN-1 CTRP2 1.8239 3.0513 1.8233 28.1195
SU-DHL-1 CTRP2 1.8376 2.6464 1.8376 28.0262
MOLT-16 CTRP2 1.8905 3.5086 1.8853 27.6913
OPM-2 CTRP2 1.9039 2.7158 1.9039 27.5848
Hs 611.T CTRP2 1.94 2.939 1.9399 27.3446
Mino CTRP2 1.9924 2.6543 1.9924 26.9951
SUP-M2 CTRP2 2.031 2.8107 2.031 26.7376
Pfeiffer CTRP2 2.0662 2.9053 2.0661 26.5037
PL21 CTRP2 2.0687 3.5355 2.0652 26.4984
PF-382 CTRP2 2.0805 3.712 2.0734 26.4319
Ku812 CTRP2 2.0961 4.4424 2.0445 26.4779
EB1 CTRP2 2.1295 3.2907 2.1288 26.0838
KMS-20 CTRP2 2.137 3.0816 2.1369 26.0318
MM1.S CTRP2 2.1444 3.3391 2.1436 25.9848
Ci-1 CTRP2 2.1619 2.8033 2.1619 25.8658
M-07e CTRP2 2.1919 3.2858 2.1914 25.6676
DND-41 CTRP2 2.203 3.4441 2.2017 25.5963
MOLT-3 CTRP2 2.2559 2.8828 2.2559 25.2395
SUP-T1 CTRP2 2.2656 4.0427 2.2507 25.2248
KE-37 CTRP2 2.2832 3.9735 2.2717 25.0963
Karpas-299 CTRP2 2.3122 3.9139 2.3035 24.8935
MOLM-6 CTRP2 2.3315 4.9221 2.2345 25.0649
A4/Fukuda CTRP2 2.3484 3.0349 2.3484 24.6233
KO52 CTRP2 2.3602 2.8997 2.3602 24.5447
SU-DHL-8 CTRP2 2.3663 4.0987 2.3516 24.5533
L-428 CTRP2 2.3832 4.3271 2.3554 24.4846
RS4;11 CTRP2 2.3837 3.8688 2.3777 24.4082
NALM-6 CTRP2 2.3841 6.1889 2.0094 25.6845
NU-DUL-1 CTRP2 2.3894 4.1354 2.3736 24.4033
SET-2 CTRP2 2.3897 2.8966 2.3897 24.3479
HuT 78 CTRP2 2.3923 3.823 2.3875 24.3467
CA46 CTRP2 2.4066 3.3748 2.4064 24.2361
F-36P CTRP2 2.4103 4.3272 2.3836 24.3004
DB CTRP2 2.4557 3.2111 2.4556 23.9087
LP-1 CTRP2 2.4755 3.3369 2.4754 23.7766
JVM-2 CTRP2 2.4815 4.662 2.3418 20.3102
KMS-28BM CTRP2 2.4825 4.1724 2.4676 23.7797
BL-70 CTRP2 2.4845 2.9856 2.4845 23.7165
Granta-519 CTRP2 2.4936 3.2722 2.4936 23.656
MOLP-8 CTRP2 2.5069 3.9149 2.5018 23.5846
MV4-11 CTRP2 2.5565 3.712 2.5551 23.2417
JeKo-1 CTRP2 2.5723 3.0869 2.5723 23.1316
KHM-1B CTRP2 2.5822 3.8521 2.5793 23.0751
SR CTRP2 2.596 3.3539 2.596 22.9735
OCI-Ly19 CTRP2 2.6069 4.0029 2.6013 22.9197
CML-T1 CTRP2 2.63 3.7387 2.6288 22.7512
SEM CTRP2 2.6346 3.1342 2.6346 22.7164
HL-60 CTRP2 2.6491 3.3578 2.6491 22.6197
ME1 CTRP2 2.6579 4.2195 2.6459 22.6013
K-562 CTRP2 2.6773 3.4155 2.6773 22.432
JVM-3 CTRP2 2.7029 4.736 2.6542 22.4257
Reh CTRP2 2.7223 3.8182 2.721 22.1366
GDM-1 CTRP2 2.7434 5.0268 2.66 22.275
KMS-34 CTRP2 2.7989 3.7964 2.7982 21.6242
MOLP-2 CTRP2 2.8007 6.6491 2.3227 23.2965
HDLM-2 CTRP2 2.8093 4.6135 2.7779 21.6583
Kasumi-1 CTRP2 2.8098 4.4433 2.7909 21.6129
JJN-3 CTRP2 2.8653 4.183 2.8594 21.1993
RCH-ACV CTRP2 2.8686 4.7336 2.8293 21.2901
Namalwa CTRP2 2.8872 3.8668 2.8865 21.0361
KMS-18 CTRP2 2.9137 4.06 2.9111 20.8661
EHEB CTRP2 2.923 4.8184 2.878 20.9471
SUP-B15 CTRP2 2.9294 4.1081 2.9261 20.7636
DEL CTRP2 2.9472 3.6301 2.9471 20.6344
THP-1 CTRP2 2.9521 4.477 2.9361 20.655
KMS-27 CTRP2 2.9992 3.8535 2.9989 20.2888
U266B1 CTRP2 3 4.5366 2.9823 20.3416
Raji CTRP2 3.0054 4.4168 2.9942 20.2835
MOLT-13 CTRP2 3.0095 4.1455 3.0066 20.2283
WSU-DLCL2 CTRP2 3.0182 4.0443 3.0168 20.1656
P31/FUJ CTRP2 3.0261 4.3882 3.0166 20.14
SIG-M5 CTRP2 3.0545 3.7815 3.0544 19.9194
HT CTRP2 3.0575 4.0005 3.0567 19.902
HEL 92.1.7 CTRP2 3.0832 3.7103 3.0831 19.7282
NB4 CTRP2 3.1108 4.2844 3.1064 19.5587
Karpas-422 CTRP2 3.1215 4.6377 3.1018 19.5389
MOLM-16 CTRP2 3.1232 5.653 2.9541 20.0454
L-540 CTRP2 3.1246 4.4314 3.1159 19.4811
RPMI-6666 CTRP2 3.1436 4.3418 3.1383 19.3431
EM-2 CTRP2 3.175 4.3494 3.1701 19.1328
SU-DHL-4 CTRP2 3.1789 5.2895 3.0862 19.4064
JURL-MK1 CTRP2 3.1836 5.1001 3.1203 19.2739
RPMI-8402 CTRP2 3.1949 4.3401 3.1905 18.9982
EJM CTRP2 3.1997 4.2078 3.1978 18.9583
RL CTRP2 3.2136 3.9434 3.2135 18.8595
MOLM-13 CTRP2 3.2304 4.9798 3.1852 18.8998
OCI-Ly3 CTRP2 3.2368 4.1187 3.236 18.7072
OCI-AML-2 CTRP2 3.2392 4.2498 3.2372 18.6952
BV-173 CTRP2 3.2782 4.9749 3.2364 18.57
P12-Ichikawa CTRP2 3.3012 4.7498 3.2809 18.3438
KM-H2 CTRP2 3.3174 4.35 3.2941 13.4015
LAMA-84 CTRP2 3.3312 4.6289 3.2696 13.4476
A3/Kawakami CTRP2 3.3333 3.8822 3.3333 18.0618
HPB-ALL CTRP2 3.3493 4.3078 3.3474 17.9615
RPMI-8226 CTRP2 3.3523 4.8156 3.3294 18.012
MC116 CTRP2 3.3548 4.0716 3.3546 17.9189
HD-MY-Z CTRP2 3.3907 4.5234 3.3848 17.699
KE-97 CTRP2 3.3968 4.3553 3.3948 17.6454
Jurkat CTRP2 3.3988 4.0935 3.3954 12.6962
AMO1 CTRP2 3.4054 4.7958 3.3861 17.6462
U-937 CTRP2 3.4247 4.4427 3.4214 17.4638
HEL CTRP2 3.4488 4.0374 3.4474 12.3035
NCI-H929 CTRP2 3.4675 4.1576 3.4673 17.1684
KCL-22 CTRP2 3.4793 4.3721 3.4778 18.3606
L-363 CTRP2 3.4906 4.853 3.4708 17.0804
SKM-1 CTRP2 3.5416 4.0868 3.5416 16.6742
TF-1 CTRP2 3.6333 4.2129 3.6333 16.0631
SK-MM-2 CTRP2 3.6407 4.6353 3.6363 16.0284
MHH-CALL-3 CTRP2 3.6432 5.9573 3.4472 16.6803
KYO-1 CTRP2 3.6508 4.9136 3.6332 16.0056
OCI-AML-5 CTRP2 3.6606 4.2738 3.6605 15.8816
SU-DHL-10 CTRP2 3.6961 4.1901 3.6961 15.6449
Karpas-620 CTRP2 3.714 6.4761 3.3714 16.744
OCI-M1 CTRP2 3.7187 4.4754 3.7179 15.497
Mono-Mac-6 CTRP2 3.8148 6.6487 3.4229 16.2578
OCI-Ly10 CTRP2 4.1491 6.3443 3.887 13.5569
L-1236 CTRP2 4.3321 5.4729 4.2951 11.5331
CMK CTRP2 4.4319 4.8987 4.4317 10.7435
Toledo CTRP2 4.4786 6.5102 4.189 11.4715
REC-1 CTRP2 4.8134 5.8019 4.7586 8.3891
KMM-1 CTRP2 4.8358 5.9222 4.7566 8.3261
P3HR-1 CTRP2 4.9608 7.123 4.4591 9.101
⏷ Show the Full List of 145 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 3.3429 4.4524 3.3382 18.0135
TE8 CTRP2 3.5408 4.2373 3.5405 16.6803
TE-5 CTRP2 2.2382 3.2695 2.238 25.3581
OE33 CTRP2 2.6921 3.3621 2.6921 22.3332
TE-1 CTRP2 2.9404 3.9549 2.9392 20.6832
OE21 CTRP2 2.9669 4.0481 2.965 20.5088
KYSE-410 CTRP2 3.178 4.667 3.1586 19.1613
KYSE-140 CTRP2 3.3066 4.6642 3.2921 18.2882
TE-14 CTRP2 3.3567 4.2911 3.3551 17.9112
TE-4 CTRP2 3.3902 5.0165 3.3503 17.8174
COLO 680N CTRP2 3.4195 4.0806 3.4194 17.4876
KYSE-30 CTRP2 3.4785 3.8877 3.4785 17.0945
TE-6 CTRP2 3.4872 4.2514 3.4867 17.038
EC-GI-10 CTRP2 3.499 4.5439 3.4945 16.973
KYSE-180 CTRP2 3.5052 4.0384 3.5052 16.9167
KYSE-70 CTRP2 3.529 4.3616 3.528 16.761
KYSE-150 CTRP2 3.5536 3.9735 3.5536 16.594
TE-10 CTRP2 3.5586 4.5783 3.5542 16.5756
KYSE-510 CTRP2 3.5944 4.8053 3.5816 16.365
TE-9 CTRP2 3.6943 4.2609 3.6942 15.6569
KYSE-520 CTRP2 4.0635 5.397 4.0188 13.3485
