Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV7IM6)

Drug Name

Histamine Phosphate Drug Info

Synonyms

Histamine acid phosphate; Histamine biphosphate; Histamine dihydrogen phosphate; Histamine diphosphate; Histamine phosphate [USP]; Histamine positive; H0147; Histamine phosphate (TN); Histamine phosphate (USP); Histamine phosphate (1:2); 1H-Imidazole-4-ethanamine, phosphate (1:2); 2-Imidazol-4-ylethylamine orthophosphoric acid (1:2); 4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate); 4-(2-Aminoethyl)imidazole di-acid phosphate; 4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate

Indication

Disease Entry	ICD 11	Status	REF
Diagnostic imaging	N.A.	Approved	[1]
Osteoarthritis	FA00-FA05	Approved	[2]

Therapeutic Class

Diagnostic Agents

Cross-matching ID

PubChem CID: 65513
ChEBI ID: CHEMBL51193
CAS Number: CAS 51-74-1
TTD Drug ID: DMV7IM6

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Histamine receptor (HR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Repirinast	DM6KI0D	Asthma	CA23	Approved	[4]
Levomequitazine	DMAYC76	Seasonal allergic rhinitis	CA08.01	Phase 3	[5]
ETX-9101	DMZOA2L	Asthma	CA23	Phase 2	[6]
LCB-2183	DMY4IWC	Asthma	CA23	Phase 2	[7]
ETS-6218	DMV96BY	Fibromyalgia	MG30.01	Phase 2	[6]
Votucalis	DMW4LTI	Allergic rhinitis	CA08.0	Phase 2	[8]
OX-NLA	DMPEHBJ	Allergic rhinitis	CA08.0	Discontinued in Phase 3	[9]
Tesmilifene	DMPB36I	Breast cancer	2C60-2C65	Discontinued in Phase 2	[10]
CP-118	DMNJD9H	Allergic rhinitis	CA08.0	Discontinued in Phase 2	[11]
REV-598	DM314CZ	Carcinoid syndrome	5B10	Terminated	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine receptor (HR)	TT7CXIM	NOUNIPROTAC	Modulator	[3]

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References

1	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 000734.
2	Histamine Phosphate FDA Label
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Mechanism of action of MY-1250, an active metabolite of Repirinast, in inhibiting histamine release from rat mast cells. Br J Pharmacol. 1992 Mar;105(3):587-90.
5	Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. J Pharmacol Exp Ther. 1998 Feb;284(2):437-42.
6	Clinical pipeline report, company report or official report of e-Therapeutics.
7	LCB 2183 inhibits the inflammation associated with oxazolone-induced contact sensitivity. Int J Immunopharmacol. 1994 Aug;16(8):675-83.
8	CA patent application no. 520580, Histamine binding compounds for treatment method for disease conditions mediated by neutrophils.
9	Clinical pipeline report, company report or official report of Orexo.
10	Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P-glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats. J Pharm Pharmacol. 2010 Aug;62(8):1084-8.
11	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025139)
12	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016819)