Details of the Drug

General Information of Drug (ID: DMP1I6Y)

Drug Name
Alectinib
Synonyms
1256580-46-7; CH5424802; CH 5424802; AF-802; Alecensa; UNII-LIJ4CT1Z3Y; AF 802; LIJ4CT1Z3Y; Alectinib (CH5424802); 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; CHEMBL1738797; AF802; 9-Ethyl-6,6-Dimethyl-8-[4-(Morpholin-4-Yl)piperidin-1-Yl]-11-Oxo-6,11-Dihydro-5h-Benzo[b]carbazole-3-Carbonitrile; 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile; AK170451; C30H34N4O2; Alectinib; 9-ethyl-6,6-dimethyl-
Indication
Disease Entry ICD 11 Status REF
Lung cancer 2C25.0 Approved [1]
Non-small-cell lung cancer 2C25.Y Phase 2 [2]
ATC Code
L01ED03: Alectinib
L01ED: Anaplastic lymphoma kinase (ALK) inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 482.6
Logarithm of the Partition Coefficient (xlogp) 5.2
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
Clearance
The drug present in the plasma can be removed from the body at the rate of 7.69 mL/min/kg [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 33 hours [3]
Metabolism
The drug is metabolized via the CYP3A4 to its major active metabolite M4 []
Unbound Fraction
The unbound fraction of drug in plasma is 0.003% [3]
Vd
The volume of distribution (Vd) of drug is 4016 L []
Chemical Identifiers
Formula
C30H34N4O2
IUPAC Name
9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
Canonical SMILES
CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C
InChI
InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3
InChIKey
KDGFLJKFZUIJMX-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
49806720
ChEBI ID
CHEBI:90936
CAS Number
1256580-46-7
UNII
LIJ4CT1Z3Y
DrugBank ID
DB11363
TTD ID
D0U3SY
INTEDE ID
DR0059
ACDINA ID
D00016
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ALK tyrosine kinase receptor (ALK) TTPMQSO ALK_HUMAN Inhibitor [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Protein Interaction/Cellular Processes [6]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Lung tissue
The Studied Disease Lung cancer [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
ALK tyrosine kinase receptor (ALK) DTT ALK 7.19E-15 0.18 0.61
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 5.59E-39 -3.76E-01 -1.64E+00
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 3.0194 6.4153 0.8493 9.6161
EW-11 GDSC1 -0.4929 2.6668 -0.8432 37.4419
ES6 GDSC1 1.4594 3.6379 0.8714 15.4113
ES7 GDSC1 1.5089 3.848 0.8243 15.5301
EW-18 GDSC1 2.1576 9.12 -1.1927 25.4747
EW-7 GDSC1 2.321 6.1188 0.4455 14.9823
EW-13 GDSC1 3.1553 8.9876 -0.3194 17.1943
ES5 GDSC1 3.2535 12.1066 -1.7929 24.3622
ES8 GDSC1 3.5928 7.0491 0.943 7.3265
EW-3 GDSC1 3.6758 9.8537 -0.3578 15.8179
HuO9 GDSC1 3.7452 7.8496 0.663 8.9284
MG-63 GDSC1 4.1306 5.646 1.8523 0.6341
EW-16 GDSC1 4.2282 7.0564 1.3218 3.3696
EW-24 GDSC1 4.2972 5.3192 2.0301 0.0889
CHSA8926 GDSC1 4.302 6.0938 1.7542 0.8969
CAL-72 GDSC1 4.3349 6.096 1.7673 0.8145
A-673 GDSC1 4.3641 5.7169 1.9177 0.2895
SK-PN-DW GDSC1 4.4337 6.7748 1.5444 1.7707
CADO-ES1 GDSC1 4.4601 6.4412 1.6885 1.0429
HuO-3N1 GDSC1 4.5312 7.4252 1.3226 2.8814
TC-71 GDSC1 4.5945 6.0612 1.8819 0.2868
CHSA0108 GDSC1 4.6044 7.7958 1.2026 3.4857
HOS GDSC1 4.6112 5.9047 1.9417 0.1579
ES1 GDSC1 4.682 6.352 1.8117 0.4352
EW-1 GDSC1 4.6951 11.9201 -0.645 14.6839
H-EMC-SS GDSC1 4.7527 7.3709 1.453 1.8683
G-292 clone A141B1 GDSC1 4.8664 10.3794 0.1935 9.349
SaOS-2 GDSC1 4.8938 6.4064 1.8704 0.2131
CAL-78 GDSC1 5.0626 6.8128 1.7908 0.3276
ES4 GDSC1 5.2196 7.6798 1.5374 1.044
NOS-1 [Human HNSCC] GDSC1 5.3426 8.342 1.3354 1.8086
U2OS GDSC1 5.3727 15.2565 -1.786 18.566
CHSA0011 GDSC1 5.3781 8.9702 1.0991 2.9643
SK-ES-1 GDSC1 5.6069 15.6557 -1.8184 18.1588
SJSA-1 GDSC1 5.9197 15.4955 -1.5339 16.2125
NY GDSC1 6.1373 8.0981 1.7312 0.16
MHH-ES-1 GDSC1 7.3665 19.1964 -2.3447 16.6186
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 3.9418 8.2715 0.5926 8.9154
SUP-M2 GDSC1 -6.4676 -4.4246 -6.4678 95.9883
SR GDSC1 -5.8832 -1.9232 -5.9201 86.0624
SU-DHL-1 GDSC1 -5.6138 -4.6312 -5.6138 95.9344
DEL GDSC1 -5.5714 4.5074 -6.9656 69.1749
Karpas-299 GDSC1 -5.218 12.1333 -9.7111 60.9048
SCC-3 GDSC1 -3.9844 -2.0585 -3.9857 77.728
MV4-11 GDSC1 -1.1324 29.6772 -14.3104 49.0944
Reh GDSC1 -0.5006 3.2032 -1.0279 38.2878
HAL-01 GDSC1 -0.3369 4.9139 -1.5308 38.9694
MOLM-13 GDSC1 -0.1155 15.2403 -6.2462 44.6966
MY-M12 GDSC1 0.6159 7.9806 -2.0116 35.2948
EB2 GDSC1 0.6926 5.7536 -0.8707 30.4093
ALL-PO GDSC1 0.7629 7.8653 -1.8175 33.9639
BALL-1 GDSC1 1.0496 3.1742 0.6462 19.1024
KMOE-2 GDSC1 1.6191 4.1076 0.8098 15.1327
697 GDSC1 1.8215 10.3423 -2.0908 30.4565
K-562 GDSC1 1.9309 4.7511 0.7881 13.9537
OPM-2 GDSC1 1.9809 2.9277 1.7188 6.5738
THP-1 GDSC1 2.2705 8.4834 -0.7792 22.9502
U-698-M GDSC1 2.342 3.6312 1.7068 5.1726
RPMI-8226 GDSC1 2.4078 3.6168 1.7684 4.4518
MOLT-4 GDSC1 2.4412 6.6696 0.2699 15.7909
P12-Ichikawa GDSC1 2.4551 4.5081 1.3615 7.4911
