Details of the Drug

General Information of Drug (ID: DMQL8XJ)

Drug Name
Decitabine
Synonyms
AzadC; Dacogen; Dezocitidine; NCGC_5ADOC; Dacogen (TN); E-7373; Decitabine (USAN/INN); Dacogen, 5-aza-2'-deoxycytidine,NSC 127716, Dacogen, DAC, Decitabine; 2'-Deoxy-5-azacytidine; 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one; 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one; 4-Amino-1-(2-deoxy-beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one; 5-AZAdC; 5-Aza-2′-Deoxycytidine; 5-Aza-2'-deoxycytidine; 5-Azadeoxycytidine; 5-Deoxy-2′-azacytidine; 5-aza-2-deoxycytidine; 5-aza-CdR; 5-aza-dC; 5A2dc
Indication
Disease Entry ICD 11 Status REF
Acute myelogenous leukaemia 2A41 Approved [1]
Adult acute monocytic leukemia N.A. Approved [1]
Myelodysplastic syndrome 2A37 Approved [2]
Refractory chronic myeloid leukaemia 2A20 Approved [1]
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
ATC Code
L01BC08: Decitabine
L01BC: Pyrimidine analogues
L01B: ANTIMETABOLITES
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 228.21
Logarithm of the Partition Coefficient (xlogp) -1.2
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 1332 mcgh/L [3]
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 73.8 mcg/L [3]
Clearance
The drug present in the plasma can be removed from the body at the rate of 130 mL/min/kg [4]
Elimination
Less than 1% of administered decitabine is excreted in the urine [5]
Half-life
The concentration or amount of drug in body reduced by one-half in 0.62 hours [3]
Metabolism
The drug is metabolized via the sequential action of deoxycytidine kinase, nucleotide monophosphate kinase, and nucleotide diphosphate kinase [6]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 4.8733 micromolar/kg/day [7]
Unbound Fraction
The unbound fraction of drug in plasma is 1% [4]
Vd
The volume of distribution (Vd) of drug is 4.59 +/- 1.42 L/kg [5]
Chemical Identifiers
Formula
C8H12N4O4
IUPAC Name
4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
Canonical SMILES
C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O
InChI
InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
InChIKey
XAUDJQYHKZQPEU-KVQBGUIXSA-N
Cross-matching ID
PubChem CID
451668
ChEBI ID
CHEBI:50131
CAS Number
2353-33-5
UNII
776B62CQ27
DrugBank ID
DB01262
TTD ID
D0X5XU
INTEDE ID
DR1763
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Modulator [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytidine aminohydrolase (CDA) DEKEDRC CDD_HUMAN Substrate [9]
Cytidine deaminase (cdd) DEYILK4 E0TLJ6_MYCHH Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) OT5I4Y9K PLCB_HUMAN Gene/Protein Processing [11]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) OTY829Z3 ABHD5_HUMAN Gene/Protein Processing [12]
1-aminocyclopropane-1-carboxylate synthase-like protein 1 (ACCS) OTHIHI9D 1A1L1_HUMAN Gene/Protein Processing [12]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2) OTGVC9MY PLCG2_HUMAN Gene/Protein Processing [12]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Gene/Protein Processing [13]
14 kDa phosphohistidine phosphatase (PHPT1) OTFYWNFX PHP14_HUMAN Gene/Protein Processing [12]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Gene/Protein Processing [14]
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) OT0ETO72 DHB14_HUMAN Gene/Protein Processing [12]
182 kDa tankyrase-1-binding protein (TNKS1BP1) OTBIZECQ TB182_HUMAN Gene/Protein Processing [15]
2'-5'-oligoadenylate synthase 2 (OAS2) OT64CCTM OAS2_HUMAN Gene/Protein Processing [16]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 149 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 -1.1984 7.4986 -2.2999 48.7089
MEC1 CTRP2 5.342 13.0016 1.9644 18.1754
JM1 CTRP2 -5.5044 5.8168 -6.4977 66.2432
JURL-MK1 CTRP2 -9.6554 -1.3653 -9.7713 85.1582
BV-173 CTRP2 -9.2454 -2.5624 -9.2851 86.9971
EoL-1 CTRP2 -7.7787 2.2038 -8.1927 76.2189
DoHH2 CTRP2 -7.7256 5.446 -8.8241 71.7998
GA-10 CTRP2 -7.6436 5.8241 -8.8342 71.212
697 CTRP2 -6.9714 -0.6689 -7.0321 79.1818
SU-DHL-8 CTRP2 -6.4888 -0.0471 -6.5693 76.7873
WSU-DLCL2 CTRP2 -6.467 1.2505 -6.6609 74.6613
MOLM-16 CTRP2 -6.0391 0.6877 -6.1552 74.2575
KE-37 CTRP2 -5.9383 -2.9217 -5.9387 78.8753
TALL-1 [Human adult T-ALL] CTRP2 -5.9072 7.4462 -7.4069 65.7815
Reh CTRP2 -5.7284 2.6208 -6.0568 70.5557
MOLT-16 CTRP2 -5.6777 -0.8401 -5.6991 75.1938
NU-DUL-1 CTRP2 -5.6694 1.2888 -5.9476 68.4987
NB4 CTRP2 -5.5759 -1.1785 -5.5879 75.2064
NALM-6 CTRP2 -5.2288 1.0038 -5.3334 70.9711
RS4;11 CTRP2 -5.2111 4.354 -5.967 67.694
KMS-21-BM CTRP2 -5.0806 5.7521 -6.018 65.0759
MOLM-13 CTRP2 -4.9613 0.5839 -5.0249 70.4052
SU-DHL-4 CTRP2 -4.9596 3.5081 -5.3793 66.9725
KMS-26 CTRP2 -4.8262 0.5658 -4.884 69.8389
KMS-12-BM CTRP2 -4.7837 15.2902 -9.1423 58.5342
NCO2 CTRP2 -4.5269 3.1512 -4.8507 65.7703
ST486 CTRP2 -4.3425 12.6894 -7.607 58.5518
EM-2 CTRP2 -4.2467 2.8612 -4.5049 64.9323
Peer CTRP2 -4.2373 3.4692 -4.5927 64.3168
SU-DHL-10 CTRP2 -4.1724 0.1732 -4.1949 67.0222
SUP-B15 CTRP2 -4.1351 3.033 -4.4112 64.3018
P12-Ichikawa CTRP2 -3.9139 1.6874 -4.0144 64.4886
BCP-1 CTRP2 -3.5192 6.5391 -4.5318 59.1715
MOLM-6 CTRP2 -3.3183 8.3938 -4.8994 57.463
RPMI-8402 CTRP2 -3.0844 3.8667 -3.4192 58.9102
CML-T1 CTRP2 -3.0247 3.5751 -3.3046 58.7808
SEM CTRP2 -2.9628 4.7065 -3.4551 57.8736
SU-DHL-6 CTRP2 -2.5973 3.0897 -2.7747 56.7602
HEL CTRP2 -2.3857 2.9548 -2.5327 55.6138
SKM-1 CTRP2 -2.3458 4.0702 -2.6585 55.0481
U-937 CTRP2 -2.2525 0.8767 -2.2609 55.2185
Daudi CTRP2 -2.066 3.5778 -2.2757 53.6172