TE-11 CTRP2 4.2668 5.1262 4.2586 11.87
OE19 CTRP2 4.5169 4.9768 4.5166 10.1773
KYSE-450 CTRP2 4.5843 5.3861 4.5711 9.7717
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 3.6407 4.7766 3.6309 16.0468
PaTu 8988s CTRP2 2.3427 2.9431 2.3427 24.6613
MIA PaCa-2 CTRP2 2.4319 2.9595 2.4319 24.0672
HPAC CTRP2 2.835 3.6124 2.8349 21.3815
Hs 766T CTRP2 3.206 4.3166 3.2023 18.9224
PK-45H CTRP2 3.2199 4.7474 3.1963 18.8965
HuP-T3 CTRP2 3.2341 4.1156 3.2334 18.7248
AsPC-1 CTRP2 3.2473 4.2475 3.2453 18.6414
BxPC-3 CTRP2 3.2491 4.7275 3.2283 18.6924
SNU-410 CTRP2 3.2507 5.2396 3.1716 18.8813
Panc 10.05 CTRP2 3.2785 4.6622 3.2631 18.4784
Panc 08.13 CTRP2 3.3251 4.2107 3.3241 18.1196
HuP-T4 CTRP2 3.3836 4.7677 3.3655 17.7873
SNU-213 CTRP2 3.4134 4.0226 3.4133 17.5283
KP-3 CTRP2 3.4496 4.7108 3.4373 17.328
PK-59 CTRP2 3.4547 4.1835 3.4544 17.2541
DAN-G CTRP2 3.4851 4.5425 3.4804 17.0661
KP-4 CTRP2 3.4879 4.0352 3.4878 17.0321
SU.86.86 CTRP2 3.5114 4.1217 3.5113 16.8756
SW1990 CTRP2 3.585 5.0242 3.555 16.4859
YAPC CTRP2 3.6113 4.0109 3.6113 16.2099
PaTu 8988t CTRP2 3.6268 3.9739 3.6268 16.1061
KP-2 CTRP2 3.7549 4.4394 3.7545 15.2541
PaTu 8902 CTRP2 3.7725 4.3295 3.7724 15.1362
Capan-2 CTRP2 3.8112 4.9346 3.7984 14.9209
HPAF-II CTRP2 3.821 4.5999 3.8197 14.817
TCC-Pan2 CTRP2 3.8369 4.8361 3.8299 14.7302
QGP-1 CTRP2 3.8499 4.5425 3.8493 15.7057
Panc 04.03 CTRP2 3.9174 4.8233 3.9127 14.1861
PSN1 CTRP2 3.9321 6.3853 3.6378 15.1174
Panc 05.04 CTRP2 3.9376 5.5833 3.8527 14.3267
L3.3 CTRP2 4.0329 4.8137 4.0305 13.4089
CFPAC-1 CTRP2 4.1227 5.073 4.1126 12.8365
Panc 03.27 CTRP2 4.2288 5.2424 4.2111 12.1551
SUIT-2 CTRP2 4.2443 4.9228 4.2425 11.9986
Panc 02.03 CTRP2 4.4285 5.2274 4.4201 10.7934
Capan-1 CTRP2 4.5378 5.1777 4.5345 10.0479
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 2.6654 4.0983 2.6581 22.5358
COLO 792 CTRP2 2.0771 3.1732 2.0767 26.4321
SK-MEL-24 CTRP2 2.3019 2.925 2.3019 24.933
Hs 934.T CTRP2 2.3022 5.1926 2.1575 25.4248
A101D CTRP2 2.455 3.0225 2.455 23.9133
HT-144 CTRP2 2.5539 3.0909 2.5539 23.2539
WM115 CTRP2 2.5736 2.924 2.5736 23.1231
Hs 294T CTRP2 2.5958 2.9142 2.5958 22.9753
Hs 852.T CTRP2 2.6814 4.6762 2.6377 22.5521
IGR-1 CTRP2 2.7325 3.3258 2.7325 22.0641
MeWo CTRP2 2.8724 3.5787 2.8723 21.1325
WM983B CTRP2 3.0013 4.1804 2.9977 20.2855
Hs 940.T CTRP2 3.1202 4.1928 3.1178 19.4895
WM88 CTRP2 3.1517 4.0118 3.1513 19.2729
SK-MEL-2 CTRP2 3.1743 4.2605 3.1714 19.1307
LOX-IMVI CTRP2 3.2039 4.0914 3.2032 18.9259
UACC-257 CTRP2 3.2827 3.9161 3.2827 18.3987
Hs 944.T CTRP2 3.329 4.6695 3.315 18.1373
MDA-MB-435S CTRP2 3.4174 4.0669 3.4173 17.5019
WM266-4 CTRP2 3.436 3.8825 3.436 17.3772
COLO 800 CTRP2 3.4496 4.2695 3.4489 17.289
Mel Ho CTRP2 3.5072 3.9872 3.5072 16.9028
Mel JuSo CTRP2 3.5408 4.0456 3.5408 16.679
HMCB CTRP2 3.541 3.9698 3.541 16.6778
WM793 CTRP2 3.5474 4.0574 3.5474 16.6352
A2058 CTRP2 3.5621 3.9667 3.5621 16.5377
A-375 CTRP2 3.5643 4.0825 3.5643 16.5227
COLO 741 CTRP2 3.569 9.6717 1.9054 22.6489
SK-MEL-1 CTRP2 3.5884 4.0484 3.5884 16.3623
WM1799 CTRP2 3.6217 4.0098 3.6217 16.1407
G-361 CTRP2 3.6412 4.1827 3.6412 16.0103
WT2-iPS CTRP2 3.732 4.3942 3.7318 15.4062
Hs 688(A).T CTRP2 3.7583 4.1635 3.7583 15.2304
SK-MEL-31 CTRP2 3.8262 4.5126 3.8257 14.7794
Hs 936.T CTRP2 4.105 4.717 4.1044 12.9225
CJM [Human melanoma] CTRP2 4.1805 5.0502 4.1734 12.4414
COLO 829 CTRP2 4.2454 5.744 4.1542 12.2991
K029AX CTRP2 4.2635 5.3151 4.2409 11.9407
IGR-37 CTRP2 4.2888 4.9037 4.2878 11.6995
Hs 895.T CTRP2 4.3083 5.0072 4.3056 11.5751
SK-MEL-30 CTRP2 4.3373 4.9023 4.3366 11.375
SK-MEL-3 CTRP2 4.3884 4.9873 4.3871 11.0369
IGR-39 CTRP2 4.4293 4.9201 4.429 10.7608
UACC-62 CTRP2 4.43 4.9063 4.4297 10.7565
IPC-298 CTRP2 4.431 4.9812 4.4302 10.7516
RVH-421 CTRP2 4.4734 5.3054 4.4617 10.5056
SK-MEL-5 CTRP2 4.5101 4.9795 4.5098 10.2226
SK-MEL-28 CTRP2 4.6541 4.952 4.6541 9.2622
Hs 839.T CTRP2 4.7558 5.4081 4.7481 8.6106
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-DZ CTRP2 1.6095 2.2551 1.6095 29.5461
CHP-212 CTRP2 2.3103 2.9835 2.3103 24.8771
NH-6 CTRP2 2.3221 2.9617 2.3221 24.7984
SK-N-AS CTRP2 2.4399 2.9684 2.4399 24.0139
MHH-NB-11 CTRP2 2.4565 6.5077 1.9932 25.5179
SK-N-FI CTRP2 2.5787 3.1637 2.5787 23.0891
SK-N-SH CTRP2 2.8972 3.8423 2.8966 20.9693
SK-N-BE(2) CTRP2 2.9131 3.8906 2.9123 20.8637
Kelly CTRP2 3.1342 4.5387 3.1208 19.4331
NB1 CTRP2 3.453 3.9267 3.453 17.2642
KP-N-SI9s CTRP2 3.4866 3.9706 3.4866 17.0406
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 2.6373 4.3367 2.6187 22.7609
HuH-28 CTRP2 3.1287 4.2818 3.1246 19.4384
SNU-478 CTRP2 3.3769 4.1449 3.3766 17.7723
HuCC-T1 CTRP2 3.4724 4.365 3.4709 17.14
SNU-869 CTRP2 3.4976 4.1327 3.4975 16.9672
SNU-1196 CTRP2 3.6169 4.2052 3.6169 16.1723
SNU-308 CTRP2 4.2461 4.9975 4.2426 11.9921
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-673 CTRP2 2.3061 2.9413 2.3061 24.9052
SK-N-MC CTRP2 2.7662 3.1962 2.7662 21.8397
MG-63 CTRP2 3.0927 3.8241 3.0926 19.665
Hs 888.T CTRP2 3.2541 4.2748 3.2518 18.5969
SaOS-2 CTRP2 3.3189 3.9916 3.3188 18.1577
MHH-ES-1 CTRP2 3.4006 4.0964 3.4005 17.6137
SK-ES-1 CTRP2 3.4364 4.1847 3.436 17.3762
U2OS CTRP2 3.4415 4.247 3.4409 17.3427
Hs 822.T CTRP2 3.4755 3.9112 3.4754 17.1147
SJSA-1 CTRP2 3.5634 4.33 3.5628 16.5308
CAL-78 CTRP2 3.6192 4.295 3.619 16.1577
TC71 CTRP2 3.6655 4.2656 3.6654 15.8492
G-292 clone A141B1 CTRP2 3.96 4.7721 3.9574 13.8953
HOS CTRP2 4.3248 5.1745 4.3158 11.4863
SW1353 CTRP2 4.4274 4.9306 4.427 10.7742
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 70 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC2218 CTRP2 2.3711 3.5348 2.37 24.4757
EFM-192A CTRP2 2.4067 3.464 2.4062 24.2364
DU4475 CTRP2 2.417 2.9953 2.417 24.1664
CAL-85-1 CTRP2 2.4223 3.3546 2.4221 24.1316
SK-BR-3 CTRP2 2.4576 3.284 2.4575 23.8959
HCC1428 CTRP2 2.5074 2.9787 2.5074 23.5639
HCC1500 CTRP2 2.5277 3.1152 2.5277 23.4289
HCC38 CTRP2 2.5302 3.3082 2.5301 23.4124
Hs 578Bst CTRP2 2.5682 3.9348 2.5636 23.1744
Hs 578T CTRP2 2.5744 3.3853 2.5743 23.1181
MDA-MB-468 CTRP2 2.5906 3.127 2.5906 23.01