Loucy GDSC1 2.5139 4.8776 1.2244 8.3639
OCI-M1 GDSC1 2.5272 10.7661 -1.7072 26.4079
BL-41 GDSC1 2.5335 7.0695 0.1456 16.3149
MOLP-8 GDSC1 2.6665 8.0527 -0.2378 18.3452
MLMA GDSC1 2.6802 5.8979 0.8476 10.7125
OCI-AML-3 GDSC1 2.7083 4.0659 1.774 3.4618
SUP-T1 GDSC1 2.7521 5.3239 1.1879 7.8643
GDM-1 GDSC1 2.9009 10.4098 -1.2262 22.9721
MN-60 GDSC1 2.9372 7.3842 0.3084 13.8021
SU-DHL-8 GDSC1 2.9973 6.4968 0.7928 10.1059
YT GDSC1 3.0311 5.7736 1.172 7.1445
ATN-1 GDSC1 3.0694 8.5718 -0.1792 16.6062
Karpas-422 GDSC1 3.1191 4.8453 1.6754 3.1531
SU-DHL-5 GDSC1 3.2068 9.9305 -0.7476 19.5011
VAL GDSC1 3.4431 6.0089 1.3366 4.8453
SU-DHL-10 GDSC1 3.4582 4.4382 2.0285 0.4523
EoL-1 GDSC1 3.4671 10.3278 -0.746 18.6704
Ramos.2G6.4C10 GDSC1 3.4929 7.6433 0.5896 10.1281
JURL-MK1 GDSC1 3.5012 6.5292 1.1293 6.2069
MC116 GDSC1 3.6151 4.4717 2.0783 0.1892
SU-DHL-6 GDSC1 3.6434 5.3864 1.7316 1.7863
WSU-DLCL2 GDSC1 3.7262 4.8194 1.9957 0.384
MOLT-13 GDSC1 3.7421 11.483 -1.11 19.7437
Namalwa GDSC1 3.7714 7.0988 1.035 6.2331
HEL GDSC1 3.7897 11.0113 -0.8426 18.221
ST486 GDSC1 3.7975 6.6815 1.2439 4.7095
TK [Human B-cell lymphoma] GDSC1 3.8 5.7621 1.6526 2.0211
EJM GDSC1 3.8101 5.9379 1.5826 2.4345
KG-1 GDSC1 3.8386 14.3965 -2.4776 25.2633
NU-DUL-1 GDSC1 3.8681 8.1581 0.5978 9.0668
SIG-M5 GDSC1 3.8904 4.785 2.0693 0.1161
CESS GDSC1 3.903 6.591 1.3466 3.7975
ME1 GDSC1 3.9035 5.1063 1.9607 0.3937
HL-60 GDSC1 3.9121 5.1454 1.9498 0.4255
LP-1 GDSC1 3.9275 10.7078 -0.5936 16.4561
BE-13 GDSC1 3.9278 9.2159 0.1313 12.0473
OCI-Ly19 GDSC1 3.9639 6.4462 1.4446 3.0458
CA46 GDSC1 3.9676 10.1758 -0.3057 14.6686
BC-3 GDSC1 3.9782 10.1757 -0.2981 14.5938
SU-DHL-16 GDSC1 3.9886 5.2663 1.9358 0.4262
P31/FUJ GDSC1 4.0208 5.6699 1.7961 0.9692
AMO1 GDSC1 4.021 6.2074 1.5772 2.1383
L-363 GDSC1 4.0315 8.9419 0.3331 10.4444
KCL-22 GDSC1 4.0839 5.8265 1.7627 1.0633
KE-37 GDSC1 4.103 5.4415 1.9168 0.421
SK-MM-2 GDSC1 4.123 8.4341 0.6333 8.1949
P32/ISH GDSC1 4.1455 5.4852 1.9175 0.3946
Kasumi-1 GDSC1 4.1456 14.3827 -2.2387 23.5309
VL51 GDSC1 4.1722 5.9554 1.7514 1.0285
KOPN-8 GDSC1 4.177 7.3488 1.1644 4.4802
RL GDSC1 4.2008 5.5224 1.9254 0.3422
U266B1 GDSC1 4.2514 6.6078 1.5249 2.1125
KMS-12-BM GDSC1 4.2539 5.7623 1.859 0.5245
DB GDSC1 4.2623 12.3192 -1.1399 18.4113
Karpas-231 GDSC1 4.2648 7.4604 1.1644 4.3135
Daudi GDSC1 4.2789 6.3185 1.656 1.3769
CTB-1 GDSC1 4.2921 9.4443 0.2664 10.2265
CTV-1 GDSC1 4.2956 6.4429 1.6138 1.5727
RC-K8 GDSC1 4.3067 5.7852 1.8715 0.451
CCRF-CEM GDSC1 4.3104 6.2198 1.7091 1.0896
RPMI-8402 GDSC1 4.3316 15.813 -2.8053 25.0601
OCI-AML-2 GDSC1 4.3336 5.4794 1.9888 0.1454
KY821 GDSC1 4.3351 6.1874 1.7324 0.9622
Hs 445 GDSC1 4.3474 6.0214 1.8006 0.6735
A4/Fukuda GDSC1 4.3848 7.1258 1.3744 2.7948
HC-1 GDSC1 4.3884 6.1575 1.7664 0.7757
Karpas-620 GDSC1 4.3999 5.9958 1.8313 0.5287
Raji GDSC1 4.4092 5.7756 1.9137 0.2812
MEG-01 GDSC1 4.4107 12.4203 -1.0835 17.7281
EM-2 GDSC1 4.4138 5.9669 1.8472 0.4682
JVM-3 GDSC1 4.4209 6.6844 1.5749 1.6271
H9 GDSC1 4.4295 7.7278 1.138 4.1834
HT GDSC1 4.482 6.0602 1.8399 0.4536
SU-DHL-4 GDSC1 4.4981 5.7701 1.9477 0.1768
L-428 GDSC1 4.5409 6.1273 1.8384 0.4276
Farage GDSC1 4.5739 6.0518 1.8776 0.3054
L-540 GDSC1 4.5851 6.6055 1.6789 0.9753
WIL2 NS GDSC1 4.5907 6.601 1.683 0.9535
LC4-1 GDSC1 4.597 11.7006 -0.6063 14.7197
NOMO-1 GDSC1 4.6243 8.8276 0.7582 6.2641
BV-173 GDSC1 4.6439 8.6152 0.8649 5.5372
LAMA-84 GDSC1 4.6556 7.8489 1.2066 3.3805
RPMI-6666 GDSC1 4.6557 13.2757 -1.3262 18.2671
ALL-SIL GDSC1 4.67 14.0258 -1.6808 19.848
Granta-519 GDSC1 4.683 6.5687 1.7332 0.6902
TUR GDSC1 4.6858 7.4407 1.3929 2.2674
HH [Human lymphoma] GDSC1 4.7848 7.1395 1.5592 1.3208
OCI-AML-5 GDSC1 4.7949 10.9075 -0.0981 11.2939
ARH-77 GDSC1 4.7975 6.7899 1.6975 0.7425
RS4;11 GDSC1 4.8112 8.5868 0.9707 4.5647
P30/OHK GDSC1 4.8431 13.3943 -1.253 17.4379
NB4 GDSC1 4.8624 14.3958 -1.7244 19.5463
Sc-1 GDSC1 4.8637 10.8333 -0.0193 10.6593
RPMI-8866 GDSC1 4.8653 6.7428 1.7415 0.5521
Ku812 GDSC1 4.886 6.6161 1.7947 0.3884
PF-382 GDSC1 4.8957 7.9 1.3057 2.4712
MHH-PREB-1 GDSC1 4.909 6.577 1.8169 0.3232
Jiyoye GDSC1 4.9308 7.0079 1.6704 0.7511
PL-21 GDSC1 4.9491 11.5015 -0.2783 11.9959
MOLT-16 GDSC1 4.9493 18.0217 -3.4346 25.5095
L-1236 GDSC1 4.9595 7.1622 1.6246 0.9003
JJN-3 GDSC1 4.973 6.4657 1.8781 0.1785
QIMR-WIL GDSC1 4.9777 7.6333 1.4512 1.6325
JSC-1 GDSC1 5.0368 7.3292 1.5938 0.9618
BC-1 GDSC1 5.0605 7.6664 1.4749 1.4416
SUP-HD1 GDSC1 5.1425 7.038 1.7413 0.4184
DND-41 GDSC1 5.1716 11.399 -0.0898 10.3896
ROS-50 GDSC1 5.1789 10.7527 0.2119 8.5687
WSU-NHL GDSC1 5.2365 6.9186 1.8167 0.2197
ML-2 GDSC1 5.2809 12.8845 -0.7157 13.6534
GR-ST GDSC1 5.3081 8.4535 1.2756 2.1338
HDLM-2 GDSC1 5.3115 7.3145 1.7066 0.4368
JVM-2 GDSC1 5.354 8.0047 1.4707 1.2054
KMS-11 GDSC1 5.384 7.2931 1.7407 0.3279
SUP-B15 GDSC1 5.4243 13.9862 -1.1436 15.5025