OCI-AML-2 CTRP2 -1.903 3.7092 -2.121 52.6493
SET-2 CTRP2 -1.7524 8.9503 -3.4036 51.2575
HT CTRP2 -1.6487 6.5628 -2.4984 50.9559
Namalwa CTRP2 -1.6458 11.4358 -4.2536 50.6885
DB CTRP2 -1.5868 13.0919 -4.8842 50.428
ALL-SIL CTRP2 -1.545 2.931 -1.6409 50.5341
PF-382 CTRP2 -1.4685 6.0215 -2.1484 50.0415
Kasumi-2 CTRP2 -1.4099 7.2224 -2.4404 49.7489
NOMO-1 CTRP2 -1.2733 11.119 -3.7321 49.2736
NU-DHL-1 CTRP2 -1.1903 8.8352 -2.757 48.7818
HPB-ALL CTRP2 -1.1569 8.6885 -2.6675 48.6149
Ku812 CTRP2 -0.8912 6.5828 -1.6782 46.9611
Jurkat CTRP2 -0.8788 6.1258 -1.5335 46.7987
DND-41 CTRP2 -0.8771 5.5734 -1.386 46.6749
CMK CTRP2 -0.6225 8.3006 -1.952 45.9427
M-07e CTRP2 -0.5438 11.0916 -2.954 46.2806
MOLT-3 CTRP2 -0.3964 10.762 -2.6633 45.5535
KCL-22 CTRP2 -0.1087 8.3443 -1.4142 43.2652
JJN-3 CTRP2 0.04 8.0542 -1.1494 42.3108
MOLP-8 CTRP2 0.1093 14.1113 -3.594 44.4863
Raji CTRP2 0.1907 9.599 -1.573 42.2962
TF-1 CTRP2 0.2977 10.0698 -1.6496 41.9978
L-363 CTRP2 0.3666 8.1659 -0.8378 40.5298
KYO-1 CTRP2 0.415 6.3622 -0.1887 39.0719
A4/Fukuda CTRP2 0.4876 8.3089 -0.7602 39.9292
MHH-CALL-4 CTRP2 0.4969 11.9288 -2.229 42.003
HEL 92.1.7 CTRP2 0.5138 8.0641 -0.6424 39.6127
OCI-Ly3 CTRP2 0.5308 14.214 -3.216 42.8934
KMS-11 CTRP2 0.5674 17.4564 -4.6863 43.9102
LAMA-84 CTRP2 0.6081 5.9415 0.1394 37.5438
OCI-M1 CTRP2 0.615 28.8739 -10.16 46.0837
P31/FUJ CTRP2 0.8831 8.7996 -0.5231 38.0125
Karpas-422 CTRP2 1.015 9.125 -0.511 37.5182
RPMI-8226 CTRP2 1.0296 11.3987 -1.4497 39.17
OPM-2 CTRP2 1.1884 10.7143 -0.9892 37.8558
Ri-1 CTRP2 1.2379 21.2252 -5.8477 43.0209
JeKo-1 CTRP2 1.7817 14.1101 -1.9238 37.6081
Granta-519 CTRP2 1.8313 12.9549 -1.3381 36.4742
Kasumi-1 CTRP2 2.1257 11.2026 -0.2437 33.2995
OCI-Ly10 CTRP2 2.1716 13.2562 -1.1407 35.1079
SUP-T11 CTRP2 2.3457 6.8862 1.7502 26.7099
PL21 CTRP2 2.5408 9.3726 0.9873 28.6505
MOLT-13 CTRP2 2.8406 10.0343 1.0052 27.7195
MV4-11 CTRP2 2.9336 6.7661 2.4282 22.5167
JVM-3 CTRP2 2.9867 19.1304 -3.1939 36.3824
MM1.S CTRP2 3.0365 15.1433 -1.2034 32.877
MOTN-1 CTRP2 3.2905 16.9529 -1.8461 33.4921
CA46 CTRP2 3.7437 8.9915 2.3891 20.3939
EB1 CTRP2 3.9937 12.228 1.1126 24.286
KMS-34 CTRP2 4.1365 7.9895 3.2332 16.0962
SIG-M5 CTRP2 4.1695 12.7698 1.015 24.167
K-562 CTRP2 4.2561 11.7398 1.597 21.9953
SU-DHL-1 CTRP2 4.3626 12.1564 1.4943 22.0948
KE-97 CTRP2 4.4753 13.2052 1.0848 23.2036
MHH-CALL-3 CTRP2 4.5476 14.3623 0.5805 24.6181
RCH-ACV CTRP2 4.574 8.5821 3.4096 14.2761
SUP-M2 CTRP2 4.6018 7.9077 3.7455 12.8624
A3/Kawakami CTRP2 4.6251 10.7145 2.4419 17.9882
RL CTRP2 4.711 14.5973 0.6115 24.1462
OCI-Ly19 CTRP2 4.8327 11.3523 2.3235 17.9596
HuNS1 CTRP2 4.8679 9.9016 3.065 14.9595
HL-60 CTRP2 4.8682 12.3166 1.8812 19.5318
Mino CTRP2 5.1939 11.5041 2.5769 16.1665
SUP-T1 CTRP2 5.3064 22.6222 -2.8672 30.9579
KM-H2 CTRP2 5.3233 20.0314 -1.5588 28.3926
SK-MM-2 CTRP2 5.4841 10.1764 2.835 9.7709
KO52 CTRP2 5.523 26.4438 -4.593 33.2019
P3HR-1 CTRP2 5.7629 21.0371 -1.6878 27.7924
F-36P CTRP2 5.7647 27.9672 -5.151 33.5138
KMS-27 CTRP2 5.8073 18.8966 -0.5803 25.1148
Hs 611.T CTRP2 5.8193 13.3882 2.1832 16.3578
EJM CTRP2 6.0037 20.1363 -1.0355 25.849
THP-1 CTRP2 6.2658 10.4196 4.0384 8.0101
OCI-AML-3 CTRP2 6.4407 9.6273 4.5716 5.4664
L-1236 CTRP2 6.4887 8.4477 5.1899 2.8194
Toledo CTRP2 6.5021 10.2056 4.3318 6.3609
Mono-Mac-1 CTRP2 6.503 12.7918 3.0449 11.6648
SR CTRP2 6.5623 12.7175 3.129 11.2178
Pfeiffer CTRP2 6.5926 22.5494 -1.7559 26.3748
LP-1 CTRP2 6.6404 13.0324 3.0338 11.4597
MC116 CTRP2 6.6826 15.3894 1.8925 15.7546
BL-70 CTRP2 6.7096 17.1516 1.035 18.6587
GDM-1 CTRP2 6.8684 12.6416 3.4049 9.5605
KHM-1B CTRP2 6.9369 15.7505 1.9136 15.2128
RPMI-6666 CTRP2 6.9733 17.6429 0.9999 18.2852
Karpas-299 CTRP2 7.0109 19.1757 0.2658 20.4841
ME1 CTRP2 7.2969 13.8556 3.1271 9.9612
HuT 78 CTRP2 7.3361 11.2346 4.4308 4.6558
JVM-2 CTRP2 7.5141 15.01 2.7197 11.2006
DEL CTRP2 7.6306 8.5402 5.753 0.0591
L-540 CTRP2 7.6525 12.4341 4.07 5.6533
Karpas-620 CTRP2 7.681 8.9776 5.6172 0.2381
SUP-HD1 CTRP2 7.7728 12.7985 3.9765 5.8574
L-428 CTRP2 7.8363 9.6058 5.4438 0.5505
EHEB CTRP2 8.124 22.3518 -0.4477 20.5528
AML-193 CTRP2 8.161 15.2266 3.0751 8.8349
KMS-18 CTRP2 8.3289 15.2485 3.1788 8.1974
Mono-Mac-6 CTRP2 8.3895 18.0106 1.8852 12.8935
HDLM-2 CTRP2 8.409 14.7076 3.4894 6.8966
KMS-20 CTRP2 8.4306 24.0577 -1.0592 21.6211
HD-MY-Z CTRP2 8.4681 13.008 4.315 3.7081
REC-1 CTRP2 8.6594 10.7755 5.3455 0.4112
MOLP-2 CTRP2 8.7595 10.1747 5.5932 0.0629
Ki-JK CTRP2 8.8979 20.9014 0.8389 15.5919
NCI-H929 CTRP2 9.889 20.0547 1.9257 10.6266
U266B1 CTRP2 12.5924 30.333 -1.1723 16.1776
OCI-AML-5 CTRP2 13.3566 29.6106 -0.3456 13.2383
⏷ Show the Full List of 149 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 6.191 10.3715 4.0018 8.3026
TE8 CTRP2 7.1639 10.3397 3.8847 2.3127
TE-4 CTRP2 7.156 17.1072 0.6695 15.7718
KYSE-450 CTRP2 7.6384 9.0694 5.5654 0.3601
EC-GI-10 CTRP2 7.8059 11.6275 4.5486 3.5896
TE-6 CTRP2 7.8541 17.9554 0.7541 14.2361
OE19 CTRP2 7.9622 9.3565 5.5893 0.201
KYSE-150 CTRP2 8.0193 9.5656 5.5356 0.2751
OE33 CTRP2 8.4049 15.4977 3.1107 8.3516
KYSE-520 CTRP2 8.4781 10.5341 5.3617 0.4463
KYSE-410 CTRP2 8.5081 10.0896 5.5338 0.1539
TE-14 CTRP2 8.5126 10.4084 5.422 0.3199
KYSE-70 CTRP2 8.5708 10.3508 5.4652 0.2335
TE-1 CTRP2 9.3494 15.7476 3.592 5.3712
OE21 CTRP2 9.4157 20.6557 1.3217 13.2854
COLO 680N CTRP2 10.0289 19.7076 2.1794 9.5822
TE-10 CTRP2 10.088 22.0156 1.1254 12.9852
KYSE-140 CTRP2 10.1672 20.6599 1.8206 10.6215
TE-9 CTRP2 10.3673 18.463 2.9606 6.4873
TE-5 CTRP2 11.7218 34.1574 -3.6076 22.4103
