General Information of Drug (ID: DM2L3PE)

Drug Name
Hyperforin Drug Info
Synonyms
hyperforin; 11079-53-1; hyperforine; hiperforina; UNII-RM741E34FP; CHEBI:5834; RM741E34FP; CHEMBL1237210; (1R,5S,6R,7S)-4-hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione; (1R,5S,6R,7S)-4-hydroxy-5-isobutyryl-6-methyl-1,3,7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione; HSDB 7646; (+)-Hyperforin; Spectrum5_002025; SCHEMBL98723; CHEMBL501711; GTPL2764; SCHEMBL15557965; Hyperforin, &gt
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
441298
ChEBI ID
CHEBI:5834
CAS Number
CAS 11079-53-1
TTD Drug ID
DM2L3PE
VARIDT Drug ID
DR00582

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [8]
Diethylcarbamazine DM1TJ8F Elephantiasis Approved [9]
Silymarin DMXBYQR N. A. N. A. Phase 4 [10]
3,4-Dihydroxycinnamic Acid DMVZL26 Thrombocytopenia 3B64 Phase 4 [11]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [12]
ABT-761 DM3FIC2 Asthma CA23 Phase 3 [13]
Tenidap DMHQRYE Rheumatoid arthritis FA20 Phase 3 [14]
FPL-62064 DMGF8MZ Inflammation 1A00-CA43.1 Phase 3 [15]
Flobufen DMPSG4D Rheumatoid arthritis FA20 Phase 3 [16]
Darbufelone DMYVKM5 Asthma CA23 Phase 2/3 [17]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [18]
Naproxen DMZ5RGV Bursitis Approved [19]
Mesalazine DMOL5IU Diverticulitis Approved [20]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [21]
Bromfenac DMKB79O Pain MG30-MG3Z Approved [22]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [23]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [24]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [23]
Suprofen DMKXJZ7 Miosis LA11.62 Approved [25]
Gamma-Homolinolenic acid DMSXKYG Malnutrition 5B50-5B71 Approved [26]
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Drug(s) Targeting Pregnane X receptor (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
WAY-214950 DM8ODI7 Discovery agent N.A. Investigative [27]
3-keto-lithocholic acid DM5LUED Discovery agent N.A. Investigative [28]
pregnenolone-16alpha-carbonitrile DM0LW7G Discovery agent N.A. Investigative [29]
trihydroxycholestane DMSP56N Discovery agent N.A. Investigative [30]
schisandrin A DMWQ480 Discovery agent N.A. Investigative [31]
Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [33]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [34]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [35]
Capsaicin DMGMF6V Back pain ME84.Z Approved [36]
Zafirlukast DMHNQOG Asthma CA23 Approved [37]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [34]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [38]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [35]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [34]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [39]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [40]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [41]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [42]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
Ethacrynic acid DM60QMR Edema MG29 Approved [45]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [46]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [47]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [48]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [49]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [32]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [50]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [35]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [51]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [52]
Capsaicin DMGMF6V Back pain ME84.Z Approved [53]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [54]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [55]
Calcidiol DMN4CV5 Hypophosphatemia Approved [56]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [62]
Testosterone DM7HUNW Hot flushes GA30 Approved [63]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [64]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [65]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [66]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [67]
Cepharanthine DM9Y5JB N. A. N. A. Approved [68]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [69]
Clozapine DMFC71L Schizophrenia 6A20 Approved [70]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [71]
Trifluoperazine DMKBYWI Anxiety Approved [72]
Olanzapine DMPFN6Y Bipolar depression Approved [70]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [75]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [5]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [80]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [81]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [82]
Selenium DM25CGV N. A. N. A. Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [83]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [84]
Leflunomide DMR8ONJ Arthritis FA20 Approved [85]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
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Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [88]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [89]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [90]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [91]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [92]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [93]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [94]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [95]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [96]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [97]
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Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [49]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [32]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [52]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [52]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [98]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [99]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [101]
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Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [102]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [104]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [105]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [106]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [108]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [96]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [105]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [109]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [110]
Trospium chloride DM32XZT Discovery agent N.A. Approved [111]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [112]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [113]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [114]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [116]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [114]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
Methotrexate DM2TEOL Anterior urethra cancer Approved [119]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [120]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [122]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [123]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [124]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [125]
Ethacrynic acid DM60QMR Edema MG29 Approved [126]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [127]
Gefitinib DM15F0X Colon adenocarcinoma Approved [128]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [129]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [130]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [131]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [132]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [133]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [134]