AU565 CTRP2 2.6763 3.8983 2.6737 22.4471
HCC202 CTRP2 2.7425 3.6945 2.7421 21.9992
MDA-MB-415 CTRP2 2.8277 3.9837 2.8254 21.4377
MDA-MB-453 CTRP2 2.9096 3.8986 2.9087 20.8874
BT-20 CTRP2 3.0995 3.9255 3.0992 19.62
MDA-MB-157 CTRP2 3.1073 4.2263 3.1041 19.578
HCC1395 CTRP2 3.1928 4.3057 3.1892 19.0099
HCC1954 CTRP2 3.3246 4.4971 3.3181 18.1414
HCC1419 CTRP2 3.3754 4.2535 3.3744 17.7843
CAL-51 CTRP2 3.3847 4.4137 3.3816 17.7296
CAL-148 CTRP2 3.3854 4.1177 3.3852 17.7152
HCC1806 CTRP2 3.45 4.1089 3.4499 17.2846
T-47D CTRP2 3.4895 4.3644 3.4882 17.0252
HCC1937 CTRP2 3.5161 4.1424 3.5161 16.8438
MDA-MB-231 CTRP2 3.532 4.367 3.5309 16.7417
HCC1143 CTRP2 3.5444 4.6565 3.5372 16.6793
KPL-1 CTRP2 3.555 3.8498 3.555 16.5849
HMC-1-8 CTRP2 3.5995 3.9245 3.5995 16.2883
BT-474 CTRP2 3.6099 4.1136 3.6098 16.2193
ZR-75-30 CTRP2 3.6547 4.5575 3.6522 15.9288
CAMA-1 CTRP2 3.6856 4.3111 3.6855 16.8798
JIMT-1 CTRP2 3.7315 4.2891 3.7314 15.409
CAL-120 CTRP2 3.7472 4.339 3.7471 15.3043
BT-549 CTRP2 4.2476 5.5239 4.1971 12.1424
ZR-75-1 CTRP2 4.3535 5.3976 4.3272 11.354
BT 239 CTRP2 0.2924 2.4944 0.286 38.3415
BT 428 CTRP2 1.8348 2.6385 1.8348 28.0447
BT 231 CTRP2 2.2172 2.9722 2.2172 25.4972
BT 112 CTRP2 2.2268 2.8747 2.2268 25.4337
BT 248 CTRP2 2.2404 3.1339 2.2403 25.343
BT 504 CTRP2 2.2971 2.9069 2.297 24.9654
BT 271 CTRP2 2.3312 3.0532 2.3312 24.7378
BT 216 CTRP2 2.3721 3.3252 2.3719 24.4662
BT164 CTRP2 2.3947 2.8922 2.3947 24.3146
BT 145 CTRP2 2.4167 2.9104 2.4167 24.1683
BT 330 CTRP2 2.4854 2.9854 2.4854 23.7105
BT 187 CTRP2 2.5198 3.0781 2.5198 23.4817
BT 422 CTRP2 2.5447 3.1748 2.5447 23.3157
BT147 CTRP2 2.5476 3.3895 2.5476 23.2962
BT 440 CTRP2 2.5506 3.1967 2.5506 23.2761
BT 228 CTRP2 2.5559 2.9347 2.5559 23.2408
BT 131 CTRP2 2.5604 3.0642 2.5604 23.2107
BT 482 CTRP2 2.5642 3.0498 2.5642 23.1855
BT 139 CTRP2 2.5714 2.888 2.5714 23.1373
BT 159 CTRP2 2.5769 2.8913 2.5769 23.1009
BT 245 CTRP2 2.5918 3.7379 2.5904 23.0062
BT 179 CTRP2 2.5971 2.9366 2.5971 22.9664
BT 224 CTRP2 2.6452 3.2033 2.6452 22.6456
BT 172 CTRP2 2.7027 3.2119 2.7027 22.2626
BT 232 CTRP2 2.7352 3.3515 2.7352 22.0462
BT 286 CTRP2 2.7537 3.3608 2.7537 21.9233
BT 359 CTRP2 2.7679 3.4765 2.7679 21.8284
BT 340 CTRP2 2.8626 3.4286 2.8626 21.1977
BT 333 CTRP2 2.9033 4.7228 2.8669 21.049
BT 328 CTRP2 3.1333 3.8359 3.1332 19.3946
BT 416 CTRP2 3.3863 4.101 3.3861 17.7092
BT 320 CTRP2 3.3962 3.9705 3.3962 17.6427
BT 444 CTRP2 3.4794 3.9966 3.4794 17.0881
BT 498 CTRP2 3.9397 4.6311 3.9389 14.0243
⏷ Show the Full List of 70 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 3.4476 3.8815 3.4476 17.3002
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
42-MG-BA CTRP2 1.0838 68.8333 -29.574 47.9482
KG-1-C CTRP2 1.9621 14.9847 -2.159 37.4647
D283 Med CTRP2 2.4649 3.0298 2.4649 23.8471
Hs 683 CTRP2 2.735 3.2205 2.735 22.0475
SF268 CTRP2 2.7442 3.7567 2.7435 21.989
SNB-75 CTRP2 2.8951 4.4785 2.8771 21.0417
CCF-STTG1 CTRP2 2.9565 3.6165 2.9564 20.5723
GMS-10 CTRP2 3.1595 3.7729 3.1595 19.2197
M059K CTRP2 3.1792 4.0475 3.1786 19.0904
LN-229 CTRP2 3.2173 4.0953 3.2166 18.8366
A-172 CTRP2 3.2757 4.4865 3.2685 18.4696
CAS-1 CTRP2 3.2997 3.9952 3.2996 18.2857
GOS-3 CTRP2 3.3043 3.9458 3.3043 18.2547
U-251MG CTRP2 3.3729 4.0634 3.3728 17.798
U-118MG CTRP2 3.416 4.3102 3.4148 17.5148
SF539 CTRP2 3.4263 4.0377 3.4262 17.4426
GaMG CTRP2 3.4327 4.004 3.4326 17.3998
LN-18 CTRP2 3.4435 3.8973 3.4435 17.3275
ONS-76 CTRP2 3.4819 4.0416 3.4819 17.0719
DK-MG CTRP2 3.4843 3.9777 3.4843 17.0558
SF126 CTRP2 3.5077 4.0063 3.5077 16.9
U-87MG ATCC CTRP2 3.5238 4.1251 3.5237 18.0376
SNU-466 CTRP2 3.5634 4.0618 3.5634 16.529
KNS-60 CTRP2 3.5894 3.9698 3.5894 16.3558
GB-1 CTRP2 3.5924 4.0179 3.5924 16.3358
SW1088 CTRP2 3.5929 4.1189 3.5929 16.3325
Daoy CTRP2 3.6101 4.868 3.594 16.2716
SNU-626 CTRP2 3.6273 4.1165 3.6273 16.1031
NMC-G1 CTRP2 3.6628 4.2435 3.6628 15.8665
SF295 CTRP2 3.8405 4.6488 3.8387 14.6888
TM-31 CTRP2 3.9066 4.5862 3.906 14.2442
YKG-1 CTRP2 3.9811 4.6496 3.9804 13.7482
KNS-42 CTRP2 4.1212 4.7975 4.12 12.8165
SNU-489 CTRP2 4.2281 5.1234 4.2187 12.132
SW1783 CTRP2 4.3634 5.7054 4.2901 11.4506
KALS-1 CTRP2 4.3703 5.8199 4.2735 11.4873
KNS-81 CTRP2 4.3733 9.3076 2.8732 16.9099
Becker CTRP2 4.4071 4.986 4.406 10.9116
DBTRG-05MG CTRP2 4.4111 5.0294 4.4095 10.8866
YH-13 CTRP2 4.4265 4.9813 4.4257 10.7815
SNU-738 CTRP2 4.45 5.0343 4.4487 10.6263
SNU-1105 CTRP2 4.5064 4.9477 4.5062 11.0064
SNU-201 CTRP2 4.5444 4.9993 4.5441 9.9942
T98G CTRP2 4.5833 5.0648 4.5827 9.7361
8-MG-BA CTRP2 4.6351 5.0959 4.6346 9.3907
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-3 CTRP2 2.6669 4.0059 2.6622 22.517
JHUEM-7 CTRP2 2.766 3.7584 2.7653 21.8434
JHUEM-2 CTRP2 3.0592 4.0838 3.0462 15.3511
RL95-2 CTRP2 3.0979 4.3339 3.092 19.6498
HEC-1-B CTRP2 3.158 4.1327 3.1567 20.6592
JHUEM-1 CTRP2 3.1878 3.8177 3.1878 19.0308
MFE-296 CTRP2 3.2507 4.5187 3.2417 18.6421
AN3-CA CTRP2 3.3279 4.1449 3.3274 18.0995
HEC-1-A CTRP2 3.4611 4.1442 3.4609 17.211
HEC-151 CTRP2 3.5166 4.0231 3.5166 16.8402
KLE CTRP2 3.5408 4.6628 3.5333 16.7046
HEC-6 CTRP2 3.6209 4.088 3.6203 10.1626
HEC-251 CTRP2 3.8086 4.8782 3.7372 9.8098
HEC-50B CTRP2 3.8562 5.514 3.7775 14.847
HEC-59 CTRP2 3.9033 4.8261 3.8512 8.3364
HEC-265 CTRP2 3.9797 4.7301 3.9781 14.7801
HEC-108 CTRP2 4.136 4.8957 4.1332 12.7235
EN CTRP2 4.216 5.4722 4.1711 12.3337
EFE-184 CTRP2 4.2868 5.1692 4.2768 11.7429
MFE-319 CTRP2 4.3162 5.1613 4.3077 11.5419
ESS-1 CTRP2 4.4502 4.9659 4.4497 10.6225
Ishikawa (Heraklio) 02 ER- CTRP2 4.5665 4.914 4.5665 9.846
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 2.4331 15.6789 -2.0358 35.9971
CAL-54 CTRP2 3.0941 4.1054 3.0926 19.6601
BFTC-909 CTRP2 3.2772 4.1589 3.2764 18.4379
VMRC-RCZ CTRP2 3.2931 4.2975 3.2909 18.3368
KMRC-20 CTRP2 3.4937 4.0794 3.4937 16.9929
VMRC-RCW CTRP2 3.5822 4.2593 3.582 16.4042
TUHR10TKB CTRP2 3.6095 4.0696 3.6095 16.2219
KMRC-2 CTRP2 3.6673 4.4749 3.6661 15.8406
OS-RC-2 CTRP2 3.685 4.4531 3.6842 15.7211
769-P CTRP2 3.7267 4.6415 3.7235 15.4513