KYSE-30 CTRP2 12.542 23.525 1.941 7.579
TE-11 CTRP2 13.1338 34.4574 -2.7766 19.1068
KYSE-510 CTRP2 13.2317 26.6944 0.916 9.9287
KYSE-180 CTRP2 14.8414 29.7818 0.4575 9.6326
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 9.5258 16.1592 3.5094 5.4734
SU.86.86 CTRP2 4.1069 7.3223 3.0537 11.9965
HPAC CTRP2 6.075 12.4139 2.8851 13.1163
PaTu 8988t CTRP2 6.9926 10.2581 4.6659 4.1995
SNU-213 CTRP2 7.0751 17.3075 1.2471 17.2865
QGP-1 CTRP2 7.1012 24.0955 -2.1163 26.2352
KP-4 CTRP2 7.148 17.1338 1.3904 16.6723
KP-2 CTRP2 7.494 9.8248 5.1818 1.6052
CFPAC-1 CTRP2 7.6593 9.3839 5.4517 0.6289
KP-3 CTRP2 7.7121 15.2115 2.7655 10.707
Panc 10.05 CTRP2 7.7312 12.2383 4.2151 4.9736
PANC-1 CTRP2 7.7442 18.699 1.0718 16.6978
PK-45H CTRP2 7.8884 10.5153 5.0943 1.5437
Panc 03.27 CTRP2 8.0144 12.5708 4.2404 4.5131
Panc 02.03 CTRP2 8.1479 11.8052 4.6707 2.7594
Panc 04.03 CTRP2 8.1565 12.811 4.2174 4.4278
Hs 766T CTRP2 8.1799 9.8787 5.4845 0.3154
YAPC CTRP2 8.2546 13.1934 4.101 4.7517
Capan-1 CTRP2 8.274 9.8258 5.54 0.1961
MIA PaCa-2 CTRP2 8.3249 10.0367 5.4838 0.2708
HuP-T4 CTRP2 8.4509 12.033 4.738 2.2351
L3.3 CTRP2 8.4681 9.6905 5.6552 0.0472
Panc 05.04 CTRP2 8.471 15.6826 3.0668 8.4269
Panc 08.13 CTRP2 8.6458 10.8593 5.3087 0.4891
Capan-2 CTRP2 8.7443 10.6558 5.4221 0.2545
PaTu 8902 CTRP2 9.1135 16.5103 3.0946 7.4718
TCC-Pan2 CTRP2 9.2433 28.4922 -2.6379 23.8864
BxPC-3 CTRP2 9.2668 24.7771 -0.7909 19.6524
SUIT-2 CTRP2 9.2991 19.5275 1.7845 11.9055
DAN-G CTRP2 9.7106 20.0357 1.8176 11.2288
AsPC-1 CTRP2 9.8873 18.3314 2.7316 7.832
HPAF-II CTRP2 9.9284 20.2862 1.842 10.858
PSN1 CTRP2 10.9842 29.289 -1.7629 19.5763
PK-59 CTRP2 11.0508 30.0686 -2.0944 20.2276
HuP-T3 CTRP2 11.0537 23.3002 1.1485 11.6721
SW1990 CTRP2 11.8937 23.6997 1.484 9.6578
PaTu 8988s CTRP2 12.157 22.9032 1.9995 7.7789
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 10.7134 29.4138 -2.0148 20.5013
Hs 852.T CTRP2 6.1033 15.6466 1.2923 18.9743
WT2-iPS CTRP2 6.8307 8.6177 5.3391 1.7462
Mel Ho CTRP2 6.8601 12.7377 3.3508 9.7942
SK-MEL-2 CTRP2 7.0242 8.0743 5.6833 0.3855
SK-MEL-30 CTRP2 7.1595 9.3932 5.1828 1.9512
IGR-39 CTRP2 7.162 8.8173 5.4413 1.026
SK-MEL-1 CTRP2 7.1836 8.5267 5.575 0.5873
WM266-4 CTRP2 7.189 10.1853 4.8324 3.2623
Hs 839.T CTRP2 7.3177 8.5722 5.6187 0.3884
SK-MEL-28 CTRP2 7.3344 8.3565 5.7077 0.1877
Hs 934.T CTRP2 7.3503 8.454 5.6779 0.2399
IGR-37 CTRP2 7.374 11.6665 4.2494 5.3289
HT-144 CTRP2 7.3868 10.7114 4.7123 3.4762
Hs 688(A).T CTRP2 7.4664 8.4798 5.7143 0.1377
WM1799 CTRP2 7.4888 11.5399 4.3871 4.6203
Hs 895.T CTRP2 7.5055 9.4227 5.3614 0.9985
UACC-62 CTRP2 7.5416 8.6691 5.675 0.1799
G-361 CTRP2 7.5842 13.0097 3.7465 7.0401
HMCB CTRP2 7.631 8.5328 5.7556 0.0567
WM115 CTRP2 7.6784 9.0454 5.591 0.2895
IPC-298 CTRP2 7.6896 11.2085 4.6706 3.2646
Hs 940.T CTRP2 7.6963 9.2189 5.5328 0.4071
COLO 829 CTRP2 7.8028 13.4102 3.7039 6.8932
A-375 CTRP2 7.9062 13.9278 3.5257 7.4484
UACC-257 CTRP2 7.9237 9.2173 5.6243 0.1579
IGR-1 CTRP2 7.9257 13.954 3.5264 7.4178
COLO 800 CTRP2 7.9372 11.0947 4.8677 2.2723
A101D CTRP2 7.9521 8.9297 5.733 0.0404
SK-MEL-31 CTRP2 8.0132 9.2935 5.6307 0.1301
MeWo CTRP2 8.033 12.3091 4.3733 3.9842
RVH-421 CTRP2 8.0719 9.3403 5.6357 0.113
SK-MEL-5 CTRP2 8.1629 12.7735 4.2387 4.3394
K029AX CTRP2 8.1745 9.3665 5.663 0.0706
WM88 CTRP2 8.2078 14.5475 3.4326 7.3879
MDA-MB-435S CTRP2 8.2472 9.6372 5.5962 0.1277
SK-MEL-24 CTRP2 8.3985 9.7474 5.6123 0.0874
WM983B CTRP2 8.4579 12.0087 4.7522 2.1812
COLO 792 CTRP2 8.4603 15.378 3.205 7.9158
Hs 936.T CTRP2 8.4703 16.0957 2.8685 9.1781
COLO 741 CTRP2 8.4928 25.7592 -1.8543 23.3759
Hs 944.T CTRP2 8.5561 16.6254 2.6725 9.7896
RPMI-7951 CTRP2 8.5655 18.8035 1.6243 13.5286
Mel JuSo CTRP2 8.7845 18.6784 1.8396 12.4571
LOX-IMVI CTRP2 8.88 15.3919 3.4695 6.3704
SK-MEL-3 CTRP2 9.4662 16.8324 3.1652 6.7823
WM793 CTRP2 9.7391 19.8257 1.9361 10.7881
CJM [Human melanoma] CTRP2 12.1224 23.4424 1.7368 8.6308
Hs 294T CTRP2 13.1086 23.551 2.241 6.1532
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 8.1232 26.5314 -2.5224 25.3673
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Kelly CTRP2 -1.3758 13.5564 -4.8657 49.7158
SiMa CTRP2 1.3592 18.8503 -4.5858 41.8155
IMR-32 CTRP2 2.1819 10.6828 0.0457 32.4126
CHP-126 CTRP2 3.8716 27.4632 -6.5255 38.2794
NB1 CTRP2 5.1831 9.3653 3.621 11.9731
KP-N-SI9s CTRP2 5.5182 15.3115 0.9654 21.2568
MHH-NB-11 CTRP2 5.8926 16.4752 0.7019 21.316
SK-N-DZ CTRP2 7.1051 10.849 4.4583 4.8757
CHP-212 CTRP2 7.2363 14.2286 2.8982 10.9649
SK-N-BE(2) CTRP2 7.3525 11.0329 4.538 4.2071
SK-N-AS CTRP2 8.0125 9.3187 5.6216 0.1419
SK-N-FI CTRP2 8.0604 9.7399 5.4877 0.3519
SK-N-SH CTRP2 8.0789 14.0735 3.5726 7.0217
KP-N-YN CTRP2 8.0943 10.5551 5.1817 1.1097
NH-6 CTRP2 8.168 16.642 2.3942 11.397
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 5.8505 20.7717 -1.4815 27.1728
SNU-478 CTRP2 6.6461 18.6225 0.2495 21.2076
SNU-245 CTRP2 6.9463 11.4911 4.0313 6.866
SNU-1196 CTRP2 7.8267 12.3306 4.2336 4.7768
HuCC-T1 CTRP2 7.9642 15.0785 3.01 9.3761
SNU-308 CTRP2 8.0965 9.4393 5.6102 0.1394
HuH-28 CTRP2 8.1502 9.3538 5.6589 0.0773
SNU-869 CTRP2 8.9227 18.9697 1.7948 12.4091
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC CTRP2 2.9105 12.0479 0.1517 30.016
MHH-ES-1 CTRP2 5.9056 25.9264 -4.0125 31.7005
A-673 CTRP2 6.5881 18.4141 0.3067 21.149
U2OS CTRP2 6.9848 10.2535 4.6627 4.2239
Hs 822.T CTRP2 7.0884 8.1453 5.6843 0.3463
Hs 888.T CTRP2 7.8964 10.0632 5.2882 0.9347
SaOS-2 CTRP2 7.8964 9.9232 5.3451 0.7743
SJSA-1 CTRP2 8.0581 19.7396 0.0317 16.4363
