Details of the Drug

General Information of Drug (ID: DMHZCPO)

Drug Name
Ibrutinib
Synonyms PCI-32765; Ibrutinib (BTK inhibitor)
Indication
Disease Entry ICD 11 Status REF
Mantle cell lymphoma 2A85.5 Approved [1]
Small lymphocytic lymphoma 2A82.0 Approved [2]
Waldenstrom macroglobulinemia 2A85.4 Approved [2]
B-cell non-hodgkin lymphoma 2B33.5 Phase 3 [3]
Diffuse large B-cell lymphoma 2A81 Phase 3 [3]
Follicular lymphoma 2A80 Phase 3 [3]
Non-hodgkin lymphoma 2B33.5 Phase 3 [3]
Pancreatic cancer 2C10 Phase 3 [3]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [4]
Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
⏷ Show the Full List of Indication(s)
Affected Organisms
Humans and other mammals
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 440.5
Logarithm of the Partition Coefficient (xlogp) 3.6
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
ADMET Property
Clearance
The drug present in the plasma can be removed from the body at the rate of 16.4 mL/min/kg [5]
Half-life
The concentration or amount of drug in body reduced by one-half in 5 hours [5]
Unbound Fraction
The unbound fraction of drug in plasma is 0.03% [5]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 9.75 L/kg [5]
Chemical Identifiers
Formula
C25H24N6O2
IUPAC Name
1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
Canonical SMILES
C=CC(=O)N1CCC[C@H](C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N
InChI
InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m1/s1
InChIKey
XYFPWWZEPKGCCK-GOSISDBHSA-N
Cross-matching ID
PubChem CID
24821094
ChEBI ID
CHEBI:76612
CAS Number
936563-96-1
UNII
1X70OSD4VX
DrugBank ID
DB09053
TTD ID
D09KTS
VARIDT ID
DR01270
INTEDE ID
DR0843
ACDINA ID
D01146
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tyrosine-protein kinase BTK (ATK) TTGM6VW BTK_HUMAN Inhibitor [6]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [7]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [8]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [8]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2) OTGVC9MY PLCG2_HUMAN Post-Translational Modifications [9]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Protein Interaction/Cellular Processes [10]
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [11]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Gene/Protein Processing [9]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [9]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Gene/Protein Processing [9]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Drug Response [9]
Hemoglobin subunit beta (HBB) OT514IKQ HBB_HUMAN Protein Interaction/Cellular Processes [11]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Gene/Protein Processing [12]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Gene/Protein Processing [9]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Mantle cell lymphoma
ICD Disease Classification 2A85.5
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tyrosine-protein kinase BTK (ATK) DTT BTK 3.54E-01 0.24 0.56
P-glycoprotein 1 (ABCB1) DTP P-GP 7.45E-02 -1.49E-01 -3.47E-01
Cytochrome P450 3A5 (CYP3A5) DME CYP3A5 1.34E-01 -2.79E-01 -7.05E-01
Cytochrome P450 2D6 (CYP2D6) DME CYP2D6 1.61E-03 -6.79E-01 -2.18E+00
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 9.81E-01 2.72E-01 6.95E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 5.4015 7.3892 2.6506 0.8684
NY GDSC2 3.3725 8.3042 0.8728 15.1018
CHSA0108 GDSC2 3.7201 6.7795 1.9127 7.8214
EW-12 GDSC2 3.977 6.9145 2.038 6.4066
U-CH2 GDSC2 4.0767 9.5723 0.8013 13.5523
HuO-3N1 GDSC2 4.1889 12.4969 -0.5645 20.0958
A-673 GDSC2 4.2038 6.5289 2.3803 3.832
CHSA0011 GDSC2 4.2566 9.1046 1.1677 10.9932
CAL-78 GDSC2; CTRP2 4.3368 5.6688 4.2684 11.6105
CAL-72 GDSC2 4.3387 6.9184 2.284 4.1358
ES5 GDSC2 4.3488 9.3211 1.1291 10.9927
CHSA8926 GDSC2 4.3964 6.5351 2.4979 2.7972
HuO9 GDSC2 4.4371 6.6626 2.4641 2.9175
NOS-1 [Human HNSCC] GDSC2 4.44 11.2546 0.2444 15.6052
U2OS GDSC2 4.5479 8.1001 1.8611 6.217
SK-N-MC CTRP2 4.564 8.5601 3.41 14.2994
SK-PN-DW GDSC2 4.5783 7.9246 1.9645 5.5446
ES7 GDSC2 4.6354 10.9561 0.5364 13.5985
EW-3 GDSC2 4.671 8.5035 1.7509 6.6141
G-292 clone A141B1 GDSC2; CTRP2 4.7296 7.459 4.0749 11.2242
TC-71 GDSC2 4.9107 6.9318 2.606 1.5102
SaOS-2 GDSC2; CTRP2 4.9378 8.5052 3.803 11.7978
EW-24 GDSC2 5.0805 6.4289 2.8793 0.3412
CADO-ES1 GDSC2 5.1077 6.7744 2.7609 0.6907
EW-16 GDSC2 5.1525 7.638 2.4309 2.0526
MHH-ES-1 GDSC2 5.1653 7.3409 2.5615 1.4351
SK-ES-1 GDSC2; CTRP2 5.2038 6.6215 4.9237 6.6338
H-EMC-SS GDSC2 5.2692 8.5598 2.0926 3.6159
Hs 888.T CTRP2 5.3477 6.3244 5.1927 5.2024
SJSA-1 CTRP2 5.3576 6.7877 5.0137 5.8705
TC71 CTRP2 5.3621 7.7736 4.5615 7.6885
ES6 GDSC2 5.4425 7.7678 2.5193 1.3432
HOS GDSC2; CTRP2 5.4577 5.9401 5.4292 4.0067
EW-22 GDSC2 5.4676 7.5321 2.6239 0.915
ES8 GDSC2 5.4935 7.3963 2.6871 0.6806
MG-63 GDSC2; CTRP2 5.5118 5.9553 5.4849 3.6407
EW-7 GDSC2 5.6356 7.5199 2.6991 0.5609
Hs 822.T CTRP2 5.6432 5.9101 5.6346 2.7018
EW-18 GDSC2 5.9054 7.6788 2.7462 0.3233
ES4 GDSC2 5.9351 7.7967 2.7155 0.3804
EW-13 GDSC2 6.0709 7.9282 2.7198 0.3221
EW-1 GDSC2 6.2752 8.7352 2.5066 0.7759
EW-11 GDSC2 6.7039 9.2731 2.4795 0.633
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 198 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 4.4625 7.2666 3.8796 12.7001
JM1 GDSC2; CTRP2 3.1496 4.8276 3.1158 19.3993
Ri-1 CTRP2 -8.1061 17.8935 -13.7037 63.2726
Pfeiffer CTRP2 -1.7391 6.3454 -2.534 51.4273
SU-DHL-16 GDSC2 -1.05 1.194 -1.0778 43.9704
SUP-B8 GDSC2 -1.0407 2.9192 -1.3355 44.5284
EoL-1 GDSC2; CTRP2 -0.9607 1.5847 -0.9661 46.6792
GA-10 GDSC2; CTRP2 -0.027 4.2901 -0.1981 40.8934
EB1 CTRP2 0.1935 6.71 -0.5344 40.6719
Hs 611.T CTRP2 0.1966 13.643 -3.2949 43.9934
Farage GDSC2 0.3342 3.8888 -0.1094 32.144
MOLM-13 GDSC2 0.4446 3.8737 0.0155 31.0092
SU-DHL-6 GDSC2; CTRP2 0.4834 4.0703 0.3786 37.3695
CTV-1 GDSC2 0.6915 3.1726 0.4906 27.4321
HT GDSC2 0.8403 10.2455 -2.3763 37.1122
DoHH2 GDSC2 0.8994 1.5872 0.8991 24.3118
Kasumi-2 CTRP2 0.9137 8.4395 -0.3523 37.545
Karpas-422 GDSC2; CTRP2 1.0169 6.9653 0.2812 35.6643
MLMA GDSC2 1.05 6.9471 -0.6124 30.9211
LAMA-84 GDSC2 1.0531 3.2521 0.8646 23.7536
WSU-NHL GDSC2 1.1453 2.8683 1.0532 22.3176
JURL-MK1 GDSC2 1.3557 4.1668 0.898 22.207
Daudi GDSC2; CTRP2 1.4001 3.478 1.3862 30.9873
P32/ISH GDSC2 1.4178 2.7849 1.362 19.3941
MEG-01 GDSC2 1.4369 2.9398 1.355 19.3396
BONNA-12 GDSC2 1.4909 10.4304 -1.8537 33.3265
RCH-ACV GDSC2; CTRP2 1.5363 8.6288 0.2385 33.9728
JVM-2 GDSC2 1.5453 8.1457 -0.6936 29.1964
NU-DUL-1 GDSC2; CTRP2 1.5603 3.7237 1.5397 29.9425
Ku812 GDSC2 1.6365 3.3746 1.4679 17.8042
Mono-Mac-1 CTRP2 1.6805 4.9948 1.5219 29.6064
SU-DHL-4 GDSC2 1.7361 3.304 1.5961 16.6509
CML-T1 GDSC2 1.7366 4.0646 1.3444 18.0536
MC116 GDSC2 1.7407 6.5652 0.2482 24.1263
JeKo-1 GDSC2; CTRP2 1.7871 7.4178 0.9621 31.076
SU-DHL-5 GDSC2 1.8004 2.8667 1.7599 15.4762
MOLM-6 CTRP2 2.0088 3.6319 2.0025 26.9068
NU-DHL-1 CTRP2 2.1264 4.6593 2.0518 26.3542
Kasumi-1 GDSC2; CTRP2 2.2089 3.7204 2.2037 25.5698
SUP-B15 GDSC2; CTRP2 2.3055 5.0323 2.1891 25.3049
OCI-Ly10 CTRP2 2.3385 12.5732 -0.6577 33.6213
KYO-1 CTRP2 2.3814 3.0075 2.3814 24.4032
SUP-T1 GDSC2; CTRP2 2.4112 7.4574 1.6203 26.9577
697 GDSC2; CTRP2 2.469 5.8269 2.1997 24.7507
BL-70 CTRP2 2.52 2.9998 2.52 23.4798
MY-M12 GDSC2 2.5412 6.371 1.1062 16.3869
NK-92MI GDSC2 2.5748 4.3354 2.1095 10.1662
BV-173 CTRP2 2.7836 4.712 2.7418 21.8647
QIMR-WIL GDSC2 2.7901 9.7082 -0.3245 23.1402
ALL-SIL GDSC2 2.8601 4.2199 2.4474 7.0445
CTB-1 GDSC2 2.9365 6.1489 1.5756 12.21
ALL-PO GDSC2 3.0354 5.4701 2.0006 9.2367
SU-DHL-10 GDSC2 3.1518 4.217 2.7258 4.3
MOLT-3 CTRP2 3.2064 6.736 2.7341 20.5902
Jiyoye GDSC2 3.2344 7.0537 1.3826 12.4767
BE-13 GDSC2 3.2623 5.3176 2.274 6.8103
OCI-Ly7 GDSC2 3.2965 4.6838 2.6197 4.521
NB4 GDSC2; CTRP2 3.3246 4.6352 3.3123 18.1608
RPMI-8866 GDSC2 3.3522 8.5112 0.7525 15.849
TALL-1 [Human adult T-ALL] GDSC2; CTRP2 3.3801 5.734 3.2152 18.3202
