Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR2SOZ)

Drug Name

Ceftiofur Drug Info

Synonyms

Excede (TN)

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Beta-lactamase (blaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-lactamase (blaB)	DENZLGX	A0A498U5Y1_BACPU	Substrate	[2] , [3]
Beta-lactamase (blaB)	DE3FVRW	BLA2_BAC17	Substrate	[4] , [2]
Beta-lactamase (blaB)	DEYM2D3	B7C8I6_9FIRM	Substrate	[5] , [6]
Beta-lactamase (blaB)	DE9ZQ3L	A0A3C0E2M8_9BACE	Substrate	[5]
Beta-lactamase (blaB)	DE69OXF	A0A1S8TSZ5_9CLOT	Substrate	[5]
Beta-lactamase (blaB)	DEPYGS9	A0A0L0LVQ7_BIFBR	Substrate	[5] , [7]
Beta-lactamase (blaB)	DEPGFHV	A0A316SS50_9PROT	Substrate	[2] , [8]
Beta-lactamase (blaB)	DEZAQPD	A0A1Q2YQ29_9PROT	Substrate	[2] , [9]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Isolation of bacterial strains from bovine fecal microflora capable of degradation of ceftiofur. Vet Microbiol. 2009 Oct 20;139(1-2):89-96.
3	MALDI-TOF identification of the human Gut microbiome in people with and without diarrhea in Senegal. PLoS One. 2014 May 1;9(5):e87419.
4	The bacterial degradation of chloramphenico. Lancet. 1967 Jun 10;1(7502):1259-60.
5	Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. Antimicrob Agents Chemother. 2011 Nov;55(11):4990-8.
6	Daily HIV pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate-emtricitabine reduced Streptococcus and increased Erysipelotrichaceae in rectal microbiota. Sci Rep. 2018 Oct 12;8(1):15212.
7	Characterization and induction of prophages in human gut-associated Bifidobacterium hosts. Sci Rep. 2018 Aug 24;8(1):12772.
8	Granulomatous infection of the hand and wrist due to Azospirillum spp. Diagn Microbiol Infect Dis. 2013 Aug;76(4):513-5.
9	Skin microbiota is the main reservoir of Roseomonas mucosa, an emerging opportunistic pathogen so far assumed to be environmental. Clin Microbiol Infect. 2016 Aug;22(8):737.e1-7.
10	Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8.