G-292 clone A141B1 CTRP2 8.2117 12.1903 4.5345 3.1839
SW1353 CTRP2 8.4523 9.8266 5.6042 0.0878
HOS CTRP2 8.4818 9.6896 5.6601 0.0432
CAL-78 CTRP2 8.7243 10.2516 5.5553 0.097
SK-ES-1 CTRP2 8.9335 19.8155 1.3927 13.7536
TC71 CTRP2 10.4945 25.2306 -0.1411 16.1726
MG-63 CTRP2 13.2728 26.5604 1.0006 9.6451
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 71 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-468 CTRP2 -2.7754 2.3273 -2.8772 58.0613
DU4475 CTRP2 0.8048 8.341 -0.4317 38.1085
HCC1806 CTRP2 2.5661 13.1971 -0.7257 33.1246
CAL-148 CTRP2 3.2484 9.1697 1.8047 23.8811
MDA-MB-157 CTRP2 6.2965 9.6988 4.4229 6.3441
KPL-1 CTRP2 6.6685 7.6656 5.6758 0.7871
HCC1419 CTRP2 7.1769 13.7622 3.0839 10.3307
ZR-75-1 CTRP2 7.3802 8.7261 5.5861 0.4368
MCF-7 CTRP2 7.418 10.7674 4.706 3.461
HMC-1-8 CTRP2 7.593 8.8001 5.6474 0.2121
MDA-MB-231 CTRP2 7.6256 10.9633 4.7444 3.0605
Hs 578Bst CTRP2 7.6792 9.1136 5.5657 0.3417
HCC1428 CTRP2 7.758 9.1913 5.5691 0.3033
SK-BR-3 CTRP2 7.7911 10.1803 5.1867 1.3245
BT-474 CTRP2 7.8232 9.1042 5.6267 0.1795
AU565 CTRP2 7.83 10.4802 5.0784 1.6474
CAL-120 CTRP2 7.9889 9.271 5.6296 0.1364
HCC2218 CTRP2 8.0383 9.9027 5.4167 0.5151
ZR-75-30 CTRP2 8.1647 9.732 5.5319 0.2372
HCC1937 CTRP2 8.1851 9.9577 5.4573 0.3657
MDA-MB-361 CTRP2 8.2235 10.0426 5.4413 0.3832
JIMT-1 CTRP2 8.224 9.8662 5.5064 0.2625
BT-20 CTRP2 8.2522 9.5936 5.6131 0.1079
HCC1395 CTRP2 8.2718 11.5589 4.8476 2.0275
CAMA-1 CTRP2 8.2789 10.9199 5.121 1.1597
BT-549 CTRP2 8.4385 10.1808 5.4756 0.2519
EFM-192A CTRP2 8.4636 12.8395 4.3884 3.4461
HCC202 CTRP2 8.6078 10.7236 5.3439 0.4329
HDQ-P1 CTRP2 8.6838 19.5093 1.3647 14.2229
MDA-MB-453 CTRP2 8.7283 10.438 5.4928 0.1622
CAL-51 CTRP2 8.893 18.152 2.1686 11.1423
T-47D CTRP2 9.4335 11.817 5.2689 0.311
CAL-85-1 CTRP2 9.7148 18.2939 2.6414 8.3608
Hs 578T CTRP2 9.7637 24.3175 -0.2087 17.3788
HCC1500 CTRP2 10.0088 19.8631 2.0935 9.9014
HCC1143 CTRP2 10.2623 24.7346 -0.0619 16.2711
HCC38 CTRP2 10.7795 30.9666 -2.7247 21.9139
HCC1954 CTRP2 11.1045 26.2094 -0.1967 15.5172
BT 444 CTRP2 7.0233 10.5204 4.5604 4.5822
BT 328 CTRP2 7.111 9.205 5.2397 1.7942
BT 286 CTRP2 7.3201 16.158 2.0075 14.1968
BT 271 CTRP2 7.3476 9.7418 5.1357 1.918
BT 504 CTRP2 7.5912 9.4086 5.4097 0.7899
BT 179 CTRP2 7.6034 8.8859 5.62 0.2601
BT 340 CTRP2 7.6814 9.0538 5.5891 0.2922
BT 320 CTRP2 7.6902 8.507 5.7845 0.0294
BT 482 CTRP2 7.7188 9.2637 5.5252 0.4142
BT 333 CTRP2 7.7665 9.2387 5.5548 0.3291
BT 416 CTRP2 7.8134 41.9435 -10.4531 35.7552
BT 216 CTRP2 7.8357 15.524 2.7018 10.7563
BT 228 CTRP2 7.8385 10.0304 5.2736 1.0182
BT 172 CTRP2 7.8876 15.3666 2.8158 10.2401
BT 248 CTRP2 7.9464 10.3609 5.1894 1.1939
BT 131 CTRP2 7.9948 9.5135 5.545 0.2661
BT 224 CTRP2 8.0253 9.4913 5.565 0.2226
BT 440 CTRP2 8.1145 9.2484 5.682 0.0617
BT 359 CTRP2 8.1255 9.3995 5.6345 0.1052
BT 428 CTRP2 8.3043 18.9211 1.3785 14.7674
BT 232 CTRP2 8.3885 9.6528 5.6407 0.0647
BT 245 CTRP2 8.4636 10.159 5.4929 0.2188
BT 498 CTRP2 8.5733 18.2586 1.895 12.5791
BT164 CTRP2 8.6832 14.4937 3.764 5.5068
BT 112 CTRP2 8.9051 17.7015 2.3931 10.3199
BT 239 CTRP2 8.9517 18.0911 2.2379 10.8116
BT 330 CTRP2 9.6601 19.5407 2.0194 10.6077
BT147 CTRP2 10.3473 24.659 0.0332 15.8891
BT 139 CTRP2 10.5778 18.7132 2.9703 6.2309
BT 231 CTRP2 12.0849 23.8863 1.5133 9.36
BT 145 CTRP2 12.0851 27.7822 -0.2968 14.5647
BT 187 CTRP2 12.2393 24.193 1.4654 9.3413
BT 159 CTRP2 12.3231 23.7991 1.6929 8.5583
⏷ Show the Full List of 71 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 11.269 22.4475 1.68 9.7456
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med CTRP2 -1.4867 6.057 -2.1779 50.1382
KNS-81 CTRP2 6.0468 9.8256 3.4289 5.8762
KNS-60 CTRP2 6.4406 8.7107 4.2025 1.8333
SF295 CTRP2 6.8009 9.5933 4.854 3.7184
CAS-1 CTRP2 6.9625 13.9339 2.8362 13.3461
CCF-STTG1 CTRP2 7.0651 8.4648 5.5417 0.7789
LN-229 CTRP2 7.1374 10.1848 4.7989 3.4631
NMC-G1 CTRP2 7.1545 8.6102 5.5259 0.7573
DK-MG CTRP2 7.4562 9.0429 5.4945 0.637
GMS-10 CTRP2 7.5047 8.5073 5.7189 0.1214
YKG-1 CTRP2 7.5229 9.0554 5.5203 0.5268
SNU-738 CTRP2 7.5538 9.208 5.4735 0.6336
SNU-489 CTRP2 7.5562 9.0804 5.5254 0.4953
Hs 683 CTRP2 7.6061 13.2755 3.6331 7.4609
SNU-626 CTRP2 7.6713 8.9534 5.6223 0.2321
SNU-1105 CTRP2 7.6816 11.576 4.4949 3.9471
SF126 CTRP2 7.7219 9.3181 5.5056 0.4585
LN-18 CTRP2 7.7308 8.6189 5.7611 0.0412
U-87MG ATCC CTRP2 7.7757 9.1799 5.5805 0.2745
TM-31 CTRP2 7.7848 9.1591 5.5918 0.2502
SNU-466 CTRP2 7.7882 8.8745 5.6945 0.0954
A-172 CTRP2 7.8769 10.3426 5.162 1.334
Becker CTRP2 7.9274 9.8278 5.3972 0.6188
Daoy CTRP2 8.0323 9.8405 5.438 0.4691
KNS-42 CTRP2 8.074 9.3934 5.618 0.134
KG-1-C CTRP2 8.0973 9.3834 5.63 0.1152
8-MG-BA CTRP2 8.1274 9.7 5.5291 0.2528
SF539 CTRP2 8.1369 9.6164 5.5628 0.1962
U-251MG CTRP2 8.1496 9.7253 5.5285 0.2472
DBTRG-05MG CTRP2 8.1561 10.349 5.2942 0.7568
M059K CTRP2 8.3009 9.4442 5.6804 0.045
42-MG-BA CTRP2 8.3077 10.1969 5.418 0.3978
KALS-1 CTRP2 8.3166 14.9117 3.3315 7.6283
SW1088 CTRP2 8.3448 12.4458 4.4967 3.1801
GaMG CTRP2 8.3586 9.6851 5.6194 0.0861
SW1783 CTRP2 8.5104 10.7992 5.2746 0.6218
T98G CTRP2 8.6088 10.0396 5.5867 0.0837
SNB-75 CTRP2 8.7347 12.5534 4.6641 2.2324
SF268 CTRP2 8.8001 10.518 5.491 0.1513
SNU-201 CTRP2 10.2767 22.9508 0.8051 13.7252
U-118MG CTRP2 10.447 22.8628 0.9607 13.022
ONS-76 CTRP2 11.2443 24.4422 0.734 12.6935
GB-1 CTRP2 11.2624 23.136 1.357 10.7727
YH-13 CTRP2 11.6332 22.2536 1.9878 8.359
GOS-3 CTRP2 11.66 22.1173 2.0652 8.0833
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-7 CTRP2 6.4656 10.426 4.194 7
