Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSC8B6)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting Cellular inhibitor of apoptosis 1 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT-406	DMVJW0S	Squamous head and neck cell carcinom	2D60.0	Phase 3	[2]
Birinapant	DM6PBUM	Lymphoma	2A80-2A86	Phase 2	[3]
PMID25980951-Compound-6	DMVSW5N	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-27	DMXAH9F	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-43	DMTJRCS	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-1	DMYPT2H	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-44	DMS5896	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-3	DMPSWXU	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-4	DM9RZSH	N. A.	N. A.	Patented	[1]
PMID25980951-Compound-21	DMIE0MR	N. A.	N. A.	Patented	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cellular inhibitor of apoptosis 1 (BIRC2)	TTQ5LRD	BIRC2_HUMAN	Antagonist	[1]

------------------------------------------------------------------------------------

References

1	Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74.
2	Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung c... Am J Cancer Res. 2014 Nov 19;4(6):943-51.
3	cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. 2014 Apr 17;123(16):2562-72.