General Information of Drug (ID: DMRVXH7)

Drug Name
ThromboMer Drug Info
Synonyms TPO peptide mimetic (thrombocytopenia), AplaGen; Thrombopoietin peptide mimetic (thrombocytopenia), AplaGen
Indication
Disease Entry ICD 11 Status REF
Thrombocytopenia 3B64 Investigative [1]
Cross-matching ID
TTD Drug ID
DMRVXH7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [2]
Eltrombopag DMOGFIX Thrombocytopenia 3B64 Approved [3]
Lusutrombopag DMH6IKO Thrombocytopenia 3B64 Approved [4]
AS-1670542 DMV05SW Thrombocytopenia 3B64 Approved [1]
LGD-4665 DM9T8A2 Immune thrombocytopenic purpura 3B64.13 Phase 2 [3]
BVI-007 DM43GPX Myocardial infarction BA41-BA43 Phase 1 [1]
NIP-004 DM0PYEQ Thrombocytopenia 3B64 Phase 1 [5]
RhTPO DMCV0BZ Idiopathic thrombocytopenic purpura 3B64.10 Discontinued in Phase 3 [3]
Totrombopag DM6SUDC Thrombocytopenia 3B64 Discontinued in Phase 1 [6]
Promegapoietin DMS4FG0 Bone marrow transplantation QB63.6 Terminated [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thrombopoietin receptor (MPL) TTIHYA4 TPOR_HUMAN Modulator [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).
2 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
3 Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
4 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
5 A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood. 2006 Jun 1;107(11):4300-7.
6 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.