Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXJMKF)

Drug Name
Ganaxolone Drug Info
Synonyms
Ganaxolone [USAN]; CCD 1042; CCD-1042; Ganaxolone (USAN/INN); (3alpha,5alpha)-3-Hydroxy-3-methylpregnan-20-one; 1-[(3R,5S,10S,13S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone; 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone; 3alpha-Hydroxy-3-methyl-5alpha-pregnan-20-one; 3alpha-Hydroxy-3beta-methyl-5alpha-pregnan-20-one
Indication
Disease Entry ICD 11 Status REF
Epileptic seizures 8A61-8A6Z Approved [1]
Complex partial seizure 8A68.0 Phase 3 [2]
Postpartum depression 6E20.0 Phase 2 [3]
Cross-matching ID
PubChem CID
6918305
CAS Number
CAS 38398-32-2
TTD Drug ID
DMXJMKF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting GABA(A) receptor delta (GABRD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [5]
Gaboxadol DMI53FU Insomnia 7A00-7A0Z Approved [6]
SAGE-217b DMRFK0B Major depressive disorder 6A70.3 Phase 2 [5]
PF-4480682 DMWYJHC Neuropathic pain 8E43.0 Discontinued in Phase 2 [7]
PF-2393296 DM5R2MG Neuropathic pain 8E43.0 Discontinued in Phase 1 [8]
Co-60549 DMGIZHX Anxiety disorder 6B00-6B0Z Terminated [9]
Org-20599 DMQU8AR Anaesthesia 9A78.6 Terminated [10]
TBPS DMFC3XP Discovery agent N.A. Investigative [8]
RU-5135 DMCASRD Discovery agent N.A. Investigative [11]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Targeting GABA(A) receptor gamma-3 (GABRG3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [12]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [3]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [13]
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [12]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [14]
Thiamylal DMHDF7B Anaesthesia 9A78.6 Approved [13]
Mebutamate DM0KYI4 Anxiety disorder 6B00-6B0Z Approved [13]
Metharbital DM5A38V Epilepsy 8A60-8A68 Approved [13]
Etomidate DMZI3WO Anaesthesia 9A78.6 Approved [13]
Remimazolam DMLVSYX Procedural sedation JB0C.3 Approved [15]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor (GABAR) TTCI43M NOUNIPROTAC Modulator [1]
GABA(A) receptor delta (GABRD) TTGXH6N GBRD_HUMAN Modulator [4]
GABA(A) receptor gamma-3 (GABRG3) TTEX6LM GBRG3_HUMAN Agonist [3]

References

1 FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215904.
2 ClinicalTrials.gov (NCT01963208) Phase 3 Study of Adjunctive Ganaxolone in Adults With Drug-resistant Partial Onset Seizures and Open-label Extension. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Ganaxolone, a selective, high-affinity steroid modulator of the gamma-aminobutyric acid-A receptor, exacerbates seizures in animal models of absence. Ann Neurol. 1998 Oct;44(4):688-91.
5 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
6 Gaboxadol--a new awakening in sleep.Curr Opin Pharmacol.2006 Feb;6(1):30-6.
7 WO patent application no. 2014,1515,17, Methods of improving microvascular integrity.
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 416).
9 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007012)
10 The anaesthetic action and modulation of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology. 1996;35(9-10):1209-22.
11 Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex. Eur J Pharmacol. 1992 Oct 1;227(2):147-51.
12 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
13 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
14 Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia. 2006 Apr;47(4):704-16.
15 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020