EB2 GDSC2 3.397 7.2179 1.4361 11.6693
MHH-PREB-1 GDSC2 3.4306 5.128 2.5078 4.8473
HAL-01 GDSC2 3.4452 5.4752 2.3462 5.8288
MN-60 GDSC2 3.4553 5.1327 2.5251 4.6703
Jurkat GDSC2 3.4723 4.8209 2.6937 3.5612
JVM-3 GDSC2 3.5112 5.5938 2.3396 5.6905
OPM-2 GDSC2; CTRP2 3.5222 5.3251 3.4496 17.0506
Hs 445 GDSC2 3.5384 6.6768 1.8213 8.8791
VAL GDSC2 3.6362 6.1162 2.1772 6.3826
KCL-22 GDSC2 3.6366 5.3781 2.5428 4.0904
DEL GDSC2 3.6466 6.5153 1.9871 7.5488
AMO1 GDSC2 3.6512 5.0746 2.7025 3.0618
EM-2 GDSC2 3.6619 5.6596 2.4229 4.7767
Granta-519 GDSC2; CTRP2 3.6657 9.0574 2.2804 21.0095
KMS-11 GDSC2; CTRP2 3.7173 5.9034 3.5418 16.1137
CA46 GDSC2; CTRP2 3.7307 5.9194 3.5524 16.0345
A4/Fukuda GDSC2; CTRP2 3.735 5.426 3.662 15.6348
K-562 GDSC2; CTRP2 3.7701 5.3206 3.716 15.3356
MOLT-13 GDSC2; CTRP2 3.7995 6.0409 3.5954 15.6694
Loucy GDSC2 3.8021 5.5287 2.5885 3.4194
RPMI-8226 GDSC2; CTRP2 3.8073 5.8511 3.653 15.4392
Namalwa GDSC2; CTRP2 3.8096 7.0206 3.2834 16.7966
P30/OHK GDSC2 3.8238 9.8641 0.4591 16.1124
RPMI-6666 GDSC2; CTRP2 3.8627 7.2998 3.2328 16.84
SCC-3 GDSC2 3.8691 5.4029 2.6945 2.6351
SKM-1 GDSC2; CTRP2 3.9016 4.9639 3.8902 14.3139
KG-1 GDSC2 3.9059 7.6051 1.6454 9.0011
CRO-AP2 GDSC2 3.9112 5.8166 2.525 3.5682
L-540 GDSC2; CTRP2 3.9269 5.1566 3.902 14.1912
SUP-M2 GDSC2; CTRP2 3.9348 5.6798 3.8304 14.4137
P12-Ichikawa GDSC2 3.9967 5.8578 2.5626 3.1631
BC-3 GDSC2 3.9981 6.1785 2.4104 4.0763
BL-41 GDSC2 3.9987 5.7642 2.6082 2.8885
NALM-6 GDSC2 4.0038 6.9933 2.0188 6.4615
CESS GDSC2 4.0503 6.1775 2.446 3.751
ST486 GDSC2; CTRP2 4.0628 5.9114 3.9166 13.7099
KY821 GDSC2 4.071 6.6425 2.2369 4.9719
MOLM-16 GDSC2 4.0757 6.9008 2.1151 5.705
H9 GDSC2 4.0994 5.92 2.5996 2.7457
L-1236 GDSC2 4.1063 7.6043 1.794 7.5995
HEL GDSC2 4.1286 6.2561 2.4603 3.5071
PF-382 GDSC2 4.1425 6.9164 2.1541 5.3192
SEM CTRP2 4.1731 5.9389 4.03 12.9648
LP-1 GDSC2; CTRP2 4.1783 5.9814 4.0247 12.968
BC-1 GDSC2 4.2229 7.5743 1.8917 6.7351
KMS-34 CTRP2 4.2327 5.4015 4.1985 12.1855
Reh GDSC2; CTRP2 4.2365 6.1975 4.0276 12.7808
JSC-1 GDSC2 4.2368 7.8099 1.7872 7.3378
THP-1 GDSC2 4.2402 7.2159 2.0769 5.575
KMS-12-BM GDSC2; CTRP2 4.2909 5.1943 4.2795 11.7205
OCI-Ly3 CTRP2 4.2926 9.2739 2.8096 17.3613
SU-DHL-1 GDSC2 4.2937 12.2358 -0.3533 18.8747
Karpas-1106P GDSC2 4.295 5.9895 2.6853 1.9296
MHH-CALL-4 GDSC2 4.3301 6.5999 2.4275 3.3151
DG-75 GDSC2 4.3509 6.5867 2.4466 3.1679
KMS-20 CTRP2 4.3853 24.5453 -4.6226 35.3243
SET-2 CTRP2 4.3942 6.4019 4.1346 11.9198
SUP-HD1 GDSC2; CTRP2 4.4032 7.3637 3.777 13.2597
GDM-1 GDSC2; CTRP2 4.4289 5.7559 4.3509 11.0309
RS4;11 GDSC2; CTRP2 4.4335 5.4237 4.4089 10.8148
HH [Human lymphoma] GDSC2 4.4536 6.8508 2.3877 3.321
HPB-ALL CTRP2 4.4585 5.2224 4.4513 10.5896
ROS-50 GDSC2 4.4733 7.5559 2.0704 5.13
KO52 CTRP2 4.4938 5.8586 4.399 10.6583
PL21 CTRP2 4.5555 5.7613 4.4871 10.1541
Karpas-299 GDSC2; CTRP2 4.5587 6.6032 4.2422 11.0411
KMS-18 CTRP2 4.6034 6.1163 4.4516 10.1338
NOMO-1 GDSC2; CTRP2 4.6102 5.3273 4.6023 9.5814
OCI-AML-2 GDSC2; CTRP2 4.6245 5.1992 4.6222 9.4672
ME1 CTRP2 4.6489 5.4697 4.6315 9.3556
SK-MM-2 GDSC2; CTRP2 4.6696 5.4646 4.6537 9.2127
MM1.S GDSC2 4.6818 6.3174 2.7483 1.1147
L-428 GDSC2; CTRP2 4.7036 7.5463 4.0099 11.5494
ARH-77 GDSC2 4.7109 6.6127 2.6391 1.5904
RL GDSC2; CTRP2 4.7144 8.8342 3.4299 13.8498
SUP-T11 CTRP2 4.7246 5.5087 4.7073 8.8511
TUR GDSC2 4.7294 6.1971 2.8195 0.7691
M-07e CTRP2 4.7649 6.6833 4.4334 9.7327
RC-K8 GDSC2 4.7766 6.3806 2.7678 0.9363
Raji GDSC2; CTRP2 4.8125 5.8513 4.7474 8.4316
F-36P CTRP2 4.8434 13.8433 1.1038 22.2862
HDLM-2 GDSC2 4.8708 7.0369 2.5411 1.868
MJ CTRP2 4.871 7.0052 4.416 9.5089
KE-37 GDSC2 4.9003 6.0484 2.9472 0.2496
Ramos.2G6.4C10 GDSC2 4.9041 6.3203 2.848 0.533
HuT 78 CTRP2 4.937 7.2669 4.3719 9.508
SR GDSC2; CTRP2 4.9375 6.0831 4.8256 7.7672
L-363 GDSC2; CTRP2 4.942 6.0063 4.8515 7.6596
CCRF-CEM GDSC2 5.0487 6.7002 2.7641 0.7225
Karpas-45 GDSC2 5.0562 7.1678 2.5798 1.469
DB GDSC2; CTRP2 5.1001 6.7074 4.7795 7.475
Karpas-231 GDSC2 5.1858 6.5176 2.888 0.2746
SU-DHL-8 GDSC2 5.2101 6.6323 2.856 0.3422
OCI-AML-3 GDSC2; CTRP2 5.2196 6.6171 4.9421 6.5194
EJM GDSC2; CTRP2 5.2219 6.6519 4.9303 6.5587
MHH-CALL-3 CTRP2 5.2348 10.2086 3.2543 13.3617
MOLP-8 GDSC2; CTRP2 5.2563 6.8835 4.8677 6.7125
HD-MY-Z CTRP2 5.2778 7.7662 4.4835 8.2076
LC4-1 GDSC2 5.2877 7.5255 2.5446 1.385
IM-9 GDSC2 5.3021 6.5533 2.9185 0.1738
AML-193 CTRP2 5.3423 5.9526 5.3012 4.8195
JJN-3 GDSC2; CTRP2 5.3454 6.1851 5.239 5.0359
OCI-AML-5 GDSC2; CTRP2 5.3493 5.8264 5.3323 4.6887
KM-H2 GDSC2 5.351 6.9801 2.7844 0.4671
ME1 GDSC2 5.3559 6.5323 2.9449 0.119
ML-2 GDSC2 5.3689 7.1213 2.7391 0.5921
SIG-M5 GDSC2; CTRP2 5.3759 5.8894 5.3506 4.54
MOTN-1 CTRP2 5.382 6.2249 5.2652 4.8316
CMK CTRP2 5.3925 5.8996 5.3666 4.4318
PL-21 GDSC2 5.3931 7.5067 2.6008 1.0607
WIL2 NS GDSC2 5.4098 7.018 2.7938 0.412
ATN-1 GDSC2 5.4373 6.9555 2.827 0.3173
MOLT-16 GDSC2 5.449 6.8405 2.872 0.2173
HEL 92.1.7 CTRP2 5.469 5.9231 5.4449 3.9161
TF-1 CTRP2 5.473 6.0355 5.4233 3.9803
BALL-1 GDSC2 5.5466 7.2845 2.7503 0.4628
HC-1 GDSC2 5.5572 6.9761 2.8642 0.2003
U-698-M GDSC2 5.5584 7.195 2.7874 0.3622
U266B1 GDSC2; CTRP2 5.5639 6.1199 5.4976 3.4365
A3/Kawakami GDSC2; CTRP2 5.564 5.9285 5.5466 3.2602
HL-60 GDSC2; CTRP2 5.5736 6.0021 5.5416 3.2475
MOLP-2 CTRP2 5.5763 6.8653 5.1996 4.5714
TK [Human B-cell lymphoma] GDSC2 5.6358 7.121 2.8425 0.2176
OCI-M1 GDSC2; CTRP2 5.6362 6.1085 5.5799 2.919
Ci-1 CTRP2 5.6537 5.9779 5.6342 2.6699
Toledo CTRP2 5.6777 8.538 4.4802 7.3186
NCI-H929 GDSC2 5.7711 7.5103 2.7555 0.352
MHH-CALL-2 GDSC2 5.7821 7.24 2.8539 0.1614
VL51 GDSC2 5.826 7.6532 2.7253 0.401
KOPN-8 GDSC2 5.9189 7.6476 2.7622 0.2857
DND-41 GDSC2 5.9545 7.5971 2.7928 0.2185
GR-ST GDSC2 6.0085 9.0806 2.254 1.9151
MOLT-4 GDSC2 6.0443 7.5178 2.8513 0.1152
REC-1 CTRP2 6.1674 8.0489 5.1427 3.5594
KMOE-2 GDSC2 6.4013 8.1649 2.757 0.1719
Karpas-620 GDSC2; CTRP2 6.5238 7.9672 5.4472 1.7217
P3HR-1 CTRP2 7.1921 21.0375 -0.5185 22.336
OCI-Ly19 GDSC2; CTRP2 9.8371 25.7344 -0.8466 18.9567
⏷ Show the Full List of 198 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 0.2541 15.7708 -4.2074 44.4637
TE8 CTRP2 2.9429 7.9204 2.0114 24.0038
OE21 GDSC2; CTRP2 -0.0864 5.4005 -0.4821 41.7462
TE-4 GDSC2; CTRP2 0.5106 8.066 -0.6465 39.6326
TE-15 GDSC2 1.0335 10.9492 -2.5339 36.7221
EC-GI-10 GDSC2; CTRP2 1.0705 9.3826 -0.5557 37.4161
TE-14 CTRP2 1.543 7.4292 0.6945 32.6884
OE19 GDSC2; CTRP2 1.983 9.38 0.4038 32.0778
KYSE-140 GDSC2 2.1429 9.1765 -0.6379 26.723
KYSE-520 GDSC2; CTRP2 2.5706 9.3298 1.0365 28.4074
TE-5 GDSC2; CTRP2 2.64 9.1557 1.1829 27.7339
TE-11 GDSC2; CTRP2 2.9009 12.6233 -0.1282 30.7751
TE-6 GDSC2; CTRP2 2.9679 6.4187 2.5777 21.8709
KYSE-270 GDSC2 3.1624 13.0235 -1.6624 27.2236
KYSE-410 GDSC2; CTRP2 3.3601 22.174 -4.3538 37.0452
KYSE-180 GDSC2 3.912 13.0865 -1.0777 22.9694
TE-10 GDSC2 3.9779 7.5988 1.7025 8.4708
TE-9 GDSC2 4.147 7.2766 1.9828 6.3518
TE-1 GDSC2; CTRP2 4.6044 10.3763 2.5863 17.4768
TE-8 GDSC2 4.7593 10.0484 1.0682 10.3817
KYSE-150 CTRP2 5.2807 10.9358 2.9363 14.5496
KYSE-70 GDSC2; CTRP2 6.1698 12.2561 3.0424 12.3005
COLO 680N GDSC2 6.6994 16.6589 -0.7852 15.3335
OE33 GDSC2; CTRP2 7.3391 22.2155 -0.9891 23.2723
KYSE-450 GDSC2; CTRP2 9.2668 19.6582 1.6997 12.2394
KYSE-510 GDSC2; CTRP2 11.0768 22.0181 1.7601 9.7108
KYSE-30 CTRP2 11.3488 26.7806 -0.3059 15.4983
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 6.6235 15.9074 1.5868 16.9541
HuP-T4 GDSC2; CTRP2 4.2902 13.9943 0.5272 25.387
CFPAC-1 GDSC2 4.4546 7.0996 2.273 3.9791
BxPC-3 GDSC2 4.5826 8.333 1.7732 6.6654
PSN1 GDSC2; CTRP2 4.6902 7.2407 4.1282 11.1182
HPAC GDSC2; CTRP2 4.9255 8.0497 4.005 11.0076
SU.86.86 GDSC2; CTRP2 5.1128 5.9506 5.0516 6.4184
Capan-1 GDSC2; CTRP2 5.1885 8.5162 4.0386 10.2417
QGP-1 GDSC2 5.2606 7.2017 2.6617 0.9364
SUIT-2 GDSC2 5.4147 7.0246 2.7933 0.4109
PL4 GDSC2 5.4454 7.3401 2.6882 0.7077
MIA PaCa-2 GDSC2; CTRP2 5.4705 5.9391 5.4434 3.9166