SNU-1272 CTRP2 3.901 5.1008 3.8798 14.351
A-498 CTRP2 4.3333 5.0919 4.3285 11.4156
786-O CTRP2 4.4101 5.27 4.3982 10.9279
RCC10RGB CTRP2 4.423 4.9456 4.4225 10.8038
ACHN CTRP2 4.4415 5.0256 4.4402 10.6831
KMRC-1 CTRP2 4.4709 4.9735 4.4704 10.4845
Caki-2 CTRP2 4.485 4.8757 4.485 10.3889
Caki-1 CTRP2 4.5099 5.283 4.501 10.2529
TUHR4TKB CTRP2 4.5854 5.0478 4.585 9.7213
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
T84 CTRP2 1.6465 2.7221 1.6463 29.3001
LS1034 CTRP2 2.0349 2.8186 2.0349 26.712
SNU-C1 CTRP2 2.2422 3.0967 2.2421 25.3311
C2BBe1 CTRP2 2.3987 3.3077 2.3986 24.2887
NCI-H747 CTRP2 2.4168 3.8177 2.4125 24.182
COLO 678 CTRP2 2.5011 3.4332 2.5009 23.6063
HCT 15 CTRP2 2.5126 3.0944 2.5126 23.529
SW948 CTRP2 2.5766 3.0879 2.5766 23.1031
GP2d CTRP2 2.6404 3.1833 2.6404 22.6782
COLO 320 CTRP2 2.6446 4.0691 2.6378 22.6726
SW1116 CTRP2 2.6793 3.3537 2.6793 22.4186
COLO201 CTRP2 2.729 3.2242 2.729 22.0875
OUMS-23 CTRP2 2.768 3.3151 2.768 21.828
SW1417 CTRP2 2.8238 3.9104 2.8224 21.4608
CL-11 CTRP2 2.8375 5.2863 2.7186 21.771
SNU-C5 CTRP2 2.8442 4.2745 2.8347 21.3517
HT-55 CTRP2 2.9305 3.7756 2.9303 20.746
RCM-1 [Human ESC] CTRP2 2.9737 3.895 2.9732 20.459
SNU-61 CTRP2 2.9797 4.4129 2.9679 20.4571
SNU-C2A CTRP2 3.0739 5.1763 2.9917 20.0697
LoVo CTRP2 3.0743 4.5714 3.0571 19.845
HT115 CTRP2 3.2616 3.9791 3.2615 18.5395
LS513 CTRP2 3.2682 4.4121 3.2632 18.5118
NCI-H716 CTRP2 3.2828 4.1207 3.2823 18.3998
CW-2 CTRP2 3.4046 4.3565 3.4026 17.5935
CCK-81 CTRP2 3.4426 4.4254 3.4399 17.3425
COLO205 CTRP2 3.4475 3.9769 3.4475 17.3007
SNU-407 CTRP2 3.4879 4.2722 3.4873 17.0337
NCI-H508 CTRP2 3.5112 4.1 3.5111 16.8769
LS180 CTRP2 3.5465 4.2831 3.5461 16.6424
LS123 CTRP2 3.5792 4.0966 3.5792 16.4237
RKO CTRP2 3.5844 4.9148 3.564 16.4573
DLD-1 CTRP2 3.596 3.9855 3.596 16.3113
SK-CO-1 CTRP2 3.6004 4.2444 3.6003 16.2825
HT-29 CTRP2 3.6129 4.0701 3.6124 10.2193
SNU-C4 CTRP2 3.6246 3.9738 3.6246 16.1209
LS411N CTRP2 3.6382 4.126 3.6382 16.0304
HCC-56 CTRP2 3.6455 4.0771 3.6455 15.9815
KM12 CTRP2 3.6747 4.5108 3.6732 15.7924
HCT 8 CTRP2 4.0477 5.3111 4.0131 13.4192
SW620 CTRP2 4.0603 4.8337 4.0578 13.2265
MDST8 CTRP2 4.1717 4.8924 4.1695 12.4837
HCT 116 CTRP2 4.3 5.3391 4.136 5.9492
SNU-503 CTRP2 4.3118 5.5917 4.2552 11.7359
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuH-6 CTRP2 1.2606 2.6115 1.2601 31.8721
JHH-5 CTRP2 2.8359 3.5893 2.8359 21.3753
Hep-G2 CTRP2 2.9179 4.0262 2.9158 20.8362
SNU-182 CTRP2 3.0203 4.5035 3.0052 20.1975
HLF CTRP2 3.1283 3.8816 3.1282 19.4276
SNU-761 CTRP2 3.1924 4.376 3.187 19.0185
JHH-4 CTRP2 3.215 4.1557 3.2139 18.8536
Hep 3B2.1-7 CTRP2 3.3309 4.0358 3.3307 18.0785
SNU-387 CTRP2 3.3975 5.1627 3.34 17.8289
Li-7 CTRP2 3.4367 4.2602 3.436 17.3754
SK-HEP-1 CTRP2 3.5628 4.185 3.5627 16.5331
JHH-2 CTRP2 3.5718 4.3596 3.571 16.4754
HuH-1 CTRP2 3.6136 4.2574 3.6134 16.195
SNU-398 CTRP2 3.656 4.4223 3.6553 15.9142
SNU-878 CTRP2 3.6952 4.4543 3.6945 15.653
SNU-449 CTRP2 3.7073 4.6807 3.7027 15.5854
SNU-886 CTRP2 3.7334 4.7989 3.7252 15.4237
SNU-423 CTRP2 4.248 5.4801 4.2042 12.1167
JHH-1 CTRP2 4.284 4.9093 4.2829 11.7316
PLC/PRF/5 CTRP2 4.3042 4.9127 4.3031 11.5972
SNU-475 CTRP2 4.4081 4.9307 4.4076 10.9026
JHH-6 CTRP2 4.5371 4.8891 4.5371 10.0417
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 134 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2087 CTRP2 1.1914 3.8106 1.1514 32.4639
NCI-H1651 CTRP2 1.32 15.6793 -3.1133 40.5005
HCC2279 CTRP2 1.5411 5.3865 1.2926 30.8299
NCI-H211 CTRP2 1.577 2.6411 1.5769 29.7631
NCI-H1341 CTRP2 1.6543 2.3427 1.6543 29.2472
DV-90 CTRP2 2.061 2.9975 2.0609 26.5381
NCI-H810 CTRP2 2.1056 2.9625 2.1056 26.2406
NCI-H1666 CTRP2 2.1069 4.2503 2.073 26.3458
COLO 668 CTRP2 2.3453 3.3174 2.3451 24.6444
NCI-H2081 CTRP2 2.3618 3.6675 2.3594 24.5418
SK-MES-1 CTRP2 2.3758 3.5626 2.3746 24.4445
DMS 454 CTRP2 2.376 3.7876 2.3718 24.4536
NCI-H1694 CTRP2 2.382 3.18 2.3819 24.3996
NCI-H522 CTRP2 2.3853 3.3772 2.3851 24.3781
NCI-H146 CTRP2 2.4392 3.2591 2.4392 24.0184
DMS 53 CTRP2 2.4867 3.5147 2.4862 23.7034
NCI-H1693 CTRP2 2.4944 3.3064 2.4944 23.6505
HCC2935 CTRP2 2.5167 3.2019 2.5167 23.5017
NCI-H1568 CTRP2 2.538 3.2521 2.538 23.3602
DMS 79 CTRP2 2.5487 4.4784 2.5165 23.3968
Calu-3 CTRP2 2.5494 3.6467 2.5485 23.2869
Lu-65 CTRP2 2.6055 3.245 2.6055 22.9106
NCI-H2029 CTRP2 2.6081 3.1252 2.6081 22.8929
NCI-H2196 CTRP2 2.6092 3.263 2.6092 22.8859
NCI-H1092 CTRP2 2.6119 3.272 2.6119 22.8678
HCC1833 CTRP2 2.6191 4.528 2.586 22.931
NCI-H841 CTRP2 2.6802 3.4108 2.6802 22.4126
ChaGo-K-1 CTRP2 2.6828 3.4604 2.6827 22.3957
NCI-H1105 CTRP2 2.7023 3.539 2.7021 22.2661
VMRC-LCD CTRP2 2.7582 3.6611 2.7579 21.8941
NCI-H2291 CTRP2 2.7623 6.015 2.4706 22.8817
SW1573 CTRP2 2.7784 5.6085 2.589 22.4114
HOP-92 CTRP2 2.8035 4.2746 2.793 46.4198
COR-L95 CTRP2 2.8109 3.5024 2.8108 21.5423
NCI-H1869 CTRP2 2.8834 3.8212 2.8829 21.0608
RERF-LC-Ad2 CTRP2 2.9049 3.5938 2.9049 20.9159
LXF 289 CTRP2 2.9099 4.5558 2.8874 20.9579
NCI-H520 CTRP2 2.9338 3.9045 2.933 20.7261
NCI-H2342 CTRP2 2.9504 3.8588 2.9499 20.6144
IA-LM CTRP2 2.9983 4.6346 2.9737 20.3762
HCC4006 CTRP2 3.0025 3.8227 3.0023 20.2661
NCI-H1184 CTRP2 3.0348 4.7642 3.0011 20.1639
T3M-10 CTRP2 3.1349 4.0908 3.1338 19.387
NCI-H446 CTRP2 3.1816 4.1989 3.1797 19.0787
NCI-H2085 CTRP2 3.19 4.888 3.1525 19.1427
EPLC-272H CTRP2 3.1969 5.1198 3.1318 19.1915
NCI-H1703 CTRP2 3.1973 4.0165 3.1969 18.9689
EBC-1 CTRP2 3.1979 4.3655 3.193 18.9801
DMS 273 CTRP2 3.2023 4.2653 3.1996 18.9432
NCI-H1650 CTRP2 3.2572 4.5369 3.2476 18.6008
HCC1588 CTRP2 3.2749 4.1615 3.2741 18.4535
LCLC-97TM1 CTRP2 3.2828 5.2505 3.2043 18.6656
HCC44 CTRP2 3.3018 4.5255 3.2938 18.2982
NCI-H1755 CTRP2 3.3211 4.7479 3.3018 18.2079
NCI-H322 CTRP2 3.3308 4.7082 3.3144 18.1333
NCI-H647 CTRP2 3.3331 4.4335 3.3287 18.0777
NCI-H1435 CTRP2 3.3419 4.2185 3.341 18.0074
NCI-H1573 CTRP2 3.3435 4.9511 3.3079 18.1138
NCI-H2009 CTRP2 3.3442 4.2966 3.3424 17.9951
SHP-77 CTRP2 3.3507 3.9787 3.3506 17.9462
RERF-LC-Ad1 CTRP2 3.3554 3.9555 3.3554 17.9145
NCI-H2106 CTRP2 3.3685 4.1566 3.3681 17.8284
