Details of the Drug

General Information of Drug (ID: DM7ZWNY)

Drug Name
Porfimer Sodium
Synonyms Photofrin
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Approved [1]
Affected Organisms
Humans and other mammals
ATC Code
L01XD01: Porfimer Sodium
L01XD: Sensitizers used in photodynamic/radiation therapy
L01X: OTHER ANTINEOPLASTIC AGENTS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
ADMET Property
Clearance
The renal clearance of drug is 199.7? +/- ?56.9 mL/min []
Half-life
The concentration or amount of drug in body reduced by one-half in 10 - 452 hours [2]
Vd
The volume of distribution (Vd) of drug is 0.49 +/- 0.28 L/kg []
Cross-matching ID
UNII
Y3834SIK5F
DrugBank ID
DB00707
TTD ID
D02JDL

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Low-density lipoprotein receptor (LDL-R) TTH0DUS LDLR_HUMAN Modulator [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Non-small-cell lung cancer
ICD Disease Classification 2C25.Y
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Low-density lipoprotein receptor (LDL-R) DTT LDLR 2.34E-41 -1.56 -1.5
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Porfimer Sodium
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Crizotinib DM4F29C Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Crizotinib. Lung cancer [2C25] [4]
Alectinib DMP1I6Y Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Alectinib. Lung cancer [2C25] [4]
Coadministration of a Drug Treating the Disease Different from Porfimer Sodium (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Tretinoin DM49DUI Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Tretinoin. Acne vulgaris [ED80] [4]
Isotretinoin DM4QTBN Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Isotretinoin. Acne vulgaris [ED80] [4]
Methyl aminolevulinate DMIUX3D Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Methyl aminolevulinate. Acne vulgaris [ED80] [4]
Sarecycline DMLZNIQ Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Sarecycline . Acne vulgaris [ED80] [4]
Trifarotene DMOL793 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Trifarotene. Acne vulgaris [ED80] [4]
Aminolevulinic acid hci DMS4BLQ Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Aminolevulinic acid hci. Acne vulgaris [ED80] [4]
Glibenclamide DM8JXPZ Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Glibenclamide. Acute diabete complication [5A2Y] [4]
Tolazamide DMIHRNA Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Tolazamide. Acute diabete complication [5A2Y] [4]
Glipizide DMZA5PQ Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Glipizide. Acute diabete complication [5A2Y] [4]
Dronedarone DMA8FS5 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Dronedarone. Angina pectoris [BA40] [4]
Nifedipine DMSVOZT Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Nifedipine. Angina pectoris [BA40] [4]
Desipramine DMT2FDC Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Desipramine. Attention deficit hyperactivity disorder [6A05] [4]
Sulfamethoxazole DMB08GE Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Sulfamethoxazole. Bacterial infection [1A00-1C4Z] [4]
Sparfloxacin DMB4HCT Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Sparfloxacin. Bacterial infection [1A00-1C4Z] [4]
Gemifloxacin DMHT34O Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Gemifloxacin. Bacterial infection [1A00-1C4Z] [4]
Norfloxacin DMIZ6W2 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Norfloxacin. Bacterial infection [1A00-1C4Z] [4]
Omadacycline DMR2J95 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Omadacycline. Bacterial infection [1A00-1C4Z] [4]
Levofloxacin DMS60RB Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Levofloxacin. Bacterial infection [1A00-1C4Z] [4]
Minocycline DMVN5OH Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Minocycline. Bacterial infection [1A00-1C4Z] [4]
Lomefloxacin DMVRH9C Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Lomefloxacin. Bacterial infection [1A00-1C4Z] [4]
Tetracycline DMZA017 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Tetracycline. Bacterial infection [1A00-1C4Z] [4]
Lapatinib DM3BH1Y Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Lapatinib. Breast cancer [2C60-2C6Y] [4]
Atorvastatin DMF28YC Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Atorvastatin. Cardiovascular disease [BA00-BE2Z] [4]
Ketoprofen DMRKXPT Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Ketoprofen. Chronic pain [MG30] [4]
Panitumumab DMQPD1F Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Panitumumab. Colorectal cancer [2B91] [4]
Capecitabine DMTS85L Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Capecitabine. Colorectal cancer [2B91] [4]
Sertraline DM0FB1J Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Sertraline. Depression [6A70-6A7Z] [4]
Trimipramine DM1SC8M Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Trimipramine. Depression [6A70-6A7Z] [4]
Paroxetine DM5PVQE Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Paroxetine. Depression [6A70-6A7Z] [4]
Escitalopram DMFK9HG Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Escitalopram. Depression [6A70-6A7Z] [4]
Phenelzine DMHIDUE Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Phenelzine. Depression [6A70-6A7Z] [4]
Clomipramine DMINRKW Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Clomipramine. Depression [6A70-6A7Z] [4]
Doxepin DMPI98T Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Doxepin. Depression [6A70-6A7Z] [4]
Diphenhydramine DMKQTBA Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Diphenhydramine. Episodic vestibular syndrome [AB31] [4]
Mefenamic acid DMK7HFI Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Mefenamic acid. Female pelvic pain [GA34] [4]
Itraconazole DMCR1MV Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Itraconazole. Fungal infection [1F29-1F2F] [4]
Terbinafine DMI6HUW Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Terbinafine. Fungal infection [1F29-1F2F] [4]
Ketoconazole DMPZI3Q Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Ketoconazole. Fungal infection [1F29-1F2F] [4]
Atovaquone DMY4UMW Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Atovaquone. Fungal infection [1F29-1F2F] [4]
Avapritinib DMK2GZX Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Avapritinib. Gastrointestinal stromal tumour [2B5B] [4]