Panc 10.05 GDSC2; CTRP2 5.4712 13.7105 1.7238 18.7725
KP-2 GDSC2; CTRP2 5.4851 8.7658 4.1935 8.9307
Capan-2 GDSC2; CTRP2 5.5065 6.7305 5.1911 4.7809
PaTu 8988s CTRP2 5.5114 13.3227 1.9521 17.8583
Panc 08.13 GDSC2; CTRP2 5.543 7.6129 4.8112 6.2401
KP-4 GDSC2 5.5478 7.0894 2.8211 0.289
DAN-G GDSC2; CTRP2 5.579 6.2761 5.4586 3.5394
HuP-T3 GDSC2; CTRP2 5.5885 6.1787 5.5046 3.3385
KP-3 GDSC2 5.5996 8.0468 2.4801 1.3596
Hs 766T CTRP2 5.633 6.3963 5.4672 3.3583
PaTu 8988t GDSC2; CTRP2 5.6501 6.0519 5.612 2.7603
PANC-1 CTRP2 5.6663 7.3527 5.0535 4.9573
SW1990 CTRP2 5.6671 12.6334 2.4305 15.7268
PK-59 CTRP2 5.738 9.4107 4.0996 8.7845
AsPC-1 GDSC2; CTRP2 5.8989 12.1034 2.8928 13.4336
Panc 04.03 CTRP2 5.9977 7.1477 5.4534 2.576
HPAF-II GDSC2 5.9978 7.9705 2.6771 0.4462
Panc 02.03 GDSC2; CTRP2 6.0315 6.9711 5.5702 2.0182
KP-1N GDSC2 6.1339 7.9892 2.7217 0.2979
PK-45H CTRP2 6.4557 13.5802 2.6136 13.4616
MZ-PC-1 GDSC2 6.5962 8.6787 2.6501 0.2959
PaTu 8902 GDSC2; CTRP2 6.8271 9.3972 4.967 3.2223
TCC-Pan2 CTRP2 6.946 9.0531 5.2086 2.1064
Panc 03.27 CTRP2 7.3412 13.8713 3.1521 9.79
YAPC GDSC2; CTRP2 7.5373 8.8955 5.5889 0.3524
L3.3 CTRP2 7.8877 19.237 0.9142 16.9647
Panc 05.04 CTRP2 9.4091 24.8273 -0.7119 19.2372
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 73 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 6.2854 18.0095 0.2615 21.8636
WM35 GDSC2 -0.4193 13.007 -4.9069 45.1993
A-431 GDSC2 1.2174 10.7551 -2.267 35.4236
A-388 GDSC2 1.4391 9.4524 -1.4256 32.2338
DJM-1 GDSC2 2.7172 13.1946 -2.127 30.0104
Hs 938.T GDSC2 3.3636 5.4679 2.2834 6.455
CP50-MEL-B GDSC2 3.6966 6.0664 2.2481 5.7837
VMRC-MELG GDSC2 3.7823 5.9484 2.3698 4.8146
MMAc-SF GDSC2 3.8139 9.0488 0.8574 13.936
WM115 GDSC2; CTRP2 3.8631 4.5126 3.8628 14.533
Mel Ho GDSC2 4.1891 7.7325 1.7909 7.4249
SK-MEL-24 GDSC2; CTRP2 4.237 8.2756 3.2104 15.923
G-mel GDSC2 4.3117 6.4791 2.4722 3.0916
GAK GDSC2 4.3165 8.404 1.5546 8.5568
MZ-MEL-7 GDSC2 4.3271 6.1221 2.6442 2.1017
CHL-1 GDSC2 4.5343 15.2635 -1.671 23.5276
LOX-IMVI GDSC2; CTRP2 4.5447 7.0814 4.042 11.8464
HT-144 GDSC2; CTRP2 4.6834 7.3574 4.0713 11.3597
Hs 940.T GDSC2; CTRP2 4.7149 6.201 4.5478 9.4481
WM1799 CTRP2 4.7618 6.6325 4.4493 9.6809
COLO 783 GDSC2 4.7943 9.4725 1.3703 8.5755
SK-MEL-5 GDSC2; CTRP2 4.81 5.7076 4.772 8.3531
A-375 GDSC2; CTRP2 4.8773 7.0643 4.3977 9.5637
MZ-MEL-2 GDSC2 4.947 7.7578 2.2672 3.1747
G-361 GDSC2; CTRP2 4.9717 6.2339 4.817 7.6961
RPMI-7951 GDSC2 5.0713 7.0003 2.6555 1.126
COLO 792 GDSC2; CTRP2 5.0783 6.4298 4.8644 7.2102
Hs 944.T CTRP2 5.0896 6.1145 4.9825 6.7381
WM266-4 CTRP2 5.112 6.476 4.8834 7.0429
LB2518-MEL GDSC2 5.125 6.4703 2.8816 0.3151
Malme-3M CTRP2 5.1376 7.1608 4.6238 7.9883
451Lu GDSC2 5.2159 7.4704 2.5328 1.5093
LB373-MEL-D GDSC2 5.2526 6.4706 2.9293 0.1683
HMCB CTRP2 5.2605 6.8786 4.8742 6.676
UACC-257 GDSC2; CTRP2 5.2998 6.4252 5.1034 5.6774
COLO 800 GDSC2; CTRP2 5.3031 7.8224 4.4813 8.1565
CP66-MEL GDSC2 5.3258 6.8429 2.8246 0.3704
WT2-iPS GDSC2; CTRP2 5.3313 6.5466 5.0886 5.6473
RVH-421 GDSC2; CTRP2 5.3453 8.4064 4.24 9.0511
MeWo CTRP2 5.3481 9.6165 3.6494 11.4886
UACC-62 GDSC2; CTRP2 5.3549 7.005 4.9141 6.2745
WM88 CTRP2 5.4096 6.0307 5.3553 4.4189
SK-MEL-31 GDSC2; CTRP2 5.4311 6.5847 5.1772 5.0331
IGR-39 CTRP2 5.4426 5.9861 5.4026 4.148
CJM [Human melanoma] CTRP2 5.4496 5.9335 5.4218 4.0581
SK-MEL-3 GDSC2; CTRP2 5.4524 5.958 5.4197 4.0565
Hs 839.T CTRP2 5.4653 5.9846 5.4277 3.9882
WM1552C GDSC2 5.4885 7.1857 2.7635 0.4555
Hs 895.T CTRP2 5.5 6.2777 5.3735 4.0856
IGR-37 GDSC2; CTRP2 5.5204 5.9709 5.4908 3.5929
COLO 679 GDSC2 5.5369 7.347 2.7234 0.5436
SH-4 GDSC2 5.5618 7.2861 2.7557 0.441
SK-MEL-28 GDSC2; CTRP2 5.5626 5.9598 5.5391 3.2905
A2058 GDSC2; CTRP2 5.5677 5.9478 5.547 3.2468
COLO 829 GDSC2; CTRP2 5.5716 6.2401 5.4643 3.5383
IGR-1 GDSC2; CTRP2 5.5782 6.1642 5.4985 3.391
MDA-MB-435S CTRP2 5.5821 7.7239 4.7939 6.2223
A101D GDSC2; CTRP2 5.6613 6.0349 5.6288 2.6656
SK-MEL-2 GDSC2; CTRP2 5.6793 6.2336 5.582 2.7873
Hs 688(A).T CTRP2 5.7674 6.1874 5.6938 2.1139
Hs 852.T CTRP2 5.8552 7.4242 5.1911 3.9695
M14 GDSC2 5.9047 7.4078 2.84 0.1556
WM793 GDSC2; CTRP2 6.0363 8.46 4.8298 5.1208
IPC-298 GDSC2; CTRP2 6.0548 6.8708 5.6398 1.6805
HMV-II GDSC2 6.1342 8.1897 2.6507 0.4533
WM983B CTRP2 6.2104 11.7756 3.3159 11.1105
WM278 GDSC2 6.2407 18.7264 -2.1041 21.1205
Hs 294T CTRP2 6.323 13.376 2.6081 13.7333
Mel JuSo GDSC2; CTRP2 6.3499 8.544 5.0392 3.6711
K029AX CTRP2 6.6385 9.658 4.7056 4.5791
Hs 936.T CTRP2 6.6628 9.6382 4.7332 4.4267
SK-MEL-30 GDSC2; CTRP2 6.9199 8.4981 5.4475 1.239
EquiPSC Line K2 GDSC2 4.5286 7.3172 2.218 4.1593
⏷ Show the Full List of 73 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYAE-1 GDSC2 2.5261 8.5813 0.0028 22.4741
TE-12 GDSC2 3.017 20.8414 -5.6932 36.3644
ESO-51 GDSC2 4.3508 6.6207 2.4308 3.2586
OACM5.1 C GDSC2 4.6605 7.2349 2.3364 3.2549
FLO-1 GDSC2 4.7653 7.1549 2.4327 2.567
KYSE-220 GDSC2 4.8208 19.3304 -3.47 28.0826
OACP4 C GDSC2 5.219 13.0908 -0.0859 15.3584
KYSE-50 GDSC2 5.305 7.3947 2.6054 1.1181
HCE-4 GDSC2 5.7913 17.0567 -1.612 20.3894
ESO-26 GDSC2 5.9965 20.8065 -3.3038 25.1384
SK-GT-4 GDSC2 6.0051 25.8788 -5.8059 30.4108
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2; CTRP2 4.2967 6.846 3.8709 13.1912
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-6 GDSC2 0.7036 2.2011 0.675 26.4199
SJNB-7 GDSC2 2.635 4.156 2.251 9.0837
SK-N-DZ GDSC2; CTRP2 2.6703 6.4428 2.2461 23.9657
KP-N-YS GDSC2 3.5651 5.5549 2.401 5.1608
SJNB-13 GDSC2 3.7907 6.2573 2.2242 5.6993
SJNB-14 GDSC2 3.8255 5.8153 2.4659 4.1193
SK-N-BE(2) CTRP2 3.8999 6.7837 3.4674 15.8451
KP-N-SI9s CTRP2 4.0797 8.6258 2.8938 17.5726
SJNB-17 GDSC2 4.0866 6.1867 2.4657 3.5591
SK-N-FI CTRP2 4.1135 6.2369 3.8815 13.6829
TGW GDSC2 4.1698 5.9218 2.6422 2.3735
MHH-NB-11 GDSC2 4.2798 7.0387 2.1884 4.8207
SK-N-MC-IXC GDSC2 4.2864 5.7759 2.7749 1.4692
NB69 GDSC2 4.2956 11.1173 0.203 16.1859
SK-N-SH CTRP2 4.3953 6.4182 4.1303 11.9327
Kelly GDSC2; CTRP2 4.6118 5.5866 4.578 9.6591
CHP-126 GDSC2; CTRP2 4.7188 6.1825 4.5578 9.3999
NB1 CTRP2 4.737 5.9101 4.6519 9.0048
KP-N-RT-BM-1 GDSC2 4.7708 7.1664 2.4306 2.5698
SiMa GDSC2 5.0276 7.0963 2.5954 1.43
NH-6 CTRP2 5.0506 7.7012 4.2906 9.5447
CHP-212 GDSC2; CTRP2 5.2157 6.5246 4.9752 6.4024
CHP-134 GDSC2 5.2212 6.8512 2.7796 0.5542
NB(TU)1 GDSC2 5.2828 8.2044 2.2562 2.7482
SK-N-AS GDSC2; CTRP2 5.6069 6.0915 5.5533 3.1042
SJNB-10 GDSC2 5.6165 7.289 2.7759 0.3659
NH-12 GDSC2 5.6847 7.5411 2.7109 0.5021
LA-N-6 GDSC2 5.7198 7.2632 2.8236 0.2283
GOTO GDSC2 5.8813 7.7545 2.7101 0.4148
IMR-5 GDSC2 5.8958 7.538 2.792 0.2358
SK-N-BE(2)-M17 GDSC2 5.9851 7.5819 2.809 0.1845
KP-N-YN GDSC2; CTRP2 6.0917 9.3364 4.4376 6.6628
GI-ME-N GDSC2 6.5386 9.0302 2.5031 0.6482
SJNB-5 GDSC2 6.5425 19.861 -2.4415 21.5816
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 4.1756 9.8967 0.7161 13.7708
SNU-869 CTRP2 5.7074 6.1938 5.6273 2.536
Cancer Drug Sensitivity Data Curated from 82 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-BR-3 CTRP2 -6.3734 14.228 -10.3725 62.2034
EFM-192A GDSC2; CTRP2 -5.882 11.8763 -8.9254 62.5183
UACC-893 GDSC2 -4.2619 1.3334 -4.5087 68.9105
AU565 GDSC2; CTRP2 -3.9419 7.8262 -5.3878 59.8846
HCC2218 GDSC2 -2.6696 3.6451 -3.3079 57.0486
ZR-75-30 GDSC2; CTRP2 -2.4672 24.5315 -10.9872 51.9855
OCUB-M GDSC2 -1.8308 7.3942 -3.7677 50.9094
HCC1419 GDSC2; CTRP2 -0.5119 15.0142 -4.6292 46.9303
MDA-MB-330 GDSC2 0.223 100.6174 -47.9317 48.9706
MDA-MB-453 GDSC2; CTRP2 0.9669 6.8407 0.2669 35.8823
HCC202 CTRP2 1.2957 15.4033 -3.0074 40.449
CAL-85-1 GDSC2; CTRP2 1.4962 13.9379 -2.1256 38.7411
HCC2157 GDSC2 2.0845 8.2955 -0.2588 25.2798
HCC1569 GDSC2 2.1901 14.6952 -3.3334 34.5759
Hs 578T GDSC2; CTRP2 2.574 4.2706 2.5569 23.1777
MDA-MB-468 GDSC2; CTRP2 2.6392 8.714 1.3682 27.1271
HCC1806 GDSC2 3.0702 11.3885 -0.923 24.804
HCC1599 GDSC2 3.148 8.9554 0.359 18.6268
BT-474 GDSC2; CTRP2 3.1902 26.2022 -6.5019 39.5019
