Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOL5IU)

Drug Name
Mesalazine Drug Info
Synonyms
Apriso; Asacol; Asacolitin; Asacolon; Asalit; Ascolitin; Canasa; Claversal; Fisalamine; Fivasa; Iialda; Ipocol; Lialda; Lixacol; Mesacol; Mesalamine; Mesalazina; Mesalazinum; Mesasal; Mesavance; Mesavancol; Mezavant; Pentacol; Pentasa; Rowasa; Salofalk; Salozinal; SfRowasa; Allphar Brand of Mesalamine; Antigen Brand of Mesalamine; Asacol HD; Axcan Brand of Mesalamine; Byk Brand of Mesalamine; Celltech Brand of Mesalamine; Falk Brand of Mesalamine; Farmasa Brand of Mesalamine; Ferring Brand of Mesalamine; GlaxoSmithKline Brand of Mesalamine; Henning Berlin Brand of Mesalamine; M Aminosalicylic Acid; Merckle Brand of Mesalamine; Mesalamine Hydrochloride; Mesalamine Monosodium Salt; Mesalamine [USAN]; Mesalazina[Spanish]; Mesalazine MMX; Mesalazinum [Latin]; Meta Aminosalicylic Acid; Mezavant XL; Minosalicylic acid; Norgine Brand of Mesalamine; Novopharm Brand of Mesalamine; Provalis Brand of Mesalamine; Sanofi Synthelabo Brand of Mesalamine; Schering Plough Brand of Mesalamine; SmithKline Brand of Mesalamine; Solvay Brand of Mesalamine; Yamanouchi Brand of Mesalamine; Novo 5 ASA; Novo5 ASA; AJG-501; Apriso (TN); Asacol (TN); Canasa (TN); Hydrochloride, Mesalamine; Iialda (TN); Ipocal (TN); Lialda (TN); M-A; M-Aminosalicylic acid; MAX-002; MD-0901; Masacol (TN); Mesalamine (USP); Meta-AminosalicylicAcid; Monosodium Salt, Mesalamine; Novo-5 ASA; P-Aminosalicylsaeure; P-Aminosalicylsaeure [German]; Pentasa (TN); Procter & Gamble Brand of Mesalamine; Rowasa (TN); SPD-476; SPD-480; Salofalk (TN); Salofalk Granu-Stix; Schering-Plough Brand of Mesalamine; Z-206; Mesalazine (JAN/INN); Salicylic acid, 5-amino-(8CI); 2-Hydroxy-5-aminobenzoic acid; 3-carboxy-4-hydroxyaniline; 5 Aminosalicylate; 5 Aminosalicylic Acid; 5-AS; 5-ASA; 5-Amino-2-hydroxybenzoic acid; 5-Aminosalicylate; 5-Aminosalicylic acid; 5-amino-2-hydroxy-benzoic acid; 5-aminosalicylic acid, Mesalazine, Asacol, Pentasa, Canasa, Mesalamine
Indication
Disease Entry ICD 11 Status REF
Diverticulitis Approved [1]
Proctitis DB33.Z Approved [2]
Ulcerative colitis DD71 Approved [3]
Ulcerative proctosigmoiditis Approved [4]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
4075
ChEBI ID
CHEBI:6775
CAS Number
CAS 89-57-6
TTD Drug ID
DMOL5IU
VARIDT Drug ID
DR00856
INTEDE Drug ID
DR1032
ACDINA Drug ID
D00401

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase 1 (COX-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [9]
Naproxen DMZ5RGV Bursitis Approved [10]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [11]
Bromfenac DMKB79O Pain MG30-MG3Z Approved [12]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [13]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [14]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [13]
Suprofen DMKXJZ7 Miosis LA11.62 Approved [15]
Gamma-Homolinolenic acid DMSXKYG Malnutrition 5B50-5B71 Approved [16]
FENBUFEN DMXGDFK Arthritis FA20 Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [18]
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
Folic Acid DMEMBJC Colorectal carcinoma Approved [20]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [25]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [26]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [29]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [30]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [31]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [30]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [32]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [33]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [34]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [35]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [30]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [37]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [38]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [30]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [39]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [33]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [35]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [40]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 2B1 (SLCO2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [41]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [42]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [43]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [31]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [44]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [45]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [46]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [47]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [48]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By RNA cytidine acetyltransferase (hALP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [50]
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [51]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [52]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [53]
Sulfadiazine DMTW3R8 Rheumatic fever 1B40-1B42 Approved [54]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [55]
Allopurinol DMLPAOB Gout FA25 Approved [56]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [57]
Clonazepam DMTO13J Absence epilepsy Approved [58]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [59]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase 1 (COX-1) TT8NGED PGH1_HUMAN Inhibitor [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [6]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [7]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [7]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [7]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
RNA cytidine acetyltransferase (hALP) Main DME DEZV4AP NAT10_HUMAN Substrate [8]

References

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25 Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7.
26 Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
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33 Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9.
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35 FDA Drug Development and Drug Interactions
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