Details of the Drug

General Information of Drug (ID: DM9PVX8)

Drug Name
Rucaparib
Synonyms
RUCAPARIB; 283173-50-2; Rubraca; AG-14447; UNII-8237F3U7EH; 8237F3U7EH; AK317822; 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one; 8-FLUORO-2-(4-((METHYLAMINO)METHYL)PHENYL)-4,5-DIHYDRO-1H-AZEPINO[5,4,3-CD]INDOL-6(3H)-ONE; 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-; 8-fluoro-2-(4-methylaminomethyl-phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one
Indication
Disease Entry ICD 11 Status REF
Ovarian cancer 2C73 Approved [1]
Affected Organisms
Humans and other mammals
ATC Code
L01XK03: Rucaparib
L01XK: Poly (ADP-ribose) polymerase (PARP) inhibitors
L01X: OTHER ANTINEOPLASTIC AGENTS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 323.4
Logarithm of the Partition Coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 16900 mcgh/L []
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 1940 mcg/L []
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 1.9 h []
Bioavailability
The bioavailability of drug is 36% []
Clearance
The clearance of drug is 15.3-79.2 L/h []
Half-life
The concentration or amount of drug in body reduced by one-half in 17 - 19 hours []
Metabolism
The drug is metabolized via the CYP2D6 and to a lesser extent by CYP1A2 and CYP3A4 []
Vd
The volume of distribution (Vd) of drug is 113-262 L []
Chemical Identifiers
Formula
C19H18FN3O
IUPAC Name
6-fluoro-2-[4-(methylaminomethyl)phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one
Canonical SMILES
CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2
InChI
InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)
InChIKey
HMABYWSNWIZPAG-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
9931954
ChEBI ID
CHEBI:94311
CAS Number
283173-50-2
UNII
8237F3U7EH
DrugBank ID
DB12332
TTD ID
D01SHZ
INTEDE ID
DR1449
ACDINA ID
D00609
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Poly [ADP-ribose] polymerase (PARP) TTEBCY8 NOUNIPROTAC Modulator [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate []
Cytochrome P450 2D6 (CYP2D6)
Main DME 		DECB0K3 CP2D6_HUMAN Substrate []
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 3.5728 6.4572 1.1806 4.2938
MHH-ES-1 GDSC1; GDSC2 -1.4588 2.3005 -1.7983 39.2717
ES1 GDSC1; GDSC2 1.1937 4.9679 -0.0284 18.4224
SK-ES-1 GDSC1; GDSC2 1.7721 5.9943 0.0096 16.1788
ES8 GDSC1; GDSC2 1.8315 3.7081 1.1872 8.7495
ES7 GDSC1; GDSC2 1.8345 4.0197 1.0391 9.6593
EW-22 GDSC1; GDSC2 1.9109 4.4639 0.8917 10.3225
EW-11 GDSC1; GDSC2 2.2326 6.6495 0.0833 14.2881
EW-12 GDSC2 2.519 6.0133 0.6378 10.0769
ES5 GDSC1; GDSC2 2.5856 5.9318 0.7318 9.3086
TC-71 GDSC1; GDSC2 2.6135 4.5116 1.4596 4.6684
SK-PN-DW GDSC2 2.8555 5.1645 1.3171 4.968
EW-1 GDSC1; GDSC2 2.9062 4.4885 1.6783 2.6566
HOS GDSC1; GDSC2 2.9662 6.1325 0.9233 7.1398
A-673 GDSC1; GDSC2 2.9892 6.3655 0.8257 7.6855
EW-7 GDSC1; GDSC2 3.0295 6.7306 0.6758 8.507
CAL-72 GDSC1; GDSC2 3.1689 4.8823 1.6598 2.2755
NY GDSC1; GDSC2 3.2557 5.8923 1.2422 4.5493
HuO-3N1 GDSC1; GDSC2 3.3761 8.0066 0.3031 9.9107
ES4 GDSC1; GDSC2 3.5092 6.4866 1.1264 4.7298
CAL-78 GDSC1; GDSC2 3.63 5.2367 1.7564 1.1342
SJSA-1 GDSC1; GDSC2 3.6371 6.1715 1.3513 3.211
EW-3 GDSC1; GDSC2 3.7642 8.2453 0.4589 8.1269
CADO-ES1 GDSC1; GDSC2 3.8149 5.5819 1.704 1.1714
EW-16 GDSC1; GDSC2 3.9117 6.3118 1.4442 2.2985
G-292 clone A141B1 GDSC1; GDSC2 4.0132 9.3899 0.0788 9.7641
EW-24 GDSC1; GDSC2 4.1664 5.413 1.9178 0.2163
U2OS GDSC1; GDSC2 4.295 8.8044 0.5403 6.6074
H-EMC-SS GDSC1; GDSC2 4.3124 6.5252 1.5564 1.3114
NOS-1 [Human HNSCC] GDSC1; GDSC2 4.4075 7.0415 1.3901 1.9455
SaOS-2 GDSC1; GDSC2 4.6356 6.7069 1.6289 0.7797
MG-63 GDSC1; GDSC2 4.6604 10.6996 -0.1152 9.4967
CHSA8926 GDSC1; GDSC2 4.7115 6.1597 1.8563 0.1739
EW-13 GDSC1; GDSC2 4.7658 6.9448 1.5932 0.8124
U-CH2 GDSC2 4.8427 6.6505 1.7327 0.3769
HuO9 GDSC1; GDSC2 4.8991 12.2102 -0.6745 11.8958
ES6 GDSC1; GDSC2 4.9583 7.3703 1.5124 0.9551
CHSA0011 GDSC1; GDSC2 5.3618 7.5157 1.6206 0.4331
EW-18 GDSC1; GDSC2 5.6063 16.0901 -2.0546 16.6001
CHSA0108 GDSC1; GDSC2 6.3224 15.5282 -1.3195 12.2161
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 170 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 3.53 5.2229 1.7115 1.4642
697 GDSC1; GDSC2 0.6894 2.3822 0.5235 17.2594
SUP-B15 GDSC1; GDSC2 1.1096 4.3493 0.1797 17.5166
BV-173 GDSC1; GDSC2 1.6502 3.3932 1.159 9.5811
MY-M12 GDSC1; GDSC2 1.6912 4.1729 0.8297 11.4541
KOPN-8 GDSC2 2.4518 5.7854 0.6972 9.896
GR-ST GDSC1; GDSC2 2.4773 5.7847 0.7183 9.6927
TALL-1 [Human adult T-ALL] GDSC2 2.4999 5.0629 1.0968 7.2524
SUP-M2 GDSC1; GDSC2 2.6257 5.4646 0.9961 7.5475
MOLT-16 GDSC1; GDSC2 2.6484 6.421 0.5377 10.34
HC-1 GDSC1; GDSC2 2.7008 4.4587 1.5505 3.8872
MOLM-13 GDSC1; GDSC2 2.7622 7.5757 0.0523 12.9505
RPMI-8866 GDSC1; GDSC2 2.7642 4.7506 1.4536 4.3375
ML-2 GDSC1; GDSC2 2.7659 4.4715 1.5909 3.4859
A3/Kawakami GDSC1; GDSC2 2.7949 5.0971 1.3061 5.1801
SCC-3 GDSC2 2.8139 6.9806 0.3888 10.8051
Loucy GDSC1; GDSC2 2.8415 5.2925 1.2442 5.4523
RPMI-8402 GDSC1; GDSC2 2.8522 4.6028 1.5874 3.3159
DoHH2 GDSC2 2.893 4.4618 1.6823 2.6593
OCI-AML-2 GDSC1; GDSC2 2.9013 4.5477 1.647 2.8532
MV4-11 GDSC1; GDSC2 2.9022 9.003 -0.5482 15.9363
DB GDSC1; GDSC2 2.9163 8.426 -0.25 14.2659
EoL-1 GDSC1; GDSC2 2.927 5.7746 1.0702 6.3261
DEL GDSC1; GDSC2 2.9343 4.8008 1.5482 3.3786
MHH-CALL-4 GDSC2 2.945 7.0265 0.4665 9.9937
U-698-M GDSC1; GDSC2 2.9935 4.6111 1.6769 2.4944
RCH-ACV GDSC1; GDSC2 2.9969 4.8549 1.5642 3.1535
VAL GDSC1; GDSC2 3.0358 5.2504 1.4015 4.0498
Karpas-1106P GDSC1; GDSC2 3.0637 5.0973 1.4931 3.4422
CTV-1 GDSC1; GDSC2 3.0682 5.625 1.2433 4.9391
Kasumi-1 GDSC1; GDSC2 3.0693 5.1029 1.4941 3.425
DG-75 GDSC1; GDSC2 3.0841 6.2404 0.9558 6.6611
JVM-3 GDSC1; GDSC2 3.0862 6.3764 0.8909 7.0539
HAL-01 GDSC1; GDSC2 3.0902 7.0652 0.5562 9.0868
Farage GDSC1; GDSC2 3.0959 5.424 1.3589 4.18
NKM-1 GDSC1; GDSC2 3.1006 7.7218 0.2403 10.9548
SU-DHL-10 GDSC1; GDSC2 3.1096 6.99 0.6074 8.7289
CML-T1 GDSC1; GDSC2 3.1164 5.445 1.3626 4.1153
ALL-PO GDSC1; GDSC2 3.1476 8.289 -0.0046 12.265
SIG-M5 GDSC2 3.1588 4.7856 1.6979 2.0791
CCRF-CEM GDSC1; GDSC2 3.1718 5.4008 1.4201 3.66
WSU-NHL GDSC1 3.1738 4.6142 1.7837 1.9759
RS4;11 GDSC1; GDSC2 3.1835 5.3717 1.4414 3.5114
Ramos.2G6.4C10 GDSC1; GDSC2 3.193 5.1115 1.569 2.7504
NB4 GDSC1; GDSC2 3.2042 4.6007 1.8067 1.4207
KE-37 GDSC1; GDSC2 3.2353 13.1485 -2.3502 23.1411
DND-41 GDSC1; GDSC2 3.2511 5.7694 1.2975 4.2291
OCI-Ly19 GDSC1; GDSC2 3.2608 7.6031 0.4171 9.5104
JVM-2 GDSC1; GDSC2 3.2745 6.8114 0.813 7.096
BC-1 GDSC1; GDSC2 3.3059 6.2541 1.1031 5.2778
Reh GDSC1; GDSC2 3.3169 5.1644 1.6193 2.254
SR GDSC1; GDSC2 3.333 8.4067 0.0755 11.3408
BONNA-12 GDSC2 3.3386 6.2132 1.1444 4.9633
CRO-AP2 GDSC1; GDSC2 3.3401 6.0428 1.2262 4.4738
MC116 GDSC1; GDSC2 3.3579 4.3603 1.9827 0.4497
YT GDSC1; GDSC2 3.3652 4.7989 1.8068 1.2053
HDLM-2 GDSC1; GDSC2 3.3791 5.3111 1.5894 2.3183
OCI-AML-5 GDSC1; GDSC2 3.3863 4.7466 1.8397 1.024
ALL-SIL GDSC1; GDSC2 3.391 5.2485 1.6243 2.1097
GA-10 GDSC1; GDSC2 3.403 4.9159 1.7765 1.3058
SU-DHL-1 GDSC2 3.4201 8.5579 0.0651 11.19
KCL-22 GDSC1; GDSC2 3.4333 7.6943 0.4961 8.6369
MOLT-13 GDSC1; GDSC2 3.4347 7.3045 0.686 7.5023
Karpas-231 GDSC1; GDSC2 3.4667 4.7854 1.8629 0.8337