Evsa-T GDSC2 3.6563 9.0492 0.7319 15.0838
HDQ-P1 GDSC2 3.7707 9.5649 0.5661 15.6818
DU4475 GDSC2; CTRP2 3.9097 4.6112 3.9089 14.224
HCC1500 GDSC2; CTRP2 3.9195 6.645 3.5375 15.526
MFM-223 GDSC2 3.9628 7.1477 1.9133 7.2097
HCC1954 GDSC2 3.9854 16.9406 -2.9427 28.7476
JIMT-1 GDSC2 4.1699 5.9472 2.6306 2.4391
YMB-1-E GDSC2 4.1753 7.1175 2.0797 5.6989
CAL-120 GDSC2 4.2713 6.3261 2.518 2.9014
HCC1937 GDSC2 4.2834 9.3554 1.0642 11.5281
MDA-MB-415 GDSC2; CTRP2 4.3487 6.7343 3.9684 12.6742
MDA-MB-436 GDSC2 4.3957 6.8162 2.3679 3.5388
HCC1143 GDSC2; CTRP2 4.652 11.7651 1.9544 19.7637
HCC1187 GDSC2 4.661 7.6246 2.1577 4.2633
MDA-MB-231 GDSC2; CTRP2 4.7261 6.4259 4.486 9.6445
CAL-51 GDSC2; CTRP2 4.7309 5.677 4.6919 8.8835
HCC38 GDSC2; CTRP2 4.7424 8.5297 3.6004 13.0929
BT-549 GDSC2; CTRP2 5.0224 7.0753 4.5434 8.6067
COLO 824 GDSC2 5.1323 7.6993 2.3942 2.2569
MRK-nu-1 GDSC2 5.2742 6.7366 2.8431 0.3464
Hs 578Bst CTRP2 5.3956 6.02 5.3429 4.5061
HCC1428 GDSC2; CTRP2 5.4952 6.6604 5.2107 4.7318
CAMA-1 GDSC2 5.6066 7.2269 2.7943 0.3267
MDA-MB-157 GDSC2 5.8809 8.475 2.4379 1.2837
HCC70 GDSC2 5.9303 7.5267 2.8084 0.1984
MCF-7 GDSC2 6.4005 8.3185 2.7042 0.2538
EFM-19 GDSC2 6.5115 8.6553 2.6273 0.3655
BT-20 GDSC2; CTRP2 6.6052 13.5894 2.7285 12.7354
ZR-75-1 CTRP2 6.869 10.6418 4.3915 5.5078
T-47D GDSC2; CTRP2 6.9411 20.7334 -0.5668 22.9139
MDA-MB-361 GDSC2; CTRP2 8.459 25.7418 -1.8715 25.7025
BT 145 CTRP2 0.9339 3.7464 0.8875 34.1992
BT 139 CTRP2 1.3111 5.9627 0.9009 32.857
BT 231 CTRP2 1.3826 5.0719 1.1855 31.7099
BT 239 CTRP2 1.8576 6.6573 1.2943 29.788
BT 112 CTRP2 2.4129 6.8116 1.848 26.1621
BT164 CTRP2 2.6823 5.6496 2.475 23.1142
BT 224 CTRP2 2.7487 8.418 1.6054 26.0009
BT 330 CTRP2 2.8872 7.9835 1.9272 24.4673
BT 271 CTRP2 3.2022 11.3722 0.7549 27.4832
BT 228 CTRP2 3.3747 6.318 3.0518 18.9254
BT 172 CTRP2 3.5381 8.5322 2.3807 20.9764
BT 428 CTRP2 3.7838 8.9906 2.4302 20.132
BT 232 CTRP2 4.0269 10.6327 1.9096 21.4465
BT 187 CTRP2 4.0881 11.0215 1.7833 21.7491
BT147 CTRP2 4.1897 9.6622 2.5267 18.7199
BT 440 CTRP2 4.4067 9.1266 2.9908 16.362
BT 416 CTRP2 4.4475 6.1342 4.2764 11.2404
BT 286 CTRP2 4.7289 5.9415 4.6355 9.0884
BT 245 CTRP2 4.7856 8.4711 3.6704 12.7045
BT 504 CTRP2 5.0428 5.7109 5.0211 6.7463
BT 333 CTRP2 5.1854 6.2011 5.0599 6.1689
BT 328 CTRP2 5.3556 8.9313 3.9932 10.0487
BT 359 CTRP2 5.415 18.0022 -0.4668 25.6271
BT 482 CTRP2 5.4175 6.1796 5.319 4.5278
BT 422 CTRP2 5.4564 5.9635 5.4229 4.033
BT 216 CTRP2 5.5393 6.0998 5.4771 3.5846
BT 131 CTRP2 5.5561 6.0527 5.5092 3.4171
BT 444 CTRP2 5.5896 5.9304 5.5739 3.0836
BT 159 CTRP2 5.632 12.5022 2.4657 15.6634
BT 320 CTRP2 5.6363 6.0081 5.6084 2.8156
BT 179 CTRP2 5.7671 15.6167 1.0253 20.5424
BT 340 CTRP2 6.4479 13.9027 2.4462 14.1241
⏷ Show the Full List of 82 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 59 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AM-38 GDSC2; CTRP2 -5.3151 14.5829 -9.403 59.9437
42-MG-BA GDSC2; CTRP2 2.7883 103.2058 -45.2757 47.6826
D-423MG GDSC2 3.1419 11.2217 -0.779 23.9999
D-245MG GDSC2 3.7049 6.8335 1.8742 8.1016
SF539 GDSC2; CTRP2 3.756 5.8312 3.6019 15.7798
D-336MG GDSC2 3.8992 10.4046 0.2494 17.0061
SF268 GDSC2; CTRP2 3.9504 7.3896 3.29 16.3781
D283 Med GDSC2; CTRP2 3.9567 5.4295 3.8996 14.1027
CAS-1 GDSC2 3.9682 5.839 2.5527 3.2811
H4 GDSC2 4.1163 9.4382 0.8979 12.9029
GI-1 GDSC2 4.1698 6.835 2.2119 4.9102
D-542MG GDSC2 4.2238 8.5638 1.4094 9.6454
SW1088 GDSC2; CTRP2 4.3193 7.2394 3.7402 13.6301
U-87MG ATCC GDSC2 4.3749 7.5986 1.9847 5.8424
D-502MG GDSC2 4.3763 15.5358 -1.9301 24.7993
D-392MG GDSC2 4.3768 8.7318 1.4377 9.1136
SW1783 CTRP2 4.3934 14.3582 0.4425 25.3921
KNS-60 CTRP2 4.3949 5.0236 4.3931 10.995
NMC-G1 GDSC2 4.5204 6.8108 2.4461 2.8781
LN-405 GDSC2 4.6104 6.4671 2.6489 1.6698
KNS-42 GDSC2; CTRP2 4.6925 8.3967 3.6132 13.1642
SF295 GDSC2 4.8401 8.5504 1.8387 5.7669
KS-1 [Human Krukenberg tumour] GDSC2 4.911 14.9278 -1.2157 20.9368
LN-18 GDSC2 4.982 5.8984 3.0289 0.0775
Onda 10 GDSC2 5.0486 12.0299 0.3096 13.8055
GaMG GDSC2; CTRP2 5.0763 6.1216 4.9658 6.839
SF126 GDSC2 5.079 9.8085 1.4001 7.8142
KALS-1 GDSC2; CTRP2 5.1032 6.6127 4.8209 7.3069
KNS-81 CTRP2 5.1149 5.8737 5.071 6.3433
GB-1 GDSC2 5.1347 7.5141 2.4743 1.8674
M059J GDSC2 5.1419 6.856 2.7442 0.7248
A-172 GDSC2; CTRP2 5.1729 10.0736 3.2643 13.4582
M059K CTRP2 5.2131 6.4659 4.9953 6.3327
DK-MG GDSC2; CTRP2 5.2597 6.2977 5.1076 5.7748
D-263MG GDSC2 5.3046 6.7417 2.853 0.3093
D-247MG GDSC2 5.3059 7.32 2.6354 0.9999
ONS-76 GDSC2 5.3111 6.8166 2.8284 0.3672
TM-31 CTRP2 5.3601 9.2308 3.8502 10.6311
U-251MG GDSC2; CTRP2 5.3821 12.7203 2.1396 17.437
GMS-10 CTRP2 5.4512 5.8378 5.4395 3.9916
SNB-75 GDSC2; CTRP2 5.4705 14.5828 1.288 20.2911
Becker GDSC2; CTRP2 5.4707 6.0703 5.411 4.0316
Onda 11 GDSC2 5.4773 8.2006 2.3585 2.0124
GOS-3 CTRP2 5.4785 10.2658 3.4454 12.049
D-566MG GDSC2 5.5434 7.1904 2.7832 0.3787
YH-13 GDSC2; CTRP2 5.6894 6.2662 5.58 2.767
YKG-1 GDSC2; CTRP2 5.6992 6.167 5.6283 2.5557
U-118MG GDSC2; CTRP2 5.7031 6.2849 5.5868 2.7034
CCF-STTG1 CTRP2 5.7698 8.2605 4.6999 6.2049
SK-MG-1 GDSC2 5.8489 7.3134 2.8525 0.1492
Hs 683 GDSC2; CTRP2 5.8868 10.0582 3.9047 9.2979
8-MG-BA GDSC2; CTRP2 5.9395 7.7805 5.0874 4.2297
Daoy GDSC2 5.9702 7.8479 2.7105 0.3782
PFSK-1 GDSC2 6.0846 8.1344 2.6514 0.4724
KINGS-1 GDSC2 6.3176 8.2179 2.709 0.2676
LN-229 GDSC2 6.4545 13.7644 0.4232 10.3492
KNS-81-FD GDSC2 6.5816 22.6731 -3.7897 25.2079
DBTRG-05MG GDSC2; CTRP2 8.1824 17.2591 2.1036 12.4356
T98G GDSC2; CTRP2 9.1129 18.8538 1.9814 11.489
⏷ Show the Full List of 59 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC2 4.3108 7.6205 1.9305 6.3053
TGBC24TKB GDSC2 4.8812 8.4103 1.93 5.1647
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-3 CTRP2 2.6946 13.0049 -0.5096 32.2758
JHUEM-7 CTRP2 3.5926 6.9147 3.0891 18.1481
AN3-CA GDSC2; CTRP2 3.8314 5.8909 3.6694 15.3063
EFE-184 CTRP2 4.2904 14.8227 0.1197 26.56
MFE-280 GDSC2 4.3586 7.3361 2.0992 5.1919
RL95-2 GDSC2 4.4236 9.4435 1.1237 10.8442
JHUEM-1 CTRP2 4.4408 13.2367 1.0377 23.4389
HEC-151 CTRP2 4.6749 5.2358 4.6725 9.1318
ESS-1 GDSC2; CTRP2 4.7944 8.674 3.5836 13.0344
HEC-50B CTRP2 4.9768 7.0939 4.4882 8.9445
MFE-296 GDSC2; CTRP2 5.3228 6.4127 5.1327 5.5008
KLE GDSC2 5.3421 10.9868 1.0141 9.435
EN GDSC2; CTRP2 5.3621 5.9874 5.3146 4.7103
MFE-319 GDSC2; CTRP2 5.4697 9.9412 3.5986 11.4353
HEC-1-A CTRP2 8.2342 16.0172 2.744 9.9898
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW13 GDSC2 0.2593 8.2001 -1.9777 38.6594
LB1047-RCC GDSC2 1.2018 12.3397 -3.0563 37.1893
LB996-RCC GDSC2 2.2853 9.0859 -0.4637 25.4746
UO-31 GDSC2 2.6145 11.2957 -1.2688 27.5549
KMRC-3 CTRP2 2.8826 6.5301 2.4499 22.5907
TK-10 GDSC2 3.0463 13.5088 -2.003 28.6548
769-P GDSC2 3.2489 10.4308 -0.2935 21.551
NCC021 GDSC2 3.2871 7.578 1.1648 13.6381
KTCTL-140 GDSC2 3.3002 9.4586 0.2355 18.8066
KTCTL-13 GDSC2 3.3477 5.7319 2.1384 7.4181
KTCTL-21 GDSC2 3.4346 14.8326 -2.3398 28.5486
BB65-RCC GDSC2 3.623 6.5966 1.9282 7.9801
KTCTL-26A GDSC2 3.7502 7.7397 1.459 10.5481
KTCTL-195 GDSC2 3.8048 5.6884 2.513 3.8769
KTCTL-1M GDSC2 4.0662 7.0814 2.0206 6.3056
LB2241-RCC GDSC2 4.1431 10.5644 0.3602 15.7733
RXF 393L GDSC2 4.338 8.8741 1.3404 9.7815
TUHR14TKB CTRP2 4.3422 7.0606 3.8362 28.1022
CAL-54 GDSC2; CTRP2 4.3805 11.3369 1.9096 20.5736
VMRC-RCW GDSC2; CTRP2 4.494 6.4214 4.2363 11.2502
TUHR10TKB CTRP2 4.5451 5.2229 4.5403 10.0045
A-704 GDSC2 4.5907 6.7392 2.519 2.3697
NCC010 GDSC2 4.6621 9.3387 1.344 9.0167
BFTC-909 GDSC2 4.7331 7.1126 2.4333 2.6118
SW156 GDSC2 4.7558 8.1587 1.9685 5.1775
KMRC-20 GDSC2 4.813 7.5917 2.2644 3.4022
786-O GDSC2; CTRP2 4.8829 6.5723 4.6017 8.7602
SN12C GDSC2 4.954 6.7778 2.6904 1.0915
KMRC-1 CTRP2 5.3097 8.9279 3.9523 10.3208
OS-RC-2 GDSC2 5.3258 10.9367 1.0271 9.3969
HA7-RCC GDSC2 5.3851 11.2841 0.9012 9.9607
VMRC-RCZ GDSC2; CTRP2 5.3861 10.2381 3.3764 12.5312
RCC10RGB GDSC2; CTRP2 5.4716 9.2754 3.9298 10.0568
A-498 GDSC2; CTRP2 5.631 6.2979 5.5055 3.2151