DG-75 GDSC1 5.4549 6.9968 1.8655 0.1054
Mono-Mac-6 GDSC1 5.5161 9.7147 0.857 4.1128
NALM-6 GDSC1 5.6935 15.796 -1.8271 17.998
A3/Kawakami GDSC1 5.7512 16.5942 -2.1708 19.2753
KM-H2 GDSC1 5.9894 16.3933 -1.9143 17.7041
NKM-1 GDSC1 6.747 17.7253 -2.0498 16.6695
Karpas-45 GDSC1 7.4919 19.4814 -2.3986 16.5875
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-50 GDSC1 0.4652 3.6144 -0.1487 27.6307
ESO-26 GDSC1 1.772 3.3688 1.3074 10.6615
ESO-51 GDSC1 4.1938 10.759 -0.4298 14.779
SK-GT-4 GDSC1 4.2124 10.038 -0.0696 12.5658
OACM5.1 C GDSC1 4.4827 10.2376 0.0155 11.3512
OACP4 C GDSC1 4.5546 12.6427 -1.0902 17.3805
TE-12 GDSC1 4.7353 10.233 0.1798 9.7286
HCE-4 GDSC1 4.787 6.8383 1.6751 0.8329
FLO-1 GDSC1 4.863 9.9238 0.4012 8.0572
KYSE-220 GDSC1 5.0636 9.9535 0.5061 6.9928
KYAE-1 GDSC1 5.1961 13.9243 -1.2666 16.6349
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 5.1111 9.1843 0.8725 4.6565
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-17 GDSC1 0.0163 9.2063 -3.1718 40.8658
SJNB-12 GDSC1 2.2976 6.3117 0.3294 15.9036
CHP-212 GDSC1 2.3803 3.447 1.8307 4.0579
IMR-5 GDSC1 2.5496 4.312 1.5344 5.813
LA-N-6 GDSC1 2.971 19.3737 -5.6458 35.3377
KP-N-YS GDSC1 3.07 6.8142 0.6904 10.6395
NH-12 GDSC1 3.2254 14.8037 -3.1589 29.2229
MHH-NB-11 GDSC1 3.6158 7.0306 0.967 7.0956
TGW GDSC1 3.7595 10.5099 -0.6185 17.0823
CHP-134 GDSC1 3.8306 5.6326 1.7224 1.5713
SK-N-MC-IXC GDSC1 4.0128 5.1173 1.9985 0.2285
NB(TU)1 GDSC1 4.0179 5.8396 1.7274 1.3102
SK-N-DZ GDSC1 4.0897 5.4685 1.9017 0.4802
SJNB-10 GDSC1 4.1421 6.848 1.366 3.2378
NB69 GDSC1 4.1455 10.0328 -0.1127 13.0088
SJNB-13 GDSC1 4.2092 5.9699 1.7619 0.9459
SJNB-6 GDSC1 4.2106 6.2837 1.6383 1.546
SiMa GDSC1 4.2808 7.3022 1.2431 3.777
CHP-126 GDSC1 4.305 10.6723 -0.3112 13.7869
SJNB-7 GDSC1 4.3826 5.9121 1.855 0.461
Kelly GDSC1 4.5209 6.0306 1.8653 0.3602
SJNB-5 GDSC1 4.6324 6.5499 1.7196 0.7754
KP-N-YN GDSC1 4.6383 7.2396 1.4524 2.0077
SK-N-FI GDSC1 4.6695 6.2417 1.8462 0.346
GOTO GDSC1 4.6973 6.8173 1.6456 1.021
SK-N-AS GDSC1 4.6975 9.3334 0.5718 7.3187
SK-N-BE(2)-M17 GDSC1 4.7175 6.3079 1.8407 0.34
SJNB-14 GDSC1 4.7251 11.3346 -0.3455 12.9215
SK-N-SH GDSC1 5.2644 17.1012 -2.7556 22.5735
GI-ME-N GDSC1 5.308 11.7566 -0.1711 10.5672
NB1 GDSC1 9.6486 33.681 -7.7243 26.4642
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 4.3503 6.4972 1.6174 1.4914
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCUB-M GDSC1 0.0366 2.0624 -0.1016 29.866
MDA-MB-231 GDSC1 1.69 2.7728 1.4844 9.7445
Evsa-T GDSC1 1.716 2.488 1.6175 8.6608
CAL-85-1 GDSC1 1.8304 8.1396 -0.9846 25.7509
MDA-MB-468 GDSC1 2.1406 3.104 1.7903 5.3097
ZR-75-30 GDSC1 2.2476 4.9368 0.9743 11.2736
CAMA-1 GDSC1 2.2929 3.5468 1.7073 5.3512
HDQ-P1 GDSC1 2.3801 3.7068 1.7007 5.0832
HCC70 GDSC1 2.3949 3.9487 1.592 5.8877
Hs 578T GDSC1 2.4205 3.6481 1.763 4.4504
T-47D GDSC1 2.4982 3.7872 1.7553 4.2489
UACC-893 GDSC1 2.6292 4.3563 1.5735 5.2509
BT-474 GDSC1 2.6945 4.3521 1.6242 4.657
MDA-MB-436 GDSC1 2.8932 5.0703 1.4164 5.6753
HCC2157 GDSC1 2.923 4.7658 1.5847 4.3114
HCC1599 GDSC1 2.9546 4.8347 1.5731 4.3144
HCC1806 GDSC1 3.1308 4.8742 1.6692 3.1706
MDA-MB-415 GDSC1 3.2169 5.2154 1.5644 3.7281
HCC1419 GDSC1 3.3114 6.1778 1.1708 6.3851
EFM-19 GDSC1 3.3121 5.7344 1.3817 4.83
CAL-148 GDSC1 3.4325 5.3031 1.6536 2.6469
MDA-MB-453 GDSC1 3.7156 5.6954 1.6371 2.25
HCC1187 GDSC1 3.7298 7.2002 0.9609 6.8578
HCC1428 GDSC1 3.901 8.6288 0.3951 10.3682
BT-483 GDSC1 4.0234 9.0273 0.2868 10.7727
CAL-120 GDSC1 4.0446 5.6306 1.8218 0.8305
MRK-nu-1 GDSC1 4.1684 5.5426 1.9056 0.4197
MFM-223 GDSC1 4.1836 6.0764 1.7089 1.219
MCF-7 GDSC1 4.2289 6.2238 1.6709 1.3578
EFM-192A GDSC1 4.2456 6.0858 1.7328 1.0431
MDA-MB-175-VII GDSC1 4.2977 7.0423 1.3649 2.988
UACC-812 GDSC1 4.3008 6.2109 1.7084 1.1023
AU565 GDSC1 4.3204 6.8731 1.4484 2.4551
HCC1937 GDSC1 4.3674 9.9036 0.0982 11.1183
HCC1395 GDSC1 4.3815 6.4654 1.6443 1.3242
YMB-1-E GDSC1 4.3899 6.5464 1.6159 1.4543
DU4475 GDSC1 4.4315 5.5276 2.0065 0.0966
HCC1500 GDSC1 4.476 11.6351 -0.6575 15.315
CAL-51 GDSC1 4.5011 6.1556 1.8127 0.53
MDA-MB-361 GDSC1 4.5188 6.3027 1.7656 0.6836
JIMT-1 GDSC1 4.5328 6.4031 1.7338 0.7943
HCC1954 GDSC1 4.673 6.9863 1.5696 1.3814
MDA-MB-157 GDSC1 4.7114 7.0638 1.5563 1.4055
BT-20 GDSC1 4.8083 6.4207 1.8346 0.3189
BT-549 GDSC1 4.8239 15.2597 -2.1726 21.4942
HCC2218 GDSC1 4.8334 12.4543 -0.8075 15.2126
HCC1569 GDSC1 4.9618 10.9625 -0.0178 10.4271
MDA-MB-330 GDSC1 4.9692 7.1569 1.6306 0.8706
HCC38 GDSC1 5.1256 7.037 1.7353 0.4415
COLO 824 GDSC1 5.5127 7.4586 1.7298 0.3091
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8-MG-BA GDSC1 3.1264 9.1941 -0.4441 18.0355
YKG-1 GDSC1 3.4832 6.6373 1.0662 6.7112
NMC-G1 GDSC1 3.5843 5.4748 1.6623 2.3125
D-247MG GDSC1 3.8756 6.5769 1.3372 3.9134
ONS-76 GDSC1 3.8923 5.7768 1.6929 1.6536
LN-18 GDSC1 3.9537 5.1348 1.97 0.3354
GaMG GDSC1 3.9555 6.3782 1.4696 2.9009
