Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQW5MH)

• Drug Name: Metampicillin Drug Info
• Synonyms: (2S,5R,6R)-3,3-dimethyl-6-{[(2R)-2-(methylideneamino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6beta-[(2R)-2-(methylideneamino)-2-phenylacetamido]penicillanic acid; Blomopen; Bonopen; CHEBI:52060; Celinmicina; Elatocilline; G0H6U7VSTK; METHAMPICILLIN; Magnipen; Metampicilina; Metampicillina; Metampicilline; Metampicillinum; Micinovo; Pangocilin; Probiotic; Relyothenate; Ruticina; Rutizina; Sedomycin; Suvipen; UNII-G0H6U7VSTK; Viderpen; Viderpin; Vioplex; metampicillin; metampilene
• Therapeutic Class: Anti-Bacterial Agents
• Cross-matching ID:
  PubChem CID: 6713928
  ChEBI ID: CHEBI:52060
  CAS Number: CAS 6489-97-0
  TTD Drug ID: DMQW5MH
  VARIDT Drug ID: DR01338

Molecule-Related Drug Atlas

Drug(s) Transported By Peptide transporter 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[2]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[3]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[4]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[5]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[6]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[7]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[8]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[3]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[5]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[5]

Drug(s) Transported By Peptide transporter 2 (SLC15A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[2]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[1]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[9]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[10]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[11]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[1]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[12]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[2]
Aminolevulinic acid hci	DMS4BLQ	Acne vulgaris	ED80	Approved	[13]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[14]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Peptide transporter 2 (SLC15A2)	DT8QKNP	S15A2_HUMAN	Substrate	[1]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[1]

References

• [1] Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60.
• [2] Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55.
• [3] Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18.
• [4] Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Res Microbiol. 2017 Jun;168(5):443-449.
• [5] High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9.
• [6] The intestinal H+/peptide symporter PEPT1: structure-affinity relationships. Eur J Pharm Sci. 2004 Jan;21(1):53-60.
• [7] Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9.
• [8] Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61.
• [9] Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes. Alcohol Clin Exp Res. 2008 May;32(5):777-84.
• [10] The oligopeptide transporter 2-mediated reabsorption of entecavir in rat kidney. Eur J Pharm Sci. 2014 Feb 14;52:41-7.
• [11] Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants. Drug Metab Dispos. 2017 Feb;45(2):130-136.
• [12] Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun. 1998 May 19;246(2):470-5.
• [13] PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes. Brain Res. 2006 Nov 29;1122(1):18-23.
• [14] Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41.