KMRC-2 CTRP2 5.9931 12.3392 2.8542 13.401
ACHN GDSC2; CTRP2 6.6621 12.5283 3.3018 10.3389
Caki-1 GDSC2; CTRP2 7.1834 16.9285 1.52 16.1648
Caki-2 CTRP2 10.2188 25.9021 -0.6574 17.9308
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CCK-81 GDSC2; CTRP2 -1.5714 9.9369 -3.5794 50.4533
GP2d CTRP2 -1.029 8.3223 -2.3983 47.9668
DiFi GDSC2 -0.2716 6.6967 -1.8483 40.9406
CW-2 GDSC2; CTRP2 0.0177 9.1866 -1.5953 42.9844
SNU-1033 CTRP2 0.5016 142.4031 -66.8073 49.2413
NCI-H508 GDSC2; CTRP2 0.7356 14.6236 -3.1988 42.2635
NCI-H716 GDSC2; CTRP2 1.7988 7.1756 1.0593 30.7342
C2BBe1 GDSC2; CTRP2 2.7866 13.7553 -0.7759 32.6272
SW48 GDSC2 2.8294 25.0864 -7.9734 39.3013
HT-55 GDSC2; CTRP2 3.0775 13.1796 -0.2206 30.5277
LoVo GDSC2; CTRP2 3.2458 12.6331 0.2022 28.964
SNU-61 GDSC2; CTRP2 3.6247 14.9782 -0.5704 29.9702
LS123 GDSC2; CTRP2 4.1108 5.896 3.9728 13.3613
T84 GDSC2; CTRP2 4.1573 14.2961 0.2568 26.4938
SNU-C4 CTRP2 4.2216 12.0303 1.4235 22.6812
HT-29 GDSC2 4.2827 11.3785 0.0637 16.9181
CaR-1 GDSC2 4.2995 7.2615 2.0953 5.338
SK-CO-1 GDSC2 4.394 6.4408 2.5394 2.5696
GP5d GDSC2 4.4502 7.0251 2.3049 3.8025
SNU-C1 GDSC2; CTRP2 4.4797 6.884 4.0517 11.9884
SNU-C5 GDSC2; CTRP2 4.4838 5.5556 4.4455 10.5269
HT115 GDSC2 4.56 7.6983 2.0595 5.0233
COLO 320 CTRP2 4.5799 6.1404 4.4189 10.3235
SNU-175 GDSC2 4.6306 19.3168 -3.6128 28.854
SNU-503 CTRP2 4.6626 13.5501 1.0858 22.761
SNU-283 GDSC2 4.6917 13.2833 -0.5683 18.82
NCI-H747 GDSC2; CTRP2 4.7169 10.995 2.3913 17.9676
KM12 GDSC2; CTRP2 4.7419 6.0185 4.6299 9.0686
SW1116 GDSC2 4.7522 11.3495 0.4288 13.8854
LS180 GDSC2 4.8154 6.3572 2.795 0.792
LS411N GDSC2 4.8225 6.2446 2.8422 0.6097
SW620 GDSC2; CTRP2 4.8828 5.8711 4.8195 7.9572
LS513 GDSC2 5.0531 6.9454 2.6691 1.0867
CL-11 GDSC2; CTRP2 5.141 6.3605 4.9571 6.6817
COLO205 GDSC2 5.2363 6.482 2.9193 0.1912
COLO201 CTRP2 5.3378 8.0824 4.3898 8.4503
HCT 8 CTRP2 5.3864 12.5687 2.2189 17.1286
RKO GDSC2; CTRP2 5.3978 6.7276 5.0812 5.4987
SW1463 GDSC2 5.4458 7.5333 2.6139 0.9687
SW1417 GDSC2; CTRP2 5.462 7.3927 4.8395 6.3132
SW948 GDSC2; CTRP2 5.4663 6.0656 5.4076 4.0574
HCC2998 GDSC2 5.4836 7.3673 2.6939 0.6648
SNU-81 GDSC2 5.5056 6.9713 2.847 0.2489
COLO 320HSR GDSC2 5.5257 7.1496 2.7912 0.3668
HCT 15 GDSC2; CTRP2 5.553 6.0895 5.4952 3.4776
LS1034 GDSC2; CTRP2 5.6772 6.1857 5.5979 2.7331
HCT 116 GDSC2 5.6932 6.9827 2.91 0.1027
SNU-1040 GDSC2 5.7341 13.8996 -0.1166 14.366
COLO 678 GDSC2; CTRP2 5.8029 24.4809 -3.3759 30.8847
MDST8 GDSC2; CTRP2 6.0335 7.3814 5.3668 2.8694
SW837 GDSC2 6.1522 7.9295 2.7491 0.2417
SW626 GDSC2 6.3128 8.0255 2.7733 0.1668
SNU-407 GDSC2; CTRP2 6.3289 17.3331 0.6354 20.6549
SNU-C2B GDSC2 6.4867 9.8123 2.1821 1.767
RCM-1 [Human ESC] GDSC2; CTRP2 6.6609 14.9394 2.0997 15.0352
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 3.7314 5.4966 2.554 3.7929
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-5 CTRP2 0.7036 8.3347 -0.5379 38.6972
Hep 3B2.1-7 GDSC2 2.0376 6.0898 0.7623 20.2058
JHH-2 GDSC2; CTRP2 2.9129 4.5032 2.894 20.9259
JHH-4 GDSC2; CTRP2 3.5817 6.7121 3.1488 17.9566
SNU-398 GDSC2; CTRP2 3.6184 5.4896 3.5251 16.4815
SNU-761 CTRP2 3.8396 5.5591 3.7513 14.9912
HLE GDSC2 3.8765 6.8533 1.9944 6.9185
SNU-449 GDSC2; CTRP2 4.1294 7.6267 3.3808 15.5391
SNU-423 GDSC2; CTRP2 4.2119 6.1749 4.0074 12.9285
JHH-7 GDSC2 4.654 9.1504 1.4293 8.5376
Huh-7 GDSC2 5.0166 6.607 2.7862 0.6673
SNU-387 GDSC2; CTRP2 5.128 7.8459 4.2998 9.3173
Hep-G2/C3A GDSC2 5.1466 6.4234 2.9067 0.2472
HLF CTRP2 5.2592 8.812 3.9619 10.395
HuH-1 GDSC2; CTRP2 5.3748 6.7873 5.0314 5.7557
SNU-475 CTRP2 5.3816 10.662 3.1624 13.4162
SK-HEP-1 GDSC2; CTRP2 5.4834 6.1499 5.4005 4.0324
JHH-6 GDSC2; CTRP2 5.8371 6.2354 5.7477 1.7153
Hep-G2 CTRP2 6.6116 12.3383 3.3568 10.2047
PLC/PRF/5 CTRP2 8.4562 16.0697 2.8714 9.1872
JHH-1 GDSC2; CTRP2 8.7895 16.6063 2.8387 8.8456
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 193 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC4006 CTRP2 -2.6357 1.6634 -2.6815 57.4786
NCI-H3255 GDSC2 -2.0342 11.3648 -5.7226 51.4513
PC-14 GDSC2; CTRP2 -1.3042 2.2183 -1.3366 48.9767
EPLC-272H GDSC2; CTRP2 -1.2462 10.2585 -3.3586 49.1214
COR-L105 GDSC2; CTRP2 -0.9196 6.2997 -1.6268 47.0637
NCI-H292 GDSC2 -0.8177 10.5959 -4.1558 46.2351
NCI-H2170 GDSC2; CTRP2 -0.2998 18.9728 -6.2484 46.8832
NCI-H1623 GDSC2; CTRP2 -0.1793 13.43 -3.5822 45.3916
Calu-3 GDSC2 0.1657 15.9325 -5.7743 43.9103
HCC2935 CTRP2 0.3638 9.0435 -1.1709 41.08
DV-90 CTRP2 0.3689 12.1047 -2.4373 42.659
CAL-12T GDSC2 1.1191 13.1315 -3.521 38.307
NCI-H1781 GDSC2 1.1719 19.3477 -6.5464 41.7628
NCI-H1975 GDSC2 1.4191 8.6956 -1.0786 31.1442
EKVX GDSC2; CTRP2 1.4893 8.7535 0.1394 34.3861
EMC-BAC-1 GDSC2 1.5062 11.3306 -2.2807 34.4087
NCI-H1568 GDSC2; CTRP2 1.5553 8.8616 0.1664 34.0963
NCI-H322 CTRP2 1.8829 10.1104 -0.0109 33.4823
NCI-H322M GDSC2 1.8885 12.7891 -2.6536 34.0152
NCI-H446 GDSC2; CTRP2 2.0397 4.6829 1.9564 26.9613
NCI-H1341 CTRP2 2.1767 4.8453 2.0801 26.0945
SK-MES-1 GDSC2; CTRP2 2.2094 9.6656 0.5183 31.0529
NCI-H2342 CTRP2 2.3786 5.3683 2.2061 25.0126
Sq-1 CTRP2 2.6297 9.3598 1.0848 28.0797
NCI-H1693 GDSC2; CTRP2 2.6607 8.7215 1.3876 26.9988
NCI-H2085 GDSC2; CTRP2 2.7266 5.0326 2.6412 22.3936
NCI-H520 GDSC2; CTRP2 2.7338 6.6483 2.2502 23.759
NCI-H661 GDSC2; CTRP2 2.8238 10.9401 0.5788 29.0624
COR-L311 GDSC2 2.8981 6.1099 1.5607 12.4266
NCI-H1703 CTRP2 3.0895 7.1594 2.4587 21.9468
NCI-H1963 GDSC2 3.216 5.1215 2.3324 6.5801
NCI-H1770 GDSC2 3.2441 7.268 1.2837 13.0504
RERF-LC-Sq1 GDSC2 3.2811 8.284 0.8068 15.7527
LC-2/ad GDSC2 3.3137 6.5415 1.7053 10.243
NCI-H1581 GDSC2 3.3565 5.9146 2.0543 7.9237
LXF 289 GDSC2; CTRP2 3.4228 5.6969 3.2702 17.9926
NCI-H1563 GDSC2; CTRP2 3.4558 5.3695 3.3709 17.5351
NCI-H1184 CTRP2 3.5117 5.74 3.3572 17.4075
NCI-H2286 CTRP2 3.5429 5.3248 3.4719 16.9067
SBC-1 GDSC2 3.566 7.1506 1.607 10.1374
NCI-H1435 GDSC2; CTRP2 3.6207 7.6735 2.8273 19.0585
HCC366 GDSC2 3.7545 13.7914 -1.5568 25.1743
BEN GDSC2 3.7808 7.1167 1.7921 8.4154
SBC-3 GDSC2 3.8194 5.7642 2.4865 4.0067
NCI-H82 GDSC2 3.8268 5.5501 2.5954 3.3227
NCI-H524 GDSC2 3.8668 5.9323 2.4382 4.1957
NCI-H810 GDSC2; CTRP2 3.8874 4.9068 3.8786 14.3994
NCI-H146 GDSC2 3.9085 5.7511 2.5546 3.3944
CPC-N GDSC2 3.912 5.8049 2.5311 3.5292
IST-SL1 GDSC2 3.9149 6.0646 2.4078 4.2737
NCI-H522 GDSC2; CTRP2 3.9194 16.784 -1.1851 30.6585
NCI-H1876 GDSC2 3.9324 6.3412 2.2859 4.9826
NCI-H2795 GDSC2 3.9406 14.8606 -1.9403 25.9592
ABC-1 GDSC2 3.9739 8.4249 1.2913 10.974
NCI-H2731 GDSC2 3.9812 11.064 -0.0144 18.1069
HCC33 GDSC2 3.9839 9.5666 0.7327 14.1814
NCI-H1694 GDSC2; CTRP2 4.0506 5.8303 3.923 13.7246
Lu-99A GDSC2 4.0937 9.4248 0.8874 13.0214
NCI-H2810 GDSC2 4.1396 7.5334 1.8526 7.1637
NCI-H1155 GDSC2 4.1685 6.3124 2.4597 3.4327
IST-SL2 GDSC2 4.1775 9.6101 0.8593 12.9647
NCI-H1105 GDSC2; CTRP2 4.1817 6.3968 3.9055 13.3922
NCI-H2171 GDSC2; CTRP2 4.201 6.0273 4.0373 12.8533
NCI-H1755 GDSC2; CTRP2 4.2216 5.3669 4.1909 12.2476
LC-1/sq GDSC2 4.2611 9.885 0.7864 13.1611
NCI-H2804 GDSC2 4.2822 8.2408 1.6096 8.3059
HCC44 GDSC2 4.2895 7.1801 2.1274 5.1661
NCI-H510A GDSC2 4.3133 7.1708 2.1478 4.995
NCI-H290 GDSC2 4.3273 6.782 2.3408 3.8241
NCI-H1436 GDSC2 4.3427 6.8812 2.3041 4.0098
NCI-H2803 GDSC2 4.3623 6.5316 2.479 2.9629
COR-L303 GDSC2 4.3901 7.851 1.8739 6.474
NCI-H2087 GDSC2; CTRP2 4.4157 5.5913 4.367 11.0165
A-427 GDSC2 4.4218 10.2547 0.724 13.1053
HOP-92 GDSC2; CTRP2 4.4233 7.0806 3.9141 14.9925
NCI-H345 GDSC2 4.4264 5.516 2.9522 0.5096
Lu-165 GDSC2 4.4461 5.8963 2.8069 1.108
NCI-H2030 GDSC2 4.4653 16.5571 -2.3686 25.951
NCI-H2081 GDSC2; CTRP2 4.5018 7.2359 3.9334 12.3847
NCI-H740 GDSC2 4.5045 7.0164 2.3425 3.488
COR-L321 GDSC2 4.5105 6.7081 2.4868 2.6697
NCI-H596 GDSC2 4.5109 10.7734 0.5347 13.9116
Lu-134-A GDSC2 4.5194 8.751 1.529 8.2482
HCC827 GDSC2 4.5233 9.5951 1.1215 10.6206
SBC-5 GDSC2 4.547 5.6986 2.9339 0.4849
NCI-H1915 GDSC2; CTRP2 4.5768 6.3277 4.3574 10.5584