Hs 445 GDSC2 3.4669 5.9702 1.3407 3.5657
KG-1 GDSC1; GDSC2 3.5069 6.3148 1.2055 4.2727
ARH-77 GDSC1; GDSC2 3.5788 6.7431 1.0505 5.0395
SU-DHL-16 GDSC1; GDSC2 3.5992 5.6221 1.5755 2.0595
AMO1 GDSC1; GDSC2 3.6133 5.0155 1.8387 0.7951
Karpas-422 GDSC1; GDSC2 3.6357 5.3967 1.6922 1.4269
MLMA GDSC1; GDSC2 3.6423 5.5009 1.6512 1.6177
ME1 GDSC1; GDSC2 3.6675 5.1683 1.8024 0.8948
P31/FUJ GDSC1; GDSC2 3.6842 7.5103 0.7563 6.5551
OCI-Ly7 GDSC1; GDSC2 3.6936 5.2315 1.7891 0.9258
NCI-H929 GDSC1; GDSC2 3.6982 5.7683 1.5655 1.9727
VL51 GDSC1; GDSC2 3.7043 6.1528 1.399 2.8402
MOLT-4 GDSC1; GDSC2 3.7188 6.1468 1.41 2.7587
TUR GDSC1; GDSC2 3.7436 6.6716 1.1867 3.952
Karpas-299 GDSC1; GDSC2 3.7695 5.6258 1.6634 1.405
OPM-2 GDSC1; GDSC2 3.7741 5.3034 1.7975 0.8174
SU-DHL-6 GDSC1; GDSC2 3.7864 5.3294 1.7928 0.8253
JeKo-1 GDSC1; GDSC2 3.804 5.4115 1.7681 0.9096
IM-9 GDSC1; GDSC2 3.8115 5.359 1.7925 0.8049
NALM-6 GDSC1; GDSC2 3.8183 6.3744 1.365 2.8473
Raji GDSC1; GDSC2 3.8205 5.2699 1.8316 0.6496
MHH-PREB-1 GDSC1; GDSC2 3.8346 5.3352 1.8122 0.7101
OCI-M1 GDSC1; GDSC2 3.8503 5.0311 1.934 0.3051
WIL2 NS GDSC1; GDSC2 3.8884 5.4328 1.7979 0.7213
Mono-Mac-6 GDSC1; GDSC2 3.8885 6.832 1.2 3.6335
MHH-CALL-2 GDSC1 3.895 5.7011 1.6936 1.4141
MM1.S GDSC1; GDSC2 3.8985 5.6277 1.7251 0.9993
GDM-1 GDSC1; GDSC2; CTRP1 3.9516 6.623 3.234 11.9522
Ku812 GDSC1; GDSC2 3.954 6.2608 1.4887 2.0195
MOLP-8 GDSC1; GDSC2 3.9575 5.4776 1.8106 0.6239
JSC-1 GDSC1; GDSC2 3.9581 5.8055 1.6811 1.1265
Sc-1 GDSC1 3.9643 5.7485 1.707 1.2613
Granta-519 GDSC1; GDSC2 4.0056 5.9023 1.6643 1.1517
BE-13 GDSC1; GDSC2 4.0078 7.4863 0.9728 4.6959
BL-41 GDSC1; GDSC2 4.0083 5.3882 1.8656 0.4157
HH [Human lymphoma] GDSC1; GDSC2 4.0175 6.172 1.5589 1.6071
MN-60 GDSC1; GDSC2 4.0269 5.9103 1.6711 1.103
BALL-1 GDSC1; GDSC2 4.0463 6.2714 1.5317 1.7007
JURL-MK1 GDSC1; GDSC2 4.0511 5.7796 1.7342 0.8311
L-428 GDSC1; GDSC2 4.0703 9.6858 -0.0245 10.2157
Namalwa GDSC1; GDSC2 4.0849 5.8478 1.7224 0.8483
ATN-1 GDSC1; GDSC2 4.0914 5.6932 1.7851 0.619
LAMA-84 GDSC1; GDSC2 4.0965 6.0066 1.6647 1.0651
CTB-1 GDSC1; GDSC2 4.0981 6.4633 1.4771 1.8975
CMK GDSC1 4.1013 8.4491 0.5839 8.268
ST486 GDSC1 4.1057 7.339 1.0979 4.7672
HEL GDSC1; GDSC2 4.108 5.4354 1.8877 0.3074
Karpas-620 GDSC1; GDSC2 4.1099 5.3703 1.9117 0.2495
KMOE-2 GDSC1; GDSC2 4.1105 6.7277 1.3705 2.4035
HL-60 GDSC1; GDSC2 4.1137 5.5095 1.863 0.3689
SUP-T1 GDSC1; GDSC2 4.1171 8.8236 0.4178 7.6383
KY821 GDSC1; GDSC2 4.1218 5.8838 1.7247 0.8106
SU-DHL-8 GDSC1; GDSC2 4.1237 5.5147 1.865 0.3586
RPMI-6666 GDSC1; GDSC2 4.1378 9.5548 0.084 9.4711
EHEB GDSC1 4.1425 8.2921 0.6832 7.4973
K-562 GDSC1; GDSC2 4.1608 5.9993 1.6967 0.8843
BC-3 GDSC2 4.1742 5.7215 1.8089 0.4917
SK-MM-2 GDSC1; GDSC2 4.1934 5.6567 1.8406 0.3906
NK-92MI GDSC2 4.197 6.0368 1.6981 0.8505
OCI-AML-3 GDSC1; GDSC2; CTRP1 4.2259 8.6844 2.5124 14.6403
L-363 GDSC1; GDSC2 4.2415 9.2146 0.314 7.9769
SUP-HD1 GDSC1; GDSC2 4.2441 6.7513 1.4298 1.9486
EM-2 GDSC1; GDSC2 4.2718 5.947 1.7645 0.5711
CA46 GDSC1; GDSC2 4.2904 7.0481 1.3276 2.383
HT GDSC1; GDSC2 4.2928 5.5551 1.9145 0.1837
LP-1 GDSC1; GDSC2 4.307 5.8275 1.8229 0.3834
P12-Ichikawa GDSC1 4.3141 5.794 1.8378 0.4262
RC-K8 GDSC1 4.3143 5.6336 1.895 0.267
P30/OHK GDSC1; GDSC2 4.3549 6.232 1.6911 0.759
Jurkat GDSC1; GDSC2 4.4044 5.8433 1.8545 0.2677
L-540 GDSC1; GDSC2 4.406 5.8967 1.8361 0.3084
SUP-B8 GDSC1; GDSC2 4.4709 6.3778 1.6846 0.703
A4/Fukuda GDSC1; GDSC2 4.5231 5.8975 1.8792 0.1833
KM-H2 GDSC1; GDSC2 4.5771 10.3732 -0.0152 9.1251
Daudi GDSC1; GDSC2 4.5818 6.223 1.7863 0.3552
TK [Human B-cell lymphoma] GDSC1; GDSC2 4.5962 5.9551 1.8855 0.155
SKM-1 GDSC1; GDSC2; CTRP1 4.6168 8.4081 3.003 11.2559
U266B1 GDSC2 4.704 6.2221 1.8321 0.2172
KMS-12-BM GDSC1; GDSC2 4.7283 6.3122 1.8096 0.2524
RL GDSC1; GDSC2 4.7323 7.2015 1.479 1.2486
P32/ISH GDSC1; GDSC2 4.7665 5.9459 1.9471 0.0564
EB2 GDSC1; GDSC2 4.7668 6.265 1.8399 0.1871
SU-DHL-5 GDSC1; GDSC2; CTRP1 4.7786 11.1105 1.7965 16.5531
KMS-11 GDSC1; GDSC2 4.7961 6.8076 1.6572 0.5961
LC4-1 GDSC1; GDSC2 4.8149 6.5808 1.747 0.3547
MEG-01 GDSC1; GDSC2 4.8184 6.7526 1.6863 0.5036
EJM GDSC1; GDSC2 4.8274 6.1372 1.9043 0.0888
PL21 CTRP1 4.9166 6.753 4.0906 9.3316
L-1236 GDSC1; GDSC2 5.0795 7.3006 1.5887 0.6422
PL-21 GDSC1; GDSC2 5.0836 7.2521 1.6082 0.5857
Jiyoye GDSC1; GDSC2 5.0854 7.074 1.6735 0.4188
CESS GDSC1; GDSC2 5.1119 6.5467 1.8648 0.0908
H9 GDSC1; GDSC2 5.1463 6.7545 1.8069 0.1533
WSU-DLCL2 GDSC1; GDSC2; CTRP1 5.1843 7.5688 3.9068 5.4428
Karpas-45 GDSC1; GDSC2 5.1973 7.191 1.6741 0.375
PF-382 GDSC1; GDSC2 5.198 15.2257 -1.9187 16.8828
JJN-3 GDSC1; GDSC2 5.2039 6.7997 1.8117 0.1365
QIMR-WIL GDSC1; GDSC2 5.2729 7.1708 1.7092 0.2799
NOMO-1 GDSC1; GDSC2; CTRP1 5.3476 9.1658 3.2408 8.386
ROS-50 GDSC1; GDSC2 5.3709 8.0313 1.4348 0.9417
THP-1 GDSC1; GDSC2; CTRP1 5.5854 8.3035 3.8517 4.8969
MOLM-16 GDSC1; GDSC2; CTRP1 5.6792 7.892 4.12 3.4242
SU-DHL-4 GDSC1; GDSC2; CTRP1 5.6955 7.6263 4.2592 2.7334
U-937 CTRP1 5.7644 8.3183 3.9731 7.2016
RPMI-8226 GDSC1; GDSC2; CTRP1 6.2034 7.9344 4.4257 1.3038
NU-DUL-1 GDSC1; GDSC2; CTRP1 6.7545 8.3318 4.5282 0.5089
⏷ Show the Full List of 170 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYAE-1 GDSC1; GDSC2 3.6334 7.052 0.9402 5.5781
ESO-51 GDSC1; GDSC2 3.9492 5.8354 1.6647 1.2057
FLO-1 GDSC1; GDSC2 3.9739 6.6495 1.3304 2.7995
KYSE-220 GDSC1; GDSC2 3.979 9.3819 0.0593 9.9468
OACP4 C GDSC1; GDSC2 4.1821 6.6327 1.4483 1.9342
TE-12 GDSC1; GDSC2 4.5376 7.1722 1.3999 1.7601
KYSE-50 GDSC1; GDSC2 4.6999 6.1872 1.8427 0.1995
ESO-26 GDSC1; GDSC2 4.9454 6.6111 1.7846 0.2353
HCE-4 GDSC1; GDSC2 5.219 7.5064 1.5686 0.6269
OACM5.1 C GDSC1; GDSC2 5.2595 7.3654 1.6355 0.4386
SK-GT-4 GDSC1; GDSC2 5.3285 8.1836 1.3586 1.2289
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 3.4322 6.1613 1.2299 4.2726
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC1; GDSC2 0.7631 5.4508 -0.676 23.6467
SK-N-MC-IXC GDSC1; GDSC2 1.909 3.6996 1.2646 7.9998
Kelly GDSC1; GDSC2 2.1955 4.7399 1.006 8.704
SJNB-17 GDSC1; GDSC2 2.6882 5.2166 1.1674 6.3103
SJNB-10 GDSC1; GDSC2 2.7659 4.7353 1.4622 4.2802
KP-N-YS GDSC2 2.8758 5.4496 1.1923 5.6925
SJNB-14 GDSC1; GDSC2 2.8888 8.6089 -0.3625 14.9653
CHP-126 GDSC1; GDSC2 3.0931 6.4624 0.8539 7.2645
GOTO GDSC1; GDSC2 3.2653 6.9092 0.759 7.4437
SJNB-13 GDSC1; GDSC2 3.2949 6.592 0.9333 6.3231
CHP-212 GDSC1; GDSC2 3.3451 7.466 0.5447 8.5497
SK-N-DZ GDSC1; GDSC2 3.3912 5.3961 1.558 2.4711
NH-12 GDSC1; GDSC2 3.416 5.9756 1.3065 3.8565
SJNB-12 GDSC1; GDSC2 3.4457 6.7552 0.9575 5.8566
SiMa GDSC1; GDSC2 3.5463 6.1697 1.2974 3.6711
NB1 GDSC1; GDSC2 3.6263 5.1102 1.8066 0.9172
IMR-5 GDSC1; GDSC2 3.6726 6.9137 1.0304 4.9764
SJNB-7 GDSC1; GDSC2 3.7277 6.8485 1.0953 4.4998
MHH-NB-11 GDSC2 3.773 8.9501 0.1254 10.0266
LA-N-6 GDSC1; GDSC2 3.8288 6.1519 1.469 2.2859
SK-N-FI GDSC1; GDSC2 4.0504 6.5591 1.4114 2.2782
TGW GDSC1; GDSC2 4.0715 7.1639 1.1568 3.5763
SJNB-5 GDSC1; GDSC2 4.0973 13.6347 -1.9317 19.369
NB(TU)1 GDSC1; GDSC2 4.1164 5.7837 1.7611 0.684
SK-N-SH GDSC1; GDSC2 4.1219 6.6312 1.418 2.1537
GI-ME-N GDSC1; GDSC2 4.1701 11.4302 -0.799 14.0742
KP-N-RT-BM-1 GDSC2 4.1811 6.8032 1.3753 2.2878
SJNB-6 GDSC1; GDSC2 4.2057 5.7048 1.8278 0.4197