JHUEM-2 CTRP2 7.0955 25.7627 -2.953 27.8795
KLE CTRP2 7.15 17.3617 1.2787 17.0463
HEC-265 CTRP2 7.2388 9.1049 5.3575 1.2401
MFE-319 CTRP2 7.4137 9.029 5.4799 0.7069
HEC-1-B CTRP2 7.5996 9.267 5.471 0.6126
HEC-1-A CTRP2 7.798 9.5331 5.4553 0.5421
HEC-6 CTRP2 7.8529 13.0369 3.9162 5.9854
EFE-184 CTRP2 7.8633 9.5613 5.4729 0.4673
ESS-1 CTRP2 7.9251 10.1014 5.2864 0.9207
EN CTRP2 7.9296 9.2644 5.6098 0.1778
AN3-CA CTRP2 8.1886 10.7344 5.1536 1.1267
HEC-251 CTRP2 8.2457 15.4174 3.0413 8.8422
HEC-50B CTRP2 8.7519 10.4094 5.5112 0.1369
JHUEM-1 CTRP2 8.7761 14.6207 3.7625 5.4016
MFE-296 CTRP2 9.6316 18.4368 2.5218 8.8892
HEC-151 CTRP2 9.7393 17.7072 2.9291 7.3076
JHUEM-3 CTRP2 10.0036 22.0657 1.0447 13.3535
HEC-59 CTRP2 11.7907 22.5551 1.9438 8.3314
RL95-2 CTRP2 12.2907 45.6641 -8.8315 29.1427
HEC-108 CTRP2 14.0749 25.5643 1.8853 6.3702
Ishikawa (Heraklio) 02 ER- CTRP2 7.06 15.2922 2.2372 13.8027
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMRC-2 CTRP2 7.5339 9.4904 5.3473 1.0207
KMRC-1 CTRP2 7.5479 10.3161 4.9933 2.2229
TUHR10TKB CTRP2 7.7386 8.9603 5.646 0.1718
OS-RC-2 CTRP2 7.7447 9.6629 5.3791 0.7754
BFTC-909 CTRP2 7.9446 9.7911 5.4192 0.5551
TUHR4TKB CTRP2 7.9671 9.6021 5.501 0.3608
UO-31 CTRP2 8.0068 10.389 5.2076 1.0946
RCC10RGB CTRP2 8.0939 9.9301 5.4299 0.4598
Caki-2 CTRP2 8.1242 9.463 5.6121 0.1315
SNU-1272 CTRP2 8.216 13.7847 3.7998 5.955
TUHR14TKB CTRP2 8.3051 14.5006 3.5194 6.9198
Caki-1 CTRP2 8.392 10.0303 5.5117 0.2088
VMRC-RCZ CTRP2 8.4626 9.8098 5.6135 0.0784
KMRC-20 CTRP2 8.5327 9.9744 5.5822 0.0974
786-O CTRP2 8.6077 10.0941 5.5679 0.1008
KMRC-3 CTRP2 8.6317 11.012 5.2449 0.6338
VMRC-RCW CTRP2 9.0265 17.6276 2.5098 9.7293
ACHN CTRP2 9.1215 14.7927 3.8906 4.5429
CAL-54 CTRP2 9.3078 17.3036 2.8466 8.1341
769-P CTRP2 10.5047 21.4323 1.6741 10.6796
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CCK-81 CTRP2 -2.1212 9.5177 -4.0088 52.6806
LS513 CTRP2 3.5374 13.1013 0.2578 28.0421
SNU-81 CTRP2 5.1347 24.684 -4.0439 33.141
SW48 CTRP2 5.9197 19.5818 -0.8285 25.5128
LS180 CTRP2 6.1952 11.6836 3.3495 11.0016
LoVo CTRP2 7.0279 18.2788 0.7262 19.0579
COLO 320 CTRP2 7.1365 10.4757 4.6595 4.0197
CL-11 CTRP2 7.3344 11.7338 4.1898 5.6254
COLO205 CTRP2 7.3681 11.8727 4.146 5.7528
DLD-1 CTRP2 7.3905 11.675 4.2565 5.2767
RCM-1 [Human ESC] CTRP2 7.3961 9.5027 5.2694 1.3956
COLO201 CTRP2 7.4278 15.4662 2.4309 12.4443
SNU-C1 CTRP2 7.4372 10.8367 4.6858 3.5153
SW948 CTRP2 7.4493 14.4325 2.9558 10.3891
COLO 678 CTRP2 7.4517 10.5761 4.8164 2.994
LS123 CTRP2 7.4589 9.3747 5.3579 1.0466
HCT 8 CTRP2 7.4857 8.6954 5.6431 0.2583
SW620 CTRP2 7.5326 13.8931 3.2806 8.976
HT115 CTRP2 7.5392 12.4202 3.9999 6.0922
CW-2 CTRP2 7.5407 13.6521 3.404 8.4733
HCT 116 CTRP2 7.6909 9.2346 5.5245 0.429
RKO CTRP2 7.743 9.4748 5.4537 0.5757
HCT 15 CTRP2 7.8245 12.7408 4.0382 5.5441
SNU-503 CTRP2 7.8494 11.7843 4.5029 3.7111
T84 CTRP2 7.8559 15.8449 2.5596 11.2639
OUMS-23 CTRP2 7.8795 8.9441 5.7031 0.0723
SNU-C4 CTRP2 7.8931 8.9476 5.7067 0.0672
SK-CO-1 CTRP2 7.9044 9.6751 5.4467 0.5091
HCC-56 CTRP2 7.9945 8.9886 5.7278 0.0402
HT-29 CTRP2 8.0005 8.9818 5.732 0.037
MDST8 CTRP2 8.0406 9.5748 5.5407 0.2594
LS411N CTRP2 8.0455 14.1892 3.4948 7.3717
KM12 CTRP2 8.1339 9.5745 5.5765 0.1768
SNU-61 CTRP2 8.1567 18.6752 1.3913 14.9603
GP2d CTRP2 8.2094 9.8129 5.52 0.244
SNU-C5 CTRP2 8.3747 14.3169 3.6516 6.3193
C2BBe1 CTRP2 8.4289 10.5096 5.3506 0.4892
NCI-H747 CTRP2 8.4373 10.689 5.2856 0.6309
HT-55 CTRP2 8.5264 19.4905 1.2609 14.809
SNU-1033 CTRP2 8.6341 12.0459 4.8281 1.7878
NCI-H716 CTRP2 8.7231 16.22 2.9785 8.4143
NCI-H508 CTRP2 8.882 19.4189 1.549 13.3072
LS1034 CTRP2 8.8909 16.6366 2.8912 8.5136
SW1417 CTRP2 9.1204 18.1926 2.303 10.3441
SNU-C2A CTRP2 10.7361 25.4803 -0.0962 15.7249
SNU-407 CTRP2 10.7567 28.7436 -1.6582 19.6399
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-886 CTRP2 6.9282 9.3834 5.0415 2.7838
JHH-5 CTRP2 7.0724 9.339 5.1547 2.1592
SNU-761 CTRP2 7.0935 8.5419 4.5729 0.222
JHH-2 CTRP2 7.1291 10.3167 4.7306 3.7462
JHH-6 CTRP2 7.1713 8.0197 5.7664 0.1354
SNU-182 CTRP2 7.2856 12.2021 3.9286 6.7541
JHH-1 CTRP2 7.3723 10.4348 4.8325 3.0291
PLC/PRF/5 CTRP2 7.5712 10.2421 5.04 2.0293
Hep-G2 CTRP2 7.6539 15.7846 2.4419 12.0305
Hep 3B2.1-7 CTRP2 7.7649 9.4115 5.4881 0.4789
SK-HEP-1 CTRP2 7.8222 8.9063 5.6957 0.0883
SNU-878 CTRP2 7.9686 10.5516 5.1204 1.3927
SNU-475 CTRP2 8.0202 9.2849 5.6362 0.1219
HuH-1 CTRP2 8.0257 9.1723 5.6768 0.0772
SNU-423 CTRP2 8.207 9.7467 5.5428 0.2085
HuH-6 CTRP2 8.2376 16.1 2.7063 18.3774
SNU-387 CTRP2 8.4825 18.2432 1.8381 12.916
JHH-4 CTRP2 8.8968 10.2793 5.6049 0.0448
HLF CTRP2 9.1193 16.7987 2.963 7.9493
SNU-449 CTRP2 9.1554 10.7326 5.5421 0.0623
Li-7 CTRP2 9.2237 25.1192 -0.9905 20.2207
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 140 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H211 CTRP2 1.9222 23.4555 -6.2969 41.8389
NCI-H1975 CTRP2 3.2636 9.2456 1.7868 23.9025
DV-90 CTRP2 3.4151 23.8857 -5.1521 37.8176
SK-MES-1 CTRP2 3.4742 9.5835 1.8499 23.1029
NCI-H510A CTRP2 4.0047 20.7333 -3.0621 33.9237
NCI-H650 CTRP2 4.6142 10.2666 2.6485 17.2104
HCC1588 CTRP2 4.6908 18.5829 -1.3858 29.349
NCI-H2141 CTRP2 5.2412 10.6754 3.0296 14.2602
NCI-H526 CTRP2 5.5338 11.0703 3.0942 13.3696
NCI-H23 CTRP2 6.2615 13.0721 2.7098 13.4518
HCC44 CTRP2 6.361 13.4023 2.6258 13.592
DMS 53 CTRP2 6.388 14.2995 2.1996 15.175
NCI-H2444 CTRP2 6.4886 7.8029 4.6036 0.3949
PC-14 CTRP2 6.5071 9.4494 3.9086 2.9853
NCI-H460 CTRP2 6.7049 9.9217 4.6249 4.8064
