Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT9BPN)

• Drug Name: 8-hydroxyguanine Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 135420630
  ChEBI ID: CHEMBL1328799
  CAS Number: CAS 5614-64-2
  TTD Drug ID: DMT9BPN

Molecule-Related Drug Atlas

Drug(s) Targeting GTP cyclohydrolase-I (GCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Guanine	DMIWLJE	N. A.	N. A.	Phase 3	[1]
ProSavin	DMJ42E6	Parkinson disease	8A00.0	Phase 1/2	[4]
OXB-102	DMXF9DM	Parkinson disease	8A00.0	Phase 1/2	[5]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[6]
Guanosine-5'-Triphosphate	DMV2OJX	Discovery agent	N.A.	Investigative	[7]

Drug(s) Affected By Metallothionein-3 (MT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[12]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[13]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[17]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GTP cyclohydrolase-I (GCH1)	TTLSWP6	GCH1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	OT81JS6K	WRN_HUMAN	Drug Response	[2]
Metallothionein-3 (MT3)	OTVCZ7HI	MT3_HUMAN	Regulation of Drug Effects	[3]

References

• [1] GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I. Arch Biochem Biophys. 2001 Apr 1;388(1):67-73.
• [2] Action-at-a-distance mutagenesis induced by oxidized guanine in Werner syndrome protein-reduced human cells. Chem Res Toxicol. 2015 Apr 20;28(4):621-8. doi: 10.1021/tx500418m. Epub 2015 Mar 2.
• [3] Metallothionein-III prevents gamma-ray-induced 8-oxoguanine accumulation in normal and hOGG1-depleted cells. J Biol Chem. 2004 Aug 13;279(33):34138-49. doi: 10.1074/jbc.M402530200. Epub 2004 Jun 8.
• [4] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [5] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [6] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [7] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [8] Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol. 2013 Dec;33(12):1460-7. doi: 10.1002/jat.2812. Epub 2012 Sep 20.
• [9] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [10] Arsenic trioxide (ATO) influences the gene expression of metallothioneins in human glioblastoma cells. Biol Trace Elem Res. 2012 Dec;149(3):331-9.
• [11] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [12] Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
• [13] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [14] Absence of Metallothionein 3 Expression in Breast Cancer is a Rare, But Favorable Marker of Outcome that is Under Epigenetic Control. Toxicol Environ Chem. 2010 Oct;92(9):1673-1695. doi: 10.1080/02772241003711274.
• [15] Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer. Cancer Res. 2005 Aug 1;65(15):6789-800. doi: 10.1158/0008-5472.CAN-04-2684.
• [16] Metallothionein 3: an androgen-upregulated gene enhances cell invasion and tumorigenesis of prostate carcinoma cells. Prostate. 2013 Oct;73(14):1495-506. doi: 10.1002/pros.22697. Epub 2013 Jun 21.
• [17] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.