SK-N-AS GDSC1; GDSC2 4.2358 6.0968 1.6918 0.8439
SK-N-BE(2)-M17 GDSC1; GDSC2 4.6223 6.6521 1.6441 0.7382
KP-N-YN GDSC1; GDSC2 4.9503 7.0512 1.629 0.5952
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 3.2852 5.124 1.619 2.308
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-51 GDSC1; GDSC2 1.6324 6.2058 -0.2208 17.9819
DU4475 GDSC1; GDSC2 2.8548 6.4816 0.6678 8.9942
CAL-148 GDSC2 2.9246 4.6223 1.6269 2.9258
MCF-7 GDSC1; GDSC2 2.9687 6.7571 0.6176 9.0136
MDA-MB-231 GDSC1; GDSC2 2.9724 6.7043 0.6464 8.828
UACC-812 GDSC2 3.2878 5.8569 1.28 4.2593
Evsa-T GDSC1; GDSC2 3.2966 5.2468 1.5698 2.5636
HCC1395 GDSC1; GDSC2 3.3136 5.2479 1.5795 2.4805
OCUB-M GDSC1; GDSC2 3.3412 5.5436 1.4605 3.1055
MDA-MB-436 GDSC1; GDSC2 3.5258 6.4416 1.1581 4.5125
CAL-120 GDSC1; GDSC2 3.6395 6.464 1.2188 3.953
Hs 578T GDSC1; GDSC2 3.6501 6.0934 1.3943 2.9521
HCC1806 GDSC1; GDSC2 3.6621 6.6044 1.1678 4.2038
HCC70 GDSC1; GDSC2 3.6654 6.0033 1.4436 2.6599
BT-549 GDSC1; GDSC2 3.7239 5.8012 1.565 1.9405
HCC1954 GDSC1; GDSC2 3.7303 6.007 1.4785 2.3769
MDA-MB-157 GDSC1; GDSC2 3.7654 6.8168 1.1332 4.2161
HCC38 GDSC1; GDSC2 3.786 6.9195 1.0985 4.377
HCC2157 GDSC1; GDSC2 3.8882 5.6101 1.7274 0.9994
HCC1569 GDSC1; GDSC2 3.9029 8.4929 0.4337 7.9811
HDQ-P1 GDSC1; GDSC2 3.9314 5.5109 1.7863 0.7306
CAMA-1 GDSC1; GDSC2 3.9645 6.0898 1.5668 1.6312
MDA-MB-415 GDSC2 3.9801 7.7105 0.8522 5.4272
HCC1937 GDSC1; GDSC2 4.0081 7.6483 0.8984 5.1145
MRK-nu-1 GDSC1; GDSC2 4.0264 5.8949 1.677 1.0787
EFM-192A GDSC1; GDSC2 4.0575 5.9302 1.6773 1.0492
HCC1500 GDSC1; GDSC2 4.087 5.4819 1.8625 0.3834
JIMT-1 GDSC1; GDSC2 4.0966 5.515 1.8542 0.4018
HCC2218 GDSC1; GDSC2 4.1195 6.1629 1.6123 1.2615
BT-20 GDSC1; GDSC2 4.1267 7.7672 0.9158 4.8086
MDA-MB-361 GDSC1; GDSC2 4.1343 6.0237 1.6752 0.9896
AU565 GDSC1; GDSC2 4.2085 7.7498 0.9724 4.3594
MDA-MB-453 GDSC1; GDSC2 4.2153 5.8439 1.7799 0.5568
HCC1419 GDSC1; GDSC2 4.2239 5.8683 1.7743 0.5693
EFM-19 GDSC1; GDSC2 4.3027 6.3236 1.6325 1.0135
BT-474 GDSC1; GDSC2 4.3951 6.4291 1.6323 0.9401
HCC1428 GDSC1; GDSC2 4.4569 6.0478 1.8013 0.3711
HCC202 GDSC1 4.4709 6.5863 1.6043 1.2263
UACC-893 GDSC1; GDSC2 4.4875 6.8444 1.5094 1.3422
MDA-MB-175-VII GDSC1; GDSC2 4.5144 6.1367 1.7914 0.3709
CAL-85-1 GDSC1; GDSC2 4.5678 6.8356 1.5495 1.1135
MFM-223 GDSC1; GDSC2 4.5978 6.734 1.6023 0.8965
MDA-MB-330 GDSC2 4.61 13.5239 -1.5057 16.3969
YMB-1-E GDSC2 4.6221 6.881 1.5559 1.0461
ZR-75-30 GDSC1; GDSC2 4.7114 6.2102 1.8389 0.2031
MDA-MB-468 GDSC1; GDSC2 4.7217 6.4981 1.7411 0.4065
HCC1599 GDSC2 4.7635 6.39 1.7953 0.2695
HCC1143 GDSC1; GDSC2 4.8065 7.2356 1.4987 1.1142
HCC1187 GDSC1; GDSC2 4.8086 11.4425 -0.3698 10.5373
BT-483 GDSC1; GDSC2 4.9131 6.7314 1.7304 0.3549
T-47D GDSC1; GDSC2 4.9835 10.6915 0.0924 7.7951
COLO 824 GDSC1; GDSC2 5.772 7.6161 1.7333 0.137
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-118MG GDSC1; GDSC2 2.6096 6.7135 0.361 11.5266
H4 GDSC1; GDSC2 2.6864 9.326 -0.8812 18.2677
A-172 GDSC1; GDSC2 2.9013 4.8376 1.5081 3.6918
GB-1 GDSC1; GDSC2 2.9495 4.5023 1.6999 2.4441
CAS-1 GDSC1; GDSC2 2.9706 4.9764 1.4886 3.6616
NMC-G1 GDSC1; GDSC2 2.9903 5.9374 1.0364 6.3846
D-263MG GDSC1; GDSC2 3.0037 4.6925 1.6452 2.6604
KNS-81-FD GDSC1; GDSC2 3.1172 5.2644 1.449 3.5973
SF295 GDSC1; GDSC2 3.1227 5.9214 1.1379 5.4608
AM-38 GDSC1; GDSC2 3.2254 5.3483 1.4791 3.2103
ONS-76 GDSC1; GDSC2 3.261 7.3513 0.5404 8.7717
U-251MG GDSC1; GDSC2 3.2834 7.1588 0.6504 8.0577
D-566MG GDSC1; GDSC2 3.3288 5.5658 1.4426 3.2307
42-MG-BA GDSC1; GDSC2 3.3618 6.2263 1.1535 4.8616
8-MG-BA GDSC1; GDSC2 3.4104 6.9806 0.8254 6.7209
PFSK-1 GDSC1 3.4117 5.3359 1.5971 2.7712
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 3.4543 6.7081 0.9856 5.6711
D283 Med GDSC1; GDSC2 3.4793 5.8974 1.382 3.3084
MOG-G-UVW GDSC1; GDSC2 3.4825 7.6311 0.5613 8.139
T98G GDSC1; GDSC2 3.5099 5.4738 1.5913 2.1061
LN-405 GDSC1; GDSC2 3.5269 9.3053 -0.2235 12.5584
KALS-1 GDSC1; GDSC2 3.5731 6.2815 1.2623 3.8235
YKG-1 GDSC1; GDSC2 3.6581 6.5814 1.176 4.1643
Hs 683 GDSC1; GDSC2 3.6773 5.1072 1.8315 0.7669
SF126 GDSC1; GDSC2 3.6993 8.1002 0.4845 8.1168
Onda 11 GDSC1; GDSC2 3.7 8.0926 0.4886 8.0914
KINGS-1 GDSC1; GDSC2 3.7369 9.5897 -0.2109 11.9903
D-247MG GDSC1; GDSC2 3.7594 8.3104 0.4244 8.3373
SW1088 GDSC1; GDSC2 3.8002 5.7271 1.6364 1.4962
D-392MG GDSC1; GDSC2 3.8314 7.2244 0.9853 4.9402
Onda 10 GDSC1; GDSC2 3.8503 5.6001 1.7135 1.0942
Daoy GDSC1; GDSC2 3.891 6.852 1.1924 3.6708
D-336MG GDSC1; GDSC2 3.9031 7.1489 1.0643 4.3643
DK-MG GDSC1; GDSC2 3.9138 9.9684 -0.2696 11.9036
SK-MG-1 GDSC1; GDSC2 3.9288 7.9688 0.699 6.4013
SF539 GDSC1; GDSC2 3.9353 7.5319 0.9073 5.1956
D-502MG GDSC1; GDSC2 3.9597 7.6023 0.8898 5.2506
D-245MG GDSC2 3.9964 7.7898 0.8255 5.5489
SF268 GDSC1; GDSC2 4.1302 8.4621 0.5963 6.6011
KNS-42 GDSC1; GDSC2 4.1577 6.6417 1.432 2.0413
U-87MG ATCC GDSC1 4.2915 5.6977 1.8637 0.3604
YH-13 GDSC1; GDSC2 4.2939 8.0981 0.8648 4.8081
SW1783 GDSC1; GDSC2 4.3261 7.8284 1.0052 3.9948
Becker GDSC1; GDSC2 4.3354 8.7576 0.5872 6.2722
D-542MG GDSC1; GDSC2 4.3808 6.2345 1.7012 0.7073
M059J GDSC1; GDSC2 4.3884 11.6289 -0.7422 13.3047
GI-1 GDSC1; GDSC2 4.4105 7.8998 1.0212 3.7811
D-423MG GDSC1; GDSC2 4.4681 7.3197 1.3038 2.279
LN-18 GDSC1; GDSC2 4.4719 5.5716 1.9716 0.068
DBTRG-05MG GDSC1; GDSC2 4.6201 10.2213 0.0838 8.5087
MOG-G-CCM GDSC1; GDSC2 4.9858 7.2647 1.564 0.7686
SNB-75 GDSC1; GDSC2 5.4292 7.742 1.5652 0.5378
LNZTA3WT4 GDSC1; GDSC2 5.5056 6.9935 1.8495 0.0614
GaMG GDSC1; GDSC2 6.3192 17.1126 -2.0662 15.2917
LN-229 GDSC1; GDSC2; CTRP1 6.6712 12.197 2.7278 8.3105
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1; GDSC2 3.2939 5.9028 1.2623 4.3521
TGBC1TKB GDSC1; GDSC2 4.1687 5.5528 1.8687 0.3283
TGBC24TKB GDSC1; GDSC2 4.7862 7.4269 1.4139 1.4596
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP1 0.4452 8.6049 -1.2475 56.9457
ESS-1 GDSC1; GDSC2 3.1281 5.5379 1.326 4.3107
RL95-2 GDSC2 3.1828 7.8065 0.2598 10.634
EN GDSC1; GDSC2 4.0921 5.8699 1.7169 0.8632
KLE GDSC1; GDSC2 4.3023 6.3398 1.6259 1.0394
AN3-CA GDSC1; GDSC2 4.3153 6.1331 1.7121 0.7145
MFE-319 GDSC1; GDSC2 5.0522 11.3165 -0.1547 8.9622
MFE-280 GDSC1; GDSC2 5.4092 7.6214 1.6009 0.4601
MFE-296 GDSC1; GDSC2 5.6553 7.5004 1.732 0.1576
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
769-P GDSC1; GDSC2 1.1717 6.084 -0.5866 21.6256
RXF 393L GDSC1; GDSC2 1.5663 8.5082 -1.4215 24.3203
LB2241-RCC GDSC1; GDSC2 3.2654 8.2417 0.1068 11.326
A-704 GDSC2 3.2993 5.749 1.3384 3.8926
BFTC-909 GDSC1; GDSC2 3.3171 5.5715 1.4327 3.3091
SN12C GDSC1; GDSC2 3.347 6.1428 1.1834 4.7141
ACHN GDSC1; GDSC2 3.4064 6.0384 1.271 4.0814
KMRC-20 GDSC1; GDSC2 3.409 5.5979 1.4768 2.8944
CAL-54 GDSC1; GDSC2 3.4302 6.7806 0.9349 6.0236
UO-31 GDSC1; GDSC2 3.4504 5.9097 1.3585 3.4933
RCC10RGB GDSC1; GDSC2 3.4518 7.5567 0.5759 8.1207
KMRC-1 GDSC1; GDSC2 3.4861 6.8475 0.9403 5.8752
A-498 GDSC1; GDSC2 3.5063 6.3055 1.2094 4.251
SW13 GDSC1; GDSC2 3.6429 6.2272 1.3294 3.3231
SW156 GDSC1; GDSC2 3.6887 6.9141 1.0404 4.8882
LB996-RCC GDSC1; GDSC2 3.7736 10.6611 -0.7084 14.5423
OS-RC-2 GDSC1; GDSC2 3.8117 6.3233 1.384 2.7559
BB65-RCC GDSC1; GDSC2 4.0401 6.1388 1.5839 1.4677
LB1047-RCC GDSC1; GDSC2 4.0837 6.954 1.257 3.0236