NCI-H226 CTRP2 6.7474 8.0974 4.5996 0.2873
NCI-H2023 CTRP2 6.7888 14.9337 2.2038 14.413
NCI-H2029 CTRP2 6.7955 8.6801 5.2876 1.99
COLO 668 CTRP2 6.801 17.4645 0.952 18.7576
NCI-H1734 CTRP2 6.8654 13.7276 2.8637 11.736
NCI-H1694 CTRP2 6.9326 9.1001 5.1781 2.2414
MOR/CPR CTRP2 6.9705 11.4187 4.0845 6.6085
NCI-H1105 CTRP2 7.0249 8.8687 5.3415 1.5133
NCI-H2009 CTRP2 7.0973 16.4612 1.6853 15.7412
NCI-H2081 CTRP2 7.1139 9.9237 4.9072 3.0668
RERF-LC-Ad1 CTRP2 7.1214 8.0254 5.7445 0.1931
NCI-H2228 CTRP2 7.1311 17.0373 0.6856 15.7576
NCI-H2196 CTRP2 7.1315 9.1081 5.2956 1.5664
HCC15 CTRP2 7.1518 14.4537 2.7232 11.7907
SBC-5 CTRP2 7.208 8.15 5.7332 0.1833
LK2 CTRP2 7.2483 8.12 5.7599 0.1242
COR-L51 CTRP2 7.287 11.7139 4.1666 5.7887
BEN CTRP2 7.3046 8.4634 5.6552 0.3082
NCI-H838 CTRP2 7.3114 10.3882 4.8158 3.1698
NCI-H1650 CTRP2 7.3281 13.1894 3.4771 8.5124
NCI-H1573 CTRP2 7.3471 10.7817 4.6536 3.7577
CAL-12T CTRP2 7.4148 11.9235 4.1537 5.6546
NCI-H209 CTRP2 7.5251 28.4101 -4.6409 28.6858
NCI-H1155 CTRP2 7.5382 9.4843 5.3521 1.0023
KNS-62 CTRP2 7.5417 9.2168 5.4643 0.6668
NCI-H661 CTRP2 7.5429 12.4701 3.9784 6.173
RERF-LC-Ad2 CTRP2 7.5777 10.9705 4.7117 3.2417
VMRC-LCD CTRP2 7.5827 9.6207 5.3171 1.0771
NCI-H1703 CTRP2 7.5917 14.2971 3.1257 9.4956
NCI-H1563 CTRP2 7.6336 9.1354 5.538 0.4247
DMS 114 CTRP2 7.6653 10.9088 4.7935 2.8304
Sq-1 CTRP2 7.6975 9.1502 5.5595 0.3473
NCI-H1581 CTRP2 7.7057 13.9134 3.3937 8.2631
LOU-NH91 CTRP2 7.7281 15.1962 2.7845 10.6085
HCC78 CTRP2 7.732 10.6043 4.9699 2.1157
NCI-H1092 CTRP2 7.7379 9.7222 5.3517 0.8583
NCI-H2286 CTRP2 7.7557 13.8157 3.476 7.8633
LC-1/sq-SF CTRP2 7.7647 8.9514 5.659 0.1459
HOP-92 CTRP2 7.8655 10.2148 5.2101 1.1916
COR-L95 CTRP2 7.9076 15.0341 2.9917 9.532
NCI-H1385 CTRP2 7.9088 9.6611 5.454 0.4896
Lu-99 CTRP2 7.9259 16.3624 2.357 11.9112
HCC2935 CTRP2 7.9306 9.8734 5.3806 0.6594
LUDLU-1 CTRP2 7.9389 11.5301 4.6733 2.9712
NCI-H1793 CTRP2 7.9581 9.9114 5.378 0.6509
Lu-65 CTRP2 7.9771 9.7634 5.444 0.4807
NCI-H196 CTRP2 7.988 9.4451 5.5673 0.2296
HCC4006 CTRP2 7.9994 9.5546 5.5318 0.2888
HCC366 CTRP2 8.0056 13.954 3.5805 7.0927
NCI-H1339 CTRP2 8.0198 9.3857 5.6007 0.1691
LCLC-103H CTRP2 8.0382 9.1862 5.6765 0.0758
NCI-H647 CTRP2 8.048 10.0529 5.3625 0.6413
NCI-H1184 CTRP2 8.0636 22.0608 -0.3495 20.3891
NCI-H2030 CTRP2 8.0681 10.2284 5.302 0.7871
IA-LM CTRP2 8.0982 9.4853 5.5947 0.1595
EBC-1 CTRP2 8.1156 17.9556 1.7144 13.9207
NCI-H1915 CTRP2 8.1407 11.4885 4.8071 2.2862
NCI-H2106 CTRP2 8.1431 15.0763 3.1352 8.6295
HCC95 CTRP2 8.1534 9.9532 5.446 0.4006
COR-L105 CTRP2 8.154 12.8999 4.1746 4.5935
HCC1438 CTRP2 8.1608 13.356 3.966 5.385
A-549 CTRP2 8.1619 13.577 3.8628 5.7821
NCI-H889 CTRP2 8.22 14.1649 3.6227 6.6348
NCI-H2170 CTRP2 8.226 10.7138 5.18 1.0254
NCI-H1435 CTRP2 8.2526 22.3993 -0.3736 20.1435
NCI-H2405 CTRP2 8.2586 28.3964 -3.3442 26.7153
HOP-62 CTRP2 8.2651 9.802 5.5451 0.1909
NCI-H2087 CTRP2 8.281 14.6971 3.41 7.3745
NCI-H1341 CTRP2 8.291 17.2629 2.1793 11.9944
NCI-H2172 CTRP2 8.3262 9.8055 5.5665 0.1488
Calu-3 CTRP2 8.3411 10.3058 5.391 0.4399
NCI-H1395 CTRP2 8.3462 11.053 5.0989 1.1782
NCI-H358 CTRP2 8.3814 18.0574 1.8566 13.0065
NCI-H441 CTRP2 8.3832 14.3674 3.6333 6.3785
NCI-H446 CTRP2 8.3915 10.1906 5.4539 0.3019
Calu-6 CTRP2 8.4105 14.6878 3.4997 6.855
LCLC-97TM1 CTRP2 8.4289 10.446 5.3745 0.4393
LXF 289 CTRP2 8.4416 14.7311 3.4996 6.8146
SK-LU-1 CTRP2 8.4452 13.1056 4.2572 3.9452
NCI-H2110 CTRP2 8.4611 12.5019 4.5379 2.9149
NCI-H1792 CTRP2 8.4733 10.1836 5.4878 0.224
NCI-H1568 CTRP2 8.521 14.3233 3.742 5.7884
HCC1195 CTRP2 8.5381 14.0051 3.9005 5.1683
NCI-H1693 CTRP2 8.5466 10.5238 5.3932 0.3606
NCI-H1666 CTRP2 8.58 17.1617 2.4307 10.6476
NCI-H2085 CTRP2 8.6135 10.6458 5.375 0.3718
NCI-H2342 CTRP2 8.6265 10.627 5.387 0.3458
EKVX CTRP2 8.6456 11.9131 4.8896 1.5886
EPLC-272H CTRP2 8.6467 10.1461 5.5639 0.0993
NCI-H1623 CTRP2 8.6911 10.5122 5.4531 0.222
T3M-10 CTRP2 8.7352 10.4117 5.5044 0.1473
NCI-H810 CTRP2 8.7368 18.5672 1.8601 12.4565
SW1271 CTRP2 8.7726 19.897 0.4483 13.8531
RERF-LC-A1 CTRP2 8.864 19.0228 1.7283 12.7239
NCI-H1755 CTRP2 8.8997 10.4536 5.548 0.0824
NCI-H69 CTRP2 8.9071 19.5711 1.4927 13.4593
ChaGo-K-1 CTRP2 8.9475 10.8725 5.4213 0.2086
NCI-H2291 CTRP2 8.9504 12.0728 4.9703 1.1519
HCC2279 CTRP2 8.9567 16.9976 2.7633 8.898
DMS 454 CTRP2 8.9576 11.0528 5.3612 0.2925
NCI-H1299 CTRP2 8.9774 14.1525 4.0951 3.9619
NCI-H1869 CTRP2 8.9888 10.716 5.4903 0.1223
NCI-H841 CTRP2 9.1293 18.9688 1.9373 11.6191
NCI-H1355 CTRP2 9.2652 11.1718 5.4324 0.1395
NCI-H727 CTRP2 9.2956 20.7205 1.2074 13.8291
HCC2108 CTRP2 9.3666 15.6947 3.6262 5.2288
NCI-H1373 CTRP2 9.5491 17.0377 3.1213 6.8429
COLO 699 CTRP2 9.8577 17.1291 3.2652 5.9782
NCI-H1944 CTRP2 9.8821 19.3733 2.2424 9.5501
NCI-H520 CTRP2 9.9392 18.4045 2.7299 7.7765
NCI-H522 CTRP2 9.9406 19.1241 2.3963 8.9427
DMS 273 CTRP2 9.9522 20.4991 1.7567 11.1131
NCI-H2126 CTRP2 9.961 22.0279 1.0341 13.4449
HCC827 CTRP2 10.1753 18.9334 2.6307 7.8453
HCC1171 CTRP2 10.2739 19.8404 2.2718 8.9644
SHP-77 CTRP2 10.3119 26.8966 -1.0748 18.8571
HARA [Human squamous cell lung carcinoma] CTRP2 10.5075 20.8837 1.9325 9.8245
NCI-H2122 CTRP2 10.5869 22.1571 1.3862 11.5065
RERF-LC-MS CTRP2 10.6129 19.3041 2.7239 7.0316
NCI-H1838 CTRP2 10.6171 22.3759 1.3026 11.7341
NCI-H292 CTRP2 10.8477 23.2256 1.0511 12.2283
NCI-H322 CTRP2 11.2527 19.5258 2.9898 5.4963
HCC1833 CTRP2 12.6642 27.4835 0.2111 12.518
Calu-1 CTRP2 15.1826 33.2433 -0.9048 12.748
Hs 888.Lu CTRP2 9.8197 19.2227 2.2731 9.5228
