Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVUW8A)

Drug Name

AVI-6002 Drug Info

Synonyms

NeuGene Plus (Ebola virus), AVI; Neugene (Ebola virus), AVI BioPharma; Polymerase cofactor VP35 modulator (Ebola virus infection,TSO), AVI BioPharma; Viral membrane associated protein VP24 modulator (Ebola virus infection, TSO), AVI BioPharma; AVI-4537 + AVI-4538 + AVI-4539 (Ebola virus infection), AVI BioPharma

Indication

Disease Entry	ICD 11	Status	REF
Ebola virus infection	1D60.0	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMVUW8A

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Ebola virus VP35 messenger RNA (EV VP35 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AVI-6003	DMIJSDO	Marburg virus infection	1D60.1	Phase 1	[2]
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Drug(s) Targeting Ebola virus VP24 messenger RNA (EV VP24 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AVI-6003	DMIJSDO	Marburg virus infection	1D60.1	Phase 1	[2]
AVI-7537	DMLI9U6	Ebola virus infection	1D60.0	Phase 1	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ebola virus VP24 messenger RNA (EV VP24 mRNA)	TTDJLWQ	VP24_EBOSU	Modulator	[2]
Ebola virus VP35 messenger RNA (EV VP35 mRNA)	TT3Z102	VP35_EBOSU	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01353027) Safety Study of Single Administration Post-Exposure Prophylaxis Treatment for Ebola Virus. U.S. National Institutes of Health.
2	Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections. Viruses. 2012 November; 4(11): 2806-2830.