Selenium DM25CGV N. A. N. A. Approved [135]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [136]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [137]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [137]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [138]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [139]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [140]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [141]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [142]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [143]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [144]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [145]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [146]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [147]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [149]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [150]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [151]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [152]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [154]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [152]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [155]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [156]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [157]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [158]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [138]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [159]
Verapamil DMA7PEW Angina pectoris BA40 Approved [160]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [161]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [162]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [163]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [164]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [165]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [163]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [166]
Gefitinib DM15F0X Colon adenocarcinoma Approved [128]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [167]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [168]
Selenium DM25CGV N. A. N. A. Approved [73]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [169]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [171]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [172]
Methotrexate DM2TEOL Anterior urethra cancer Approved [173]
Epinephrine DM3KJBC Acute asthma CA23 Approved [174]
Quercetin DM3NC4M Obesity 5B81 Approved [175]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [176]
Fructose DM43AN2 Vomiting MD90 Approved [177]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [178]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [179]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [180]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [181]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [162]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [182]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [183]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [184]
Gefitinib DM15F0X Colon adenocarcinoma Approved [185]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [188]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [180]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [189]
Paclitaxel DMLB81S Breast carcinoma Approved [190]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [191]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [179]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [138]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [192]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [162]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [182]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [193]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [195]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [196]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [197]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [198]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [199]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [200]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [201]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [202]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [203]
Gefitinib DM15F0X Colon adenocarcinoma Approved [204]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Epinephrine DM3KJBC Acute asthma CA23 Approved [174]
Quercetin DM3NC4M Obesity 5B81 Approved [206]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
Fructose DM43AN2 Vomiting MD90 Approved [177]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [207]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [208]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [125]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [192]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [209]
Gefitinib DM15F0X Colon adenocarcinoma Approved [210]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [211]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [212]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [213]
Methotrexate DM2TEOL Anterior urethra cancer Approved [214]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [215]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [216]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [155]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [202]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [159]
Verapamil DMA7PEW Angina pectoris BA40 Approved [160]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [117]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [211]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [167]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [217]
Meloxicam DM2AR7L Arthritis FA20 Approved [218]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [219]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [162]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [117]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [220]
Methotrexate DM2TEOL Anterior urethra cancer Approved [119]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [221]
Quercetin DM3NC4M Obesity 5B81 Approved [175]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [222]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [223]
Ethacrynic acid DM60QMR Edema MG29 Approved [126]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [224]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [226]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [192]
Gefitinib DM15F0X Colon adenocarcinoma Approved [204]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [172]
Selenium DM25CGV N. A. N. A. Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [228]
Methotrexate DM2TEOL Anterior urethra cancer Approved [214]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [229]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [217]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [230]
Methotrexate DM2TEOL Anterior urethra cancer Approved [231]
Quercetin DM3NC4M Obesity 5B81 Approved [232]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [233]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [234]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [235]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [236]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [237]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [2]
Pregnane X receptor (NR1I2) TT7LCTF NR1I2_HUMAN Binder [3]
Prostaglandin G/H synthase 1 (COX-1) TT8NGED PGH1_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Gene/Protein Processing [4]
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) OTQY6ZSF HEM1_HUMAN Gene/Protein Processing [5]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [6]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [7]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [5]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [6]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Gene/Protein Processing [6]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [6]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [6]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Gene/Protein Processing [7]

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135 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
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