Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUDIR8)

Drug Name
Fludrocortisone Drug Info
Synonyms
fludrocortisone; Fluorocortisone; Fluorocortisol; Fluohydrisone; Florinef; Fluohydrocortisone; Astonin-H; Fludrocortone; Alflorone; Fludronef; Fludrone; Fluodrocortisone; 127-31-1; F-Cortef; 9alpha-Fluorocortisol; Fludrocortisona; Fludrocortisonum; F-COL; 9-Fluorocortisol; 9 alpha FF; 9-Fluorohydrocortisone; Cortisol, 9-fluoro-; StC 1400; 9alpha-Fludrocortisone; 9-AFH; 9-alpha-Fluorocortisol; 9-alpha-Fludrocortisone; Fludrocortisonum [INN-Latin]; Fludrocortisona [INN-Spanish]; 9-AF; Alflorone; Astonin; FCOL; Astonin H; Astonin Merck; Merck Brand of Fludrocortisone; U 5963; ZK5; F-Cortef;Florinef (TN); Fludrocortisone (INN); Fludrocortisone [INN:BAN]; Merck, Astonin; Astonin-H (TN); Hydrocortisone-9alpha-fluoro; Pregn-4-ene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-(8CI); (11beta)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione; (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one; 9 Fluoro 17 Hydroxycortisone; 9 Fluorocortisol; 9 Fluorohydrocortisone; 9 alpha Fludrohydrocortisone; 9 alpha Fluoro 17 Hydroxycorticosterone; 9 alpha Fluorohydrocortisone; 9 alpha-Fludrocortisone; 9 alpha-Fluoro-17-Hydroxycorticosterone; 9 alpha-Fluorocortisol; 9 alpha-Fluorohydrocortisone; 9-Fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione; 9-Fluoro-11beta,17,21-trihydroxypregn-4-ene-3,20-dione; 9-Fluoro-17-Hydroxycortisone; 9-alpha-Fluoro-17-hydroxycorticosterone; 9-alpha-Fluorohydrocortisone; 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione; 9alpha-Fluoro-17-hydroxycorticosterone; 9alpha-Fluorohydrocortisone; 9alpha-Fluoro-hydrocortisone
Indication
Disease Entry ICD 11 Status REF
Addison disease 5A74.0 Approved [1]
Cerebral salt-wasting syndrome 5C72 Approved [2]
Congenital adrenal hyperplasia 5A71.01 Approved [1]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
31378
ChEBI ID
CHEMBL50885
CAS Number
CAS 127-31-1
TTD Drug ID
DMUDIR8
INTEDE Drug ID
DR0705
ACDINA Drug ID
D00282

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [8]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [9]
Darolutamide DMV7YFT Prostate cancer 2C82.0 Approved [10]
Testosterone DM7HUNW Hot flushes GA30 Approved [11]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [12]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [13]
ARN-509 DMT81LZ Acute myeloid leukaemia 2A60 Approved [14]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [15]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [16]
Fluoxymesterone DMUHCF1 Breast cancer 2C60-2C65 Approved [17]
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Drug(s) Targeting Mineralocorticoid receptor (MR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [18]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [19]
Desoxycorticosterone Acetate DMS0AFE Discovery agent N.A. Approved [19]
Desoxycorticosterone Pivalate DMSA4B3 Addison disease 5A74.0 Approved [20]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [21]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [19]
Finerenone DMM4FJ3 Chronic kidney disease GB61 Approved [22]
ZK-91587 DMJ94L0 Cardiovascular disease BA00-BE2Z Phase 2 [23]
Nerenone DMBJ3GL Diabetic nephropathy GB61.Z Phase 2 [24]
LY-2623091 DMFGNB4 Chronic kidney disease GB61 Phase 2 [25]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [33]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [27]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
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Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [6]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [6]
Methotrexate DM2TEOL Anterior urethra cancer Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [6]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [6]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [6]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [6]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [6]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [6]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [6]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [42]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [43]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [6]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [6]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [6]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [44]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [46]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [47]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [49]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [50]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [53]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [6]
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Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [54]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [60]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [7]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [7]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [54]
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Drug(s) Affected By C-C motif chemokine 4 (CCL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [60]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [62]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [64]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [7]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [65]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Gefitinib DM15F0X Colon adenocarcinoma Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [69]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [70]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [72]
Quercetin DM3NC4M Obesity 5B81 Approved [73]
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Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Selenium DM25CGV N. A. N. A. Approved [75]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [6]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [6]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [6]
Trihexyphenidyl DMB19L8 Dystonia 8A02 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [6]
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Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [6]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [6]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [6]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [6]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [6]
Amikacin DM5PDRB Bacteremia 1A73 Approved [6]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [6]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [6]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Androgen receptor (AR) TTS64P2 ANDR_HUMAN Inhibitor [3]
Mineralocorticoid receptor (MR) TT26PHO MCR_HUMAN Agonist [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [6]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [7]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Gene/Protein Processing [7]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Gene/Protein Processing [7]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Gene/Protein Processing [6]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [6]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Gene/Protein Processing [6]
PTB-containing, cubilin and LRP1-interacting protein (PID1) OT5YJ7FI PCLI1_HUMAN Gene/Protein Processing [6]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Gene/Protein Processing [6]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [7]

References

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