D-542MG GDSC1 4.03 5.4524 1.8835 0.5879
Becker GDSC1 4.0506 6.1021 1.6359 1.7607
KNS-81-FD GDSC1 4.104 7.1569 1.2085 4.3289
U-87MG ATCC GDSC1 4.1113 5.2889 1.9746 0.2487
SF539 GDSC1 4.1184 5.7765 1.7974 0.8715
D283 Med GDSC1 4.1908 5.5552 1.9098 0.3942
SF126 GDSC1 4.2204 6.0993 1.7164 1.1445
GB-1 GDSC1 4.225 7.0074 1.3414 3.2519
SK-MG-1 GDSC1 4.2319 7.4935 1.131 4.5948
KS-1 [Human Krukenberg tumour] GDSC1 4.2381 7.6402 1.0688 4.9942
Onda 10 GDSC1 4.2894 6.2138 1.7022 1.1423
KNS-42 GDSC1 4.3111 5.8832 1.8373 0.5638
SF295 GDSC1 4.3806 5.6562 1.9449 0.2187
YH-13 GDSC1 4.3935 5.9009 1.8632 0.4292
LN-405 GDSC1 4.3957 7.1728 1.3601 2.8638
D-566MG GDSC1 4.4132 6.001 1.8346 0.5097
LNZTA3WT4 GDSC1 4.484 6.3851 1.7202 0.8872
LN-229 GDSC1 4.5129 5.9089 1.9052 0.2622
Hs 683 GDSC1 4.5274 5.7097 1.9784 0.1179
SF268 GDSC1 4.5674 9.4486 0.4396 8.4545
GI-1 GDSC1 4.5912 6.6304 1.672 0.9992
AM-38 GDSC1 4.6024 6.7019 1.6494 1.0868
A-172 GDSC1 4.6034 6.1831 1.8422 0.3861
KINGS-1 GDSC1 4.7184 6.5986 1.7364 0.656
42-MG-BA GDSC1 4.8089 6.3746 1.8509 0.2806
CAS-1 GDSC1 4.8147 14.4474 -1.7832 19.9205
U-118MG GDSC1 4.8507 6.3377 1.8786 0.2095
D-336MG GDSC1 4.8518 8.1981 1.1593 3.36
H4 GDSC1 4.8569 6.5732 1.799 0.3895
MOG-G-CCM GDSC1 4.8648 6.8178 1.714 0.6417
DBTRG-05MG GDSC1 4.887 6.5559 1.8162 0.3332
SW1783 GDSC1 4.9064 7.6006 1.4319 1.8018
SW1088 GDSC1 4.911 6.5367 1.8317 0.2881
M059J GDSC1 4.9301 6.5332 1.8398 0.264
PFSK-1 GDSC1 4.9392 6.9067 1.7108 0.6085
MOG-G-UVW GDSC1 4.9697 6.8763 1.7336 0.5208
D-392MG GDSC1 4.9712 8.0061 1.2985 2.4137
Daoy GDSC1 5.0116 6.549 1.8633 0.1944
D-263MG GDSC1 5.0382 6.5654 1.8671 0.1813
U-251MG GDSC1 5.0399 7.3702 1.5796 1.0149
D-423MG GDSC1 5.0642 8.2298 1.2515 2.5478
Onda 11 GDSC1 5.0939 6.8671 1.7833 0.3336
D-502MG GDSC1 5.1053 7.259 1.6475 0.7198
DK-MG GDSC1 5.1109 13.8435 -1.2856 16.9314
T98G GDSC1 5.3083 7.1367 1.7675 0.2952
SNB-75 GDSC1 5.3374 8.9377 1.0927 3.052
KALS-1 GDSC1 5.7119 8.1675 1.5541 0.6765
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 4.2854 6.4398 1.6103 1.603
TGBC1TKB GDSC1 4.3669 6.0954 1.7809 0.735
ETK-1 GDSC1 4.8079 7.9673 1.2344 2.9891
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EN GDSC1 4.1946 5.6571 1.8741 0.5095
RL95-2 GDSC1 4.2242 5.7716 1.8436 0.5995
KLE GDSC1 4.4147 6.6971 1.5669 1.6759
MFE-296 GDSC1 4.7307 6.4361 1.8002 0.4448
MFE-319 GDSC1 4.7628 6.2001 1.8945 0.2039
ESS-1 GDSC1 4.9638 12.7204 -0.847 15.0987
AN3-CA GDSC1 5.2618 7.1486 1.7465 0.358
MFE-280 GDSC1 5.8189 7.8456 1.7061 0.2669
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCZ GDSC1 1.9802 2.4661 1.9113 5.163
KTCTL-195 GDSC1 2.5184 4.0939 1.6185 5.2553
KTCTL-1M GDSC1 2.8735 6.3229 0.7857 10.5476
NCC021 GDSC1 2.9437 6.1622 0.9178 9.3329
A-498 GDSC1 3.0763 5.1711 1.4941 4.5892
KTCTL-140 GDSC1 3.2038 6.7653 0.8119 9.3449
RXF 393L GDSC1 3.7099 9.883 -0.3473 15.6549
OS-RC-2 GDSC1 3.8452 8.8837 0.2345 11.5933
ACHN GDSC1 4.0165 10.1501 -0.2588 14.251
RCC10RGB GDSC1 4.118 5.5434 1.8854 0.5194
A-704 GDSC1 4.1417 6.1034 1.6788 1.4166
KMRC-20 GDSC1 4.2138 5.8277 1.8183 0.7044
BFTC-909 GDSC1 4.2545 5.8157 1.8395 0.5936
KTCTL-21 GDSC1 4.2792 11.0785 -0.525 15.0952
SN12C GDSC1 4.3684 5.9755 1.8262 0.5659
KTCTL-26A GDSC1 4.3796 7.5324 1.1963 3.9009
LB1047-RCC GDSC1 4.4158 7.2121 1.3538 2.8706
KMRC-1 GDSC1 4.4907 6.1978 1.7931 0.6032
BB65-RCC GDSC1 4.5725 6.3632 1.7648 0.6501
769-P GDSC1 4.6538 6.4793 1.7545 0.634
SW13 GDSC1 4.6815 6.2291 1.8551 0.3184
CAL-54 GDSC1 4.7427 6.3764 1.8259 0.3678
UO-31 GDSC1 4.7445 7.8703 1.2432 3.0302
LB996-RCC GDSC1 4.7513 6.8978 1.6378 1.0086
SW156 GDSC1 4.8165 7.9442 1.2483 2.8972
TK-10 GDSC1 4.9251 8.6052 1.0236 4.0515
786-O GDSC1 4.9287 8.9017 0.897 4.8162
KTCTL-13 GDSC1 4.9627 6.9093 1.719 0.5693
LB2241-RCC GDSC1 5.0536 6.8509 1.7742 0.3711
VMRC-RCW GDSC1 5.275 6.9493 1.8198 0.2044
HA7-RCC GDSC1 5.4151 7.3093 1.7463 0.3057
Caki-1 GDSC1 7.336 20.0068 -2.7443 18.1435
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKO GDSC1 1.774 2.3956 1.7096 7.7018
LS411N GDSC1 1.8257 6.6998 -0.2721 21.7927
SNU-C2B GDSC1 2.6682 9.3979 -0.9082 22.18
SW1417 GDSC1 2.878 4.9884 1.4455 5.4967
GP5d GDSC1 2.9995 4.6917 1.6712 3.4679
SW48 GDSC1 3.2554 5.5815 1.4172 4.7085
CCK-81 GDSC1 3.3273 7.0502 0.761 9.3626
T84 GDSC1 3.6139 5.7411 1.5613 2.9182
SNU-61 GDSC1 3.6988 8.324 0.4035 10.8541
COLO205 GDSC1 3.7163 5.3574 1.7804 1.4003
SW948 GDSC1 3.7768 5.368 1.805 1.1908
C2BBe1 GDSC1 3.8041 6.1754 1.4755 3.1309
HCC2998 GDSC1 3.8638 6.5262 1.3531 3.8295
RCM-1 [Human ESC] GDSC1 3.9186 5.5019 1.8166 0.9753
NCI-H747 GDSC1 3.9484 13.3902 -1.8967 22.7229
LS123 GDSC1 4.0031 6.5351 1.4271 3.0892
SNU-81 GDSC1 4.0155 5.9797 1.6692 1.6223
MDST8 GDSC1 4.0159 6.0802 1.6279 1.8526
HT115 GDSC1 4.0248 5.6404 1.8094 0.9041
LS180 GDSC1 4.0906 5.7552 1.7936 0.914
LS1034 GDSC1 4.1573 5.6774 1.8515 0.6175
HCT 116 GDSC1 4.1923 5.8893 1.7858 0.8568