NCI-H2286 CTRP2 3.3851 4.7541 3.3678 17.7747
NCI-H1915 CTRP2 3.3959 4.1039 3.3957 17.6451
HCC827 CTRP2 3.4227 4.4275 3.3971 12.5991
Sq-1 CTRP2 3.4618 4.108 3.4617 17.2058
NCI-H23 CTRP2 3.4625 4.3147 3.4615 17.2046
NCI-H1355 CTRP2 3.4744 4.8355 3.4552 17.1861
SK-LU-1 CTRP2 3.4744 4.4442 3.4718 17.1303
NCI-H292 CTRP2 3.4809 4.0836 3.4809 17.0785
NCI-H441 CTRP2 3.4846 4.6101 3.4777 17.0766
NCI-H1395 CTRP2 3.4892 4.8358 3.4705 17.0861
SW1271 CTRP2 3.4918 4.3004 3.4911 17.0083
HCC366 CTRP2 3.4975 4.189 3.4973 16.9685
COLO 699 CTRP2 3.4976 4.4591 3.495 16.9756
NCI-H1581 CTRP2 3.4979 4.1201 3.4978 16.9656
HOP-62 CTRP2 3.5096 4.1578 3.5095 16.8875
HCC1438 CTRP2 3.5286 4.0999 3.5286 16.7605
NCI-H650 CTRP2 3.536 4.1069 3.536 17.9496
HARA [Human squamous cell lung carcinoma] CTRP2 3.5372 4.1894 3.5371 16.7036
LUDLU-1 CTRP2 3.5396 5.185 3.4886 16.8602
NCI-H1373 CTRP2 3.544 4.2936 3.5435 16.6597
NCI-H889 CTRP2 3.5465 4.344 3.5458 16.6438
MOR/CPR CTRP2 3.5497 3.9612 3.5497 16.6202
NCI-H661 CTRP2 3.5515 5.2428 3.4934 16.805
HCC1171 CTRP2 3.5554 4.6873 3.5472 16.6093
Calu-6 CTRP2 3.5593 4.146 3.5593 16.5561
NCI-H1838 CTRP2 3.5714 4.1996 3.5713 16.4758
CAL-12T CTRP2 3.5866 4.5022 3.5843 16.3817
NCI-H1734 CTRP2 3.5887 4.4925 3.5866 16.3673
NCI-H2126 CTRP2 3.5905 4.0651 3.5905 16.3482
RERF-LC-A1 CTRP2 3.5929 4.0622 3.5929 16.3321
NCI-H2023 CTRP2 3.5948 4.1461 3.5948 16.3194
LK2 CTRP2 3.6006 3.8925 3.6006 16.2812
NCI-H358 CTRP2 3.6102 4.2998 3.6099 16.218
LOU-NH91 CTRP2 3.6247 4.3059 3.6245 16.1209
Lu-99 CTRP2 3.6248 4.1306 3.6247 16.12
DMS 114 CTRP2 3.6254 4.603 3.6215 16.1288
HCC2108 CTRP2 3.6312 4.5727 3.6281 17.2794
NCI-H196 CTRP2 3.6571 4.2045 3.657 15.9049
HCC15 CTRP2 3.6703 4.5416 3.6683 15.8235
NCI-H727 CTRP2 3.6764 4.605 3.6733 15.7862
NCI-H1944 CTRP2 3.6789 4.669 3.6741 15.7753
NCI-H1563 CTRP2 3.7462 5.1251 3.7148 15.4166
Calu-1 CTRP2 3.7504 4.4422 3.75 15.2845
NCI-H2170 CTRP2 3.7708 4.6789 3.7674 15.1583
BEN CTRP2 3.7791 4.2997 3.7791 15.0915
A-549 CTRP2 3.8083 4.639 3.8063 14.9039
NCI-H2110 CTRP2 3.9061 4.984 3.8937 14.2873
NCI-H2405 CTRP2 3.9117 4.8039 3.9074 14.2227
NCI-H2172 CTRP2 3.9313 5.0298 3.9169 14.1258
NCI-H460 CTRP2 3.9619 4.9007 3.9554 13.8957
NCI-H2122 CTRP2 4.0054 4.808 4.0027 13.5931
HCC78 CTRP2 4.0463 4.8887 4.0422 13.3253
NCI-H2228 CTRP2 4.0625 5.6519 3.9746 13.5056
NCI-H2444 CTRP2 4.073 5.1055 4.059 13.1808
LCLC-103H CTRP2 4.1151 4.8646 4.1128 12.8609
HCC95 CTRP2 4.1393 4.8829 4.1368 12.7004
NCI-H1793 CTRP2 4.1503 4.9673 4.1458 12.6338
COR-L105 CTRP2 4.273 5.2704 4.2551 11.8616
KNS-62 CTRP2 4.3292 5.0701 4.3251 11.4406
NCI-H1623 CTRP2 4.3721 5.6964 4.3013 11.3838
RERF-LC-MS CTRP2 4.3746 5.1999 4.3658 11.1539
NCI-H1792 CTRP2 4.4159 5.4278 4.3898 10.9377
NCI-H1339 CTRP2 4.4187 4.9182 4.4184 10.8317
NCI-H838 CTRP2 4.42 4.964 4.4193 10.8246
LC-1/sq-SF CTRP2 4.4306 4.884 4.4304 10.752
NCI-H1299 CTRP2 4.4611 5.1212 4.458 10.5585
HCC1195 CTRP2 4.4725 4.958 4.4722 10.4731
NCI-H2030 CTRP2 4.5196 5.1119 4.452 4.3216
SBC-5 CTRP2 4.5908 5.1691 4.5887 9.6913
PC-14 CTRP2 4.7467 5.9497 4.6529 8.9715
NCI-H226 CTRP2 4.7776 5.7439 4.7309 8.5994
Hs 888.Lu CTRP2 4.3847 5.3067 4.3689 11.1102
⏷ Show the Full List of 134 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 2.2739 3.3697 2.2734 25.1213
COV434 CTRP2 1.6357 3.1363 1.6336 29.3785
OV7 CTRP2 2.3097 4.0735 2.2946 24.9316
COV644 CTRP2 2.5237 3.0508 2.5237 23.4556
COV362 CTRP2 2.5584 3.5512 2.558 23.2256
FU-OV-1 CTRP2 2.8659 6.1921 2.5342 22.3369
OV-90 CTRP2 2.903 3.7559 2.9027 20.9293
A2780 CTRP2 3.1009 4.6896 3.0766 19.6916
TYK-nu CTRP2 3.1636 4.4633 3.1546 19.2222
RMG-I CTRP2 3.1765 4.4794 3.1672 19.1374
OVCAR-5 CTRP2 3.2042 4.2821 3.2012 18.9317
OAW28 CTRP2 3.3673 4.6446 3.3558 17.8739
Caov-3 CTRP2 3.4224 4.373 3.4204 17.475
IGROV-1 CTRP2 3.4253 4.7941 3.407 17.5104
OVK18 CTRP2 3.4432 4.1137 3.4431 17.3299
OAW42 CTRP2 3.4632 3.9981 3.4632 17.1963
JHOS-2 CTRP2 3.4651 3.9588 3.4651 17.1837
SNU-8 CTRP2 3.4778 3.9414 3.4778 17.099
OVTOKO CTRP2 3.4845 4.2541 3.4841 17.0556
OC 314 CTRP2 3.514 4.0228 3.514 16.8579
ONCO-DG-1 CTRP2 3.5265 4.0673 3.5265 16.7746
ES2 CTRP2 3.5278 3.9708 3.5277 16.7663
SNU-119 CTRP2 3.5312 4.23 3.531 16.744
OVSAHO CTRP2 3.5338 4.046 3.5337 16.7262
Kuramochi CTRP2 3.5358 4.204 3.5356 16.7134
OVCAR-4 CTRP2 3.564 4.5997 3.5591 16.541
HEY A8 CTRP2 3.5959 3.9462 3.5959 16.312
TOV-21G CTRP2 3.6372 4.4863 3.6357 16.0418
OV56 CTRP2 3.6384 4.1739 3.6384 16.0292
JHOC-5 CTRP2 3.6666 4.8302 3.6549 15.8806
SK-OV-3 CTRP2 3.7222 4.5261 3.721 15.4748
JHOM-1 CTRP2 3.801 5.2862 3.7537 15.1061
SNU-840 CTRP2 4.0342 5.1686 4.0136 13.4614
TOV-112D CTRP2 4.1302 5.2355 4.1083 12.8265
DOV13 CTRP2 4.3144 5.1278 4.3075 11.5486
OVCAR-8 CTRP2 4.3355 5.212 4.3246 11.4213
EFO-27 CTRP2 4.3381 5.1847 4.329 11.3979
EFO-21 CTRP2 4.4207 5.004 4.4195 10.8214
OVISE CTRP2 4.5184 4.9252 4.5183 10.167
MCAS CTRP2 4.5278 6.2619 4.3252 10.8217
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 2.5373 4.4656 2.5056 23.4713
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 2.5722 2.9887 2.5722 23.1324
P-STS CTRP2 2.8654 3.7834 2.865 21.1805
SYO-1 CTRP2 3.097 4.5404 3.0824 19.6848
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 2.7589 3.3909 2.7589 21.8887
Yamato-SS CTRP2 3.7261 4.3356 3.726 15.4453
TE 441.T CTRP2 1.6555 2.1133 1.6555 29.2391
TTC-709 CTRP2 2.3836 5.7957 2.1143 25.3177
TE 617.T CTRP2 2.44 3.0443 2.44 24.0132
GCT CTRP2 2.5146 3.1308 2.5146 23.5162
A-204 CTRP2 2.6816 3.8652 2.6795 22.4104
G-401 CTRP2 2.9432 4.1306 2.9398 20.672
BT-16 CTRP2 3.1224 4.1227 3.121 19.4714
Tm87-16 CTRP2 3.1545 4.1722 3.1527 19.2591
G-402 CTRP2 3.1765 4.154 3.1751 19.111
RD CTRP2 3.3079 4.5214 3.3002 18.2567
Rh18 CTRP2 3.3324 5.0238 3.2883 18.2166
Rh41 CTRP2 3.3398 4.2776 3.3383 18.0236
KYM-1 CTRP2 3.3717 4.2592 3.3707 17.8093
BT-12 CTRP2 3.3987 3.8453 3.3987 17.6258
HT-1080 CTRP2 3.4012 3.9892 3.4011 17.6097
Hs 729.T CTRP2 3.453 3.9779 3.453 17.2643
SW982 CTRP2 3.6146 4.2731 3.6145 16.188
RKN CTRP2 3.8095 4.3255 3.8095 14.8892
