Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8JWNA)

• Drug Name: NVP-LAQ824 Drug Info
• Synonyms: Dacinostat; 404951-53-7; LAQ824; LAQ-824; LAQ824 (Dacinostat); UNII-V10P524501; (E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide; CHEMBL356066; V10P524501; (2E)-N-hydroxy-3-[4-({(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide; Dacinostat [INN]; (E)-N-Hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]meth yl]phenyl]prop-2-enamide; (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl}phenyl)prop-2-enamide; Dacinostat; NVP-LAQ 824; NVP-LAQ824, Dacinostat, LAQ824; LBH539

Indication

Disease Entry	ICD 11	Status	REF
Mood disorder	6A60-6E23	Phase 3	[1]
leukaemia	2A60-2B33	Discontinued in Phase 1/2	[1]
Multiple myeloma	2A83	Investigative	[2]

• Cross-matching ID:
  PubChem CID: 6445533
  ChEBI ID: CHEBI:94063
  CAS Number: CAS 404951-53-7
  TTD Drug ID: DM8JWNA
  VARIDT Drug ID: DR00797

Molecule-Related Drug Atlas

Drug(s) Targeting Histone deacetylase (HDAC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[7]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[8]
HBI-8000	DMDWYUN	Non-small-cell lung cancer	2C25.Y	Registered	[9]
ITF2357	DMFZBNE	Duchenne dystrophy	8C70	Phase 3	[10]
Pracinostat	DMTD7AB	Acute myeloid leukaemia	2A60	Phase 3	[11]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[9]
CMS-024-02	DMC4X7L	Solid tumour/cancer	2A00-2F9Z	Phase 3	[12]
Abexinostat	DM91LGU	Follicular lymphoma	2A80	Phase 3	[13]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[14]
MGCD-0103	DM726HX	Non-small-cell lung cancer	2C25.Y	Phase 2	[9]

Drug(s) Targeting Histone deacetylase 1 (HDAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[15]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[16]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
HBI-8000	DMDWYUN	Non-small-cell lung cancer	2C25.Y	Registered	[14]
ITF2357	DMFZBNE	Duchenne dystrophy	8C70	Phase 3	[17]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[2]
Phenylbutyrate	DMBHPDW	Urea cycle disorder	5C50.A	Phase 2	[18]
MGCD-0103	DM726HX	Non-small-cell lung cancer	2C25.Y	Phase 2	[15]
Resminostat	DMNE1FR	Hepatocellular carcinoma	2C12.02	Phase 2	[19]
Sodium butyrate	DMKNIVG	Acute myeloid leukaemia	2A60	Phase 2	[20]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[21]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[27]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[32]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[35]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]

Drug(s) Affected By Retinoic acid receptor beta (RARB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[45]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[46]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[47]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[39]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[51]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[54]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[55]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[60]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[61]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[64]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[65]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[66]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[21]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[69]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[69]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[82]

Drug(s) Affected By Histone H1.2 (H1-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[85]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[86]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[88]

Drug(s) Affected By p21 protein (HRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[6]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[6]
Indomethacin	DMSC4A7	Bursitis		Approved	[6]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[91]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histone deacetylase (HDAC)	TTBH0VX	NOUNIPROTAC	Inhibitor	[2]
Histone deacetylase 1 (HDAC1)	TT6R7JZ	HDAC1_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[4]
DNA repair protein RAD50 (RAD50)	OTYMU9G1	RAD50_HUMAN	Gene/Protein Processing	[5]
Heat shock protein HSP 90-alpha (HSP90AA1)	OTLG1WPK	HS90A_HUMAN	Drug Response	[6]
Histone H1.2 (H1-2)	OT0AVI4M	H12_HUMAN	Drug Response	[5]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Gene/Protein Processing	[5]
p21 protein (HRAS)	OTFYE6AJ	P78460_HUMAN	Drug Response	[6]
Retinoic acid receptor beta (RARB)	OT367U3E	RARB_HUMAN	Post-Translational Modifications	[4]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Gene/Protein Processing	[5]
Thioredoxin-interacting protein	OT46QN4B	TXNIP_HUMAN	Gene/Protein Processing	[5]
Transgelin (TAGLN)	OTAEZ0KP	TAGL_HUMAN	Gene/Protein Processing	[4]

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