TK-10 GDSC1; GDSC2 4.0917 6.5511 1.4365 2.1013
NCC021 GDSC1; GDSC2 4.1777 6.0251 1.6941 0.8805
KTCTL-140 GDSC1; GDSC2 4.2997 12.8177 -1.3829 16.5471
VMRC-RCW GDSC2 4.3098 7.9035 0.962 4.2523
KTCTL-195 GDSC1; GDSC2 4.6894 6.4258 1.7546 0.3869
KTCTL-21 GDSC1; GDSC2 4.729 7.217 1.4714 1.2808
NCC010 GDSC1; GDSC2 4.8045 7.2121 1.507 1.0854
KTCTL-1M GDSC1; GDSC2 4.8275 7.1668 1.5345 0.9699
KTCTL-26A GDSC1; GDSC2 4.8479 6.662 1.7305 0.3798
HA7-RCC GDSC1; GDSC2 4.9237 7.1415 1.5846 0.7416
KTCTL-13 GDSC1; GDSC2 5.0062 7.0549 1.6498 0.5117
786-O GDSC1; GDSC2 5.1079 6.8924 1.7459 0.2597
Caki-1 GDSC1; GDSC2 6.0891 14.573 -1.0211 11.3037
VMRC-RCZ GDSC1; GDSC2 6.7736 16.171 -1.3381 11.5302
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-CO-1 GDSC1; GDSC2 3.0758 5.2809 1.4137 3.8925
LS513 GDSC1; GDSC2 3.208 5.5108 1.3917 3.7567
LS1034 GDSC1; GDSC2 3.3871 4.8821 1.7827 1.2957
COLO205 GDSC1; GDSC2 3.4347 5.9805 1.3159 3.7671
SNU-C2B GDSC1; GDSC2 3.5057 6.4105 1.1598 4.541
NCI-H716 GDSC1; GDSC2 3.509 7.3513 0.7145 7.1699
KM12 GDSC1; GDSC2 3.6441 5.5416 1.6346 1.6971
SW48 GDSC1; GDSC2 3.7571 5.6738 1.6369 1.5447
SW1116 GDSC1; GDSC2 3.7579 5.7108 1.6217 1.6168
LS180 GDSC1; GDSC2 3.786 7.0279 1.0483 4.6625
SW1463 GDSC1; GDSC2 3.7978 5.3072 1.8068 0.7608
CW-2 GDSC1; GDSC2 3.9554 6.0843 1.5645 1.6525
LS411N GDSC1; GDSC2 3.9605 5.3789 1.8494 0.4926
CCK-81 GDSC1; GDSC2 4.1067 6.114 1.6261 1.2153
C2BBe1 GDSC1; GDSC2 4.1275 5.965 1.6953 0.9168
SNU-283 GDSC2 4.1525 5.7098 1.8044 0.5181
CL-11 GDSC1; GDSC2 4.2394 8.4945 0.6496 6.0978
SW948 GDSC1; GDSC2 4.2901 5.589 1.9017 0.2088
SNU-C1 GDSC1; GDSC2 4.344 5.9761 1.783 0.4746
GP5d GDSC1; GDSC2 4.4168 6.0812 1.7734 0.4639
CaR-1 GDSC1; GDSC2 4.4497 10.0176 0.07 8.9142
SW837 GDSC1; GDSC2 4.4734 6.8431 1.5034 1.3803
SW1417 GDSC1; GDSC2 4.5187 6.2014 1.7697 0.4245
SNU-61 GDSC1; GDSC2 4.643 6.3592 1.7608 0.3915
SNU-407 GDSC1; GDSC2 4.6654 6.6649 1.6572 0.6701
SNU-81 GDSC1; GDSC2 4.7166 8.0841 1.1068 2.922
COLO 320HSR GDSC1; GDSC2 4.7531 6.5889 1.7203 0.4448
HT115 GDSC1; GDSC2; CTRP1 4.8021 6.4795 4.1247 5.2612
SW626 GDSC1; GDSC2 4.9511 6.8046 1.7187 0.367
SNU-175 GDSC2 4.957 6.6582 1.7725 0.2542
DiFi GDSC1; GDSC2 4.9926 7.3731 1.5259 0.8869
SNU-C5 GDSC1; GDSC2 5.0308 6.7825 1.7561 0.2633
HCT 15 GDSC1; GDSC2 5.0782 6.4993 1.8691 0.0909
NCI-H747 GDSC1; GDSC2 5.082 7.2905 1.5935 0.6274
CL-34 CTRP1 5.2052 7.0532 4.1809 7.3261
T84 GDSC1; GDSC2 5.306 8.0763 1.3902 1.1337
NCI-H508 GDSC1; GDSC2; CTRP1 5.369 6.7512 4.4552 2.3608
RCM-1 [Human ESC] GDSC1; GDSC2; CTRP1 5.4998 10.3704 2.761 10.4009
RKO GDSC1; GDSC2; CTRP1 5.5646 7.0795 4.4326 2.129
CL-40 CTRP1 5.6836 9.3504 3.4089 12.2325
LoVo GDSC1; GDSC2; CTRP1 5.7487 9.1152 3.573 5.9465
MDST8 GDSC1; GDSC2; CTRP1 5.9961 9.7098 3.4607 6.0349
COLO 678 GDSC1; GDSC2; CTRP1 6.0016 8.5444 4.0253 3.34
HCC2998 GDSC1; GDSC2 6.2557 14.175 -0.7357 9.7135
HCT 116 GDSC1; GDSC2; CTRP1 6.2973 10.9955 3.0487 7.4646
HT-29 GDSC1; GDSC2; CTRP1 6.3743 7.6837 4.6139 0.4896
LS123 GDSC1; GDSC2; CTRP1 6.5844 8.942 4.193 1.8257
HCT 8 CTRP1 6.6273 7.845 4.6586 0.4539
SNU-1040 CTRP1 6.7551 8.4985 4.4635 1.2631
SW480 CTRP1 6.82 9.8236 3.9348 4.7236
HT-55 GDSC1; GDSC2; CTRP1 6.8517 8.056 4.6687 0.1608
SW620 GDSC1; GDSC2; CTRP1 7.4591 10.9625 3.7859 2.5151
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 3.2655 5.8763 1.2562 4.4456
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-1 GDSC1; GDSC2 3.2608 5.063 1.6323 2.2744
Huh-7 GDSC1; GDSC2 3.4814 5.1195 1.7304 1.4331
JHH-6 GDSC1; GDSC2 3.5898 8.1432 0.3882 8.9194
SK-HEP-1 GDSC1; GDSC2 3.8279 5.8737 1.5885 1.6909
JHH-2 GDSC1; GDSC2 4.0444 6.2462 1.5413 1.658
Hep-G2/C3A GDSC1; GDSC2 4.1086 6.3562 1.5274 1.6498
JHH-7 GDSC1; GDSC2 4.1923 7.9906 0.8531 5.0448
Hep 3B2.1-7 GDSC1; GDSC2 4.282 5.9091 1.7828 0.5089
HuH-1 GDSC1; GDSC2 4.304 5.8837 1.8012 0.444
HLE GDSC1; GDSC2 4.3889 6.2757 1.6889 0.7432
SNU-423 GDSC1; GDSC2 4.5411 5.9492 1.8677 0.1985
SNU-449 GDSC1; GDSC2 4.7167 6.6387 1.6878 0.5505
SNU-398 GDSC1; GDSC2 4.7594 6.2999 1.8252 0.2142
SNU-387 GDSC1; GDSC2 5.2973 7.2586 1.6874 0.3139
JHH-4 GDSC1; GDSC2 5.3472 12.9004 -0.7087 11.1897
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 187 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H209 GDSC1; GDSC2 0.2603 3.287 -0.2494 23.4371
NCI-H740 GDSC2 2.5709 4.9417 1.2133 6.3272
COR-L311 GDSC2 2.6945 6.2511 0.6586 9.4696
Lu-99A GDSC1; GDSC2 2.699 6.9782 0.3 11.6502
DMS 79 GDSC1; GDSC2 2.7305 5.1475 1.2335 5.7899
NCI-H1651 GDSC1; GDSC2 2.7476 12.4061 -2.37 24.5265
SHP-77 GDSC1; GDSC2 2.7983 4.7956 1.4561 4.2424
NCI-H2227 GDSC1; GDSC2 2.8311 5.495 1.1372 6.1425
NCI-H1876 GDSC1; GDSC2 2.8579 7.3473 0.2407 11.579
NCI-H292 GDSC1; GDSC2 2.8704 5.5567 1.1358 6.0557
SBC-5 GDSC1; GDSC2 2.9264 3.8861 1.9676 0.9802
NCI-H1155 GDSC1; GDSC2 3.0213 5.3422 1.3474 4.4085
NCI-H211 GDSC1; GDSC2 3.0897 6.763 0.7042 8.1876
COR-L303 GDSC2 3.1258 5.0487 1.5561 2.9495
NCI-H64 GDSC1; GDSC2 3.1505 4.4066 1.8622 1.2097
NCI-H1437 GDSC1; GDSC2 3.1833 6.5794 0.8614 7.0094
Lu-135 GDSC1; GDSC2 3.1867 7.1079 0.6058 8.5538
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 3.1882 5.3302 1.4639 3.3695
NCI-H2804 GDSC1; GDSC2 3.2124 7.1545 0.6016 8.5182
COR-L279 GDSC1; GDSC2 3.2178 5.3459 1.4754 3.246
BEN GDSC1; GDSC2 3.2274 5.0314 1.6268 2.3615
NCI-H23 GDSC1; GDSC2 3.2431 5.6067 1.3691 3.8207
LK-2 GDSC1; GDSC2 3.2708 5.7114 1.3377 3.9519
NCI-H1048 GDSC1; GDSC2 3.2728 7.2073 0.6192 8.2705
NCI-H526 GDSC1; GDSC2 3.2809 7.5587 0.4534 9.2457
LCLC-97TM1 GDSC1; GDSC2 3.2909 7.0559 0.7058 7.7064
NCI-H460 GDSC1; GDSC2; CTRP1 3.2979 15.7188 -1.8015 32.3168
NCI-H838 GDSC1; GDSC2 3.3239 4.97 1.7102 1.7527
IST-SL2 GDSC1; GDSC2 3.3308 5.7179 1.373 3.6298
NCI-H810 GDSC1; GDSC2 3.3504 6.2304 1.144 4.9411
NCI-H2081 GDSC1; GDSC2 3.4086 5.7342 1.4139 3.2514
NCI-H290 GDSC1; GDSC2 3.4103 5.9903 1.2961 3.9279
COR-L95 GDSC1; GDSC2 3.4235 5.3398 1.6021 2.1796
NCI-H1563 GDSC1; GDSC2 3.4727 5.2291 1.6783 1.7062
HOP-62 GDSC1; GDSC2 3.4869 5.5177 1.5587 2.3151
NCI-H345 GDSC1; GDSC2 3.4964 4.5351 1.975 0.3799
COR-L105 GDSC1; GDSC2 3.508 6.2322 1.2447 4.0433
NCI-H358 GDSC1; GDSC2 3.521 5.6162 1.5342 2.3949
EBC-1 GDSC1; GDSC2 3.5275 6.1482 1.2958 3.714
NCI-H1792 GDSC1; GDSC2 3.5398 6.6969 1.0471 5.1355
NCI-H2170 GDSC1; GDSC2 3.5528 5.3532 1.6675 1.6528
NCI-H1915 GDSC1; GDSC2 3.5644 6.4285 1.1887 4.2626
VMRC-LCD GDSC1; GDSC2 3.5849 5.1747 1.7598 1.1682
Lu-165 GDSC1; GDSC2 3.6134 5.0417 1.8282 0.8383
COR-L321 GDSC1; GDSC2 3.6173 5.4972 1.6395 1.7077
NCI-H187 GDSC1 3.6174 5.0434 1.8294 1.0334
NCI-H82 GDSC1; GDSC2 3.6213 5.2141 1.7615 1.1206
UMC-11 GDSC1; GDSC2 3.6227 5.6907 1.5583 2.1153
DMS 53 GDSC1; GDSC2 3.6277 6.2994 1.2873 3.5856
RERF-LC-KJ GDSC1; GDSC2 3.6312 7.112 0.9104 5.7572
Ms-1 GDSC1; GDSC2 3.6375 5.6047 1.6039 1.8602
SK-MES-1 GDSC1; GDSC2 3.6458 8.0596 0.4673 8.3328
SBC-3 GDSC1; GDSC2 3.6702 9.2224 -0.0794 11.4171
NCI-H146 GDSC1; GDSC2 3.6714 6.42 1.2584 3.6727
PC-14 GDSC1; GDSC2 3.6839 5.9892 1.4604 2.5415
NCI-H510A GDSC1; GDSC2 3.7105 6.0708 1.4392 2.6148
KNS-62 GDSC1; GDSC2 3.7171 5.9554 1.4939 2.3153
LXF 289 GDSC1; GDSC2 3.7583 8.0082 0.5684 7.5018
NCI-H2405 GDSC1; GDSC2 3.7618 7.2935 0.9092 5.509