SK-UT-1 CTRP2 4.2702 5.4939 4.2259 11.9706
SK-LMS-1 CTRP2 4.3827 5.4786 4.3483 11.1868
MES-SA CTRP2 7.4524 8.4683 5.7131 0.1432
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 2.7285 6.0126 2.4343 23.1153
MPP 89 CTRP2 2.8575 3.8693 2.8566 21.2347
NCI-H2452 CTRP2 3.3475 4.7845 3.3266 18.0372
NCI-H2052 CTRP2 3.5134 4.646 3.5058 16.8873
NCI-H28 CTRP2 3.5814 4.4033 3.5804 16.4122
IST-Mes1 CTRP2 4.2888 5.711 4.2081 11.9732
JL-1 CTRP2 4.35 5.4185 4.3211 11.3861
ACC-MESO-1 CTRP2 4.3517 5.0717 4.348 11.2894
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP CTRP2 2.7812 3.5256 2.7811 21.7401
22Rv1 CTRP2 3.4513 4.2564 3.4507 17.2777
LNCaP clone FGC CTRP2 4.0133 5.5661 3.9376 13.7904
DU145 CTRP2 4.0185 5.3244 3.9804 13.626
PaCa-3 CTRP2 4.5777 4.967 4.5776 9.7716
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 3.5341 3.9785 3.5341 16.7241
A-253 CTRP2 5.3002 7.6537 4.5586 7.8475
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 CTRP2 2.0247 3.1101 2.0244 26.781
MKN74 CTRP2 2.1494 4.4138 2.1034 26.1039
HGC-27 CTRP2 2.3265 3.5179 2.3253 24.7733
Fu97 CTRP2 2.5579 3.0648 2.5579 23.2276
OCUM-1 CTRP2 2.5599 3.9365 2.5551 23.2302
IM95 CTRP2 2.5791 3.3008 2.579 23.0866
HuG1-N CTRP2 2.6973 4.6141 2.6605 22.4225
SNU-719 CTRP2 2.7833 3.9764 2.7667 16.1989
SNU-1 CTRP2 2.9179 3.759 2.9177 20.83
Hs 746.T CTRP2 3.1263 4.4371 3.1174 19.4703
SNU-620 CTRP2 3.1328 4.0698 3.1319 19.4005
GSS CTRP2 3.161 4.1804 3.1592 19.2158
SNU-216 CTRP2 3.2689 5.6246 3.1189 19.0079
LMSU CTRP2 3.2901 5.0605 3.2389 18.5227
MKN7 CTRP2 3.3032 4.3024 3.301 18.2697
NUGC-3 CTRP2 3.3425 4.0839 3.3423 18.0013
KE-39 CTRP2 3.3441 4.5244 3.3371 18.0131
AGS CTRP2 3.4228 4.3469 3.4054 11.6373
SNU-601 CTRP2 3.4535 4.0271 3.4535 17.261
SNU-668 CTRP2 3.4948 3.9334 3.4948 16.9859
NUGC-4 CTRP2 3.5007 4.4589 3.4982 16.9549
23132/87 CTRP2 3.5309 4.0264 3.5308 16.7456
KATO III CTRP2 3.5528 4.5442 3.5492 16.6112
GSU CTRP2 3.597 3.8576 3.597 16.305
SNU-5 CTRP2 3.5973 4.1168 3.5973 16.3031
MKN1 CTRP2 3.6132 4.0849 3.6132 16.1969
ECC10 CTRP2 3.6214 4.2295 3.6213 16.1425
ECC12 CTRP2 4.368 4.8686 4.3677 11.1691
SH-10-TC CTRP2 4.462 4.9387 4.4617 10.5432
MKN45 CTRP2 4.7102 5.098 4.71 8.8895
SNU-685 CTRP2 2.8032 3.3349 2.8032 21.5935
SNG-M CTRP2 3.4365 5.2313 3.3721 17.5929
SNU-1077 CTRP2 3.6307 4.3089 3.6304 16.0813
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 2.4742 2.8996 2.4742 23.785
FTC-238 CTRP2 3.0817 3.9351 3.0813 19.7393
8305C CTRP2 3.2771 4.181 3.2761 18.4394
CAL-62 CTRP2 3.3797 4.0053 3.3797 17.7525
TT CTRP2 3.4516 4.0121 3.4516 17.2737
8505C CTRP2 3.5574 4.1463 3.5574 16.5686
B-CPAP CTRP2 3.6144 4.0727 3.6144 16.1892
ML-1 [Human leukemia] CTRP2 3.6326 4.526 3.6304 16.0751
BHT-101 CTRP2 3.9038 4.9041 3.8957 14.2881
CGTH-W-1 CTRP2 4.1997 4.8791 4.1981 12.2949
TT2609-C02 CTRP2 4.369 5.5245 4.3272 11.3035
FTC-133 CTRP2 4.6734 5.1893 4.672 9.1386
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-3 CTRP2 2.5175 4.0754 2.5078 25.2728
CAL-27 CTRP2 2.969 3.867 2.9685 20.4905
SCC-25 CTRP2 3.0144 4.6339 2.9906 20.2664
CAL-33 CTRP2 3.1024 4.4177 3.0936 19.6295
SNU-1214 CTRP2 3.1853 4.5644 3.1722 19.0917
BICR 6 CTRP2 3.1874 3.7582 3.1873 19.034
PE/CA-PJ15 CTRP2 3.2036 4.3196 3.1999 18.9381
Detroit 562 CTRP2 3.2473 4.2857 3.2448 18.6428
FaDu CTRP2 3.2752 3.8381 3.2751 18.4491
HSC-4 CTRP2 3.4193 3.9318 3.4193 17.4885
BHY CTRP2 3.4286 4.0617 3.4285 17.427
YD-8 CTRP2 3.4691 4.009 3.4691 17.1571
BICR 18 CTRP2 3.4743 4.3108 3.4734 17.1254
SCC-4 CTRP2 3.4826 4.2174 3.4823 17.0682
PE/CA-PJ49 CTRP2 3.498 3.9438 3.498 16.9644
PE/CA-PJ34 (clone C12) CTRP2 3.4986 3.9814 3.4986 16.9601
PE/CA-PJ41 (clone D2) CTRP2 3.5094 4.0592 3.5094 16.8886
BICR 16 CTRP2 3.5328 4.1507 3.5328 16.7326
SNU-1066 CTRP2 3.5386 4.1134 3.5386 16.6939
SNU-1076 CTRP2 3.5458 3.9593 3.5458 16.6459
YD-10B CTRP2 3.5628 4.0369 3.5628 16.5328
SNU-899 CTRP2 3.7055 4.1952 3.7055 15.5821
BICR 31 CTRP2 3.738 5.4034 3.6689 15.6009
SNU-46 CTRP2 3.8605 5.4496 3.7932 14.7788
BICR 22 CTRP2 4.014 5.1238 3.9962 13.5867
HSC-2 CTRP2 4.2779 4.8682 4.2772 11.771
SNU-1041 CTRP2 4.3596 4.9137 4.359 11.2265
SCC-9 CTRP2 4.4126 5.4834 4.3795 10.9835
BICR 56 CTRP2 4.5252 5.0195 4.5247 10.1227
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-BLC1 CTRP2 2.2966 3.0107 2.2966 24.9681
647V CTRP2 2.5062 2.9257 2.5062 23.5719
5637 CTRP2 3.0529 4.6436 3.03 20.0067
KMBC-2 CTRP2 3.1981 4.0905 3.1973 18.9651
HT-1197 CTRP2 3.1985 4.0228 3.1981 18.9611
SCaBER CTRP2 3.3556 3.9352 3.3556 17.9132
VM-CUB-1 CTRP2 3.4676 4.2896 3.4668 17.1696
639V CTRP2 3.4824 3.9393 3.4824 17.0681
RT-4 CTRP2 3.4833 4.2924 3.4826 17.0646
UM-UC-3 CTRP2 3.5126 4.0265 3.5126 16.867
253J-BV CTRP2 3.52 4.1687 3.5199 16.8183
RT-112 CTRP2 3.5248 3.9763 3.5248 16.7862
TCCSUP CTRP2 3.5838 4.0421 3.5838 16.3929
JMSU-1 CTRP2 3.6062 4.2397 3.606 16.2443
BFTC-905 CTRP2 3.6205 4.2035 3.6205 16.1483
J82 CTRP2 3.6305 4.6491 3.6255 16.0985
HT-1376 CTRP2 3.6713 4.3315 3.6711 15.8108
T24 CTRP2 3.8142 5.3519 3.7586 15.0469
SW1710 CTRP2 4.1397 5.5084 4.0838 12.8798
BC-3C CTRP2 4.4505 5.0722 4.4485 10.6255
KU-19-19 CTRP2 4.4682 4.9518 4.4678 10.5022
UM-UC-1 CTRP2 4.4706 6.3544 4.2332 11.3303
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 3.4337 3.9015 3.4336 17.3932

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Fingolimod
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Tecfidera DM2OVDT Major Additive immunosuppressive effects by the combination of Fingolimod and Tecfidera. Multiple sclerosis [8A40] [7]
Ocrelizumab DMEZ2KH Major Additive immunosuppressive effects by the combination of Fingolimod and Ocrelizumab. Multiple sclerosis [8A40] [7]
Ozanimod DMT6AM2 Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Ozanimod. Multiple sclerosis [8A40] [7]
Coadministration of a Drug Treating the Disease Different from Fingolimod (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Increased risk of hepatotoxicity by the combination of Fingolimod and Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [8]
