General Information of Drug (ID: DMXBQAM)

Drug Name
Miglitol Drug Info
Synonyms Diastabol; Glyset; Plumarol; Seibule; Glyset (TN); SK-983; Bay-m-1099; Miglitol (JAN/USAN/INN); (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
Indication
Disease Entry ICD 11 Status REF
Diabetic complication 5A2Y Approved [1]
Therapeutic Class
Hypoglycemic Agents
Cross-matching ID
PubChem CID
441314
ChEBI ID
CHEMBL6935
CAS Number
CAS 72432-03-2
TTD Drug ID
DMXBQAM
ACDINA Drug ID
D00433

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Voglibose DMUBP9O Diabetic complication 5A2Y Approved [4]
Acarbose DMRM3AW Diabetic complication 5A2Y Approved [5]
Rh-alphaglucosidase DMNF0G8 Pompe disease 5C51.3 Approved [6]
Deoxynojirimycin DM2ATZB Pompe disease 5C51.3 Phase 3 [7]
Alpha-glucosidase DM2RTGP Muscle disease FB3Z Phase 3 [8]
PAZ-320 DMU0812 Type-2 diabetes 5A11 Phase 2 [9]
SC-49483 DM180VX Acquired immune deficiency syndrome 1C62.3 Phase 2 [10]
Maltose DMH0ROP N. A. N. A. Phase 1/2 [11]
SALACINOL DMVKQT8 N. A. N. A. Phase 1/2 [12]
Celgosivir DMD1V7I Dengue fever 1D2Z Phase 1/2 [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A9 (S100A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [14]
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [18]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [19]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [20]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [21]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A6 (S100A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Selenium DM25CGV N. A. N. A. Approved [24]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Panobinostat DM58WKG Chronic graft versus host disease Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [27]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A4 (S100A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [33]
Panobinostat DM58WKG Chronic graft versus host disease Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [35]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [28]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A11 (S100A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Panobinostat DM58WKG Chronic graft versus host disease Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [39]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [20]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A10 (S100A10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Panobinostat DM58WKG Chronic graft versus host disease Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [28]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Folic Acid DMEMBJC Colorectal carcinoma Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A12 (S100A12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [19]
Arsenic DMTL2Y1 N. A. N. A. Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [47]
Arecoline DMFJZK3 Parkinson disease 8A00.0 Phase 1 [48]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [49]
Milchsaure DM462BT Pruritus EC90 Investigative [50]
D-glucose DMMG2TO Discovery agent N.A. Investigative [51]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Intestinal maltase-glucoamylase (MGAM) TTXWASR MGA_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Gene/Protein Processing [3]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Gene/Protein Processing [3]
Protein S100-A12 (S100A12) OTF9IIXW S10AC_HUMAN Gene/Protein Processing [3]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Gene/Protein Processing [3]
Protein S100-A6 (S100A6) OTHHPZQ8 S10A6_HUMAN Gene/Protein Processing [3]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Gene/Protein Processing [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4842).
2 Drug therapy of postprandial hyperglycaemia. Drugs. 1999 Jan;57(1):19-29.
3 The -glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus. Metabolism. 2010 Dec;59(12):1816-22. doi: 10.1016/j.metabol.2010.06.006. Epub 2010 Jul 29.
4 Effects of changeover from voglibose to acarbose on postprandial triglycerides in type 2 diabetes mellitus patients. Adv Ther. 2009 Jun;26(6):660-6.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
7 Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. J Med Chem. 1994 Oct 28;37(22):3701-6.
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2627).
9 Treatment With Novel Galactomannan Derivative Reduces 2-Hour Postprandial Glucose Excursions in Individuals With Type 2 Diabetes Treated With Oral Medications and/or Insulin. J Diabetes Sci Technol. 2014 September; 8(5): 1018-1022.
10 Pathology of perbutylated-N-butyl-1-deoxynojiromycin (an alpha-glucosidase-1 inhibitor) in Sprague-Dawley rats. Toxicol Pathol. 1996 Sep-Oct;24(5):531-8.
11 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
12 Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membe... Bioorg Med Chem. 2010 Nov 15;18(22):7794-8.
13 Celgosivir, an alpha-glucosidase I inhibitor for the potential treatment of HCV infection.Curr Opin Investig Drugs.2009 Aug;10(8):860-70.
14 Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 Jul;37(7):863-872. doi: 10.1002/jat.3435. Epub 2017 Jan 31.
15 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
16 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
17 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
18 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
19 Retinoic acid and hydroquinone induce inverse expression patterns on cornified envelope-associated proteins: implication in skin irritation. J Dermatol Sci. 2014 Nov;76(2):112-9. doi: 10.1016/j.jdermsci.2014.08.003. Epub 2014 Aug 26.
20 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
21 1 alpha,25-(OH)2 vitamin D3 enhances expression of the genes encoding Ca(2+)-binding proteins MRP-8 and MRP-14. Am J Physiol. 1992 Jan;262(1 Pt 1):C235-42. doi: 10.1152/ajpcell.1992.262.1.C235.
22 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
23 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
24 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
25 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
26 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
27 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
28 Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts. Cancer Lett. 2018 Aug 28;430:1-10. doi: 10.1016/j.canlet.2018.04.043. Epub 2018 May 5.
29 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
30 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
31 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
32 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
33 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
34 Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
35 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
36 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
37 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
38 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
39 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
40 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
41 Detection of gene expression alteration of myeloma cells treated with arsenic trioxide. Zhonghua Xue Ye Xue Za Zhi. 2005 Apr;26(4):209-13.
42 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
43 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
44 Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
45 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
46 Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
47 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
48 Characterization of arecoline-induced effects on cytotoxicity in normal human gingival fibroblasts by global gene expression profiling. Toxicol Sci. 2007 Nov;100(1):66-74.
49 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
50 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
51 Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands. Diabetes. 2010 Jan;59(1):249-55. doi: 10.2337/db09-0801. Epub 2009 Oct 15.