Acetazolamide DM1AF5U Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Acetazolamide. Glaucoma [9C61] [4]
Chlorothiazide DMLHESP Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Chlorothiazide. Heart failure [BD10-BD1Z] [4]
Hydroflumethiazide DMVPUQI Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Hydroflumethiazide. Heart failure [BD10-BD1Z] [4]
Isoniazid DM5JVS3 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Isoniazid. HIV-infected patients with tuberculosis [1B10-1B14] [4]
Tipranavir DM8HJX6 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Tipranavir. Human immunodeficiency virus disease [1C60-1C62] [4]
Fenofibrate DMFKXDY Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Fenofibrate. Hyper-lipoproteinaemia [5C80] [4]
Methyldopa DM5I621 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Methyldopa. Hypertension [BA00-BA04] [4]
Indapamide DMGN1PW Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Indapamide. Hypertension [BA00-BA04] [4]
Trichlormethiazide DMHAQCO Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Trichlormethiazide. Hypertension [BA00-BA04] [4]
Quinapril DMR8H31 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Quinapril. Hypertension [BA00-BA04] [4]
Telmisartan DMS3GX2 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Telmisartan. Hypertension [BA00-BA04] [4]
Irbesartan DMTP1DC Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Irbesartan. Hypertension [BA00-BA04] [4]
Hydrochlorothiazide DMUSZHD Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Hydrochlorothiazide. Hypertension [BA00-BA04] [4]
Pirfenidone DM6VZFQ Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Pirfenidone. Idiopathic interstitial pneumonitis [CB03] [4]
TP-434 DM5A31S Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and TP-434. Infectious gastroenteritis/colitis [1A40] [4]
Meclofenamic acid DM05FXR Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Meclofenamic acid. Inflammatory spondyloarthritis [FA92] [4]
Propiomazine DMKY8V1 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Propiomazine. Insomnia [7A00-7A0Z] [4]
Hydroxychloroquine DMSIVND Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Hydroxychloroquine. Malaria [1F40-1F45] [4]
Vemurafenib DM62UG5 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Vemurafenib. Melanoma [2C30] [4]
Dacarbazine DMNPZL4 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Dacarbazine. Melanoma [2C30] [4]
Ethinyl estradiol DMODJ40 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Ethinyl estradiol. Menopausal disorder [GA30] [4]
Thalidomide DM70BU5 Major Additive thrombogenic effects by the combination of Porfimer Sodium and Thalidomide. Multiple myeloma [2A83] [5]
Hydroxyurea DMOQVU9 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Hydroxyurea. Myeloproliferative neoplasm [2A20] [4]
Promethazine DM6I5GR Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Promethazine. Nausea/vomiting [MD90] [4]
Polythiazide DMCH80F Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Polythiazide. Oedema [MG29] [4]
Naproxen DMZ5RGV Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Naproxen. Osteoarthritis [FA00-FA05] [4]
Etodolac DM6WJO9 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Etodolac. Pain [MG30-MG3Z] [4]
Diflunisal DM7EN8I Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Diflunisal. Pain [MG30-MG3Z] [4]
Ibuprofen DM8VCBE Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Ibuprofen. Pain [MG30-MG3Z] [4]
Ranitidine DM0GUSX Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Ranitidine. Peptic ulcer [DA61] [4]
Esomeprazole DM7BN0X Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Esomeprazole. Peptic ulcer [DA61] [4]
Bicalutamide DMZMSPF Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Bicalutamide. Prostate cancer [2C82] [4]
Tazarotene DM8SMD1 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Tazarotene. Psoriasis [EA90] [4]
Levomepromazine DMIKFEL Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Levomepromazine. Psychotic disorder [6A20-6A25] [4]
Oxaprozin DM9UB0P Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Oxaprozin. Rheumatoid arthritis [FA20] [4]
Sulfasalazine DMICA9H Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Sulfasalazine. Rheumatoid arthritis [FA20] [4]
Mesoridazine DM2ZGAN Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Mesoridazine. Schizophrenia [6A20] [4]
Aripiprazole DM3NUMH Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Aripiprazole. Schizophrenia [6A20] [4]
Perphenazine DMA4MRX Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Perphenazine. Schizophrenia [6A20] [4]
Thiothixene DMDINC4 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Thiothixene. Schizophrenia [6A20] [4]
Trifluoperazine DMKBYWI Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Trifluoperazine. Schizophrenia [6A20] [4]
Risperidone DMN6DXL Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Risperidone. Schizophrenia [6A20] [4]
Imiquimod DM1TMA3 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Imiquimod. Skin cancer [2C30-2C37] [4]
Vandetanib DMRICNP Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Vandetanib. Solid tumour/cancer [2A00-2F9Z] [4]
Taxol DMUOT9V Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Taxol. Solid tumour/cancer [2A00-2F9Z] [4]
Doxorubicin DMVP5YE Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Doxorubicin. Solid tumour/cancer [2A00-2F9Z] [4]
Clopidogrel DMOL54H Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Clopidogrel. Thrombosis [DB61-GB90] [4]
Tolbutamide DM02AWV Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Tolbutamide. Type 2 diabetes mellitus [5A11] [4]
Nalidixic acid DMRM0JV Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Nalidixic acid. Urinary tract infection [GC08] [4]
Trimeprazine DMEMV9D Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [4]
Amiodarone DMUTEX3 Moderate Increased risk of photosensitivity reactions by the combination of Porfimer Sodium and Amiodarone. Ventricular tachyarrhythmia [BC71] [4]
⏷ Show the Full List of 91 DDI Information of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
5 Figg WD, Arlen P, Gulley J, et al. "A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer." Semin Oncol 28(4 Suppl 15) (2001): 62-6. [PMID: 11685731]