NCI-H889 CTRP2 4.5888 5.5902 4.5529 9.8191
NCI-H2135 GDSC2 4.6031 11.0175 0.4826 13.9624
NCI-H2196 GDSC2; CTRP2 4.6158 6.3079 4.4062 10.2631
LC-1/sq-SF CTRP2 4.6242 10.5931 2.5 17.7655
DMS 53 GDSC2; CTRP2 4.6306 6.2348 4.4456 10.074
DMS 273 GDSC2; CTRP2 4.6425 9.465 3.0606 15.5089
NCI-H841 GDSC2; CTRP2 4.6663 7.2543 4.0976 11.302
RERF-LC-KJ GDSC2 4.6706 7.6203 2.1657 4.2004
NCI-H2126 CTRP2 4.7084 6.0694 4.5795 9.3525
NCI-H358 GDSC2 4.7236 15.9899 -1.8852 23.7908
HARA [Human squamous cell lung carcinoma] GDSC2 4.7528 19.0983 -3.4078 28.0852
COLO 668 GDSC2; CTRP2 4.7718 6.4174 4.5384 9.3157
Calu-6 GDSC2; CTRP2 4.7938 5.737 4.7495 8.4829
NCI-H513 GDSC2 4.8049 11.1162 0.5809 12.9581
NCI-H23 GDSC2; CTRP2 4.8134 6.9386 4.3832 9.7922
SW1573 GDSC2; CTRP2 4.823 7.3938 4.1993 10.4884
NCI-H1355 GDSC2; CTRP2 4.8257 6.1006 4.6986 8.5656
NCI-H2461 GDSC2 4.8294 7.4575 2.3342 2.9959
EBC-1 GDSC2; CTRP2 4.864 6.8467 4.474 9.3025
NCI-H2722 GDSC2 4.8793 7.4345 2.3726 2.7157
NCI-H2029 GDSC2; CTRP2 4.8819 6.5482 4.6097 8.7324
HOP-62 GDSC2; CTRP2 4.9616 8.8183 3.6767 12.2558
NCI-H2444 GDSC2; CTRP2 4.9924 5.8976 4.9328 7.2143
NCI-H1666 GDSC2; CTRP2 5.0353 29.474 -6.5216 36.2767
NCI-H526 GDSC2 5.0955 6.4683 2.8708 0.3565
NCI-H1092 GDSC2; CTRP2 5.1006 6.6029 4.822 7.3095
NCI-H2818 GDSC2 5.1082 6.9927 2.6756 1.0107
DMS 454 CTRP2 5.1285 6.6959 4.8141 7.2638
LK-2 GDSC2 5.1818 7.0841 2.6727 0.9588
NCI-H211 GDSC2 5.1843 7.2778 2.5963 1.2663
NCI-H196 GDSC2 5.1848 6.6345 2.8453 0.3821
NCI-H2369 GDSC2 5.1852 6.6051 2.8562 0.353
Lu-139 GDSC2 5.1893 6.705 2.8212 0.4471
NCI-H1793 GDSC2; CTRP2 5.1898 7.4882 4.5274 8.2434
NCI-H2228 GDSC2; CTRP2 5.2165 6.2545 5.0759 6.0185
COR-L51 CTRP2 5.2255 6.8616 4.8455 6.881
COR-L95 CTRP2 5.2263 7.1422 4.7222 7.3689
IA-LM GDSC2; CTRP2 5.2326 6.4074 5.0383 6.1141
SW1271 GDSC2; CTRP2 5.2401 6.358 5.0648 5.9924
NCI-H748 GDSC2 5.2599 7.7826 2.4246 1.9545
DMS 114 GDSC2; CTRP2 5.2619 6.6078 4.9905 6.2163
HCC1195 CTRP2 5.2678 5.9854 5.2122 5.3669
LB647-SCLC GDSC2 5.2971 8.0521 2.3294 2.3658
SHP-77 GDSC2 5.3211 6.8829 2.8082 0.416
NCI-H2291 GDSC2 5.3378 9.4581 1.7267 5.4942
LCLC-103H GDSC2 5.3591 6.8988 2.8173 0.374
ChaGo-K-1 GDSC2; CTRP2 5.3791 10.4681 3.2563 13.0385
NCI-H720 GDSC2 5.3889 6.7924 2.8667 0.2473
COR-L23 GDSC2 5.3896 6.9927 2.7951 0.4181
LCLC-97TM1 GDSC2; CTRP2 5.3935 6.5987 5.1321 5.3098
NCI-H838 GDSC2; CTRP2 5.4087 6.0032 5.3615 4.3993
Ms-1 GDSC2 5.4418 7.0401 2.7983 0.3855
NCI-H1395 CTRP2 5.4468 7.8634 4.5989 7.337
NCI-H1373 CTRP2 5.4517 7.8304 4.6196 7.2404
VMRC-LCD GDSC2; CTRP2 5.4524 6.0889 5.3857 4.1788
SK-LU-1 GDSC2; CTRP2 5.4577 7.0046 5.0173 5.6014
HCC78 GDSC2 5.4598 6.9694 2.8306 0.3004
Lu-135 GDSC2 5.5075 7.3787 2.6995 0.6325
RERF-LC-MS GDSC2; CTRP2 5.5428 7.1395 5.0381 5.3092
NCI-H727 GDSC2 5.5485 7.5122 2.6662 0.7133
NCI-H2141 GDSC2 5.565 7.1679 2.7996 0.3306
DMS 79 GDSC2 5.5677 7.5507 2.6596 0.7225
NCI-H1437 GDSC2 5.5779 8.0072 2.4859 1.3556
LK2 CTRP2 5.5813 5.8747 5.5732 3.1124
NCI-H1651 GDSC2; CTRP2 5.6233 12.2362 2.5909 15.1933
NCI-H1048 GDSC2 5.629 7.5443 2.6873 0.5991
NCI-H2869 GDSC2 5.6469 9.0446 2.087 3.1102
NCI-H1836 GDSC2 5.6822 7.3435 2.7813 0.3274
NCI-H1993 GDSC2 5.6956 7.598 2.6943 0.5428
HCC15 GDSC2 5.7091 7.6595 2.677 0.5854
EMC-BAC-2 GDSC2 5.715 21.44 -3.8282 27.0161
NCI-H226 GDSC2; CTRP2 5.7166 6.1968 5.6359 2.4774
NCI-H250 GDSC2 5.7171 7.3522 2.7914 0.293
NCI-H1339 CTRP2 5.7475 6.6406 5.4733 3.0425
NCI-H650 GDSC2 5.7741 7.4111 2.7918 0.2731
Calu-1 CTRP2 5.7811 6.334 5.6472 2.259
NCI-H1734 GDSC2 5.809 7.6473 2.7209 0.419
NCI-H2591 GDSC2 5.8306 7.7619 2.6877 0.494
COR-L32 GDSC2 5.8311 7.7024 2.7095 0.4376
NCI-H2373 GDSC2 5.8397 7.5068 2.7824 0.2708
NCI-H1299 GDSC2 5.9006 7.7488 2.7195 0.3846
NCI-H2172 GDSC2; CTRP2 5.9029 11.5146 3.1905 12.2215
NCI-H3122 GDSC2 5.9382 8.0243 2.6341 0.5871
NCI-H2227 GDSC2 5.99 7.4187 2.8659 0.1069
UMC-11 GDSC2 6.018 7.8829 2.7161 0.3482
LUDLU-1 CTRP2 6.0942 14.2623 1.9769 16.574
NCI-H209 GDSC2 6.1456 8.1533 2.668 0.4079
NCI-H1869 GDSC2; CTRP2 6.1522 18.1372 0.0876 22.6261
KNS-62 GDSC2; CTRP2 6.179 7.1144 5.617 1.5529
NCI-H441 GDSC2; CTRP2 6.2405 8.2086 5.1211 3.5184
NCI-H2595 GDSC2 6.3812 8.3031 2.7025 0.2618
LOU-NH91 GDSC2; CTRP2 6.3831 16.5417 1.0753 19.1482
NCI-H2023 GDSC2; CTRP2 6.5496 9.9915 4.4744 5.6855
HCC1438 CTRP2 6.5572 13.8237 2.5734 13.4291
NCI-H2405 GDSC2 6.9559 9.113 2.6294 0.2403
T3M-10 CTRP2 7.052 14.6937 2.5281 12.7159
NCI-H2110 GDSC2; CTRP2 7.1071 17.1747 1.3382 16.9224
NCI-H460 GDSC2; CTRP2 7.109 8.6969 5.4651 0.9936
NCI-H647 GDSC2; CTRP2 7.1868 17.0031 1.4856 16.2775
NCI-H1650 GDSC2; CTRP2 7.7497 19.9217 0.4706 18.5734
Lu-65 GDSC2; CTRP2 8.3137 28.5337 -3.3696 26.6763
A-549 GDSC2; CTRP2 8.5982 20.4088 0.8634 15.9771
NCI-H1792 GDSC2; CTRP2 9.1685 17.2654 2.7749 8.5746
NCI-H1944 GDSC2; CTRP2 9.4331 23.7833 -0.1841 17.7934
NCI-H2122 GDSC2; CTRP2 9.5521 17.9344 2.7066 8.3312
RERF-LC-Ad2 CTRP2 10.8684 25.2304 0.1127 14.9693
Hs 888.Lu CTRP2 5.7006 7.8198 4.856 5.7009
⏷ Show the Full List of 193 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 4.1705 6.655 2.2985 4.3874
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 0.3189 8.8481 -1.1437 41.2092
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 2.4267 3.2324 2.4266 24.102
SYO-1 CTRP2 7.9896 21.2066 0.0171 19.4965
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 3.3506 5.7965 3.1684 18.578
IGROV-1 GDSC2; CTRP2 1.9209 7.4383 1.0991 30.2139
FU-OV-1 CTRP2 2.2808 7.6855 1.3958 28.1169
JHOS-4 GDSC2 2.8645 15.2353 -3.0201 31.9251
SNU-840 CTRP2 3.4443 21.6107 -3.9993 36.435
TOV-21G GDSC2 3.9793 7.2523 1.874 7.4123
OV7 CTRP2 4.0707 13.5201 0.5567 25.8317
DOV13 GDSC2 4.1171 5.9819 2.5818 2.816
A2780 GDSC2; CTRP2 4.1805 6.2155 3.9611 13.1917
Caov-3 GDSC2; CTRP2 4.5108 5.9729 4.3897 10.6388
JHOM-1 CTRP2 4.5468 6.1946 4.3667 10.6128
JHOS-2 GDSC2; CTRP2 4.6724 10.1312 2.7691 16.5979
OVCAR-3 GDSC2 4.7664 6.81 2.5837 1.7912
COV362 CTRP2 4.774 11.5976 2.149 18.7563
RMG-I CTRP2 4.7764 12.9953 1.4629 21.2288
OVK18 GDSC2; CTRP2 4.8872 5.8279 4.8333 7.8945
COV434 CTRP2 4.9743 6.8619 4.5838 8.5765
TYK-nu GDSC2; CTRP2 5.0025 5.8874 4.946 7.1359
ES-2 GDSC2 5.0056 6.3898 2.8639 0.4222
MCAS CTRP2 5.0201 8.6438 3.8164 11.5472
OVISE GDSC2 5.0344 6.3491 2.8903 0.3337
OC 314 CTRP2 5.0832 7.6774 4.334 9.2886
OV56 GDSC2; CTRP2 5.3443 5.9088 5.3127 4.7727
OAW28 GDSC2; CTRP2 5.4111 9.9164 3.5582 11.7283
OVCAR-5 GDSC2; CTRP2 5.4315 6.0739 5.3672 4.3091
OAW42 GDSC2; CTRP2 5.4506 5.8964 5.43 4.0261
OVCAR-4 GDSC2; CTRP2 5.5108 7.0438 5.0518 5.331
OV-90 GDSC2; CTRP2 5.5117 6.003 5.4738 3.6802
OVTOKO GDSC2 5.5378 14.4627 -0.5271 16.6504
Kuramochi GDSC2 5.8375 12.053 0.8325 9.4305
EFO-27 GDSC2; CTRP2 5.9705 16.368 0.8208 20.7849
EFO-21 GDSC2; CTRP2 6.198 8.9764 4.7043 5.3433
HEY A8 CTRP2 6.2398 7.7311 5.3578 2.5302
OVCAR-8 GDSC2; CTRP2 6.6245 9.947 4.5529 5.2345
TOV-112D GDSC2; CTRP2 8.279 19.5853 1.0339 15.9399
SK-OV-3 GDSC2; CTRP2 9.4685 25.5475 -1.0216 19.9329
COV644 CTRP2 10.7374 26.8979 -0.7777 17.531
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 5.5257 6.0831 5.4673 3.6616
TE 617.T CTRP2 -4.7704 2.9978 -5.0876 66.8558
BT-16 CTRP2 0.7212 9.1409 -0.8289 39.1856
Rh18 CTRP2 3.36 5.6604 3.21 18.4015
STS-0421 GDSC2 3.4814 5.8631 2.1817 6.7681
TTC-709 CTRP2 3.5513 6.0691 3.3168 17.4301
Rh41 GDSC2 3.6078 5.3529 2.5338 4.2182
A-204 GDSC2; CTRP2 4.1554 6.1992 3.9387 13.3486
G-401 GDSC2; CTRP2 4.2082 9.2656 2.73 17.8846
GCT GDSC2; CTRP2 4.308 6.7275 3.9271 12.946
G-402 GDSC2; CTRP2 4.5461 7.9639 3.6638 13.3303
KYM-1 GDSC2; CTRP2 4.6319 7.0009 4.1667 11.1259
SW872 GDSC2 4.7057 7.1076 2.42 2.7251
TE 441.T GDSC2; CTRP2 4.8093 6.9134 4.3893 9.7796
SW684 GDSC2 4.9742 6.4751 2.8187 0.5846
EW-8 GDSC2 5.1035 6.6221 2.8171 0.5077
RD GDSC2; CTRP2 5.133 8.3184 4.0806 10.1996
BT-12 CTRP2 5.2028 5.7943 5.1801 5.6839
Hs 729.T CTRP2 5.236 7.059 4.7694 7.1553
MES-SA GDSC2; CTRP2 5.3404 6.0211 5.2823 4.8929
Tm87-16 CTRP2 5.3442 7.1056 4.8575 6.5283