SW1463 GDSC1 4.2344 6.037 1.747 0.9896
HT-29 GDSC1 4.2828 5.6857 1.8981 0.3812
COLO 678 GDSC1 4.3398 6.8845 1.4534 2.3979
HCT 15 GDSC1 4.3891 7.9247 1.028 4.9686
NCI-H716 GDSC1 4.4125 7.1582 1.3749 2.7505
CW-2 GDSC1 4.453 6.5932 1.626 1.3378
HT-55 GDSC1 4.5798 5.9752 1.9064 0.2358
SW1116 GDSC1 4.6158 5.984 1.9163 0.204
SNU-175 GDSC1 4.6681 14.8959 -2.1069 21.6315
CaR-1 GDSC1 4.7122 6.7005 1.696 0.8075
COLO 320HSR GDSC1 4.7457 6.7892 1.6765 0.8578
LS513 GDSC1 4.7856 6.415 1.8283 0.3437
SNU-407 GDSC1 4.814 10.3485 0.1753 9.5786
SNU-1040 GDSC1 4.854 10.2087 0.2648 8.9329
CL-11 GDSC1 4.9594 6.9909 1.688 0.6719
SNU-C1 GDSC1 4.9716 6.9509 1.7074 0.601
SW837 GDSC1 5.1291 7.0687 1.7254 0.467
SNU-C5 GDSC1 5.2071 7.1192 1.7366 0.4034
LoVo GDSC1 5.2232 7.3118 1.6742 0.5682
SW626 GDSC1 5.4831 7.7653 1.6109 0.6242
KM12 GDSC1 6.5812 18.3925 -2.4732 18.6493
SW620 GDSC1 7.8129 18.0785 -1.5576 12.6259
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 4.462 10.9713 -0.3479 13.5953
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-4 GDSC1 2.2457 4.7714 1.0553 10.651
HLE GDSC1 3.2979 5.0126 1.7064 2.5528
SNU-423 GDSC1 3.4507 5.5627 1.5471 3.3367
JHH-6 GDSC1 3.7747 4.5171 2.1194 0.0629
HuH-1 GDSC1 3.9448 5.2807 1.9128 0.5377
SNU-398 GDSC1 3.9725 5.9062 1.6787 1.6264
JHH-1 GDSC1 4.0766 5.7547 1.7877 0.954
JHH-7 GDSC1 4.2565 6.2031 1.6917 1.2256
Hep 3B2.1-7 GDSC1 4.3443 6.0838 1.7759 0.7722
SK-HEP-1 GDSC1 4.4738 5.758 1.9433 0.1925
Hep-G2/C3A GDSC1 4.5677 6.2972 1.7872 0.5753
SNU-475 GDSC1 4.6296 6.0235 1.9077 0.2172
JHH-2 GDSC1 4.6802 12.2781 -0.827 15.7016
Huh-7 GDSC1 4.6983 7.1884 1.501 1.6873
SNU-387 GDSC1 4.7551 6.5755 1.7593 0.5571
SNU-449 GDSC1 5.0356 6.7312 1.8094 0.2949
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 171 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3122 GDSC1 -3.4641 19.0671 -11.2359 54.3713
SK-MES-1 GDSC1 0.325 1.5145 0.3002 25.5463
SK-LU-1 GDSC1 0.8435 1.7466 0.8233 19.0354
COR-L105 GDSC1 1.2162 3.3936 0.7301 17.6438
PC-14 GDSC1 1.5944 3.1674 1.2187 12.1747
NCI-H1838 GDSC1 1.6542 3.8674 0.9579 13.8546
EMC-BAC-1 GDSC1 1.7491 7.7242 -0.8492 25.3958
NCI-H1648 GDSC1 2.2474 4.2693 1.3075 8.6705
NCI-H2087 GDSC1 2.255 4.3236 1.2869 8.8031
COR-L303 GDSC1 2.2702 3.8379 1.5425 6.7345
NCI-H650 GDSC1 2.3356 3.449 1.7925 4.5199
NCI-H2085 GDSC1 2.4174 3.8369 1.6662 5.2234
NCI-H196 GDSC1 2.499 3.5189 1.8891 3.1975
NCI-H1975 GDSC1 2.588 5.7412 0.8527 10.9855
NCI-H2030 GDSC1 2.9505 8.9005 -0.4348 18.5636
NCI-H2731 GDSC1 3.059 8.2433 -0.0242 15.6484
NCI-H810 GDSC1 3.1838 4.9149 1.6831 2.9537
BEN GDSC1 3.2052 5.6506 1.3515 5.3194
HCC15 GDSC1 3.3444 6.791 0.8985 8.3081
NCI-H2804 GDSC1 3.3603 5.2453 1.6378 2.8969
EPLC-272H GDSC1 3.3939 12.5481 -1.9029 24.3801
NCI-H1734 GDSC1 3.4072 5.9187 1.3561 4.7892
PaCa-3 GDSC1 3.415 9.0575 -0.1582 15.3802
Ms-1 GDSC1 3.4239 6.8659 0.9171 7.9552
NCI-H1304 GDSC1 3.4314 5.9188 1.3713 4.6225
NCI-H1694 GDSC1 3.4627 9.6975 -0.4381 16.9354
NCI-H290 GDSC1 3.4784 5.7802 1.4644 3.8554
COR-L321 GDSC1 3.4907 6.4543 1.1579 6.0257
CAL-12T GDSC1 3.4972 9.7466 -0.4366 16.8209
NCI-H2869 GDSC1 3.5015 6.2839 1.245 5.3681
DMS 79 GDSC1 3.5701 6.4108 1.2291 5.3208
Lu-139 GDSC1 3.5902 7.7281 0.6161 9.6718
NCI-H2227 GDSC1 3.6141 7.0151 0.9731 7.0557
NCI-H345 GDSC1 3.6381 4.6031 2.04 0.2887
NCI-H524 GDSC1 3.6637 7.2946 0.8731 7.6481
NCI-H526 GDSC1 3.6739 13.2365 -2.0286 24.0475
NCI-H2595 GDSC1 3.7741 5.7829 1.6303 2.1975
NCI-H1755 GDSC1 3.7847 8.9729 0.1494 12.3214
NCI-H1836 GDSC1 3.8075 7.4937 0.8728 7.2934
SBC-5 GDSC1 3.8638 4.7298 2.0787 0.1063
NCI-H64 GDSC1 3.8676 5.0548 1.9654 0.3997
NCI-H2444 GDSC1 3.9159 5.2556 1.9103 0.5687
NCI-H1693 GDSC1 3.9319 6.519 1.3949 3.4238
NCI-H2803 GDSC1 3.9613 6.1432 1.5739 2.2476
HOP-62 GDSC1 3.9733 5.9079 1.6784 1.627
NCI-H2196 GDSC1 3.9806 6.2042 1.5578 2.3145
NCI-H2369 GDSC1 3.9837 5.9314 1.6737 1.639
CPC-N GDSC1 4.0098 7.3817 1.0512 5.5847
NCI-H2405 GDSC1 4.0163 7.5115 0.9955 5.9535
NCI-H2029 GDSC1 4.0356 5.4485 1.8873 0.5693
LCLC-103H GDSC1 4.0429 5.5689 1.8448 0.7334
NCI-H1781 GDSC1 4.0542 5.685 1.8049 0.8968
Lu-135 GDSC1 4.0583 11.2092 -0.7445 16.9218
NCI-H187 GDSC1 4.0766 9.4975 0.0976 11.8672
NCI-H2141 GDSC1 4.0867 5.6646 1.8268 0.7721
NCI-H460 GDSC1 4.0903 5.1455 2.0168 0.1601
NCI-H2171 GDSC1 4.1307 5.7132 1.8269 0.7354
Calu-6 GDSC1 4.137 6.6842 1.4341 2.8216
NCI-H2795 GDSC1 4.1374 6.9584 1.3151 3.5699
NCI-H1573 GDSC1 4.1398 5.8086 1.7943 0.866
NCI-H838 GDSC1 4.1454 5.8241 1.7907 0.8768
NCI-H1092 GDSC1 4.1523 6.9004 1.3487 3.3296
NCI-H522 GDSC1 4.1695 6.5065 1.5263 2.2197
LK-2 GDSC1 4.171 6.2344 1.6396 1.5867
NCI-H226 GDSC1 4.1765 5.8356 1.7996 0.8113
NCI-H3255 GDSC1 4.1777 8.6524 0.5658 8.5214
NCI-H2347 GDSC1 4.181 6.6198 1.4844 2.4485
NCI-H2818 GDSC1 4.1886 7.5465 1.0823 5.0029
NCI-H1915 GDSC1 4.1913 6.3685 1.5944 1.805
NCI-H720 GDSC1 4.1999 5.3032 2.0017 0.1576
