Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2JGQ3)

Drug Name
Trametinib Drug Info
Synonyms
GSK 1120212; GSK-1120212; GSK1120212; JTP 74057; JTP-74057; Mekinist; Trametinib (GSK1120212); Trametinib (GSK1120212JTP 74057); Trametinib (MEK inhibitor); 33E86K87QN; A1-01871; AK174783; CHEBI:75998; UNII-33E86K87QN
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Approved [1]
Metastatic melanoma 2E2Z Approved [2]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [3]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [3]
Cross-matching ID
PubChem CID
11707110
ChEBI ID
CHEBI:75998
CAS Number
CAS 871700-17-3
TTD Drug ID
DM2JGQ3
ACDINA Drug ID
D00694

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting MAPK/ERK kinase kinase (MAP3K)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ARRY-162 DM1P6FR Melanoma 2C30 Approved [7]
BAY 86-9766 DMPW5SB Solid tumour/cancer 2A00-2F9Z Phase 3 [8]
Selumetinib DMC7W6R Neurofibromatosis type 1 LD2D.10 Phase 3 [9]
MSC1936369B DMH1DYU Colorectal cancer 2B91.Z Phase 2 [10]
RO-5126766 DM3U9BY Non-small-cell lung cancer 2C25 Phase 2 [11]
E6201 DMOSL9P Psoriasis vulgaris EA90 Phase 2 [12]
PD-0325901 DM27D4J Breast cancer 2C60-2C65 Phase 2 [7]
WX-554 DMRABOS Solid tumour/cancer 2A00-2F9Z Phase 1/2 [7]
RG7304 DMGFAVQ Solid tumour/cancer 2A00-2F9Z Phase 1 [13]
BI-847325 DMY4B6J Solid tumour/cancer 2A00-2F9Z Phase 1 [14]
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Drug(s) Targeting HUMAN ERK activator kinase 1 (MEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selumetinib DMC7W6R Neurofibromatosis type 1 LD2D.10 Phase 3 [3]
Drug(s) Targeting HUMAN ERK activator kinase 2 (MEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selumetinib DMC7W6R Neurofibromatosis type 1 LD2D.10 Phase 3 [3]
Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [18]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [19]
Panobinostat DM58WKG Chronic graft versus host disease Approved [20]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [21]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [22]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [24]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [25]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [26]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Gefitinib DM15F0X Colon adenocarcinoma Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Selenium DM25CGV N. A. N. A. Approved [30]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [31]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [34]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Gefitinib DM15F0X Colon adenocarcinoma Approved [37]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 16 (NGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Panobinostat DM58WKG Chronic graft versus host disease Approved [20]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [48]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
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Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [53]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Gefitinib DM15F0X Colon adenocarcinoma Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Testosterone DM7HUNW Hot flushes GA30 Approved [62]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [63]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [64]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [66]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [67]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [69]
Gefitinib DM15F0X Colon adenocarcinoma Approved [70]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [73]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [64]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [74]
Paclitaxel DMLB81S Breast carcinoma Approved [75]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [76]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [63]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [77]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [66]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [67]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [79]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [80]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [82]
Gefitinib DM15F0X Colon adenocarcinoma Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [84]
Selenium DM25CGV N. A. N. A. Approved [85]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [86]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [31]
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Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [77]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [90]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [93]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [94]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Gefitinib DM15F0X Colon adenocarcinoma Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [97]
Methotrexate DM2TEOL Anterior urethra cancer Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [102]
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Drug(s) Affected By Guanine nucleotide-binding protein subunit alpha-11 (GNA11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [104]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [105]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [106]
Arsenic DMTL2Y1 N. A. N. A. Approved [107]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
Urethane DM7NSI0 N. A. N. A. Phase 4 [110]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [51]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [111]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Ethacrynic acid DM60QMR Edema MG29 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [116]
Testosterone DM7HUNW Hot flushes GA30 Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [117]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [105]
Menthol DMG2KW7 Back pain ME84.Z Approved [118]
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Drug(s) Affected By Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Leflunomide DMR8ONJ Arthritis FA20 Approved [119]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [105]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [120]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [106]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [121]
Urethane DM7NSI0 N. A. N. A. Phase 4 [110]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
MAPK/ERK kinase kinase (MAP3K) TTROQ37 NOUNIPROTAC Modulator [4]
HUMAN ERK activator kinase 1 (MEK1) TTAW3TO MP2K1_HUMAN Inhibitor [3]
HUMAN ERK activator kinase 2 (MEK2) TTWX403 MP2K2_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [5]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Drug Response [6]
Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) OTOODWTU GNAQ_HUMAN Drug Response [5]
Guanine nucleotide-binding protein subunit alpha-11 (GNA11) OT0K99TO GNA11_HUMAN Drug Response [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [5]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [5]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [5]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Post-Translational Modifications [5]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Post-Translational Modifications [5]

References

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19 Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
20 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
21 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
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23 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
24 BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD. Mol Cancer Ther. 2014 Oct;13(10):2315-27. doi: 10.1158/1535-7163.MCT-14-0258. Epub 2014 Jul 22.
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26 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
27 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
28 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
29 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
30 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
31 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
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38 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
39 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
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41 Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
42 HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects. J Pharmacol Exp Ther. 2008 Jan;324(1):352-9. doi: 10.1124/jpet.107.128959. Epub 2007 Oct 10.
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45 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
46 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
47 TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18952-7. doi: 10.1073/pnas.1221172110. Epub 2013 Nov 4.
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50 The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells. Cancer Res. 2007 Apr 1;67(7):3254-62.
51 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
52 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
53 Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood. 2004 Apr 15;103(8):3138-47. doi: 10.1182/blood-2003-05-1543. Epub 2003 Dec 24.
54 Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
55 EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
56 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
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