COR-L88 GDSC1; GDSC2 3.7751 6.8801 1.1099 4.3311
NCI-H720 GDSC1; GDSC2 3.7841 5.1174 1.8747 0.5239
NCI-H2461 GDSC1; GDSC2 3.7879 9.0164 0.1037 10.1167
NCI-H2722 GDSC1; GDSC2 3.79 5.8843 1.5643 1.8572
CAL-12T GDSC1; GDSC2 3.7935 6.3811 1.3479 2.9778
LCLC-103H GDSC1; GDSC2 3.8094 8.0236 0.5951 7.2408
NCI-H2347 GDSC1; GDSC2 3.8139 7.0304 1.0644 4.5208
COR-L23 GDSC1; GDSC2 3.8166 8.1756 0.5274 7.6187
NCI-H2023 GDSC1; GDSC2 3.8223 5.7623 1.6327 1.4877
NCI-H727 GDSC1; GDSC2 3.8346 7.6922 0.7685 6.1833
NCI-H1623 GDSC1; GDSC2 3.8533 7.8065 0.7267 6.3886
NCI-H1993 GDSC1; GDSC2 3.8668 9.4748 -0.0632 10.8768
DMS 114 GDSC1; GDSC2 3.8705 5.734 1.6684 1.2712
NCI-H2171 GDSC2 3.885 6.0721 1.5335 1.8872
NCI-H522 GDSC1; GDSC2 3.8926 7.1035 1.0787 4.3011
NCI-H226 GDSC1; GDSC2 3.8932 9.4969 -0.0554 10.7749
NCI-H1573 GDSC1; GDSC2 3.9185 5.5195 1.7772 0.7749
NCI-H2444 GDSC1; GDSC2 3.9306 5.2813 1.8738 0.4348
NCI-H1975 GDSC1; GDSC2 3.9733 6.1902 1.5288 1.8006
HCC78 GDSC1; GDSC2 3.9998 8.067 0.6984 6.268
NCI-H661 GDSC1; GDSC2 4.0087 7.4353 0.9968 4.5601
NCI-H2795 GDSC1; GDSC2 4.0088 6.5579 1.3896 2.4437
IA-LM GDSC1; GDSC2 4.0211 5.6638 1.7662 0.7357
IST-SL1 GDSC1; GDSC2 4.0262 5.9386 1.6593 1.1531
NCI-H1963 GDSC1; GDSC2 4.0313 5.956 1.6546 1.1678
NCI-H69 GDSC1; GDSC2 4.0757 6.4578 1.4679 1.9684
NCI-H2141 GDSC1; GDSC2 4.0837 5.5465 1.8372 0.4578
NCI-H1694 GDSC1; GDSC2 4.0928 5.7385 1.7684 0.6753
NCI-H1703 GDSC1; GDSC2 4.1022 6.0714 1.6413 1.1561
NCI-H2342 GDSC1; GDSC2 4.1098 6.2371 1.5774 1.4231
NCI-H513 GDSC1; GDSC2 4.1228 5.9123 1.714 0.8497
NCI-H1793 GDSC1; GDSC2 4.1245 9.333 0.1809 8.9581
Lu-134-A GDSC1; GDSC2 4.1287 11.0709 -0.6536 13.4354
NCI-H2196 GDSC2 4.1375 5.5296 1.865 0.3521
NCI-H1105 GDSC2 4.1402 6.4087 1.5212 1.6431
SW1573 GDSC1; GDSC2 4.1467 7.8667 0.8823 4.9609
NCI-H1693 GDSC1; GDSC2 4.1478 9.9501 -0.0987 10.4569
NCI-H2110 GDSC1; GDSC2 4.1508 7.8927 0.8729 5.0063
Lu-139 GDSC1; GDSC2 4.18 8.6337 0.5475 6.7826
HOP-92 GDSC1; GDSC2 4.1915 6.7024 1.4236 2.0402
LC-2/ad GDSC1; GDSC2 4.2093 6.1988 1.6397 1.0652
NCI-H196 GDSC1; GDSC2 4.2173 5.8245 1.788 0.5303
NCI-H1648 GDSC1; GDSC2 4.2185 10.1838 -0.1628 10.6548
A-427 GDSC1; GDSC2 4.25 7.3216 1.1872 3.1474
NCI-H2591 GDSC1; GDSC2 4.2559 6.763 1.4308 1.9299
NCI-H847 GDSC1; GDSC2 4.2677 5.6386 1.8758 0.2709
SBC-1 GDSC1; GDSC2 4.2854 5.8954 1.7894 0.4877
NCI-H1299 GDSC1; GDSC2 4.2862 6.3139 1.6289 1.0415
SW1271 GDSC1; GDSC2 4.2864 6.4499 1.5746 1.2601
NCI-H1355 GDSC1; GDSC2 4.287 7.5155 1.1222 3.4331
NCI-H748 GDSC2 4.2922 7.7496 1.021 3.9625
NCI-H1836 GDSC1; GDSC2 4.2965 5.6347 1.888 0.2343
NCI-H650 GDSC1; GDSC2 4.3135 6.1828 1.6922 0.7845
NCI-H2085 GDSC1; GDSC2 4.3348 6.6189 1.529 1.4055
Calu-3 GDSC1; GDSC2 4.3532 11.1692 -0.5446 12.3803
NCI-H2029 GDSC1; GDSC2 4.3636 5.707 1.8874 0.2138
A-549 GDSC1; GDSC2 4.3651 9.6672 0.1805 8.4752
NCI-H1568 GDSC1; GDSC2 4.3875 8.5365 0.7207 5.4413
NCI-H2030 GDSC1; GDSC2 4.3924 11.2961 -0.5788 12.4707
NCI-H1304 GDSC1 4.3968 5.9333 1.8195 0.4385
Lu-65 GDSC1; GDSC2 4.4008 6.3206 1.6768 0.7766
NCI-H250 GDSC2 4.4198 6.4242 1.645 0.875
NCI-H2818 GDSC1; GDSC2 4.4317 8.3468 0.8331 4.7539
NCI-H1838 GDSC1; GDSC2 4.4415 6.1206 1.7687 0.4645
CPC-N GDSC1; GDSC2 4.442 6.4886 1.6296 0.9137
NCI-H2087 GDSC1; GDSC2 4.4615 6.8481 1.4958 1.4232
NCI-H2291 GDSC1; GDSC2 4.4633 6.8526 1.4948 1.4255
NCI-H1436 GDSC1; GDSC2 4.4672 6.1519 1.7674 0.4552
Calu-6 GDSC1; GDSC2 4.4735 5.9605 1.8389 0.2769
HCC44 GDSC1; GDSC2 4.4746 8.7412 0.6794 5.5192
EPLC-272H GDSC1; GDSC2 4.4811 6.6078 1.6004 0.9913
NCI-H520 GDSC1; GDSC2 4.485 8.4075 0.8368 4.6486
NCI-H524 GDSC1; GDSC2 4.511 11.1019 -0.405 11.3232
ChaGo-K-1 GDSC1; GDSC2 4.512 6.728 1.5669 1.0927
NCI-H2135 GDSC1; GDSC2 4.5236 6.0657 1.8204 0.2993
EKVX GDSC1; GDSC2 4.5954 8.0888 1.0402 3.4163
NCI-H2373 GDSC1; GDSC2 4.6053 6.3576 1.7467 0.4443
NCI-H1666 GDSC1; GDSC2 4.6067 6.5509 1.6758 0.6471
NCI-H2009 GDSC1; GDSC2 4.6173 6.3639 1.7491 0.4325
NCI-H1581 GDSC1; GDSC2 4.6219 6.3738 1.7473 0.435
LC-1/sq GDSC1; GDSC2 4.6247 7.8294 1.1679 2.7407
NCI-H2803 GDSC1; GDSC2 4.6287 7.51 1.3047 2.0895
COR-L32 GDSC2 4.6711 6.6457 1.6667 0.6375
NCI-H1341 GDSC1; GDSC2 4.6746 6.2454 1.8132 0.2622
NCI-H1770 GDSC1; GDSC2 4.6887 5.9215 1.9289 0.0823
NCI-H2810 GDSC1; GDSC2 4.6898 11.2045 -0.3349 10.5932
NCI-H446 GDSC1; GDSC2 4.6901 6.3502 1.7819 0.3231
NCI-H1435 GDSC1; GDSC2 4.6943 6.3333 1.7895 0.3049
NCI-H841 GDSC1; GDSC2 4.7009 6.3406 1.7894 0.3027
HCC33 GDSC2 4.7047 6.5024 1.7329 0.4345
NCI-H1869 GDSC1 4.7065 6.4377 1.7569 0.4664
LOU-NH91 GDSC1; GDSC2 4.7108 6.4223 1.7641 0.3557
DMS 273 GDSC1; GDSC2 4.7722 8.2993 1.0437 3.1607
NCI-H3255 GDSC1; GDSC2 4.7887 6.2538 1.8515 0.1635
NCI-H1092 GDSC1; GDSC2 4.7998 6.4132 1.8005 0.2481
NCI-H835 GDSC1; GDSC2 4.8 6.8544 1.6414 0.6403
ABC-1 GDSC1; GDSC2 4.8096 6.8511 1.6465 0.6199
NCI-H1944 GDSC1; GDSC2 4.8138 6.6792 1.7112 0.441
LB647-SCLC GDSC1; GDSC2 4.815 6.3077 1.8424 0.1715
NCI-H2172 GDSC1; GDSC2 4.8271 6.9473 1.6178 0.6963
NCI-H2066 GDSC1; GDSC2 4.829 6.5095 1.7775 0.284
NCI-H1734 GDSC1; GDSC2 4.8683 6.9488 1.634 0.6245
EMC-BAC-2 GDSC1; GDSC2 4.8925 6.9266 1.6519 0.561
NCI-H2369 GDSC1; GDSC2 4.9245 6.284 1.8884 0.0919
NCI-H596 GDSC1; GDSC2; CTRP1 4.9343 8.4354 3.2657 9.1905
COLO 668 GDSC1; GDSC2 4.9425 6.5225 1.8142 0.1862
NCI-H1688 GDSC1; GDSC2 4.9572 9.411 0.658 4.8614
NCI-H3122 GDSC1; GDSC2 5.0191 7.0825 1.6448 0.5187
RERF-LC-MS GDSC1; GDSC2 5.0242 10.1179 0.3793 6.214
NCI-H1650 GDSC1; GDSC2 5.0998 7.0981 1.6703 0.4205
RERF-LC-Sq1 GDSC1; GDSC2 5.1579 7.2566 1.6356 0.48
EMC-BAC-1 GDSC1; GDSC2 5.1725 7.622 1.5068 0.8353
NCI-H322M GDSC1; GDSC2 5.2268 7.2478 1.665 0.3842
NCI-H2595 GDSC1; GDSC2 5.2593 7.5335 1.5746 0.591
NCI-H2228 GDSC1; GDSC2 5.2807 7.357 1.6465 0.4053
HCC366 GDSC1; GDSC2 5.353 7.0513 1.7785 0.1522
NCI-H2731 GDSC1; GDSC2 5.5121 7.4581 1.696 0.2392
NCI-H2869 GDSC1; GDSC2 5.5966 7.4362 1.7333 0.1665
NCI-H647 GDSC1; GDSC2 5.6399 13.4874 -0.7973 11.071
NCI-H2122 GDSC1; GDSC2; CTRP1 5.6621 7.7271 4.1878 3.129
PaCa-3 GDSC1; GDSC2 5.8515 14.8725 -1.312 13.0308
SK-LU-1 GDSC1; CTRP1 5.9125 9.9101 3.3027 8.2032
HCC15 GDSC1; GDSC2; CTRP1 6.1316 9.6532 3.5826 5.2149
T3M-10 CTRP1 6.1589 9.7782 3.5411 9.5704
NCI-H1781 GDSC1; GDSC2; CTRP1 6.3743 8.0872 4.4496 1.0418
NCI-H1755 GDSC1; GDSC2; CTRP1 7.0861 9.3712 4.2665 1.0898
HCC827 GDSC1; GDSC2 7.1091 18.0589 -2.0048 13.6777
NCI-H441 GDSC1; GDSC2; CTRP1 7.2561 9.1549 4.4266 0.5151
⏷ Show the Full List of 187 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 4.6529 6.4607 1.7278 0.472
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-9 GDSC1; GDSC2 2.9044 16.4586 -4.267 29.762
KYSE-270 GDSC1; GDSC2 3.2703 6.0128 1.1944 4.8046
EC-GI-10 GDSC1; GDSC2 3.5528 5.6168 1.5519 2.2514
TE-10 GDSC1; GDSC2 3.59 7.5029 0.6968 7.1018
OE33 GDSC1; GDSC2 3.7502 6.8579 1.1049 4.4043
TE-8 GDSC1; GDSC2 3.809 8.838 0.2045 9.4965
KYSE-510 GDSC1; GDSC2 3.8192 5.9556 1.549 1.8953
TE-6 GDSC1; GDSC2 3.8574 5.9179 1.5849 1.6726
KYSE-180 GDSC1; GDSC2 3.8605 6.2155 1.4585 2.2959
KYSE-450 GDSC1; GDSC2 3.8657 7.0383 1.0924 4.2711
OE21 GDSC1; GDSC2 3.8974 5.6045 1.7339 0.9641
OE19 GDSC1; GDSC2 4.0919 6.2728 1.5538 1.5476
TE-15 GDSC1; GDSC2 4.1012 6.3966 1.5068 1.7537
