Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ4R3Q)

Drug Name
Zinc salts Drug Info
Indication
Disease Entry ICD 11 Status REF
Arthritis FA20 Approved [1]
Cross-matching ID
TTD Drug ID
DMZ4R3Q
VARIDT Drug ID
DR00068

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Iron-regulated transporter 1 (SLC40A1) DTD3FHQ S40A1_HUMAN Substrate [2]
Zinc transporter ZIP8 (SLC39A8) DTLPQGT S39A8_HUMAN Substrate [3]
Zinc transporter ZIP14 (SLC39A14) DTZ6IJW S39AE_HUMAN Substrate [4]
Zinc transporter ZIP9 (SLC39A9) DTJH79E S39A9_HUMAN Substrate [5]
Zinc transporter SLC39A7 (SLC39A7) DTDQSAM S39A7_HUMAN Substrate [5]
Zinc transporter ZIP6 (SLC39A6) DTT1S93 S39A6_HUMAN Substrate [5]
Zinc transporter ZIP4 (SLC39A4) DTEZCUM S39A4_HUMAN Substrate [6]
Zinc transporter ZIP3 (SLC39A3) DTH08M7 S39A3_HUMAN Substrate [7]
Zinc transporter ZIP13 (SLC39A13) DTOTKBS S39AD_HUMAN Substrate [8]
Zinc transporter ZIP12 (SLC39A12) DT1UIT5 S39AC_HUMAN Substrate [9]
Zinc transporter ZIP11 (SLC39A11) DTEOAND S39AB_HUMAN Substrate [10]
Zinc transporter ZIP10 (SLC39A10) DTK02RZ S39AA_HUMAN Substrate [11]
Zinc transporter ZIP1 (SLC39A1) DTLWPXS S39A1_HUMAN Substrate [12]
Zinc transporter 9 (SLC30A9) DT2I79L ZNT9_HUMAN Substrate [13]
Zinc transporter 8 (SLC30A8) DT7NVLY ZNT8_HUMAN Substrate [14]
Zinc transporter 7 (SLC30A7) DTQK38X ZNT7_HUMAN Substrate [15]
Zinc transporter 6 (SLC30A6) DTKPRIL ZNT6_HUMAN Substrate [16]
Zinc transporter 5 (SLC30A5) DTVHQT2 ZNT5_HUMAN Substrate [16]
Zinc transporter 4 (SLC30A4) DT280XI ZNT4_HUMAN Substrate [17]
Zinc transporter 3 (SLC30A3) DTKMECW ZNT3_HUMAN Substrate [18]
Zinc transporter 2 (SLC30A2) DTIAF6C ZNT2_HUMAN Substrate [19]
Zinc transporter 10 (SLC30A10) DTYBI73 ZNT10_HUMAN Substrate [20]
Zinc transporter 1 (SLC30A1) DT1BO38 ZNT1_HUMAN Substrate [3]
Zinc transporter ZIP5 (SLC39A5) DTN9ACR S39A5_HUMAN Substrate [21]
Zinc transporter ZIP2 (SLC39A2) DTL8VXO S39A2_HUMAN Substrate [22]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Ferroportin-mediated iron transport: expression and regulation. Biochim Biophys Acta. 2012 Sep;1823(9):1426-33.
3 Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency. J Nutr. 2008 Nov;138(11):2076-83.
4 SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1769-E1778.
5 A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition. Sci Rep. 2017 Jan 18;7:40313.
6 Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa. PLoS Genet. 2014 Feb 20;10(2):e1004128.
7 The SLC39 family of zinc transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):612-9.
8 Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):E3530-8.
9 The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia. Nature. 2015 Aug 20;524(7565):356-60.
10 Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. J Nutr. 2013 Dec;143(12):1882-8.
11 Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5.
12 SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms. Biochem J. 2016 May 1;473(9):1113-24.
13 SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome. Brain. 2017 Apr 1;140(4):928-939.
14 Zinc transporter 8 (ZnT8) and cell function. Trends Endocrinol Metab. 2014 Aug;25(8):415-24.
15 Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation. J Biol Chem. 2007 Dec 21;282(51):37053-63.
16 Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk. Genes Nutr. 2015 Sep;10(5):487.
17 Mutation analysis of the zinc transporter gene SLC30A4 reveals no association with periodic catatonia on chromosome 15q15. J Neural Transm (Vienna). 2003 Nov;110(11):1329-32.
18 Loss of synaptic Zn2+ transporter function increases risk of febrile seizures. Sci Rep. 2015 Dec 9;5:17816.
19 Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant. PLoS One. 2013 May 31;8(5):e64045.
20 Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease. Am J Hum Genet. 2012 Mar 9;90(3):467-77.
21 The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. J Biol Chem. 2004 Dec 3;279(49):51433-41.
22 Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2. Biochemistry. 2018 Jul 3;57(26):3976-3986.