SK-LMS-1 GDSC2; CTRP2 5.4865 6.2109 5.3831 4.0882
Rh30 GDSC2 5.5044 7.1431 2.7853 0.3907
SW982 GDSC2; CTRP2 5.6078 6.0785 5.5582 3.0837
HT-1080 GDSC2; CTRP2 5.6736 6.1643 5.6017 2.729
VA-ES-BJ GDSC2 5.914 7.7528 2.7232 0.371
RKN GDSC2; CTRP2 6.6269 9.126 4.9579 3.5578
SK-UT-1 GDSC2; CTRP2 6.8444 11.4074 3.9969 7.1732
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2 3.6764 5.76 2.3842 4.9826
NCI-H28 GDSC2 4.1412 13.7585 -1.2303 22.9395
NCI-H2452 CTRP2 4.5534 5.6576 4.5042 10.1012
MPP 89 GDSC2; CTRP2 5.1355 6.9359 4.7204 7.6113
IST-Mes1 GDSC2; CTRP2 5.4131 6.6202 5.1434 5.2131
JL-1 CTRP2 5.6499 6.3359 5.51 3.1458
NCI-H2052 GDSC2; CTRP2 7.5762 11.6869 4.3749 4.5514
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 GDSC2 4.553 7.0914 2.3375 3.4314
NCI-H660 GDSC2 5.1125 6.5313 2.8545 0.3927
DU145 GDSC2; CTRP2 5.2501 8.1905 4.2542 9.2125
VCaP GDSC2; CTRP2 5.2513 6.4208 5.0533 6.0042
LNCaP clone FGC GDSC2; CTRP2 5.4227 6.4837 5.2104 4.9261
PaCa-3 CTRP2 5.8899 6.459 5.6975 1.7865
PC-3 GDSC2 6.2757 8.0869 2.7392 0.2267
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2; CTRP2 5.8778 11.9215 2.9659 13.1823
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 1.4655 4.3753 0.9354 21.5243
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-N87 GDSC2 -5.6641 4.8622 -6.9449 68.3685
SK-GT-2 GDSC2 -4.2464 0.4398 -4.3656 70.5318
NCC-StC-K140 CTRP2 -2.4105 27.0943 -12.1514 51.723
SNU-216 CTRP2 -0.9233 8.7097 -2.4238 47.5163
SNU-16 CTRP2 1.5047 3.8503 1.4747 30.3442
GCIY GDSC2 2.0208 7.5388 0.0507 24.0453
HGC-27 GDSC2; CTRP2 2.8288 4.6035 2.7992 21.5221
KE-39 CTRP2 2.852 14.4641 -1.0518 33.046
RERF-GC-1B GDSC2 3.2115 8.6239 0.5784 17.246
NUGC-3 GDSC2; CTRP2 3.4012 12.5664 0.384 28.0415
NUGC-4 GDSC2 3.656 9.7199 0.3969 16.9158
Fu97 CTRP2 3.7116 6.0826 3.488 16.3248
KATO III GDSC2; CTRP2 3.9875 8.9419 2.658 18.7274
ECC12 GDSC2 4.0483 5.5905 2.7207 2.1412
SNU-5 GDSC2 4.2623 6.768 2.3054 4.1597
LMSU CTRP2 4.4327 6.9216 3.987 12.3669
MKN45 GDSC2 4.4635 5.5148 2.9688 0.4226
ECC10 GDSC2; CTRP2 4.5261 5.2082 4.5214 10.1308
MKN74 CTRP2 4.6709 7.107 4.1642 11.0295
Hs 746.T GDSC2; CTRP2 4.7132 6.2133 4.5423 9.4735
HuG1-N CTRP2 4.8172 7.7001 4.0571 11.0692
MKN1 GDSC2 4.9744 12.2436 0.1521 14.7691
SNU-1 GDSC2; CTRP2 5.3361 6.8001 4.9862 6.0358
23132/87 GDSC2 5.3647 13.3749 -0.1206 15.1927
MKN7 GDSC2; CTRP2 5.3704 14.8315 1.0773 21.2076
SCH GDSC2 5.3769 13.7001 -0.2703 15.8604
TMK-1 GDSC2 5.3915 7.4031 2.6408 0.9114
AGS GDSC2 5.5327 12.1496 0.5869 11.3204
OCUM-1 GDSC2 5.584 7.3241 2.7505 0.4442
IM95 GDSC2; CTRP2 5.6396 15.9574 0.7466 21.6976
RF-48 GDSC2 5.7091 7.5301 2.7245 0.4542
SH-10-TC CTRP2 5.7897 6.4612 5.5986 2.4312
MKN28 GDSC2 5.8233 8.3835 2.4481 1.292
SNU-601 CTRP2 14.0587 32.8219 -1.4003 15.0702
SNG-M GDSC2; CTRP2 5.3988 7.7771 4.5949 7.4649
SNU-685 CTRP2 5.7318 7.6058 4.99 5.0745
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC2 4.2101 7.2331 2.0479 5.8155
SW579 CTRP2 4.2702 6.0209 4.1146 12.3635
ML-1 [Human leukemia] GDSC2; CTRP2 4.565 7.1026 4.0547 11.742
KMH-2 GDSC2 4.5816 7.6467 2.0975 4.7594
CAL-62 GDSC2 4.9136 6.5118 2.7781 0.7756
HTC-C3 GDSC2 5.0824 7.407 2.4929 1.8412
BHT-101 GDSC2 5.1409 7.1617 2.6229 1.1963
B-CPAP GDSC2 5.2511 6.8281 2.8005 0.4739
FTC-238 CTRP2 5.3287 5.8357 5.3088 4.8358
IHH-4 GDSC2 5.3615 6.8859 2.8229 0.3587
8305C GDSC2 5.4347 6.936 2.833 0.3044
FTC-133 GDSC2; CTRP2 5.4623 6.0039 5.4197 4.0258
8505C GDSC2 5.5674 7.3827 2.7225 0.5299
ASH-3 GDSC2 5.855 7.2902 2.8625 0.1342
WRO GDSC2 5.9081 7.4102 2.8403 0.1544
TT2609-C02 GDSC2; CTRP2 5.9179 7.583 5.1673 3.9381
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UPCI-SCC-090 GDSC2 -3.4384 9.5696 -6.3614 57.0491
SCC-25 GDSC2; CTRP2 -2.6292 7.173 -3.752 55.3275
BB30-HNC GDSC2 -0.8336 5.8749 -2.0974 44.4343
PCI-15A GDSC2 -0.3577 5.9723 -1.6343 40.9438
BICR 56 CTRP2 -0.2478 7.7775 -1.3633 43.7781
JHU-029 GDSC2 0.2342 8.2755 -2.0374 38.9048
JHU-022 GDSC2 0.478 11.7787 -3.4601 40.4575
PE/CA-PJ34 (clone C12) CTRP2 0.4929 9.0792 -1.0474 40.4012
CAL-27 GDSC2; CTRP2 0.7077 8.2232 -0.4922 38.5905
PCI-06A GDSC2 0.7729 8.2771 -1.5047 35.1783
SAT [Human HNSCC] GDSC2 1.0111 9.5092 -1.8591 35.1795
HSC-2 GDSC2; CTRP2 1.3011 4.7392 1.1569 32.0772
KON GDSC2 1.3623 7.4535 -0.5403 29.3105
PE/CA-PJ41 (clone D2) CTRP2 1.442 13.6539 -2.0481 38.7886
CAL-33 GDSC2; CTRP2 1.6153 8.8349 0.2405 33.7051
PE/CA-PJ15 GDSC2; CTRP2 1.6556 9.2081 0.1318 33.8537
DOK GDSC2 1.6882 10.901 -1.9025 32.7494
JHU-011 GDSC2 1.832 15.0657 -3.8336 36.5941
KOSC-2 GDSC2 1.849 9.5903 -1.1109 29.6243
PCI-04B GDSC2 2.0923 8.629 -0.4151 25.9527
NCI-H3118 GDSC2 2.9056 14.8461 -2.7907 31.2489
Ca9-22 GDSC2 3.1767 10.0485 -0.1631 21.1615
HO-1-N-1 GDSC2 3.3031 5.7436 2.0954 7.8192
YD-8 CTRP2 3.5604 11.1175 1.2261 25.0268
SCC-15 GDSC2 3.6019 10.3717 0.0275 18.9661
SKN-3 GDSC2 3.6904 13.7248 -1.5757 25.4173
FaDu GDSC2; CTRP2 3.9891 11.1072 1.6471 22.4822
Detroit 562 GDSC2 4.0331 9.2601 0.9226 12.9781
HSC-3 GDSC2 4.2454 13.2647 -0.9023 21.3737
OSC-20 GDSC2 4.4716 9.5769 1.0931 10.9054
SCC-4 GDSC2; CTRP2 4.5759 6.6882 4.2293 11.0413
BICR 6 CTRP2 4.6047 12.1739 1.7103 20.7588
BICR 16 CTRP2 4.6077 9.4746 3.0225 15.745
HSC-4 GDSC2; CTRP2 4.6094 17.2679 -0.8039 28.2057
BB49-HNC GDSC2 4.6877 7.89 2.051 4.8285
BICR 10 GDSC2 4.7086 11.9771 0.0886 15.7195
PE/CA-PJ49 CTRP2 4.8379 18.6327 -1.2815 28.803
BICR 31 GDSC2; CTRP2 4.9655 14.6885 0.7933 23.0078
BHY GDSC2 5.2209 13.2102 -0.1429 15.6233
BICR 18 CTRP2 5.323 7.9367 4.4457 8.2552
BICR 22 GDSC2; CTRP2 5.4754 6.012 5.432 3.9418
OSC-19 GDSC2 5.5177 22.1414 -4.3264 28.5362
BICR 78 GDSC2 5.7142 8.0297 2.5384 1.0396
LB771-HNC GDSC2 5.8616 7.776 2.6947 0.4616
SAS GDSC2 5.981 19.7286 -2.7846 23.7478
SCC-9 GDSC2; CTRP2 6.2007 18.2458 0.0734 22.571
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCaBER CTRP2 -1.8586 6.72 -2.7739 51.9735
U-BLC1 CTRP2 -0.5777 4.0313 -0.7491 44.4461
CAL-29 GDSC2 3.1317 6.1661 1.7384 10.5817
UM-UC-1 CTRP2 3.1321 5.0381 3.0737 19.5998
BC-3C CTRP2 3.8206 13.8509 0.162 27.5876
RT-112 GDSC2; CTRP2 4.1972 9.5755 2.5746 18.5158
RT-4 GDSC2; CTRP2 4.3443 5.9035 4.2256 11.7381
HT-1376 CTRP2 4.6042 5.7298 4.5461 9.7938
SW1710 GDSC2 4.6318 8.6852 1.6378 7.3612
BFTC-905 GDSC2 4.6803 6.2088 2.7921 0.9263
639V GDSC2 4.7925 5.9906 2.9259 0.357
TCCSUP GDSC2 4.9081 10.2012 1.0976 9.8858
J82 GDSC2; CTRP2 4.933 7.5614 4.2366 10.0569
HT-1197 GDSC2; CTRP2 5.0667 6.0344 4.9802 6.8159
KU-19-19 GDSC2 5.1296 7.0287 2.671 1.01
KMBC-2 CTRP2 5.1884 21.823 -2.5691 30.6598
647V GDSC2; CTRP2 5.3832 6.4683 5.175 5.1711
T24 GDSC2; CTRP2 5.5252 9.6492 3.7929 10.5106
UM-UC-3 CTRP2 5.5314 6.5501 5.2961 4.2998
5637 GDSC2 5.5614 12.0456 0.6557 10.903
SW780 GDSC2 5.8364 18.1201 -2.1006 21.9597
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-39 GDSC2 -1.7752 2.4682 -2.0331 50.9883
DSH1 GDSC2 -1.0753 12.907 -5.4931 47.8128
BPH-1 GDSC2 -0.3618 21.6197 -9.0529 46.824
DoTc2 4510 GDSC2 0.2897 8.7617 -2.2073 39.0215
OVCA420 GDSC2 1.113 7.7946 -0.9446 31.9123
SW954 GDSC2 1.4422 5.6954 0.3508 24.8052
PA-1 GDSC2 2.3255 5.528 1.3083 15.9448
UWB1.289 GDSC2 2.8056 10.4595 -0.6858 24.6706
NEC8 GDSC2 2.8905 4.7152 2.2397 8.219
OMC-1 [Human cervical carcinoma] GDSC2 3.2199 8.812 0.4914 17.6955
OV17R GDSC2 3.2851 6.679 1.6126 10.9053
OVCA433 GDSC2 3.5195 9.6836 0.3042 17.7981
JAR GDSC2 3.7754 6.0514 2.3142 5.1761
OVMIU GDSC2 3.8268 12.8463 -1.0264 23.0026
SW962 GDSC2 3.996 8.3902 1.3253 10.7146
LB831-BLC GDSC2 4.044 6.3972 2.3365 4.4256
JHOS-3 GDSC2 4.3085 10.8392 0.3505 15.3931
C-4-I GDSC2 4.3298 7.3308 2.0824 5.3515
Ca Ski GDSC2 4.4047 10.6642 0.5095 14.3103
ACC-OV7 GDSC2 4.451 8.6244 1.5426 8.3208
JEG-3 GDSC2 4.5173 12.2406 -0.1846 17.5151
HT-3 GDSC2 4.596 16.0247 -2.0014 24.4849
PWR-1E GDSC2 4.7463 7.1627 2.4185 2.6707
SKG-IIIa GDSC2 4.7906 11.6031 0.3325 14.2925
TC-YIK GDSC2 5.1149 7.4371 2.4967 1.7851
SiHa GDSC2 5.1657 6.6772 2.8219 0.4577
PEO1 GDSC2 5.1883 7.6039 2.4636 1.855