KYSE-520 GDSC1; GDSC2 4.1371 7.2419 1.1593 3.4614
COLO 680N GDSC1; GDSC2 4.2093 9.7885 0.0202 9.6748
KYSE-70 GDSC1; GDSC2 4.3829 7.1892 1.3154 2.3268
KYSE-140 GDSC1; GDSC2 4.4359 6.8387 1.4876 1.4828
TE-5 GDSC1; GDSC2 4.6432 11.7838 -0.6423 12.2599
KYSE-410 GDSC1; GDSC2 4.8341 6.7401 1.697 0.4681
TE-11 GDSC1; GDSC2 4.866 11.9279 -0.5623 11.4025
TE-4 GDSC1; GDSC2 4.9347 6.6843 1.7552 0.2948
T.T GDSC1; GDSC2 4.958 6.696 1.7596 0.2785
KYSE-150 GDSC1; GDSC2 6.5804 15.4318 -1.1157 10.8889
TE-1 GDSC1; GDSC2 8.3262 22.2699 -3.2026 15.9449
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC1; GDSC2 1.4683 7.1284 -0.8251 21.813
OAW42 GDSC1 3.0894 5.6187 1.261 5.955
Kuramochi GDSC1; GDSC2 3.3407 6.2162 1.1443 4.9592
EFO-27 GDSC1; GDSC2 3.6008 5.5756 1.5967 1.9472
EFO-21 GDSC1; GDSC2 3.6203 6.9623 0.9741 5.4057
FU-OV-1 GDSC1; GDSC2 3.6311 5.6648 1.5742 2.0211
SK-OV-3 GDSC1; GDSC2 3.6976 5.5152 1.6736 1.4412
OVCAR-3 GDSC1; GDSC2 3.7483 6.7766 1.1413 4.2008
DOV13 GDSC1; GDSC2 3.7871 6.7928 1.1574 4.0415
OVISE GDSC1; GDSC2 3.9565 7.5614 0.9067 5.1603
TOV-112D GDSC1; GDSC2 3.9662 6.5741 1.3593 2.6596
OV56 GDSC1; GDSC2 4.0478 8.9277 0.323 8.3152
OVK18 GDSC1; GDSC2 4.1781 8.4012 0.6548 6.1811
ES-2 GDSC1; GDSC2 4.1835 5.6809 1.8277 0.4314
JHOS-4 GDSC1; GDSC2 4.2318 6.2092 1.6458 1.0217
OVCAR-8 GDSC1; GDSC2 4.2756 9.5669 0.1696 8.7133
OAW28 GDSC1; GDSC2 4.3404 10.1621 -0.0704 9.8988
IGROV-1 GDSC1; GDSC2 4.3974 8.7962 0.6075 6.0486
OC 314 GDSC1; GDSC2 4.5398 9.2572 0.4822 6.4861
OVTOKO GDSC1; GDSC2 4.6876 8.9671 0.7023 5.0457
RMG-I GDSC1; GDSC2 4.7803 7.086 1.5453 0.9659
OVKATE GDSC1; GDSC2 4.8083 6.4561 1.7886 0.2685
JHOS-2 GDSC1; GDSC2 4.8382 11.4306 -0.3449 10.3511
OVCAR-5 GDSC1; GDSC2 4.8459 6.3821 1.8279 0.1872
TOV-21G GDSC1; GDSC2 4.878 11.365 -0.2882 9.9809
OVCAR-4 GDSC1; GDSC2 4.9985 7.1302 1.6192 0.5982
Caov-4 GDSC1; GDSC2 5.0913 6.8724 1.7469 0.2627
TYK-nu GDSC1; GDSC2; CTRP1 5.3165 7.6923 3.9502 4.9468
COV644 CTRP1 5.3783 6.8118 4.4322 4.4557
Caov-3 GDSC2; CTRP1 5.5978 8.5422 3.7434 5.4026
OV7 CTRP1 6.2233 10.5112 3.2316 11.8079
OV-90 GDSC1; GDSC2; CTRP1 6.4798 9.261 3.9906 2.8078
RMUG-S CTRP1 6.6829 13.4454 2.1299 17.7989
SNU-840 CTRP1 7.0125 13.0907 2.5314 14.3286
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PSN1 GDSC1; GDSC2 3.0593 4.5725 1.7356 2.0371
YAPC GDSC1; GDSC2 3.0737 4.9235 1.5816 2.8993
Panc 02.03 GDSC1; GDSC2 3.1692 5.3489 1.4429 3.5305
KP-4 GDSC1; GDSC2 3.1819 8.7641 -0.2136 13.3632
QGP-1 GDSC1; GDSC2 3.3542 6.0281 1.2423 4.3509
DAN-G GDSC1; GDSC2 3.4596 5.3478 1.6189 2.0349
PaTu 8902 GDSC1; GDSC2 3.4721 6.4079 1.1396 4.7248
BxPC-3 GDSC1; GDSC2 3.4824 6.9445 0.8916 6.1726
MIA PaCa-2 GDSC1; GDSC2 3.5456 5.7154 1.5039 2.5204
SU.86.86 GDSC1; GDSC2 3.661 5.8376 1.5147 2.2879
CFPAC-1 GDSC1; GDSC2 3.672 5.9736 1.4606 2.5584
PaTu 8988t GDSC1; GDSC2 3.6952 8.3124 0.3795 8.7373
SUIT-2 GDSC1; GDSC2 3.7287 6.6863 1.1709 4.0674
Panc 03.27 GDSC1; GDSC2 3.7777 5.4373 1.7454 1.0296
Panc 10.05 GDSC1; GDSC2 3.7905 7.5215 0.8204 5.9685
HPAF-II GDSC1 3.905 7.6057 0.854 6.8716
MZ-PC-1 GDSC1; GDSC2 3.9206 8.7946 0.3015 8.7022
HPAC GDSC1; GDSC2 4.1369 11.3759 -0.7961 14.1358
PL4 GDSC1; GDSC2 4.1694 5.9841 1.7065 0.8409
SW1990 GDSC1; GDSC2 4.2334 6.304 1.6087 1.1686
HuP-T4 GDSC1; GDSC2 4.2549 7.5 1.1111 3.5393
Panc 08.13 GDSC1; GDSC2 4.3174 6.9902 1.3662 2.1625
Capan-1 GDSC1; GDSC2 4.3487 6.4291 1.6116 1.0562
AsPC-1 GDSC1; GDSC2 4.4461 6.8898 1.4716 1.5411
KP-2 GDSC1; GDSC2 4.4928 5.9227 1.8594 0.2283
HuP-T3 GDSC1; GDSC2 4.5544 6.9137 1.5125 1.2694
Hs 766T GDSC1; GDSC2 4.5899 6.3638 1.7384 0.474
KP-3 GDSC1; GDSC2 4.701 6.87 1.5943 0.8519
KP-1N GDSC1; GDSC2 5.2883 7.1835 1.7103 0.2734
Capan-2 GDSC1 5.3258 7.0225 1.7788 0.1954
Panc 04.03 GDSC1; GDSC2 5.3762 15.8214 -2.0831 17.1731
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1; GDSC2 3.3191 5.8947 1.2825 4.1825
NCI-H2452 GDSC1; GDSC2 3.4211 6.2114 1.1992 4.4738
NCI-H28 GDSC1; GDSC2 3.7724 8.4961 0.3441 8.7744
MPP 89 GDSC1; GDSC2 3.9743 6.3256 1.4716 2.0778
NCI-H2052 GDSC1; GDSC2 4.249 6.7033 1.4524 1.8372
MSTO-211H GDSC1; GDSC2 5.0665 6.6919 1.8001 0.1795
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1; GDSC2 3.0176 5.2947 1.3678 4.2928
NCI-H660 GDSC2 3.598 5.594 1.5871 2.0007
22Rv1 GDSC1; GDSC2 3.9332 8.5393 0.4318 7.9298
VCaP GDSC1; GDSC2 3.9725 5.3683 1.8584 0.4575
DU145 GDSC1; GDSC2 4.6414 10.2059 0.1046 8.3559
PC-3 GDSC1; GDSC2 5.0888 7.942 1.3469 1.4615
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 3.9601 5.8648 1.6579 1.2241
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 800 GDSC1; GDSC2 -0.3865 2.5841 -0.7094 28.8328
RVH-421 GDSC1; GDSC2 3.1171 5.0642 1.5433 3.0406
WM278 GDSC1; GDSC2 3.1657 7.5388 0.379 9.9682
GAK GDSC1; GDSC2 3.2174 4.8359 1.7095 1.9198
MMAc-SF GDSC1; GDSC2 3.3085 5.1715 1.6112 2.313
HT-144 GDSC1; GDSC2 3.3655 5.7807 1.3656 3.6078
IGR-1 GDSC1; GDSC2 3.3993 5.1023 1.6937 1.7296
CP66-MEL GDSC1; GDSC2 3.4278 4.8256 1.8274 1.034
COLO 679 GDSC1; GDSC2 3.5166 5.3762 1.638 1.8525
M14 GDSC1 3.5359 5.6241 1.5392 2.9203
451Lu GDSC1; GDSC2 3.5408 5.3988 1.6412 1.8021
RPMI-7951 GDSC1; GDSC2 3.6101 6.2827 1.2843 3.633
WT2-iPS GDSC1; GDSC2 3.7014 6.3904 1.2899 3.4451
LB373-MEL-D GDSC1; GDSC2 3.8286 5.0434 1.9208 0.3523
A-431 GDSC1; GDSC2 3.8463 9.1925 0.0591 10.2389
LB2518-MEL GDSC1; GDSC2 3.8833 5.3914 1.8118 0.674
Hs 938.T GDSC1; GDSC2 3.9151 6.0776 1.5468 1.7853
COLO 783 GDSC2 3.928 5.636 1.7354 0.9303
CHL-1 GDSC1; GDSC2 3.9876 5.5837 1.7827 0.701
SH-4 GDSC1; GDSC2 4.036 6.4026 1.4709 2.0033
WM115 GDSC1; GDSC2 4.063 8.2678 0.6445 6.4549
WM1552C GDSC1; GDSC2 4.0751 6.7455 1.3437 2.5868
COLO 829 GDSC1; GDSC2 4.08 6.8866 1.2846 2.8848
SK-MEL-2 GDSC1; GDSC2 4.0927 5.3336 1.9183 0.2413
IST-MEL1 GDSC1; GDSC2 4.1002 6.3001 1.5466 1.5714
SK-MEL-30 GDSC1; GDSC2 4.1095 5.7861 1.7572 0.7023
UACC-257 GDSC1; GDSC2 4.1505 8.3503 0.6612 6.1958
Mel JuSo GDSC1; GDSC2 4.1932 6.4017 1.55 1.4568
IGR-37 GDSC1; GDSC2 4.1953 5.4816 1.9043 0.2347
Hs 940.T GDSC1; GDSC2 4.2199 5.8169 1.7919 0.5169
SK-MEL-3 GDSC1; GDSC2 4.2343 5.4409 1.9329 0.1668
A101D GDSC1; GDSC2 4.2356 5.6969 1.8425 0.3654
IPC-298 GDSC1; GDSC2 4.3382 5.9754 1.781 0.4835
WM793 GDSC1; GDSC2 4.4175 9.9362 0.0875 8.8823
MeWo GDSC1; GDSC2 4.4237 5.9834 1.8118 0.3596
LOX-IMVI GDSC1; GDSC2 4.5201 6.5693 1.6323 0.8468
VMRC-MELG GDSC1; GDSC2 4.5439 6.1957 1.7815 0.3827
UACC-62 GDSC1; GDSC2 4.5504 8.4299 0.8644 4.3981
CP50-MEL-B GDSC1; GDSC2 4.5646 6.1123 1.8192 0.287
A-388 GDSC1; GDSC2 4.7104 7.1253 1.4993 1.1887
MZ-MEL-7 GDSC1; GDSC2 4.7295 6.3108 1.8105 0.2502
G-361 GDSC1; GDSC2 4.7424 6.3161 1.8134 0.2408
WM35 GDSC1; GDSC2 4.765 6.7493 1.6663 0.5865
G-mel GDSC1; GDSC2 4.773 6.436 1.7826 0.2922
SK-MEL-31 GDSC1; GDSC2 4.775 6.2505 1.8478 0.1724
HMV-II GDSC1; GDSC2 4.96 6.9983 1.6523 0.5267
Mel Ho GDSC1; GDSC2 5.0146 6.2546 1.9284 0.0478
SK-MEL-24 GDSC1; GDSC2 5.0838 6.9398 1.7205 0.3163
DJM-1 GDSC1; GDSC2 5.1203 7.0554 1.6933 0.3609
COLO 792 GDSC1; GDSC2 5.179 6.8013 1.8025 0.153
MZ-MEL-2 GDSC1; GDSC2 5.3719 7.3389 1.6867 0.2929
A2058 GDSC1; GDSC2 5.7185 14.2574 -1.1082 12.3674
A-375 GDSC1; GDSC2; CTRP1 5.7235 9.7786 3.2274 7.679
SK-MEL-5 GDSC1; GDSC2; CTRP1 6.3983 7.9674 4.5112 0.8016
