Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQYCFI)

Drug Name

2,2-dimethyl-2H-benzo[g]chromene-5,10-dione Drug Info

Synonyms

Xyloidone; Dehydro-alpha-lapachone; 15297-92-4; Dehydrolapachone; DEHYDROPLAPACHONE; Dehydro-.alpha.-lapachol; Dehydro-.alpha.-lapacone; NSC106453; NSC629748; 2,2-Dimethyl-2H-benzo[g]chromene-5,10-dione; Dehydro-.alpha.-lapachone; NSC 629748; NSC 106453; UNII-305WY61CUF; .alpha.-Lapachone, dehydro-; 2H-Naphtho[2,3-b]pyran-5,10-dione, 2,2-dimethyl-; 305WY61CUF; 2,2-dimethylbenzo[g]chromene-5,10-dione; 2H-Naphtho[2,3-b]pyran-5,10-dione,2,2-dimethyl-; 2,2-dimethyl-2H,5H,10H-benzo[g]chromene-5,10-dione; Xyloidone (VAN)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 72734
CAS Number: CAS 15297-92-4
TTD Drug ID: DMQYCFI

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Indoleamine 2,3-dioxygenase 1 (IDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[2]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[1]
BMS-986205	DM3MAYQ	Melanoma	2C30	Phase 3	[3]
INCB24360	DMIJGT9	Urothelial carcinoma	2C92.0	Phase 3	[4]
NLG8189	DM0798Z	Melanoma	2C30	Phase 2/3	[3]
DN1406131	DMQFX8R	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
HTI-1090	DMI4TEC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
KHK2455	DMLSUQ8	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
LY3381916	DMONZ1L	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
PF-06840003	DMOX6EJ	Glioma	2A00.0	Phase 1	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Indoleamine 2,3-dioxygenase 1 (IDO1)	TTZJYKH	I23O1_HUMAN	Inhibitor	[1]

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References

1	Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18.
2	Interactions between nitric oxide and indoleamine 2,3-dioxygenase. Biochemistry. 2006 Jul 18;45(28):8527-38.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Incyte. Product Development Pipeline.
5	ClinicalTrials.gov (NCT03641794) Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Healthy Volunteers. U.S. National Institutes of Health.
6	Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation. J Enzyme Inhib Med Chem. 2019 Dec;34(1):250-263.
7	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)