NCI-H1876 GDSC1 4.2029 6.3513 1.6071 1.7211
Calu-3 GDSC1 4.2238 5.9384 1.7804 0.8523
NCI-H647 GDSC1 4.2362 9.304 0.2964 10.1697
NCI-H520 GDSC1 4.2486 6.6409 1.5097 2.2032
NCI-H1048 GDSC1 4.2607 5.9472 1.7927 0.7705
HARA [Human squamous cell lung carcinoma] GDSC1 4.2659 10.0877 -0.0572 12.3493
NCI-H1666 GDSC1 4.2803 6.4471 1.6049 1.6376
HCC78 GDSC1 4.3115 6.7894 1.479 2.2906
NCI-H358 GDSC1 4.313 10.6072 -0.2745 13.5482
NCI-H2373 GDSC1 4.3704 6.6945 1.547 1.8346
IA-LM GDSC1 4.3889 6.475 1.6438 1.3185
SBC-1 GDSC1 4.3924 6.078 1.7979 0.652
COR-L311 GDSC1 4.3988 9.5705 0.2761 9.904
NCI-H211 GDSC1 4.4028 9.6518 0.2404 10.1248
NCI-H2170 GDSC1 4.4037 7.5853 1.1863 3.9219
UMC-11 GDSC1 4.4128 6.4271 1.6733 1.1552
NCI-H2081 GDSC1 4.4131 6.4171 1.6773 1.1366
Lu-165 GDSC1 4.435 6.0035 1.8422 0.4724
NCI-H1770 GDSC1 4.4377 5.7279 1.9407 0.2089
NCI-H1651 GDSC1 4.4446 6.3079 1.733 0.8667
NCI-H2122 GDSC1 4.4511 6.0448 1.8335 0.4911
NCI-H510A GDSC1 4.4601 6.0822 1.8234 0.5191
RERF-LC-KJ GDSC1 4.4722 6.2923 1.7504 0.7751
RERF-LC-MS GDSC1 4.4738 6.0545 1.8388 0.4617
NCI-H513 GDSC1 4.4791 6.4835 1.6803 1.0616
HCC33 GDSC1 4.4906 6.1006 1.8286 0.4844
EBC-1 GDSC1 4.5127 6.5602 1.6653 1.0976
LOU-NH91 GDSC1 4.5215 6.5499 1.6731 1.0553
NCI-H1435 GDSC1 4.527 6.0386 1.8648 0.3589
DMS 53 GDSC1 4.5348 6.6462 1.6415 1.1838
NCI-H1568 GDSC1 4.5391 9.5266 0.3858 8.867
SBC-3 GDSC1 4.5477 6.5697 1.6767 1.0168
NCI-H1623 GDSC1 4.5617 6.4206 1.7391 0.7526
NCI-H446 GDSC1 4.5797 6.1248 1.854 0.3644
COR-L95 GDSC1 4.5941 6.417 1.7536 0.6762
COLO 668 GDSC1 4.5998 11.3795 -0.4505 13.8369
ChaGo-K-1 GDSC1 4.6018 6.8488 1.592 1.3479
NCI-H82 GDSC1 4.6042 6.1472 1.8552 0.3503
NCI-H841 GDSC1 4.608 6.1916 1.8409 0.3877
SHP-77 GDSC1 4.6089 6.4118 1.7614 0.6384
NCI-H69 GDSC1 4.6235 6.5419 1.719 0.7842
NCI-H1436 GDSC1 4.6274 6.3526 1.7904 0.5294
NCI-H1793 GDSC1 4.6295 6.2192 1.8392 0.3824
NCI-H748 GDSC1 4.6305 6.9428 1.5678 1.4334
NCI-H2135 GDSC1 4.6512 6.4079 1.7796 0.5508
NCI-H2291 GDSC1 4.6639 6.924 1.59 1.2957
Lu-65 GDSC1 4.6794 9.587 0.4445 8.1757
NCI-H2461 GDSC1 4.6927 6.6631 1.7021 0.7986
NCI-H1563 GDSC1 4.6974 12.4539 -0.8999 16.0398
A-427 GDSC1 4.7087 7.6635 1.3119 2.6873
ABC-1 GDSC1 4.711 7.2844 1.4684 1.8377
COR-L23 GDSC1 4.7119 6.1135 1.9061 0.1961
NCI-H1993 GDSC1 4.7151 7.2319 1.4914 1.7169
NCI-H661 GDSC1 4.716 10.8441 -0.1191 11.6076
NCI-H1703 GDSC1 4.7397 6.9497 1.613 1.1233
NCI-H847 GDSC1 4.7583 6.3996 1.8235 0.3673
NCI-H2110 GDSC1 4.7627 8.0077 1.1944 3.2885
NCI-H2591 GDSC1 4.7676 7.1937 1.5303 1.4715
NCI-H1581 GDSC1 4.7799 6.3787 1.8389 0.3195
NCI-H1944 GDSC1 4.7847 7.1165 1.568 1.281
NCI-H2722 GDSC1 4.7986 6.4129 1.8338 0.3247
Lu-99A GDSC1 4.8149 6.9072 1.6608 0.8675
HCC44 GDSC1 4.818 7.7439 1.3322 2.4273
HCC827 GDSC1 4.8198 6.6255 1.7663 0.5001
NCI-H2228 GDSC1 4.8324 30.7839 -9.8505 36.7429
DMS 273 GDSC1 4.8375 8.1443 1.1748 3.2909
NCI-H2009 GDSC1 4.8438 6.815 1.7067 0.6796
NCI-H2342 GDSC1 4.8529 8.5297 1.0179 4.204
DMS 114 GDSC1 4.8645 7.1951 1.5722 1.19
NCI-H292 GDSC1 4.8802 6.7969 1.7276 0.5878
SW1271 GDSC1 4.8921 7.6913 1.3889 2.0352
NCI-H1299 GDSC1 4.9431 10.3695 0.2452 8.8614
NCI-H441 GDSC1 4.9482 6.7172 1.7822 0.3944
EKVX GDSC1 4.971 8.1024 1.2589 2.6282
LCLC-97TM1 GDSC1 4.9782 7.4749 1.5133 1.3462
NCI-H2172 GDSC1 5.0065 6.6429 1.8294 0.2613
NCI-H727 GDSC1 5.0079 10.9464 0.0184 10.1059
NCI-H1155 GDSC1 5.0128 6.6921 1.8146 0.2911
IST-SL1 GDSC1 5.0172 13.128 -1.006 15.7861
LXF 289 GDSC1 5.0675 6.9404 1.7478 0.4337
A-549 GDSC1 5.069 6.942 1.7478 0.4331
NCI-H1650 GDSC1 5.0792 11.7525 -0.3129 11.8937
NCI-H596 GDSC1 5.0937 12.7584 -0.7786 14.4254
NCI-H1355 GDSC1 5.1413 7.3999 1.61 0.8278
SW1573 GDSC1 5.152 8.2133 1.2998 2.1892
NCI-H209 GDSC1 5.1531 13.4502 -1.0687 15.7721
EMC-BAC-2 GDSC1 5.1552 7.6533 1.5206 1.162
NCI-H2023 GDSC1 5.2027 7.2932 1.6731 0.5824
RERF-LC-Sq1 GDSC1 5.2164 11.5158 -0.1162 10.4467
NCI-H23 GDSC1 5.2682 16.0033 -2.2193 20.5873
COR-L88 GDSC1 5.2689 15.899 -2.1682 20.3853
NCI-H322M GDSC1 5.3461 8.6135 1.229 2.3243
LC-1/sq GDSC1 5.3762 13.2768 -0.839 14.0812
NCI-H1688 GDSC1 5.4088 6.9071 1.8796 0.0964
NCI-H1437 GDSC1 5.4549 10.4765 0.495 6.3292
IST-SL2 GDSC1 5.4831 8.7613 1.2329 2.1522
HOP-92 GDSC1 5.5275 7.5878 1.6904 0.3915
NCI-H1869 GDSC1 5.5313 11.4055 0.1237 8.3869
LC-2/ad GDSC1 5.6457 15.3882 -1.6642 17.404
Lu-134-A GDSC1 6.0619 8.4329 1.5909 0.4279
NCI-H1792 GDSC1 6.6583 16.5477 -1.555 14.7601
⏷ Show the Full List of 171 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 3.6595 7.6999 0.6769 9.055
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-520 GDSC1 2.0583 11.644 -2.5382 31.0791
KYSE-450 GDSC1 2.4421 4.4556 1.3772 7.4135
OE33 GDSC1 3.5976 9.6758 -0.3277 15.8694
TE-4 GDSC1 4.0609 6.2079 1.597 1.9662
OE19 GDSC1 4.0665 5.6659 1.8177 0.8291
TE-11 GDSC1 4.2422 6.0958 1.7274 1.0712
COLO 680N GDSC1 4.2476 13.1192 -1.542 20.3556
TE-10 GDSC1 4.2648 7.2337 1.2643 3.6703
