Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDFG1O)

Drug Name

HLF 1-11 Drug Info

Synonyms

Antimicrobial peptides, AM-Pharma; HLF(1-11); Antimicrobial peptides (bacterial infections), AM-Pharma; Antimicrobial peptides (fungal infections), AM-Pharma; HLF 1-11, AM-Pharma; Human lactoferrin 1-11, AM-Pharma; Human lactoferrin peptides (antibacterial), AM-Pharma

Indication

Disease Entry	ICD 11	Status	REF
Bacteremia	1A73	Phase 1/2	[1]
Bacterial infection	1A00-1C4Z	Phase 1/2	[2]
Candidemia	1F23.3Y	Phase 1/2	[3]

Cross-matching ID

TTD Drug ID: DMDFG1O

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Lactotransferrin (LTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Parecoxib	DMIV8CT	N. A.	N. A.	Phase 4	[5]
Talactoferrin	DMV7T64	Diabetic foot ulcer	BD54	Phase 3	[6]
Nimesulide	DMR1NMD	Metastatic colorectal cancer	2B91	Terminated	[7]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[8]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[8]
Lauric Acid	DM9C8KQ	Discovery agent	N.A.	Investigative	[8]
Alpha-D-Fucose	DM6VH7A	Discovery agent	N.A.	Investigative	[8]
Nitrilotriacetic Acid	DMIOQFU	Discovery agent	N.A.	Investigative	[8]
3h-Indole-5,6-Diol	DMBFCTZ	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lactotransferrin (LTF)	TTSZDQU	TRFL_HUMAN	Modulator	[4]

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References

1	ClinicalTrials.gov (NCT00509847) A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Bacteremia Due to S. Epidermidis (LIST). U.S. National Institutes of Health.
2	ClinicalTrials.gov (NCT00509847) A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Bacteremia Due to S. Epidermidis. U.S. National Institutes of Health.
3	ClinicalTrials.gov (NCT00509834) A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Proven Candidaemia (SLIC). U.S. National Institutes of Health.
4	The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2004 Dec;48(12):4919-21.
5	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
6	Talactoferrin alfa, a recombinant human lactoferrin promotes healing of diabetic neuropathic ulcers: a phase 1/2 clinical study. Am J Surg. 2007 Jan;193(1):49-54.
7	Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
8	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.