Ivosidenib DM8S6T7 Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Ivosidenib. Acute myeloid leukaemia [2A60] [9]
Arn-509 DMT81LZ Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Arn-509. Acute myeloid leukaemia [2A60] [9]
Oliceridine DM6MDCF Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Oliceridine. Acute pain [MG31] [9]
Siltuximab DMGEATB Major Additive immunosuppressive effects by the combination of Fingolimod and Siltuximab. Anemia [3A00-3A9Z] [7]
Ivabradine DM0L594 Moderate Increased risk of bradycardia by the combination of Fingolimod and Ivabradine. Angina pectoris [BA40] [7]
Bedaquiline DM3906J Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [9]
Levalbuterol DM5YBO1 Moderate Increased risk of ventricular arrhythmias by the combination of Fingolimod and Levalbuterol. Asthma [CA23] [10]
Dupilumab DMOAD2Y Major Additive immunosuppressive effects by the combination of Fingolimod and Dupilumab. Atopic eczema [EA80] [7]
Eribulin DM1DX4Q Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Eribulin. Breast cancer [2C60-2C6Y] [7]
Talazoparib DM1KS78 Major Additive immunosuppressive effects by the combination of Fingolimod and Talazoparib. Breast cancer [2C60-2C6Y] [7]
LY2835219 DM93VBZ Major Additive immunosuppressive effects by the combination of Fingolimod and LY2835219. Breast cancer [2C60-2C6Y] [7]
Palbociclib DMD7L94 Major Additive immunosuppressive effects by the combination of Fingolimod and Palbociclib. Breast cancer [2C60-2C6Y] [7]
PF-04449913 DMSB068 Major Additive immunosuppressive effects by the combination of Fingolimod and PF-04449913. Chronic myelomonocytic leukaemia [2A40] [7]
Olodaterol DM62B78 Moderate Increased risk of ventricular arrhythmias by the combination of Fingolimod and Olodaterol. Chronic obstructive pulmonary disease [CA22] [11]
Vilanterol DMF5EK1 Moderate Increased risk of prolong QT interval by the combination of Fingolimod and Vilanterol. Chronic obstructive pulmonary disease [CA22] [10]
Aflibercept DMT3D5I Major Additive immunosuppressive effects by the combination of Fingolimod and Aflibercept. Colorectal cancer [2B91] [7]
Osilodrostat DMIJC9X Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Osilodrostat. Cushing syndrome [5A70] [9]
Polatuzumab vedotin DMF6Y0L Major Additive immunosuppressive effects by the combination of Fingolimod and Polatuzumab vedotin. Diffuse large B-cell lymphoma [2A81] [7]
Lisocabtagene maraleucel DMP45ME Major Additive immunosuppressive effects by the combination of Fingolimod and Lisocabtagene maraleucel. Diffuse large B-cell lymphoma [2A81] [7]
Axicabtagene ciloleucel DMYHN59 Major Additive immunosuppressive effects by the combination of Fingolimod and Axicabtagene ciloleucel. Diffuse large B-cell lymphoma [2A81] [7]
Deutetrabenazine DMUPFLI Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Deutetrabenazine. Dystonic disorder [8A02] [9]
Ingrezza DMVPLNC Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Ingrezza. Dystonic disorder [8A02] [9]
Cannabidiol DM0659E Moderate Increased risk of hepatotoxicity by the combination of Fingolimod and Cannabidiol. Epileptic encephalopathy [8A62] [12]
Bay 80-6946 DMLOS5R Major Additive immunosuppressive effects by the combination of Fingolimod and Bay 80-6946. Follicular lymphoma [2A80] [7]
Avapritinib DMK2GZX Major Additive immunosuppressive effects by the combination of Fingolimod and Avapritinib. Gastrointestinal stromal tumour [2B5B] [7]
Levobetaxolol DMSREPX Moderate Increased risk of atrioventricular block by the combination of Fingolimod and Levobetaxolol. Glaucoma [9C61] [7]
177Lu-DOTATATE DMT8GVU Major Additive immunosuppressive effects by the combination of Fingolimod and 177Lu-DOTATATE. Hepatitis virus infection [1E50-1E51] [7]
Brentuximab vedotin DMWLC57 Major Additive immunosuppressive effects by the combination of Fingolimod and Brentuximab vedotin. Hodgkin lymphoma [2B30] [7]
Fostemsavir DM50ILT Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Fostemsavir. Human immunodeficiency virus disease [1C60-1C62] [9]
Teriflunomide DMQ2FKJ Major Additive immunosuppressive effects by the combination of Fingolimod and Teriflunomide. Hyper-lipoproteinaemia [5C80] [13]
Levamlodipine DM92S6N Moderate Increased risk of atrioventricular block by the combination of Fingolimod and Levamlodipine. Hypertension [BA00-BA04] [7]
Brigatinib DM7W94S Major Additive immunosuppressive effects by the combination of Fingolimod and Brigatinib. Lung cancer [2C25] [7]
Ceritinib DMB920Z Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Ceritinib. Lung cancer [2C25] [9]
Lurbinectedin DMEFRTZ Major Additive immunosuppressive effects by the combination of Fingolimod and Lurbinectedin. Lung cancer [2C25] [7]
Alectinib DMP1I6Y Moderate Increased risk of atrioventricular block by the combination of Fingolimod and Alectinib. Lung cancer [2C25] [7]
Osimertinib DMRJLAT Major Additive immunosuppressive effects by the combination of Fingolimod and Osimertinib. Lung cancer [2C25] [7]
Selpercatinib DMZR15V Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Selpercatinib. Lung cancer [2C25] [9]
Belimumab DM3OBQF Major Additive immunosuppressive effects by the combination of Fingolimod and Belimumab. Lupus erythematosus [4A40] [7]
Obinutuzumab DM3BVAE Major Additive immunosuppressive effects by the combination of Fingolimod and Obinutuzumab. Mature B-cell leukaemia [2A82] [7]
Idelalisib DM602WT Major Additive immunosuppressive effects by the combination of Fingolimod and Idelalisib. Mature B-cell leukaemia [2A82] [7]
GDC-0199 DMH0QKA Major Additive immunosuppressive effects by the combination of Fingolimod and GDC-0199. Mature B-cell leukaemia [2A82] [7]
IPI-145 DMWA24P Major Additive immunosuppressive effects by the combination of Fingolimod and IPI-145. Mature B-cell leukaemia [2A82] [7]
Acalabrutinib DM7GCVW Major Additive immunosuppressive effects by the combination of Fingolimod and Acalabrutinib. Mature B-cell lymphoma [2A85] [7]
Blinatumomab DMGECIJ Major Additive immunosuppressive effects by the combination of Fingolimod and Blinatumomab. Mature B-cell lymphoma [2A85] [7]