⏷ Show the Full List of 140 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 2.0942 17.4501 -3.2114 38.5667
P-STS CTRP2 6.6743 14.6218 2.2687 14.3787
H-STS CTRP2 6.7406 7.7174 5.6921 0.5619
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 7.4575 8.9247 5.5425 0.5062
Aska-SS CTRP2 7.8988 9.4611 5.5258 0.3368
BT-16 CTRP2 6.7677 10.0594 4.6031 4.7966
BT-12 CTRP2 6.8447 8.1165 5.5748 0.8631
MES-SA CTRP2 7.0344 15.8408 1.9448 14.9253
RD CTRP2 7.9729 10.7113 5.0545 1.6019
SW982 CTRP2 7.9837 9.8178 5.4259 0.5197
RKN CTRP2 8.1257 9.2646 5.6805 0.0617
G-402 CTRP2 8.206 18.8546 1.3393 15.0554
SK-UT-1 CTRP2 8.2097 12.8535 4.2305 4.3149
Rh18 CTRP2 8.3208 9.6376 5.6223 0.0885
G-401 CTRP2 8.3831 20.4426 0.6892 16.8604
HT-1080 CTRP2 8.4617 9.6632 5.6621 0.0436
SK-LMS-1 CTRP2 8.6335 16.1952 2.9308 8.7153
GCT CTRP2 8.6549 10.127 5.5732 0.0898
Rh41 CTRP2 8.7148 26.9925 -2.2959 23.9793
TE 441.T CTRP2 8.9638 16.807 2.8583 8.5382
Tm87-16 CTRP2 9.2165 17.5439 2.6746 8.8768
TTC-709 CTRP2 9.364 24.9208 -0.7905 19.5059
A-204 CTRP2 9.3689 19.4982 1.8458 11.5988
KYM-1 CTRP2 9.8817 20.1384 1.8814 10.7861
TE 617.T CTRP2 10.1795 26.9361 -1.188 19.3192
Hs 729.T CTRP2 14.0649 26.8296 1.3296 7.9529
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 7.8264 18.7211 1.123 16.3926
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 8.0867 12.8525 4.1545 4.7531
MCAS CTRP2 1.3711 8.7746 0.0056 35.1195
JHOC-5 CTRP2 3.7865 13.1041 0.4927 26.7303
A2780 CTRP2 6.2941 11.2521 3.6456 9.594
OVK18 CTRP2 6.8283 21.2785 -0.9296 24.0371
SNU-8 CTRP2 7.4898 8.7095 5.6394 0.264
COV434 CTRP2 7.5522 16.477 2.0252 13.7379
OVISE CTRP2 7.6681 8.9042 5.639 0.2035
EFO-21 CTRP2 7.7051 10.384 5.0524 1.8523
DOV13 CTRP2 7.7769 14.2564 3.2773 8.6152
OV56 CTRP2 7.806 8.7087 5.7568 0.0373
SK-OV-3 CTRP2 7.8261 15.0764 2.9133 9.9594
OC 314 CTRP2 7.8567 9.1212 5.6333 0.161
ES2 CTRP2 7.8812 13.3536 3.784 6.4671
TOV-21G CTRP2 8.1321 9.6626 5.5444 0.2261
OV7 CTRP2 8.2709 20.2233 0.7141 16.964
OVCAR-5 CTRP2 8.2841 9.6341 5.6106 0.1055
TOV-112D CTRP2 8.2857 13.8584 3.81 5.8256
JHOS-2 CTRP2 8.3419 10.1092 5.4641 0.2995
JHOM-1 CTRP2 8.345 9.6631 5.6221 0.0854
OVCAR-4 CTRP2 8.3548 13.0098 4.2469 4.085
COV644 CTRP2 8.3784 9.9093 5.5494 0.16
IGROV-1 CTRP2 8.4018 10.8724 5.198 0.8682
SNU-840 CTRP2 8.4061 10.2853 5.425 0.3492
FU-OV-1 CTRP2 8.4114 9.9747 5.5385 0.1673
SNU-119 CTRP2 8.4177 16.5164 2.63 10.1477
HEY A8 CTRP2 8.4356 17.2484 2.2884 11.3798
OAW28 CTRP2 8.7052 10.9954 5.2821 0.5207
OVTOKO CTRP2 8.7349 10.5943 5.4404 0.2299
RMG-I CTRP2 8.7459 17.1015 2.573 9.8882
OV-90 CTRP2 8.7808 10.2778 5.566 0.081
EFO-27 CTRP2 8.7996 10.3463 5.5495 0.0927
COV362 CTRP2 8.8033 16.4545 2.92 8.5242
Kuramochi CTRP2 8.828 15.3419 3.4601 6.4697
Caov-3 CTRP2 9.2637 15.7161 3.5553 5.6002
OAW42 CTRP2 9.6541 17.8143 2.8267 7.7754
OVCAR-8 CTRP2 9.6758 17.2478 3.1019 6.7642
TYK-nu CTRP2 10.2498 19.7743 2.2875 8.9399
OVSAHO CTRP2 13.0801 26.5515 0.8915 10.1545
ONCO-DG-1 CTRP2 13.7227 41.2275 -5.6319 23.4803
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 6.5689 9.501 4.7314 4.5857
NCI-H2452 CTRP2 6.8949 9.6319 4.0474 1.9592
NCI-H28 CTRP2 6.9006 15.0784 2.2196 14.152
NCI-H2052 CTRP2 7.7342 12.271 4.2016 5.0228
MPP 89 CTRP2 7.7366 10.6542 4.9502 2.1812
ACC-MESO-1 CTRP2 7.894 9.1625 5.6327 0.153
IST-Mes1 CTRP2 7.9796 10.3027 5.23 1.0476
JL-1 CTRP2 8.2173 9.6669 5.575 0.1602
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP CTRP2 7.1308 12.5913 3.6263 8.2242
NCI-H660 CTRP2 7.3354 10.2628 4.8895 2.8552
LNCaP clone FGC CTRP2 7.5835 10.9495 4.725 3.184
PaCa-3 CTRP2 8.0343 9.0433 5.7231 0.0399
DU145 CTRP2 8.5894 10.4228 5.4465 0.2572
22Rv1 CTRP2 10.2286 25.6824 -0.5439 17.6208
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 8.2938 13.6708 3.9031 5.4581
YD-15 CTRP2 10.0082 23.5207 0.3484 15.4555
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-620 CTRP2 0.971 5.9212 0.5407 35.1201
GSS CTRP2 3.5604 15.1998 -0.7385 30.5276
SNU-5 CTRP2 4.0347 13.8481 0.3629 26.4889
NCI-N87 CTRP2 5.4393 13.9818 1.5608 19.4182
MKN45 CTRP2 6.7631 10.4999 4.3835 5.7095
GSU CTRP2 6.9145 7.5975 5.8196 0.1224
HGC-27 CTRP2 7.0033 11.737 3.9523 7.0984
MKN1 CTRP2 7.1887 10.0928 4.8759 3.5722
ECC12 CTRP2 7.3089 11.8074 4.1366 5.8777
SNU-16 CTRP2 7.4429 10.8074 4.703 3.4412
SNU-719 CTRP2 7.5089 13.527 3.4422 8.37
AGS CTRP2 7.7345 10.3423 5.0868 1.7055
ECC10 CTRP2 7.7798 13.7199 3.539 7.5786
IM95 CTRP2 7.8168 12.4505 4.1706 5.0353
23132/87 CTRP2 7.8608 12.0398 4.3914 4.1232
SNU-668 CTRP2 7.8856 8.9919 5.6889 0.0855
SH-10-TC CTRP2 7.898 9.0456 5.6749 0.0986
KATO III CTRP2 7.9009 10.6651 5.0362 1.7258
SNU-216 CTRP2 8.002 10.3761 5.2106 1.0893
KE-39 CTRP2 8.3425 14.0545 3.7543 5.9667
SNU-601 CTRP2 8.3789 9.722 5.614 0.0884
NCC-StC-K140 CTRP2 8.4357 13.6666 3.9939 4.9388
MKN74 CTRP2 8.5089 10.7549 5.291 0.5852
MKN7 CTRP2 8.666 10.1524 5.5685 0.0926
LMSU CTRP2 8.765 10.1239 5.6119 0.0503
NUGC-3 CTRP2 8.9797 27.0699 -2.1336 23.2326
NUGC-4 CTRP2 9.3257 18.1061 2.48 9.4343
HuG1-N CTRP2 9.8098 21.0808 1.3854 12.529
SNU-1 CTRP2 10.0247 21.3413 1.4046 12.1768
Hs 746.T CTRP2 11.1092 20.5903 2.4331 7.4723
SNU-685 CTRP2 7.8999 9.1212 5.6494 0.1292
SNU-1077 CTRP2 8.2877 9.967 5.4946 0.2636
SNG-M CTRP2 8.5985 10.1406 5.5488 0.1213
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ML-1 [Human leukemia] CTRP2 6.2611 12.3902 2.3296 10.5886
BHT-101 CTRP2 6.8988 8.5244 5.4234 1.35
CAL-62 CTRP2 7.082 12.0798 3.8417 7.4252
TT2609-C02 CTRP2 7.3837 13.0992 3.5613 8.0867
CGTH-W-1 CTRP2 7.6855 10.7377 4.8832 2.4767
