Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOD5CK)

Drug Name

L-lysine Drug Info

Synonyms

Enisyl

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting G-protein coupled receptor GPCR33 (GPRC6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-citrulline	DMT4K0Z	Acute lung injury	NB32.3	Phase 3	[2]
L-ornithine	DMHKGCM	Discovery agent	N.A.	Investigative	[2]
calindol	DMY9P6E	Discovery agent	N.A.	Investigative	[4]
L-serine	DM6WPIS	Pulmonary tuberculosis	1B10.Z	Investigative	[2]
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Drug(s) Transported By Mitochondrial ornithine transporter 3 (SLC25A29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arginine	DMRE4FC	Growth hormone deficiency	5A61.3	Approved	[3]
L-Homoarginine	DML83XP	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled receptor GPCR33 (GPRC6A)	TTI1PRE	GPC6A_HUMAN	Agonist	[2]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Mitochondrial ornithine transporter 3 (SLC25A29)	DT96BT4	MCATL_HUMAN	Substrate	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 724).
2	Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol. 2005 Mar;67(3):589-97.
3	The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84.
4	Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor. Cell Calcium. 2009 Nov-Dec;46(5-6):323-32.