SK-MEL-28 GDSC1; GDSC2; CTRP1 6.5495 7.5537 4.7334 0.1354
SK-MEL-1 GDSC1; GDSC2; CTRP1 7.194 8.2884 4.7102 0.0536
EquiPSC Line K2 GDSC1; GDSC2 5.1631 7.4219 1.5775 0.6307
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 2.8585 5.9274 0.9445 7.2726
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EW-8 GDSC1; GDSC2 2.3004 4.1324 1.3986 5.9087
G-402 GDSC1; GDSC2 2.5482 4.7345 1.2986 5.8501
KYM-1 GDSC1; GDSC2 2.5755 7.0908 0.1454 12.9184
MES-SA GDSC1; GDSC2 2.8613 3.9689 1.8927 1.492
SW684 GDSC1; GDSC2 3.0343 6.0869 0.9951 6.536
GCT GDSC1; GDSC2 3.0812 6.7518 0.7035 8.2122
RKN GDSC1; GDSC2 3.0891 4.3826 1.8389 1.4196
SK-LMS-1 GDSC1; GDSC2 3.2268 5.2491 1.5261 2.9355
A-204 GDSC1; GDSC2 3.2348 9.3741 -0.4753 14.6618
Rh30 GDSC1; GDSC2 3.2902 5.9211 1.2512 4.4257
SK-UT-1 GDSC1; GDSC2 3.3449 6.3559 1.0806 5.331
VA-ES-BJ GDSC1; GDSC2 3.3894 5.8195 1.3625 3.5817
Rh41 GDSC1; GDSC2 3.5816 5.5664 1.5902 2.0079
G-401 GDSC1; GDSC2 3.6976 6.5631 1.2086 3.9082
SW872 GDSC1; GDSC2 3.7517 5.7018 1.6223 1.6215
Rh18 GDSC1 3.8962 7.765 0.7739 7.4508
TE 441.T GDSC2 4.0459 5.9859 1.6494 1.1758
MFH-ino GDSC1; GDSC2 4.0785 6.5544 1.4282 2.1587
RD GDSC1; GDSC2 4.1683 8.6177 0.5476 6.8041
SW982 GDSC1; GDSC2 4.2108 12.4408 -1.2627 16.2041
STS-0421 GDSC1; GDSC2 4.8312 7.3525 1.4639 1.2251
Hs 633.T GDSC1; GDSC2 4.8771 11.2268 -0.2238 9.6485
HT-1080 GDSC1; GDSC2; CTRP1 6.5564 12.1223 2.6839 8.7143
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 GDSC1; GDSC2 1.178 4.7543 0.0577 17.977
SNU-5 GDSC1; GDSC2 2.7052 4.4065 1.5792 3.6985
AGS GDSC1; GDSC2 3.0249 5.2835 1.3781 4.2143
NUGC-3 GDSC1; GDSC2 3.0535 9.4167 -0.6357 15.9902
HSC-39 GDSC1; GDSC2 3.3051 5.6657 1.3811 3.631
MKN45 GDSC1; GDSC2 3.3098 6.0128 1.2206 4.5682
ECC12 GDSC2 3.3173 7.0198 0.742 7.4281
ECC10 GDSC1; GDSC2 3.3282 5.8383 1.315 3.974
SCH GDSC1; GDSC2 3.4854 5.9515 1.3607 3.4183
KATO III GDSC1; GDSC2 3.4888 7.119 0.8123 6.6309
Fu97 GDSC1; GDSC2 3.6077 6.7262 1.0769 4.8295
RF-48 GDSC1; GDSC2 3.6758 5.3649 1.7257 1.2233
RERF-GC-1B GDSC1; GDSC2 3.708 6.637 1.1809 4.0469
OCUM-1 GDSC1; GDSC2 3.758 6.5503 1.2508 3.568
23132/87 GDSC1; GDSC2 3.8026 5.5011 1.7312 1.0659
NCI-N87 GDSC1 3.9968 6.6522 1.3419 3.3668
TGBC11TKB GDSC1; GDSC2 3.9982 7.1541 1.1186 3.9014
MKN7 GDSC1; GDSC2 4.0803 6.7785 1.3322 2.6386
NUGC-4 GDSC1; GDSC2 4.1257 5.8661 1.7333 0.7762
SNU-16 GDSC1; GDSC2 4.1544 6.7206 1.3967 2.2167
SK-GT-2 GDSC1; GDSC2 4.1805 6.4389 1.5285 1.5659
MKN1 GDSC1; GDSC2 4.2531 8.1555 0.8142 5.1558
Hs 746.T GDSC1; GDSC2 4.2663 6.0334 1.7294 0.6891
TMK-1 GDSC1; GDSC2 4.277 6.5377 1.5345 1.439
GCIY GDSC1; GDSC2 4.3125 6.1187 1.7165 0.7016
IM95 GDSC1; GDSC2 4.9111 7.1079 1.5921 0.7261
SNU-1 GDSC1; GDSC2 5.1672 6.943 1.7499 0.2365
MKN28 GDSC1; GDSC2 7.2901 20.9682 -3.2568 17.7892
SNG-M GDSC1; GDSC2 4.3061 5.9414 1.7806 0.5021
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8305C GDSC1; GDSC2 2.5878 7.111 0.1452 12.8853
CGTH-W-1 GDSC1; GDSC2 2.8102 4.2641 1.7214 2.5948
CAL-62 GDSC1; GDSC2 2.9991 6.0577 0.984 6.6872
B-CPAP GDSC1; GDSC2 3.401 5.2812 1.6154 2.1421
TT GDSC1; GDSC2 3.529 7.0733 0.8613 6.2552
IHH-4 GDSC1; GDSC2 3.551 6.5161 1.1393 4.5743
KMH-2 GDSC1; GDSC2 3.6261 5.5585 1.6178 1.8054
FTC-133 GDSC1; GDSC2 3.6279 7.7715 0.5937 7.6295
TT2609-C02 GDSC1; GDSC2 3.7706 7.4021 0.8638 5.7552
ML-1 [Human leukemia] GDSC1; GDSC2 3.8545 6.2735 1.4299 2.4523
ASH-3 GDSC1; GDSC2 3.8643 5.4469 1.7816 0.803
WRO GDSC1; GDSC2 4.1485 5.9571 1.7078 0.8524
HTC-C3 GDSC1; GDSC2 4.2516 7.4543 1.1295 3.447
K5 GDSC1; GDSC2 4.4242 9.3173 0.3825 7.2454
BHT-101 GDSC1; GDSC2 4.6618 11.9173 -0.6937 12.4778
8505C GDSC1; GDSC2 5.0603 11.1687 -0.081 8.5649
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-38 GDSC1 2.8559 5.2956 1.2532 6.6741
HSC-2 GDSC1; GDSC2 2.9337 4.8721 1.5136 3.5886
FaDu GDSC1; GDSC2 3.0828 7.809 0.1839 11.3327
PCI-30 GDSC1; GDSC2 3.111 5.1055 1.52 3.1894
PCI-15A GDSC1; GDSC2 3.2542 6.2269 1.0811 5.519
PCI-06A GDSC1; GDSC2 3.366 5.6464 1.4283 3.2453
SCC-4 GDSC1; GDSC2 3.4551 6.1326 1.2578 4.0661
CAL-27 GDSC1; GDSC2 3.5785 7.2127 0.8278 6.3509
BB49-HNC GDSC1 3.5861 6.3634 1.2324 4.9386
NCI-H3118 GDSC1; GDSC2 3.6193 6.1379 1.3561 3.2139
KON GDSC1; GDSC2 3.6208 7.2275 0.8489 6.1401
BICR 10 GDSC1 3.621 5.7104 1.5487 2.6999
HO-1-u-1 GDSC1; GDSC2 3.6549 6.319 1.2947 3.4971
KOSC-2 GDSC1; GDSC2 3.6921 7.916 0.568 7.6435
HO-1-N-1 GDSC1; GDSC2 3.7849 5.9953 1.5135 2.1188
BICR 78 GDSC1; GDSC2 3.8436 6.1477 1.4789 2.215
Detroit 562 GDSC1; GDSC2 3.8669 7.6857 0.7923 5.9831
SCC-9 GDSC1; GDSC2 3.881 6.1827 1.4838 2.1396
SAS GDSC1; GDSC2 3.8825 9.0316 0.1618 9.5789
BB30-HNC GDSC1; GDSC2 3.9034 8.5515 0.4061 8.139
CAL-33 GDSC1; GDSC2 3.911 7.5614 0.8784 5.405
Ca9-22 GDSC1; GDSC2 4.1112 7.798 0.8923 4.9665
BHY GDSC1; GDSC2 4.1258 6.1764 1.6098 1.2659
DOK GDSC1; GDSC2 4.2829 8.1762 0.8226 5.0586
HSC-3 GDSC1; GDSC2 4.3037 5.7154 1.862 0.2885
OSC-20 GDSC1; GDSC2 4.3747 11.0525 -0.4737 11.9683
JHU-011 GDSC1; GDSC2 4.3776 8.9928 0.5043 6.6563
BICR 22 GDSC1; GDSC2 4.3964 10.044 0.0227 9.2781
SCC-25 GDSC1; GDSC2 4.4695 6.888 1.4834 1.4678
SKN-3 GDSC1; GDSC2 4.4712 7.961 1.028 3.6557
OSC-19 GDSC1; GDSC2 4.5339 6.5192 1.6574 0.7518
PCI-04B GDSC1; GDSC2 4.7386 12.3065 -0.8283 12.9806
JHU-029 GDSC1; GDSC2 4.763 7.0239 1.5618 0.9208
PE/CA-PJ15 GDSC1; GDSC2 4.7908 8.6346 0.9081 3.8161
UPCI-SCC-090 GDSC1; GDSC2 4.8532 6.8862 1.6511 0.5834
LB771-HNC GDSC1; GDSC2 4.992 7.1706 1.6017 0.6516
BICR 31 GDSC2 5.075 6.7421 1.786 0.1996
HSC-4 GDSC1; GDSC2 5.0872 12.1935 -0.5434 10.8736
JHU-022 GDSC1; GDSC2 5.0897 7.088 1.6701 0.4251
SAT [Human HNSCC] GDSC1; GDSC2 5.2008 8.0512 1.3541 1.3426
SCC-15 GDSC1; GDSC2 6.558 18.9349 -2.7747 17.4624
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC1; GDSC2 3.3127 8.265 0.1303 11.0736
BFTC-905 GDSC1; GDSC2 3.4886 6.4111 1.1486 4.6397
5637 GDSC1; GDSC2 3.5896 7.3652 0.7625 6.7143
639V GDSC1; GDSC2 3.7624 4.9413 1.932 0.3555
CAL-29 GDSC1; GDSC2 3.8064 7.4682 0.8557 5.733
HT-1376 GDSC1; GDSC2 3.8337 6.1426 1.4757 2.2448
J82 GDSC1; GDSC2 3.8431 7.3092 0.9533 5.1019
SW1710 GDSC1; GDSC2 4.3727 7.1469 1.3281 2.278
T24 GDSC1; GDSC2 4.4374 7.1731 1.35 2.0973
TCCSUP GDSC1; GDSC2 4.5102 6.3913 1.6959 0.6421
SW780 GDSC1; GDSC2 4.5367 6.4772 1.6745 0.6939
RT-112 GDSC1; GDSC2 4.5677 9.5374 0.3698 7.0513
UM-UC-3 GDSC1; GDSC2 4.7135 8.0462 1.1214 2.8549
647V GDSC1; GDSC2 4.7863 9.6034 0.4723 6.1143
RT-4 GDSC1; GDSC2 4.795 6.6953 1.698 0.4835
HT-1197 GDSC1; GDSC2 5.72 13.5427 -0.7727 10.8096
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC1; GDSC2 2.8377 6.2073 0.7905 8.2797
BPH-1 GDSC1; GDSC2 3.0744 6.8002 0.6748 8.4038
NT2-D1 GDSC1; GDSC2 3.1156 9.6953 -0.726 16.2944
JEG-3 GDSC1; GDSC2 3.1206 7.9753 0.1301 11.5524
HEY GDSC1; GDSC2 3.1406 5.8292 1.1948 5.0761
DSH1 GDSC1; GDSC2 3.2216 7.1547 0.6081 8.4568
DoTc2 4510 GDSC1; GDSC2 3.313 5.7205 1.3605 3.7365
HEC-1 GDSC1; GDSC2 3.3479 6.4757 1.0254 5.6555
MS751 GDSC1; GDSC2 3.413 5.2242 1.6476 1.9521
SiSo GDSC1; GDSC2 3.4146 5.1779 1.6689 1.8372
JHOS-3 GDSC1; GDSC2 3.5975 5.8111 1.4908 2.5106
SW962 GDSC1; GDSC2 3.6388 7.1207 0.9112 5.7373
NCC-IT GDSC2 3.7766 5.6318 1.6645 1.3919