FTC-238 CTRP2 7.7089 11.1738 4.6984 3.1371
FTC-133 CTRP2 7.8959 9.4278 5.5371 0.3154
8305C CTRP2 7.9491 9.4357 5.5555 0.2622
B-CPAP CTRP2 8.3919 13.4467 4.0686 4.7095
8505C CTRP2 8.4432 14.4692 3.624 6.3363
SW579 CTRP2 9.6848 16.1681 3.598 4.9888
TT CTRP2 11.7935 28.199 -0.6858 15.9342
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BICR 18 CTRP2 5.51 14.9293 1.1491 20.6728
SNU-1076 CTRP2 6.9315 9.3629 5.0534 2.732
PE/CA-PJ49 CTRP2 7.3661 9.4552 5.2738 1.4086
HSC-2 CTRP2 7.507 8.8384 5.5979 0.3459
BICR 6 CTRP2 7.5773 8.7655 5.6539 0.2056
BICR 22 CTRP2 7.5851 21.7314 -0.555 21.744
YD-10B CTRP2 7.6826 14.3114 3.1839 9.1259
PE/CA-PJ41 (clone D2) CTRP2 7.7578 12.5335 4.0927 5.4197
BHY CTRP2 7.8156 17.7325 1.6027 14.7961
BICR 56 CTRP2 8.0273 9.7925 5.4542 0.4354
SCC-25 CTRP2 8.0616 16.4012 2.4357 11.407
YD-8 CTRP2 8.0937 13.6756 3.7717 6.2254
SNU-1066 CTRP2 8.1026 9.4825 5.5974 0.1549
BICR 16 CTRP2 8.1671 9.7775 5.5164 0.2626
SNU-1214 CTRP2 8.8203 11.015 5.3215 0.4008
BICR 31 CTRP2 8.9345 10.3991 5.578 0.0578
SCC-9 CTRP2 9.1725 17.555 2.6406 9.0581
HSC-3 CTRP2 9.3912 18.0477 2.5502 9.0968
CAL-27 CTRP2 9.4642 20.4111 1.4726 12.7215
Detroit 562 CTRP2 9.6416 20.244 1.6724 11.8108
SCC-4 CTRP2 10.0306 20.136 1.9792 10.2627
SNU-46 CTRP2 10.1734 21.3369 1.5048 11.655
PE/CA-PJ15 CTRP2 11.178 23.9479 0.9239 12.206
CAL-33 CTRP2 11.3712 25.0442 0.5323 13.1297
SNU-1041 CTRP2 11.8276 20.527 2.8654 5.3672
PE/CA-PJ34 (clone C12) CTRP2 12.527 27.7301 0.0104 13.222
SNU-899 CTRP2 13.653 25.4924 1.6901 7.2918
FaDu CTRP2 13.7898 25.7566 1.6492 7.2882
HSC-4 CTRP2 13.8006 30.1523 -0.3226 12.7034
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
253J CTRP2 4.1521 14.2859 0.257 26.5057
647V CTRP2 7.0627 15.7899 1.9921 14.7026
BC-3C CTRP2 7.1842 12.2053 3.8545 7.2116
JMSU-1 CTRP2 7.2664 21.4503 -0.6653 22.5858
HT-1197 CTRP2 7.4094 9.0503 5.469 0.7416
253J-BV CTRP2 7.4113 13.0975 3.5819 7.9608
639V CTRP2 7.6038 9.2019 5.4988 0.537
KU-19-19 CTRP2 7.6957 8.8032 5.6856 0.1245
HT-1376 CTRP2 7.7157 9.7247 5.3399 0.9081
5637 CTRP2 7.7322 18.5507 1.1361 16.508
TCCSUP CTRP2 7.735 9.5176 5.4331 0.6339
CAL-29 CTRP2 7.8752 9.3076 5.5732 0.2543
SCaBER CTRP2 7.9393 22.3124 -0.5694 21.1811
BFTC-905 CTRP2 8.0399 9.3334 5.6265 0.1301
RT-4 CTRP2 8.0532 11.2153 4.8789 2.121
J82 CTRP2 8.3532 9.8942 5.5453 0.1706
SW1710 CTRP2 8.3533 10.0243 5.4992 0.2376
KMBC-2 CTRP2 8.7032 10.4527 5.4785 0.1848
UM-UC-3 CTRP2 8.9437 10.5465 5.532 0.0904
U-BLC1 CTRP2 9.8677 19.3246 2.2561 9.5211
VM-CUB-1 CTRP2 10.8537 25.17 0.1317 14.9349
RT-112 CTRP2 11.6377 23.3168 1.5048 9.8781
T24 CTRP2 12.1114 21.8898 2.424 6.4947
UM-UC-1 CTRP2 13.529 26.5613 1.1479 8.97
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.915 8.8993 5.7305 0.0455

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Decitabine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Roflumilast DMPGHY8 Moderate Additive immunosuppressive effects by the combination of Decitabine and Roflumilast. Asthma [CA23] [17]
Teriflunomide DMQ2FKJ Major Additive myelosuppressive effects by the combination of Decitabine and Teriflunomide. Hyper-lipoproteinaemia [5C80] [18]
Denosumab DMNI0KO Moderate Additive myelosuppressive effects by the combination of Decitabine and Denosumab. Low bone mass disorder [FB83] [19]
Tecfidera DM2OVDT Moderate Additive immunosuppressive effects by the combination of Decitabine and Tecfidera. Multiple sclerosis [8A40] [20]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Decitabine and Siponimod. Multiple sclerosis [8A40] [21]
Fingolimod DM5JVAN Major Additive immunosuppressive effects by the combination of Decitabine and Fingolimod. Multiple sclerosis [8A40] [22]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Decitabine and Ocrelizumab. Multiple sclerosis [8A40] [23]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of Decitabine and Ozanimod. Multiple sclerosis [8A40] [17]
Omacetaxine mepesuccinate DMPU2WX Moderate Additive immunosuppressive effects by the combination of Decitabine and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [24]
Canakinumab DM8HLO5 Moderate Additive immunosuppressive effects by the combination of Decitabine and Canakinumab. Rheumatoid arthritis [FA20] [25]
Rilonacept DMGLUQS Moderate Additive immunosuppressive effects by the combination of Decitabine and Rilonacept. Rheumatoid arthritis [FA20] [25]
Golimumab DMHZV7X Major Additive immunosuppressive effects by the combination of Decitabine and Golimumab. Rheumatoid arthritis [FA20] [26]
Anthrax vaccine DM9GSWY Moderate Antagonize the effect of Decitabine when combined with Anthrax vaccine. Sepsis [1G40-1G41] [27]
Valganciclovir DMS2IUH Moderate Additive myelosuppressive effects by the combination of Decitabine and Valganciclovir. Virus infection [1A24-1D9Z] [21]
⏷ Show the Full List of 14 DDI Information of This Drug

References

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18 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
19 Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
20 Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
21 Cerner Multum, Inc. "Australian Product Information.".
22 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
23 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
24 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
25 Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
26 Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
27 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]