ME-180 GDSC2 5.309 15.2346 -1.0704 19.4319
C-33 A GDSC2 5.4488 13.6309 -0.1856 15.3084
SKN GDSC2 5.608 7.5431 2.6792 0.6358
SW756 GDSC2 5.7248 7.2586 2.827 0.2206
SiSo GDSC2 5.7862 7.8032 2.6548 0.6082
HEC-1 GDSC2 5.893 7.316 2.8669 0.1216
MS751 GDSC2 6.0104 7.8358 2.7299 0.3215
HEY GDSC2 6.0867 8.064 2.6776 0.4088
HeLa GDSC2; CTRP2 6.201 7.1185 5.6316 1.4552
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Ibrutinib
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Acalabrutinib DM7GCVW Major Increased risk of bleeding by the combination of Ibrutinib and Acalabrutinib. Mature B-cell lymphoma [2A85] [13]
Coadministration of a Drug Treating the Disease Different from Ibrutinib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Moderate Increased metabolism of Ibrutinib caused by Ivosidenib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [14]
Arn-509 DMT81LZ Major Increased metabolism of Ibrutinib caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [15]
Gilteritinib DMTI0ZO Moderate Decreased clearance of Ibrutinib due to the transporter inhibition by Gilteritinib. Acute myeloid leukaemia [2A60] [15]
Pexidartinib DMS2J0Z Moderate Increased metabolism of Ibrutinib caused by Pexidartinib mediated induction of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [14]
Talazoparib DM1KS78 Moderate Decreased clearance of Ibrutinib due to the transporter inhibition by Talazoparib. Breast cancer [2C60-2C6Y] [16]
Tucatinib DMBESUA Major Decreased metabolism of Ibrutinib caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [17]
Lumacaftor DMCLWDJ Major Increased metabolism of Ibrutinib caused by Lumacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [15]
Vortioxetine DM6F1PU Moderate Increased risk of bleeding by the combination of Ibrutinib and Vortioxetine. Depression [6A70-6A7Z] [18]
Tazemetostat DMWP1BH Major Increased risk of bleeding by the combination of Ibrutinib and Tazemetostat. Follicular lymphoma [2A80] [19]
Ripretinib DM958QB Moderate Decreased clearance of Ibrutinib due to the transporter inhibition by Ripretinib. Gastrointestinal stromal tumour [2B5B] [17]
Avapritinib DMK2GZX Major Increased risk of bleeding by the combination of Ibrutinib and Avapritinib. Gastrointestinal stromal tumour [2B5B] [15]
Cobicistat DM6L4H2 Major Decreased metabolism of Ibrutinib caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [17]
Epanova DMHEAGL Major Increased risk of bleeding by the combination of Ibrutinib and Epanova. Hyper-lipoproteinaemia [5C80] [20]
Ceritinib DMB920Z Major Decreased metabolism of Ibrutinib caused by Ceritinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [17]
PF-06463922 DMKM7EW Moderate Increased metabolism of Ibrutinib caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [14]
Idelalisib DM602WT Major Decreased metabolism of Ibrutinib caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [17]
GDC-0199 DMH0QKA Major Decreased clearance of Ibrutinib due to the transporter inhibition by GDC-0199. Mature B-cell leukaemia [2A82] [17]
Arry-162 DM1P6FR Major Increased risk of bleeding by the combination of Ibrutinib and Arry-162. Melanoma [2C30] [19]
LGX818 DMNQXV8 Major Increased risk of bleeding by the combination of Ibrutinib and LGX818. Melanoma [2C30] [19]
Ubrogepant DM749I3 Moderate Decreased clearance of Ibrutinib due to the transporter inhibition by Ubrogepant. Migraine [8A80] [21]
Rimegepant DMHOAUG Moderate Decreased clearance of Ibrutinib due to the transporter inhibition by Rimegepant. Migraine [8A80] [22]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Ibrutinib and Siponimod. Multiple sclerosis [8A40] [17]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Ibrutinib and Ocrelizumab. Multiple sclerosis [8A40] [23]
Fedratinib DM4ZBK6 Major Increased risk of bleeding by the combination of Ibrutinib and Fedratinib. Myeloproliferative neoplasm [2A20] [14]
Lefamulin DME6G97 Moderate Decreased clearance of Ibrutinib due to the transporter inhibition by Lefamulin. Pneumonia [CA40] [24]
Relugolix DMK7IWL Moderate Decreased clearance of Ibrutinib due to the transporter inhibition by Relugolix. Prostate cancer [2C82] [15]
Anthrax vaccine DM9GSWY Moderate Antagonize the effect of Ibrutinib when combined with Anthrax vaccine. Sepsis [1G40-1G41] [25]
Voxelotor DMCS6M5 Moderate Decreased metabolism of Ibrutinib caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [14]
Larotrectinib DM26CQR Moderate Decreased clearance of Ibrutinib due to the transporter inhibition by Larotrectinib. Solid tumour/cancer [2A00-2F9Z] [14]
Lusutrombopag DMH6IKO Moderate Decreased clearance of Ibrutinib due to the transporter inhibition by Lusutrombopag. Thrombocytopenia [3B64] [26]
Elagolix DMB2C0E Moderate Increased metabolism of Ibrutinib caused by Elagolix mediated induction of CYP450 enzyme. Uterine fibroid [2E86] [14]
Betrixaban DM2C4RF Major Increased risk of bleeding by the combination of Ibrutinib and Betrixaban. Venous thromboembolism [BD72] [19]
⏷ Show the Full List of 32 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Carmellose sodium E00625 Not Available Disintegrant
Ferrosoferric oxide E00231 14789 Colorant
Gelatin E00630 Not Available Other agent
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 4000 E00654 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyvinyl alcohol E00666 Not Available Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Colcothar yellow E00436 518696 Colorant
Haematite red E00236 14833 Colorant
Hydrophobic colloidal silica E00285 24261 Anticaking agent; Emulsion stabilizing agent; Glidant; Suspending agent; Viscosity-controlling agent
Cellulose microcrystalline E00698 Not Available Adsorbent; Suspending agent; Diluent
⏷ Show the Full List of 15 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Ibrutinib 280mg tablet 280mg Tablet Oral
Ibrutinib 140mg tablet 140mg Tablet Oral
Ibrutinib 560mg tablet 560mg Tablet Oral
Ibrutinib 420mg tablet 420mg Tablet Oral
Ibrutinib 70mg capsule 70mg Capsule Oral
Ibrutinib 140mg capsule 140mg Capsule Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6912).
2 Ibrutinib FDA Label
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization
5 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1948).
7 P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability. Mol Pharm. 2018 Nov 5;15(11):5124-5134.
8 Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.
9 Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib. Blood. 2015 Sep 24;126(13):1565-74.
10 Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.
11 Label-Free Bottom-Up Proteomic Workflow for Simultaneously Assessing the Target Specificity of Covalent Drug Candidates and Their Off-Target Reactivity to Selected Proteins. Chem Res Toxicol. 2016 Jan 19;29(1):109-16. doi: 10.1021/acs.chemrestox.5b00460. Epub 2015 Dec 29.
12 Blockade of oncogenic IB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11365-70. doi: 10.1073/pnas.1411701111. Epub 2014 Jul 21.
13 Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
14 Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
15 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
16 Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
17 Cerner Multum, Inc. "Australian Product Information.".
18 Alderman CP, Moritz CK, Ben-Tovim DI "Abnormal platelet aggregation associated with fluoxetine therapy." Ann Pharmacother 26 (1992): 1517-9. [PMID: 1482806]
19 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
20 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
21 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
22 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
23 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
24 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
25 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
26 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".