OVCA433 GDSC1; GDSC2 3.8266 6.319 1.3943 2.6792
OV17R GDSC1; GDSC2 3.8551 6.5217 1.3202 3.0315
NEC8 GDSC1; GDSC2 3.8989 5.798 1.6558 1.297
OVMIU GDSC1; GDSC2 3.9045 7.9712 0.6822 6.5454
OVCA420 GDSC1; GDSC2 3.9239 5.66 1.7239 0.9808
ME-180 GDSC1; GDSC2 3.962 8.9998 0.2312 9.0147
PWR-1E GDSC1; GDSC2 3.9757 5.8635 1.6659 1.1743
LB831-BLC GDSC1; GDSC2 4.0325 5.847 1.699 0.9836
SW954 GDSC1; GDSC2 4.0495 13.5531 -1.927 19.4636
PEO1 GDSC1; GDSC2 4.1014 6.5504 1.4418 2.0631
JAR GDSC1; GDSC2 4.1785 5.7191 1.8116 0.4812
CAL-39 GDSC1; GDSC2 4.2092 6.8943 1.351 2.3717
SKG-IIIa GDSC1; GDSC2 4.2942 6.2498 1.6577 0.9245
TC-YIK GDSC1; GDSC2 4.3171 6.289 1.6526 0.9258
SW756 GDSC1; GDSC2 4.3335 5.7689 1.8543 0.2948
C-4-I GDSC1; GDSC2 4.3841 6.1893 1.7197 0.6443
UWB1.289 GDSC1; GDSC2 4.3875 7.5749 1.1515 3.1367
SiHa GDSC1; GDSC2 4.433 5.6338 1.9374 0.114
Ca Ski GDSC1; GDSC2 4.4383 6.9907 1.4264 1.7471
HeLa GDSC1; GDSC2 4.4819 5.7647 1.9101 0.1431
C-33 A GDSC1; GDSC2 4.657 6.5499 1.6966 0.5567
SKN GDSC1; GDSC2 4.8712 6.7861 1.6948 0.4572
ACC-OV7 GDSC1; GDSC2 4.943 8.737 0.9455 3.422
HT-3 GDSC1; GDSC2 5.1436 7.3519 1.5954 0.5911
KGN GDSC1; GDSC2 5.1697 14.4817 -1.5795 15.527
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 5.1894 7.1592 1.6824 0.36
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Rucaparib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of Rucaparib and Ivosidenib. Acute myeloid leukaemia [2A60] [3]
Oliceridine DM6MDCF Moderate Increased risk of prolong QT interval by the combination of Rucaparib and Oliceridine. Acute pain [MG31] [4]
Levalbuterol DM5YBO1 Moderate Increased risk of prolong QT interval by the combination of Rucaparib and Levalbuterol. Asthma [CA23] [5]
Troleandomycin DMUZNIG Moderate Decreased metabolism of Rucaparib caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [6]
Ag-221 DMS0ZBI Moderate Decreased clearance of Rucaparib due to the transporter inhibition by Ag-221. BCR-ABL1-negative chronic myeloid leukaemia [2A41] [7]
Pexidartinib DMS2J0Z Major Decreased metabolism of Rucaparib caused by Pexidartinib mediated inhibition of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [8]
Tazemetostat DMWP1BH Moderate Increased metabolism of Rucaparib caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [9]
Ripretinib DM958QB Moderate Decreased metabolism of Rucaparib caused by Ripretinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [7]
Avapritinib DMK2GZX Moderate Decreased metabolism of Rucaparib caused by Avapritinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [10]
Berotralstat DMWA2DZ Major Decreased clearance of Rucaparib due to the transporter inhibition by Berotralstat. Innate/adaptive immunodeficiency [4A00] [11]
Pemigatinib DM819JF Moderate Decreased metabolism of Rucaparib caused by Pemigatinib mediated inhibition of CYP450 enzyme. Liver cancer [2C12] [10]
Lurbinectedin DMEFRTZ Moderate Decreased metabolism of Rucaparib caused by Lurbinectedin mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [12]
Pralsetinib DMWU0I2 Moderate Decreased metabolism of Rucaparib caused by Pralsetinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [13]
Selpercatinib DMZR15V Moderate Decreased metabolism of Rucaparib caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [10]
Ubrogepant DM749I3 Moderate Decreased metabolism of Rucaparib caused by Ubrogepant mediated inhibition of CYP450 enzyme. Migraine [8A80] [14]
Rimegepant DMHOAUG Moderate Decreased clearance of Rucaparib due to the transporter inhibition by Rimegepant. Migraine [8A80] [15]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Rucaparib and Siponimod. Multiple sclerosis [8A40] [7]
Ozanimod DMT6AM2 Major Increased risk of ventricular arrhythmias by the combination of Rucaparib and Ozanimod. Multiple sclerosis [8A40] [16]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Rucaparib caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [10]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of Rucaparib and Macimorelin. Pituitary gland disorder [5A60-5A61] [17]
Lefamulin DME6G97 Moderate Decreased metabolism of Rucaparib caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [18]
Darolutamide DMV7YFT Moderate Decreased clearance of Rucaparib due to the transporter inhibition by Darolutamide. Prostate cancer [2C82] [19]
Voxelotor DMCS6M5 Moderate Decreased metabolism of Rucaparib caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [20]
Tedizolid DMG2SKR Moderate Decreased clearance of Rucaparib due to the transporter inhibition by Tedizolid. Skin and skin-structure infection [1F28-1G0Z] [10]
Larotrectinib DM26CQR Moderate Decreased clearance of Rucaparib due to the transporter inhibition by Larotrectinib. Solid tumour/cancer [2A00-2F9Z] [7]
Lusutrombopag DMH6IKO Moderate Decreased clearance of Rucaparib due to the transporter inhibition by Lusutrombopag. Thrombocytopenia [3B64] [6]
⏷ Show the Full List of 26 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
FD&C blue no. 1 E00263 19700 Colorant
FD&C blue no. 2 E00446 2723854 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 4000 E00654 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyvinyl alcohol E00666 Not Available Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Acid blue 9 aluminum lake E00583 56841154 Colorant
Colcothar yellow E00436 518696 Colorant
Hydrophobic colloidal silica E00285 24261 Anticaking agent; Emulsion stabilizing agent; Glidant; Suspending agent; Viscosity-controlling agent
Cellulose microcrystalline E00698 Not Available Adsorbent; Suspending agent; Diluent
⏷ Show the Full List of 13 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Rucaparib 200 mg tablet 200 mg Oral Tablet Oral
Rucaparib Camsylate eq 200mg base tablet eq 200mg base Tablet Oral
Rucaparib Camsylate eq 300mg base tablet eq 300mg base Tablet Oral
Rucaparib Camsylate eq 250mg base tablet eq 250mg base Tablet Oral
Rucaparib 300 mg tablet 300 mg Oral Tablet Oral
Rucaparib 250 mg tablet 250 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
2 Rucaparib: the past, present, and future of a newly approved PARP inhibitor for ovarian cancer. Onco Targets Ther. 2017 Jun 19;10:3029-3037.
3 Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
4 Canadian Pharmacists Association.
5 Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
6 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
7 Cerner Multum, Inc. "Australian Product Information.".
8 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
9 Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
10 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
11 Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
12 Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
13 Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
14 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
15 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
16 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
17 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
18 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
19 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
20 Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.