Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR38M4)

Drug Name

UNBS-1450 Drug Info

Synonyms

UNBS-1244; Na+ K+ ATPase inhibitor, (intravenous, cancer), Unibioscreen; 2''-oxovoruscharin

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Sodium pump subunit alpha-1 (ATP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[3]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[4]
Lumefantrine	DM29GAD	Malaria	1F40-1F45	Approved	[3]
Chloroprocaine	DMSOQK1	Anaesthesia	9A78.6	Approved	[5]
Deslanoside	DMB3ZSK	Arrhythmia	BC9Z	Approved	[4]
Almitrine	DM0SYAN	Chronic obstructive pulmonary disease	CA22	Approved	[6]
Acetyldigitoxin	DMHAUO0	Congestive heart failure	BD10	Approved	[7]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[8]
DIGITOXIGENIN	DM5AOFW	Discovery agent	N.A.	Investigative	[9]
------------------------------------------------------------------------------------


⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sodium pump subunit alpha-1 (ATP1A1)	TTWK8D0	AT1A1_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029692)
2	Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450. Cell Death Dis. 2015 Jun 11;6:e1782.
3	The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics. Pharmacol Res. 2001 Apr;43(4):399-403.
6	Almitrine, a new kind of energy-transduction inhibitor acting on mitochondrial ATP synthase. Biochim Biophys Acta. 1989 Aug 3;975(3):325-9.
7	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
8	The inhibitory effect of aluminium on the (Na+/K+)ATPase activity of rat brain cortex synaptosomes. J Inorg Biochem. 2003 Sep 15;97(1):143-50.
9	17beta-O-Aminoalkyloximes of 5beta-androstane-3beta,14beta-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity r... J Med Chem. 2000 Jun 15;43(12):2332-49.