Details of the Drug

General Information of Drug (ID: DMDFG1O)

Drug Name

HLF 1-11

Synonyms

Antimicrobial peptides, AM-Pharma; HLF(1-11); Antimicrobial peptides (bacterial infections), AM-Pharma; Antimicrobial peptides (fungal infections), AM-Pharma; HLF 1-11, AM-Pharma; Human lactoferrin 1-11, AM-Pharma; Human lactoferrin peptides (antibacterial), AM-Pharma

Indication

Disease Entry	ICD 11	Status	REF
Bacteremia	1A73	Phase 1/2	[1]
Bacterial infection	1A00-1C4Z	Phase 1/2	[2]
Candidemia	1F23.3Y	Phase 1/2	[3]
------------------------------------------------------------------------------------

Drug Type

Peptide

Structure

3D Structure is Not Available

3D MOL

2D MOL

Cross-matching ID

TTD ID: D0D8EY

Repurposed Drugs (RPD)

Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lactotransferrin (LTF)	TTSZDQU	TRFL_HUMAN	Modulator	[4]

------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT00509847) A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Bacteremia Due to S. Epidermidis (LIST). U.S. National Institutes of Health.
2	ClinicalTrials.gov (NCT00509847) A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Bacteremia Due to S. Epidermidis. U.S. National Institutes of Health.
3	ClinicalTrials.gov (NCT00509834) A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Proven Candidaemia (SLIC). U.S. National Institutes of Health.
4	The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2004 Dec;48(12):4919-21.