Details of the Drug Reposition

General Information of This Drug (ID: DMZA017)

• Drug Name: Tetracycline (DMZA017)
• Synonyms: Amycin; Biocycline; Bristaciclin; Bristaciclina; Bristacycline; Ciclibion; Copharlan; Cyclomycin; Cytome; Dumocyclin; Enterocycline; Medocycline; Resteclin; Robitet; Sanclomycine; Tetrachel; Veracin; Bristaciclin alpha; Cefracycline suspension; Component of Tetrastatin; Sumycin syrup; Tetracycline Free Base; Tetracycline I; Tetracycline II; Tetracycline Monohydrochloride; Achromycin (naphthacene derivative); Achromycin, naphthacene derivative; Centet (base); Lemtrex (base); Liquamycin (Veterinary); Liquamycin, veterinary; Panmycin (TN); Piracaps (base); Polycycline (VAN); Polycycline (antibiotic); Polycycline, antibiotic; SK-Tetracycline; Sumycin (TN); T-125; Tetra-Co; Tetraciclina [INN-Spanish]; Tetracycline & VRC3375; Tetracycline (internal use); Tetracyclinum [INN-Latin]; Tetracyn (TN); Vetquamycin-324 (free base); Tetracycline (JAN/USP/INN); Tetracycline [USAN:INN:BAN:JAN]; Methyl-1,11-dioxo-2-naphthacenecarboxamide; 6-Methyl-1,11-dioxy-2-naphthacenecarboxamide
• Therapeutic Class: Antibiotics
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

19 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Yaws	DISLTH3X	N.A.	Approved	[1]
Typhus	DISJ5JX1	N.A.	Approved	[1]
Trachoma	DIS2WZUR	N.A.	Approved	[1]
Syphilis	DISJ73BS	N.A.	Approved	[1]
Rocky mountain spotted fever	DISFN72S	N.A.	Approved	[1]
Rickettsialpox	DISEMENW	N.A.	Approved	[1]
Relapsing fever	DISEA4L7	N.A.	Approved	[1]
Q fever	DISK1S90	N.A.	Approved	[1]
Ornithosis	DIS4YMZ8	N.A.	Approved	[1]
Lymphogranuloma venereum	DIS0MMFT	N.A.	Approved	[1]
Brucellosis	DISEAYGH	N.A.	Approved	[1]
Acute gonococcal epididymo-orchitis	DISBF6L8	N.A.	Approved	[1]
Acute gonococcal cervicitis	DIS4LKDT	N.A.	Approved	[1]
Actinomycosis	DIS7YFRP	N.A.	Approved	[1]
Bacterial infection	DIS5QJ9S	1A00-1C4Z	Approved	[2]
Bronchitis	DISBM6EQ	CA20	Approved	[1]
Pneumonia	DIS8EF3M	CA40	Approved	[1]
Acne vulgaris	DISKW8PI	ED80	Approved	[1]
Urinary tract infection	DISMT6UV	GC08	Approved	[1]

1 Withdrawn Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Acute gonococcal endometritis	DISZ8BW7	N.A.	Withdrawn	[3]

1 Discontinued in Phase 3 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Ophthalmia neonatorum	DISR74MC	N.A.	Discontinued in Phase 3	[4]

3 Discontinued in Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Granuloma inguinale	DISRKXBH	N.A.	Discontinued in Phase 2	[5]
Gonorrhea	DISQ5AO6	1A7Z	Discontinued in Phase 2	[6]
Pharyngitis	DISSN548	CA02.Z	Discontinued in Phase 2	[7]

1 Discontinued in Phase 1 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Bacterial conjunctivitis	DIST79FU	N.A.	Discontinued in Phase 1	[8]

2 Investigative Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Sinusitis	DISX5NCF	CA0A.Z	Investigative	[1]
Pelvic inflammatory disease	DISWQR4J	GA05	Investigative	[1]

References

• [1] Tetracycline FDA Label
• [2] How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
• [3] Everolimus, Erlotinib Hydrochloride, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer Previously Treated With Radiation Therapy
• [4] Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis
• [5] Hormone Treatment in Growth Hormone and Testosterone Deficient Patients
• [6] Phase I/II Trial of RAD001 Plus Docetaxel in Patients With Metastatic or Recurrent Non-Small Cell Lung Cancer
• [7] ClinicalTrials.gov (NCT00975806) Study of Lenalidomide in Combination With Sunitinib to Evaluate the Safety and Efficacy in Patients With Renal Cell Carcinoma
• [8] Safety and Value of Self Bone Marrow Transplants Following Chemotherapy in Scleroderma Patients