Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTSZDQU)

• DTT Name: Lactotransferrin (LTF)
• Synonyms: Talalactoferrin; Lactoferrin; LF; Growth-inhibiting protein 12; GIG12
• Gene Name: LTF
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Transferrin
• UniProt ID: TRFL_HUMAN
• TTD ID: T67801
• EC Number: EC 3.4.21.-
• Sequence:
  MKLVFLVLLFLGALGLCLAGRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDS
  PIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKG
  GSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGA
  DKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDE
  AERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKD
  KSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAAR
  RARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYT
  AGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHT
  AVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNS
  NERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRK
  PVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNL
  LFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK
• Function: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
• Reactome Pathway:
  Amyloid formation (R-HSA-977225)
  ROS production in response to bacteria (R-HSA-1222556)

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Parecoxib	DMIV8CT	N. A.	N. A.	Phase 4	[1]

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talactoferrin	DMV7T64	Diabetic foot ulcer	BD54	Phase 3	[2]
HLF 1-11	DMDFG1O	Bacteremia	1A73	Phase 1/2	[3]

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nimesulide	DMR1NMD	Metastatic colorectal cancer	2B91	Terminated	[4]

6 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3h-Indole-5,6-Diol	DMBFCTZ	Discovery agent	N.A.	Investigative	[5]
Alpha-D-Fucose	DM6VH7A	Discovery agent	N.A.	Investigative	[5]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[5]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[5]
Lauric Acid	DM9C8KQ	Discovery agent	N.A.	Investigative	[5]
Nitrilotriacetic Acid	DMIOQFU	Discovery agent	N.A.	Investigative	[5]

References

• [1] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [2] Talactoferrin alfa, a recombinant human lactoferrin promotes healing of diabetic neuropathic ulcers: a phase 1/2 clinical study. Am J Surg. 2007 Jan;193(1):49-54.
• [3] The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2004 Dec;48(12):4919-21.
• [4] Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
• [5] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.