KYSE-150 GDSC1 4.2993 5.904 1.8248 0.6169
TE-6 GDSC1 4.3901 6.1241 1.7797 0.7223
OE21 GDSC1 4.4821 8.9375 0.6232 7.4446
TE-5 GDSC1 4.488 6.1755 1.8002 0.5802
T.T GDSC1 4.5959 6.3849 1.7662 0.6301
TE-8 GDSC1 4.6727 6.6635 1.6936 0.846
TE-9 GDSC1 4.6814 6.1794 1.8724 0.2768
TE-1 GDSC1 4.8379 6.7341 1.7339 0.5916
KYSE-510 GDSC1 4.8943 6.5768 1.8116 0.3417
TE-15 GDSC1 4.98 7.9643 1.3197 2.2902
KYSE-180 GDSC1 5.0026 6.6491 1.8259 0.2701
KYSE-70 GDSC1 5.0453 7.1795 1.6529 0.7387
KYSE-140 GDSC1 5.1657 11.9739 -0.3615 11.9729
EC-GI-10 GDSC1 5.4019 7.1202 1.8062 0.1969
KYSE-270 GDSC1 5.4631 7.784 1.5965 0.6789
KYSE-410 GDSC1 5.5443 7.5792 1.6995 0.3644
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OV56 GDSC1 2.0694 2.5097 1.9911 4.1209
OC 314 GDSC1 3.0291 4.7713 1.6528 3.531
JHOS-2 GDSC1 3.7532 6.1811 1.4443 3.433
Caov-4 GDSC1 3.8221 6.734 1.2347 4.7216
OAW42 GDSC1 3.8928 5.1379 1.9449 0.4555
TYK-nu GDSC1 3.953 5.6496 1.7736 1.1491
DOV13 GDSC1 3.9867 5.7 1.7689 1.1355
OVCAR-8 GDSC1 4.0657 7.0309 1.2429 4.1742
OVCAR-4 GDSC1 4.1235 7.4323 1.0958 5.0433
TOV-21G GDSC1 4.1847 5.7256 1.8447 0.6236
FU-OV-1 GDSC1 4.2566 9.0276 0.4401 9.1732
OAW28 GDSC1 4.4768 8.1898 0.9596 5.2456
ES-2 GDSC1 4.5706 6.3353 1.7743 0.6178
OVKATE GDSC1 4.63 8.7796 0.7832 6.091
Caov-3 GDSC1 4.6524 6.1006 1.8892 0.2491
OV-90 GDSC1 4.7607 6.3029 1.8583 0.2808
OVCAR-3 GDSC1 4.8059 6.326 1.8666 0.2471
OVK18 GDSC1 4.8863 6.5252 1.8267 0.3085
Kuramochi GDSC1 5.0303 7.2101 1.6355 0.8099
IGROV-1 GDSC1 5.0394 7.171 1.6536 0.7398
OVTOKO GDSC1 5.0736 10.5292 0.2509 8.5493
EFO-27 GDSC1 5.3026 11.8256 -0.2064 10.7822
TOV-112D GDSC1 5.3328 13.5162 -0.9808 14.9062
RMG-I GDSC1 5.4208 7.5532 1.663 0.5051
OVCAR-5 GDSC1 5.9108 13.6851 -0.6912 12.1427
OVISE GDSC1 6.3269 14.5855 -0.8516 12.1145
A2780 GDSC1 6.4187 16.0127 -1.4563 14.8042
SK-OV-3 GDSC1 7.658 17.3441 -1.3163 11.8413
EFO-21 GDSC1 8.4775 21.7443 -2.8356 16.4149
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-2 GDSC1 3.6641 5.3803 1.7448 1.677
SU.86.86 GDSC1 3.7413 5.5584 1.7089 1.7749
SUIT-2 GDSC1 3.8215 7.7111 0.7793 7.9179
MZ-PC-1 GDSC1 3.9596 7.4831 0.9738 6.2296
PaTu 8988t GDSC1 4.0369 5.7021 1.7907 0.9788
KP-4 GDSC1 4.2192 5.6422 1.8892 0.4437
QGP-1 GDSC1 4.2502 10.0252 -0.0379 12.2699
Panc 08.13 GDSC1 4.2712 12.6517 -1.296 19.1472
Capan-1 GDSC1 4.3475 6.5617 1.5901 1.6343
PaTu 8902 GDSC1 4.3643 6.3802 1.6702 1.2179
HPAC GDSC1 4.3658 6.273 1.7126 1.0218
Panc 10.05 GDSC1 4.4377 7.6128 1.1928 3.8223
YAPC GDSC1 4.4745 6.3454 1.7313 0.8493
MIA PaCa-2 GDSC1 4.5949 5.8945 1.9395 0.166
SW1990 GDSC1 4.6194 6.7164 1.6511 1.0644
HuP-T3 GDSC1 4.6779 7.6263 1.3121 2.7294
HuP-T4 GDSC1 4.6864 6.9666 1.5833 1.3049
KP-3 GDSC1 4.7467 11.2521 -0.2921 12.5585
Capan-2 GDSC1 4.7698 9.6486 0.4711 7.8115
PSN1 GDSC1 4.8054 7.676 1.354 2.325
Panc 03.27 GDSC1 4.8454 6.5244 1.8119 0.3606
Panc 02.03 GDSC1 4.855 12.941 -1.0263 16.2898
DAN-G GDSC1 4.9719 6.997 1.6907 0.6553
BxPC-3 GDSC1 4.9815 13.0285 -0.9824 15.7537
PL4 GDSC1 5.1177 7.0887 1.714 0.5045
CFPAC-1 GDSC1 5.1243 6.5947 1.887 0.1326
Hs 766T GDSC1 5.4328 7.048 1.841 0.1388
HPAF-II GDSC1 5.6306 12.251 -0.2019 10.0643
AsPC-1 GDSC1 6.8876 14.7343 -0.5889 9.7434
Panc 04.03 GDSC1 7.0218 14.9753 -0.6202 9.6653
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2052 GDSC1 4.2399 9.9989 -0.0322 12.2617
MPP 89 GDSC1 4.4598 6.2942 1.7445 0.8078
MSTO-211H GDSC1 4.5844 6.6321 1.6684 1.0203
IST-Mes1 GDSC1 4.704 6.4617 1.7807 0.5176
NCI-H28 GDSC1 4.8107 6.8175 1.6925 0.7516
NCI-H2452 GDSC1 5.1399 7.0263 1.7444 0.4113
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 2.3157 4.8502 1.0753 10.2344
PC-3 GDSC1 4.1802 6.5362 1.5193 2.2448
DU145 GDSC1 4.5762 6.2798 1.7969 0.538
22Rv1 GDSC1 4.8022 6.6085 1.7656 0.5114
LNCaP clone FGC GDSC1 4.9607 7.1522 1.6288 0.8832
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 5.0811 6.7089 1.8333 0.2311
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-30 GDSC1 3.5047 6.6939 1.0536 6.7488
SK-MEL-28 GDSC1 3.5339 4.3544 2.0894 0.195
SK-MEL-3 GDSC1 3.5499 5.9384 1.435 3.9082
SK-MEL-2 GDSC1 3.602 4.5453 2.0469 0.2869
UACC-62 GDSC1 3.6533 4.9043 1.9331 0.6941
COLO 783 GDSC1 3.7978 5.1358 1.9062 0.6818
COLO 829 GDSC1 3.9046 7.1178 1.1086 5.4168
IGR-37 GDSC1 3.9289 5.0738 1.9824 0.3108
IPC-298 GDSC1 3.947 6.9246 1.222 4.5488
A101D GDSC1 3.9834 5.0931 1.9961 0.2469
SK-MEL-1 GDSC1 3.9888 5.2388 1.9459 0.3922
WT2-iPS GDSC1 3.9931 5.4092 1.8845 0.6117
LB373-MEL-D GDSC1 4.1095 5.4554 1.9143 0.4254
CP66-MEL GDSC1 4.1219 5.9606 1.7268 1.197
SK-MEL-5 GDSC1 4.1277 5.7257 1.8209 0.7629
MZ-MEL-2 GDSC1 4.2377 6.6062 1.5188 2.1662
IGR-1 GDSC1 4.2472 5.5655 1.9276 0.3141
RPMI-7951 GDSC1 4.2615 6.5632 1.5483 1.9675
WM1552C GDSC1 4.2685 6.2949 1.6607 1.365
Hs 938.T GDSC1 4.2804 5.849 1.8376 0.583
LB2518-MEL GDSC1 4.2902 5.5626 1.9445 0.2522
A2058 GDSC1 4.2919 5.6259 1.9229 0.3067
