Details of the Drug Reposition

General Information of This Drug (ID: DMVRLT7)

Drug Name
Fludarabine   DMVRLT7
Synonyms
FaraA; Fludarabina; Fludarabinum; Fluradosa; Fludarabina [Spanish]; Fludarabine [INN]; Fludarabinum [Latin]; SQ Fludarabine; Fludara, Fludarabine; Fludarabine (INN); Fluradosa (TN); F-Ara-A; (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 2-F-ara-A; 2-Fluoro Ara-A; 2-Fluoro-9-beta-D-arabinofuranosyladenine; 9-beta-D-Arabinofuranosyl-2-fluoroadenine; 9-beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine; 9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro-(9CI)
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)
18 Approved Indication(s)
Indication Name Indication ID ICD-11 Status REF
Testicular lymphoma DISC2M2N N.A. Approved [1]
Splenic marginal zone lymphoma DISCGTZY N.A. Approved [1]
Small intestine lymphoma DISDOS6S N.A. Approved [1]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified DIS5OHQF N.A. Approved [1]
MALT lymphoma DIS1AVVE N.A. Approved [1]
Hepatosplenic T-cell lymphoma DIS7KMY9 N.A. Approved [1]
Myeloproliferative neoplasm DIS5KAPA 2A20 Approved [1]
Acute myelogenous leukaemia DISCSPTN 2A41 Approved [1]
Recurrent adult burkitt lymphoma DIS6V60A 2A85.6 Approved [1]
Large granular lymphocytic leukemia DISHOPPI 2A90.1 Approved [1]
Haematological malignancy DISCDP7W 2B33.Y Approved [2]
Lung cancer DISCM4YA 2C25.0 Approved [1]
Cutaneous melanoma DIS3MMH9 2C30 Approved [1]
Hematologic disease DIS9XD9A 3C0Z Approved [1]
Immunodeficiency DIS093I0 4A00-4A85 Approved [1]
Systemic lupus erythematosus DISI1SZ7 4A40.0 Approved [1]
Systemic sclerosis DISF44L6 4A42 Approved [1]
Multiple sclerosis DISB2WZI 8A40 Approved [1]
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⏷ Show the Full List of 18 Indications(s)
1 Discontinued in Phase 3 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Metastatic melanoma DISSL43L 2E2Z Discontinued in Phase 3 [3]
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3 Discontinued in Phase 2 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Leukemia DISNAKFL N.A. Discontinued in Phase 2 [4]
Post-transplant lymphoproliferative disorder DISTS43D 2B32 Discontinued in Phase 2 [5]
Skin cancer DISTM18U 2C30-2C37 Discontinued in Phase 2 [6]
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4 Investigative Indication(s)
Indication Name Indication ID ICD-11 Status REF
Classic Hodgkin lymphoma DISV1LU6 N.A. Investigative [1]
Gastric cancer DISXGOUK 2B72 Investigative [1]
Colon cancer DISVC52G 2B90.Z Investigative [1]
Neuroblastoma DISVZBI4 2D11.2 Investigative [1]
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References

1 Fludarabine FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4802).
3 A Study in Patients With Chronic Obstructive Pulmonary Disease (FAIR)
4 Double Cord Blood Transplant for Patients With Malignant and Non-malignant Disorders
5 Trisenox in Women With Metastatic Endometrial Cancer
6 Study of Weekly DCF to Treat Advanced Gastric Cancer