Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTRDPI)

Drug Name

Bicine Drug Info

Synonyms

Bicine; 150-25-4; N,N-Bis(2-hydroxyethyl)glycine; Diethylolglycine; Dihydroxyethylglycine; 2-(bis(2-hydroxyethyl)amino)acetic acid; Diethanol glycine; N,N-Di(2-hydroxyethyl)glycine; Bicene; N,N-Dihydroxyethylglycine; N,N-Dihydroxyethyl glycine; Fe-3-Specific; DHEG; Glycine, N,N-bis(2-hydroxyethyl)-; Bis(2-Hydroxyethyl)glycine; N,N-(2-Hydroxyethyl)glycine; 2-[bis(2-hydroxyethyl)amino]acetic acid; N,N-Bis(2-hydroxyethyl)aminoacetic acid; N,N-Bis(beta-hydroxyethyl)glycine; NSC 7342; GLYCINE, N,N-DIHYDROXYETHYL-; UNII-1J484QFI1O

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 8761
ChEBI ID: CHEBI:40957
CAS Number: CAS 150-25-4
TTD Drug ID: DMTRDPI

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Plasminogen (PLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranolazine	DM0C9IL	Acute coronary syndrome	BA41	Approved	[2]
Aminocaproic Acid	DMFGND4	Bleeding disorder	GA20-GA21	Approved	[3]
Streptokinase	DM5JQ0D	Pulmonary embolism	BB00	Approved	[4]
Tranexamic Acid	DMFI8A7	Excessive bleeding	GA30.02	Approved	[5]
Alteplase	DMRJ3YX	Acute myocardial infarction	BA41	Approved	[6]
Tenecteplase	DMJYN25	Acute myocardial infarction	BA41	Approved	[6]
Anistreplase	DM6Q4B0	Acute coronary syndrome	BA41	Approved	[7]
Reteplase	DML0D1P	Heart attack	BA41	Approved	[8]
MELAGATRAN	DM4W8RE	N. A.	N. A.	Phase 3	[9]
Desmoteplase	DMDLU4Z	Ischemic stroke	8B11.5Z	Phase 3	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasminogen (PLG)	TTP86E2	PLMN_HUMAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Tranexamic acid in trauma: how should we use it. J Trauma Acute Care Surg. 2013 Jun;74(6):1575-86.
3	The blockage of the high-affinity lysine binding sites of plasminogen by EACA significantly inhibits prourokinase-induced plasminogen activation. Biochim Biophys Acta. 2002 Apr 29;1596(2):182-92.
4	Acute anuric renal failure with streptokinase therapy in a patient with acute venous thromboembolic disease and the review of renal side effects of streptokinase. Tuberk Toraks. 2008;56(4):456-61.
5	Evaluation of aprotinin and tranexamic acid in different in vitro and in vivo models of fibrinolysis, coagulation and thrombus formation. J Thromb Haemost. 2007 Oct;5(10):2113-8.
6	Thrombolytic therapies: the current state of affairs. J Endovasc Ther. 2005 Apr;12(2):224-32.
7	Evaluation of thrombolytic agents. Drugs. 1997;54 Suppl 3:11-6; discussion 16-7.
8	Fibrin binding and the regulation of plasminogen activators during thrombolytic therapy. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):212-23.
9	Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety. Bioorg Med Chem Lett. 2006 May 15;16(10):2641-7.
10	Vampire bat salivary plasminogen activator (desmoteplase): a unique fibrinolytic enzyme that does not promote neurodegeneration. Stroke. 2003 Feb;34(2):537-43.