Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTYBC9)

Drug Name
OXAMATE Drug Info
Synonyms
Oxamic acid; OXAMIC ACID; 471-47-6; 2-Amino-2-oxoacetic acid; oxamate; Acetic acid, aminooxo-; Oxalamic acid; Oxamidic acid; Oxalic acid monoamide; amino(oxo)acetic acid; Aminooxoacetic acid; Glycine, 2-oxo-; Oxamate (repellent); Glyoxylic acid, amino-; Formic acid, carbamoyl-; UNII-QU60N5OPLG; Oxamate, (aminocarbonyl)-; carbamoylformic acid; Formic acid, (aminocarbonyl)-; QU60N5OPLG; Oxamate (insect repellant); Acetic acid, 2-amino-2-oxo-; CHEBI:18058; Oxamic acid, 98%; OXM; C2H3NO3; Oxalic monoamide; Oxamate, 3; EINECS 207-443-0; NSC 47001; Oxamic Acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
974
ChEBI ID
CHEMBL18058
CAS Number
CAS 471-47-6
TTD Drug ID
DMTYBC9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting GABA transaminase (ABAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Alanine DMZDN4W Dietary shortage 5B5K Approved [3]
Pyridoxal Phosphate DMO2K0J Malnutrition 5B50-5B71 Approved [3]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [3]
Vigabatrin DMYT0OG Alcohol dependence 6C40.2 Approved [4]
Divalproex sodium DM4RK0G Seizure disorder 8A6Z Approved [3]
CPP-115 DMK9NQI Tourette syndrome 8A05.00 Phase 2 [5]
K-828-AB DMJLNZQ Dementia 6D80-6D86 Phase 2 [6]
CPP -15 DMQCHU3 Infantile spasm 8A62.0 Phase 1 [5]
T83193 DMHO29Y Discovery agent N.A. Patented [7]
4-hydroxybenzaldehyde DM471P5 Discovery agent N.A. Patented [8]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting L-lactate dehydrogenase (LDH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [1]
3,7-DIHYDROXYNAPHTHALENE-2-CARBOXYLIC ACID DMJ0654 Discovery agent N.A. Investigative [9]
4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid DM6WJ4K Discovery agent N.A. Investigative [1]
3-Hydroxyisoxazole-4-Carboxylic Acid DMKLZXV Discovery agent N.A. Investigative [1]
Naphthalene-2,6-disulfonic acid DMLHWNG Discovery agent N.A. Investigative [10]
4-Hydroxy-1,2,5-Thiadiazole-3-Carboxylic Acid DME29PX Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA transaminase (ABAT) TTT2LD9 GABT_HUMAN Inhibitor [2]
L-lactate dehydrogenase (LDH) TTAZHU0 LDHA_HUMAN; LDHB_HUMAN; LDHC_HUMAN Inhibitor [1]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Aminomethyl-1,2,4-benzothiadiazines as potential analogues of gamma-aminobutyric acid. Unexpected discovery of a taurine antagonist. J Med Chem. 1982 Feb;25(2):113-6.
3 DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
4 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
5 Clinical pipeline report, company report or official report of Catalyst Pharma.
6 Phase II clinical trial of K-828-AB for treating behavioral and psychological symptoms of dementia. Kowa Co. Ltd.
7 Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.
8 Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4.
9 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
10 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.