Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUNSWV)

• Drug Name: Cefradine Drug Info
• Synonyms: Anspor; Cefradin; Cefradina; Cefradinum; Cephradin; Cephradine; Eskacef; Sefril; Velosef; CEPHRADINE SODIUM; SKF D 39304; SQ 11436; VELOSEF 125; VELOSEF 250; VELOSEF 500; Anspor (TN); Cefradina [INN-Spanish]; Cefradinum [INN-Latin]; Cephradine (USP); Cephradine (anhydrous); Cephradine [USAN:BAN]; SQ-11436; SQ-22022; Velosef (TN); Cefradine (JAN/INN); SK&F D-39304; SK-D-39304; (6R,7R)-7-((R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-(D-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-caboxylic acid; 7-(D-2-Amino-2-(1,4-cyclohexadienyl)acetamide)desacetoxycephalosporanicacid; 7beta-[(2R)-2-(cyclohexa-1,4-dienyl)-2-phenylacetamido]-3-methyl-3,4-didehydrocepham-4-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Acute otitis media	AB00	Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Pars planitis		Approved	[3]
Pneumonia	CA40	Approved	[4]
Prostatitis		Approved	[5]
Respiratory tract infection	CA45	Approved	[4]
Staphylococcal pneumonia		Approved	[4]
Staphylococcus aureus infection		Approved	[4]
Urinary tract infection	GC08	Approved	[6]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 38103
  ChEBI ID: CHEBI:3547
  CAS Number: CAS 38821-53-3
  TTD Drug ID: DMUNSWV
  VARIDT Drug ID: DR00544

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Penicillin binding protein (Bact PBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[10]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[11]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[12]
Ticarcillin	DM4ME02	Aspiration pneumonia		Approved	[13]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[14]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[12]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[15]
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[17]
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[18]

Drug(s) Transported By Peptide transporter 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[19]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[20]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[21]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[22]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[23]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[24]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[25]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[20]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[22]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[22]

Drug(s) Transported By Peptide transporter 2 (SLC15A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[19]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[8]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[26]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[27]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[28]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[8]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[29]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[19]
Aminolevulinic acid hci	DMS4BLQ	Acne vulgaris	ED80	Approved	[30]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[31]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Penicillin binding protein (Bact PBP)	TTJP4SM	NOUNIPROTAC	Binder	[7]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Peptide transporter 2 (SLC15A2)	DT8QKNP	S15A2_HUMAN	Substrate	[8]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[9]

References

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• [18] Resistance of Pseudomonas aeruginosa to cefsulodin: modification of penicillin-binding protein 3 and mapping of its chromosomal gene. J Antimicrob Chemother. 1990 Apr;25(4):513-23.
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• [20] Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18.
• [21] Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Res Microbiol. 2017 Jun;168(5):443-449.
• [22] High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9.
• [23] The intestinal H+/peptide symporter PEPT1: structure-affinity relationships. Eur J Pharm Sci. 2004 Jan;21(1):53-60.
• [24] Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9.
• [25] Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61.
• [26] Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes. Alcohol Clin Exp Res. 2008 May;32(5):777-84.
• [27] The oligopeptide transporter 2-mediated reabsorption of entecavir in rat kidney. Eur J Pharm Sci. 2014 Feb 14;52:41-7.
• [28] Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants. Drug Metab Dispos. 2017 Feb;45(2):130-136.
• [29] Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun. 1998 May 19;246(2):470-5.
• [30] PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes. Brain Res. 2006 Nov 29;1122(1):18-23.
• [31] Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41.