Ibrutinib DMHZCPO Major Additive immunosuppressive effects by the combination of Fingolimod and Ibrutinib. Mature B-cell lymphoma [2A85] [7]
Tisagenlecleucel DMM9BJD Major Additive immunosuppressive effects by the combination of Fingolimod and Tisagenlecleucel. Mature B-cell lymphoma [2A85] [7]
Ponatinib DMYGJQO Major Additive immunosuppressive effects by the combination of Fingolimod and Ponatinib. Mature B-cell lymphoma [2A85] [7]
Vemurafenib DM62UG5 Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Vemurafenib. Melanoma [2C30] [9]
LGX818 DMNQXV8 Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and LGX818. Melanoma [2C30] [9]
Carfilzomib DM48K0X Major Additive immunosuppressive effects by the combination of Fingolimod and Carfilzomib. Multiple myeloma [2A83] [7]
Selinexor DMBD4K3 Major Additive immunosuppressive effects by the combination of Fingolimod and Selinexor. Multiple myeloma [2A83] [7]
Belantamab mafodotin DMBT3AI Major Additive immunosuppressive effects by the combination of Fingolimod and Belantamab mafodotin. Multiple myeloma [2A83] [7]
Daratumumab DMKCIUZ Major Additive immunosuppressive effects by the combination of Fingolimod and Daratumumab. Multiple myeloma [2A83] [7]
Deflazacort DMV0RNS Major Additive immunosuppressive effects by the combination of Fingolimod and Deflazacort. Muscular dystrophy [8C70] [7]
Ruxolitinib DM7Q98D Major Additive immunosuppressive effects by the combination of Fingolimod and Ruxolitinib. Myeloproliferative neoplasm [2A20] [7]
Inebilizumab DMI0RHA Major Additive immunosuppressive effects by the combination of Fingolimod and Inebilizumab. Nervous system paraneoplastic/autoimmune disorder [8E4A] [7]
Atezolizumab DMMF8U0 Major Additive immunosuppressive effects by the combination of Fingolimod and Atezolizumab. Non-small cell lung cancer [2C25] [7]
Entrectinib DMMPTLH Major Additive immunosuppressive effects by the combination of Fingolimod and Entrectinib. Non-small cell lung cancer [2C25] [7]
Olaparib DM8QB1D Major Additive immunosuppressive effects by the combination of Fingolimod and Olaparib. Ovarian cancer [2C73] [7]
Rucaparib DM9PVX8 Major Additive immunosuppressive effects by the combination of Fingolimod and Rucaparib. Ovarian cancer [2C73] [7]
MK-4827 DMLYGH4 Major Additive immunosuppressive effects by the combination of Fingolimod and MK-4827. Ovarian cancer [2C73] [7]
Triclabendazole DMPWGBR Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Triclabendazole. Parasitic worm infestation [1F90] [9]
Macimorelin DMQYJIR Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Macimorelin. Pituitary gland disorder [5A60-5A61] [9]
Lefamulin DME6G97 Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Lefamulin. Pneumonia [CA40] [9]
Enzalutamide DMGL19D Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Enzalutamide. Prostate cancer [2C82] [9]
Relugolix DMK7IWL Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Relugolix. Prostate cancer [2C82] [9]
Brodalumab DMASDQ6 Major Additive immunosuppressive effects by the combination of Fingolimod and Brodalumab. Psoriasis [EA90] [7]
Tildrakizumab DMLW9HG Major Additive immunosuppressive effects by the combination of Fingolimod and Tildrakizumab. Psoriasis [EA90] [7]
Risankizumab DMM32GT Major Additive immunosuppressive effects by the combination of Fingolimod and Risankizumab. Psoriasis [EA90] [7]
Ixekizumab DMXW92T Major Additive immunosuppressive effects by the combination of Fingolimod and Ixekizumab. Psoriasis [EA90] [7]
Upadacitinib DM32B5U Major Additive immunosuppressive effects by the combination of Fingolimod and Upadacitinib. Rheumatoid arthritis [FA20] [7]
Baricitinib DM4ONW5 Major Additive immunosuppressive effects by the combination of Fingolimod and Baricitinib. Rheumatoid arthritis [FA20] [7]
Tofacitinib DMBS370 Major Additive immunosuppressive effects by the combination of Fingolimod and Tofacitinib. Rheumatoid arthritis [FA20] [7]
Sarilumab DMOGNXY Major Additive immunosuppressive effects by the combination of Fingolimod and Sarilumab. Rheumatoid arthritis [FA20] [7]
Mogamulizumab DMISH0Z Major Additive immunosuppressive effects by the combination of Fingolimod and Mogamulizumab. Sezary syndrome [2B02] [7]
LEE011 DMMX75K Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and LEE011. Solid tumour/cancer [2A00-2F9Z] [7]
Pitolisant DM8RFNJ Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Pitolisant. Somnolence [MG42] [9]
Pomalidomide DMTGBAX Major Additive immunosuppressive effects by the combination of Fingolimod and Pomalidomide. Systemic sclerosis [4A42] [7]
Lenvatinib DMB1IU4 Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Lenvatinib. Thyroid cancer [2D10] [9]
Cabozantinib DMIYDT4 Major Increased risk of ventricular arrhythmias by the combination of Fingolimod and Cabozantinib. Thyroid cancer [2D10] [9]
Durvalumab DM4PVDY Major Additive immunosuppressive effects by the combination of Fingolimod and Durvalumab. Ureteral cancer [2C92] [7]
⏷ Show the Full List of 82 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Mannitol E00103 6251 Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Magnesium stearate E00208 11177 lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Fingolimod 0.5 mg capsule 0.5 mg Oral Capsule Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2407).
3 ClinicalTrials.gov (NCT04280588) Fingolimod in COVID-19
4 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
5 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
6 CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis. Drug Metab Dispos. 2011 Feb;39(2):191-8.
7 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
8 Cerner Multum, Inc. "Australian Product Information.".
9 Canadian Pharmacists Association.
10 Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
11 Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
12 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
13 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.