General Information of Drug (ID: DMU3D2O)

Drug Name
BARETTIN Drug Info
Synonyms (-)-Barettine; GBB 1-Z; 104311-70-8; AC1O5Z3U; 606933-69-1
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11177588
CAS Number
CAS 104311-70-8
TTD Drug ID
DMU3D2O

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting 5-HT 2A receptor (HTR2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [2]
ZOTEPINE DMF3VXA Anxiety disorder 6B00-6B0Z Approved [3]
Iloperidone DM6AUFY Schizophrenia 6A20 Approved [4]
Flibanserin DM70DTN Depression 6A70-6A7Z Approved [5]
Lurasidone hydrochloride DMCVPXO Schizophrenia 6A20 Approved [6]
Aniracetam DMOIFW0 Cerebrovascular ischaemia 8B1Z Approved [7]
lumateperone tosylate DMQ8HOJ Schizophrenia 6A20 Approved [8]
Sarpogrelate DMGLP6S Diabetic complication 5A2Y Approved [9]
Pimavanserin DMR7IVC Parkinson disease 8A00.0 Approved [10]
Zicronapine DMP8ESD Schizophrenia 6A20 Phase 3 [11]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting 5-HT 4 receptor (HTR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisapride DMY7PED Gastroesophageal reflux disease DA22.Z Approved [12]
Tegaserod DM3XYD1 Irritable bowel syndrome DD91.0 Approved [13]
R0-93877 DMM4U9G Constipation DD91.1 Approved [14]
HTF 919 DM78G6F Constipation DD91.1 Approved [15]
Mosapride DM2VOQ3 N. A. N. A. Phase 4 [16]
Renzapride DM7HQNX Irritable bowel syndrome DD91.0 Phase 3 [17]
Lintopride DMSHGWN Nausea MD90 Phase 2 [18]
TD-8954 DM3C9NV Gastrointestinal disease DE2Z Phase 2 [19]
SB-207266A DM27KFY Irritable bowel syndrome DD91.0 Phase 2 [14]
YKP-GI DM740LV Constipation DD91.1 Phase 2 [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting 5-HT 2C receptor (HTR2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [2]
Lorcaserin DMG6OYJ Obesity 5B81 Approved [21]
Tramadol DMRQD04 Osteoarthritis FA00-FA05 Approved [22]
Mirtazapine DML53ZJ Depression 6A70-6A7Z Approved [23]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [24]
Methysergide DM1EF73 Migraine 8A80 Approved [25]
Eltoprazine DMW6C81 Attention deficit hyperactivity disorder 6A05.Z Phase 3 [26]
M100907 DM7ZFBA Sleep-wake disorder 7A00-7B2Z Phase 3 [27]
SR46349B DM1ODMR Primary insomnia 7A00 Phase 3 [28]
Vabicaserin DM9GZW6 Psychotic disorder 6A20-6A25 Phase 2 [29]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Inhibitor [1]
5-HT 2C receptor (HTR2C) TTWJBZ5 5HT2C_HUMAN Inhibitor [1]
5-HT 4 receptor (HTR4) TT07C3Y 5HT4R_HUMAN Inhibitor [1]

References

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2 Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23.
3 Current and novel approaches to the drug treatment of schizophrenia. J Med Chem. 2001 Feb 15;44(4):477-501.
4 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
5 Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
6 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
7 Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43.
8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
9 Beneficial effects of sarpogrelate hydrochloride, a 5-HT2A receptor antagonist, supplemented with pioglitazone on diabetic model mice. Endocr Res. 2009;34(1-2):18-30.
10 Pimavanserin, a selective serotonin (5-HT)2A-inverse agonist, enhances the efficacy and safety of risperidone, 2mg/day, but does not enhance efficacy of haloperidol, 2mg/day: comparison with reference dose risperidone, 6mg/day.Schizophr Res.2012 Nov;141(2-3):144-52.
11 Clinical pipeline report, company report or official report of Lundbeck.
12 Metoclopramide stimulates catecholamine- and granin-derived peptide secretion from pheochromocytoma cells through activation of serotonin type 4 (5... Endocr Relat Cancer. 2009 Mar;16(1):281-90.
13 Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
14 Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. Drugs. 2001;61(3):317-32.
15 5-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist. J Vet Pharmacol Ther. 2002 Feb;25(1):49-58.
16 The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):125-37.
17 Pharmacology and metabolism of renzapride : a novel therapeutic agent for the potential treatment of irritable bowel syndrome. Drugs R D. 2008;9(1):37-63.
18 The effects of lintopride, a 5HT-4 antagonist, on oesophageal motility. Aliment Pharmacol Ther. 1995 Oct;9(5):563-9.
19 The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties. Front Pharmacol. 2011 May 30;2:25.
20 A randomized trial of 5-hydroxytryptamine4-receptor agonist, YKP10811, on colonic transit and bowel function in functional constipation. Clin Gastroenterol Hepatol. 2015 Apr;13(4):701-8.e1.
21 Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50.
22 The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. Anesth Analg. 2004 May;98(5):1401-6, table of contents.
23 Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulatio... Mol Pharmacol. 2008 Mar;73(3):748-57.
24 Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie. 2005 Sep-Oct;60(5):441-60.
25 Spinal serotonin receptor activation modulates the exercise ventilatory response with increased dead space in goats. Respir Physiol Neurobiol. 2008 May 31;161(3):230-8.
26 Clinical pipeline report, company report or official report of Jazz Pharmaceuticals.
27 Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists ... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3708-12.
28 SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Neuropsychopharmacology. 2002 Sep;27(3):430-41.
29 Prediction of Efficacy of Vabicaserin, a 5-HT2C Agonist, for the Treatment of Schizophrenia Using a Quantitative Systems Pharmacology Model.CPT Pharmacometrics Syst Pharmacol.2014 Apr 23;3:e111.