GAK GDSC1 4.3105 5.9177 1.8243 0.6111
COLO 679 GDSC1 4.318 6.0912 1.762 0.8505
SH-4 GDSC1 4.3189 12.4519 -1.1642 18.3769
G-361 GDSC1 4.3218 9.1116 0.4423 9.0025
COLO 800 GDSC1 4.3254 6.4173 1.6378 1.4163
VMRC-MELG GDSC1 4.3318 5.9318 1.8276 0.5847
RVH-421 GDSC1 4.3408 12.4669 -1.1559 18.2766
MZ-MEL-7 GDSC1 4.3618 6.408 1.6581 1.2781
Mel Ho GDSC1 4.3751 9.1976 0.4359 8.9191
WM115 GDSC1 4.4256 5.9427 1.8605 0.4205
COLO 792 GDSC1 4.4502 7.7101 1.1571 4.0253
UACC-257 GDSC1 4.4559 5.879 1.8946 0.3105
HT-144 GDSC1 4.5026 6.3987 1.7229 0.8613
M14 GDSC1 4.5393 6.1687 1.8229 0.4756
CP50-MEL-B GDSC1 4.5452 6.3035 1.7759 0.6286
G-mel GDSC1 4.5577 6.3373 1.7685 0.647
SK-MEL-24 GDSC1 4.5906 6.1027 1.8659 0.3282
A-431 GDSC1 4.5947 7.3235 1.3969 2.3652
IST-MEL1 GDSC1 4.6388 8.7072 0.8208 5.8307
WM793 GDSC1 4.6623 12.0381 -0.7239 15.1964
LOX-IMVI GDSC1 4.7011 6.2195 1.8656 0.2855
451Lu GDSC1 4.7082 6.5459 1.7516 0.6099
Hs 940.T GDSC1 4.7874 6.6387 1.7489 0.5721
CHL-1 GDSC1 4.8175 6.7698 1.7129 0.6748
A-375 GDSC1 4.8334 6.0969 1.9537 0.0961
WM35 GDSC1 4.8978 8.8626 0.8972 4.8685
MeWo GDSC1 4.9404 7.6377 1.4327 1.7612
WM278 GDSC1 5.0584 7.1866 1.6555 0.7214
DJM-1 GDSC1 5.0937 7.227 1.6546 0.7027
MMAc-SF GDSC1 5.1219 6.5243 1.9096 0.104
HMV-II GDSC1 5.1537 8.1096 1.3421 1.975
A-388 GDSC1 5.6339 7.5875 1.7288 0.2751
Mel JuSo GDSC1 8.1472 19.6261 -2.063 14.1237
EquiPSC Line K2 GDSC1 5.2774 7.3821 1.6698 0.5541
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 4.7913 6.3716 1.8456 0.2992
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh30 GDSC1 3.034 4.9815 1.5563 4.2332
SW982 GDSC1 3.7204 5.777 1.6043 2.4484
EW-8 GDSC1 3.8223 5.9765 1.5724 2.4777
TE 441.T GDSC1 3.969 5.3801 1.8854 0.6264
RD GDSC1 3.9796 5.9582 1.6607 1.7171
HT-1080 GDSC1 4.1028 5.4555 1.9117 0.4381
SK-LMS-1 GDSC1 4.1569 6.3064 1.6034 1.8006
SW684 GDSC1 4.1931 5.5777 1.9025 0.4156
RKN GDSC1 4.3796 12.318 -1.0558 17.6716
GCT GDSC1 4.4303 5.9241 1.869 0.3929
MES-SA GDSC1 4.4498 5.7411 1.9405 0.2056
VA-ES-BJ GDSC1 4.5708 6.2648 1.8003 0.5301
Hs 633.T GDSC1 4.5721 6.0877 1.8643 0.3402
SK-UT-1 GDSC1 4.7268 6.4337 1.7995 0.4485
SW872 GDSC1 4.7383 6.2878 1.8554 0.2956
MFH-ino GDSC1 4.7796 6.6381 1.7461 0.5858
KYM-1 GDSC1 4.8871 6.0929 1.973 0.0678
Rh41 GDSC1 4.8973 6.1697 1.9511 0.0894
A-204 GDSC1 5.5664 7.9225 1.5864 0.6548
G-401 GDSC1 5.8072 8.1083 1.611 0.4762
G-402 GDSC1 5.995 8.064 1.6936 0.2443
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-39 GDSC1 1.5154 4.1657 0.6817 16.5635
MKN45 GDSC1 3.8414 4.7316 2.0702 0.1279
23132/87 GDSC1 3.9475 5.7646 1.7246 1.4085
MKN7 GDSC1 4.216 6.5061 1.5497 2.0211
SCH GDSC1 4.2572 5.76 1.8611 0.5149
Hs 746.T GDSC1 4.2576 5.9108 1.8052 0.7227
SNU-16 GDSC1 4.3364 5.5521 1.965 0.1903
RF-48 GDSC1 4.3599 6.4932 1.6234 1.4504
NUGC-4 GDSC1 4.3857 6.4727 1.6433 1.3244
Fu97 GDSC1 4.4186 6.2216 1.7548 0.7987
MKN1 GDSC1 4.4412 6.2276 1.7619 0.7533
ECC10 GDSC1 4.4657 6.4639 1.6822 1.0656
AGS GDSC1 4.481 6.0409 1.8465 0.4342
HGC-27 GDSC1 4.7017 6.2472 1.8562 0.3078
SNU-5 GDSC1 4.7134 6.101 1.9109 0.1867
IM95 GDSC1 4.7443 7.1818 1.5246 1.5227
SNU-1 GDSC1 4.8918 6.6984 1.7676 0.4601
TGBC11TKB GDSC1 4.8963 6.5542 1.8202 0.32
OCUM-1 GDSC1 4.9014 6.7247 1.7619 0.4718
TMK-1 GDSC1 4.9756 6.8132 1.7584 0.4464
MKN28 GDSC1 5.0941 7.6127 1.5102 1.2569
NCI-N87 GDSC1 5.13 7.4216 1.5974 0.8813
GCIY GDSC1 5.1493 6.9642 1.7697 0.3452
NUGC-3 GDSC1 5.1938 6.7777 1.8495 0.1742
RERF-GC-1B GDSC1 5.2279 10.9223 0.1637 8.7585
SNG-M GDSC1 2.8134 4.2517 1.7571 3.3026
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HTC-C3 GDSC1 3.4162 6.5277 1.074 6.8265
8305C GDSC1 3.4256 5.92 1.3671 4.6664
K5 GDSC1 4.049 6.079 1.6446 1.7141
CGTH-W-1 GDSC1 4.2072 5.7563 1.8424 0.616
FTC-133 GDSC1 4.2751 5.4597 1.9748 0.1891
B-CPAP GDSC1 4.3305 6.0057 1.7996 0.6897
TT GDSC1 4.3769 6.4125 1.6631 1.2387
ML-1 [Human leukemia] GDSC1 4.4927 6.5848 1.647 1.1993
CAL-62 GDSC1 4.56 5.9433 1.9103 0.234
KMH-2 GDSC1 4.5761 6.3166 1.7834 0.5831
BHT-101 GDSC1 4.5991 11.8686 -0.6855 15.1494
WRO GDSC1 4.5994 6.2527 1.8158 0.4653
IHH-4 GDSC1 4.6043 6.0524 1.8885 0.2676
ASH-3 GDSC1 4.7908 6.1866 1.909 0.1701
TT2609-C02 GDSC1 5.0435 11.6435 -0.2845 11.8127
8505C GDSC1 5.2897 11.3318 0.0135 9.5268
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BICR 22 GDSC1 3.8096 6.4569 1.353 3.9371
HSC-3 GDSC1 3.8983 5.6811 1.7353 1.4127
BB30-HNC GDSC1 3.9048 7.998 0.6979 8.2798
HSC-2 GDSC1 3.9151 5.3349 1.88 0.6929
BICR 78 GDSC1 3.9273 6.1881 1.5369 2.5266
BHY GDSC1 3.9379 7.1743 1.1029 5.3839
OSC-20 GDSC1 3.9741 6.7291 1.3254 3.8026
OSC-19 GDSC1 4.0083 5.9414 1.6815 1.5644
FaDu GDSC1 4.102 9.1074 0.3012 10.475
PCI-38 GDSC1 4.1696 6.751 1.4226 2.84
HO-1-N-1 GDSC1 4.1742 6.0185 1.7276 1.1385
CAL-27 GDSC1 4.303 5.8903 1.8314 0.5903
SAS GDSC1 4.333 7.1565 1.3344 3.1176
Detroit 562 GDSC1 4.3423 6.3244 1.6823 1.1826
PCI-30 GDSC1 4.3541 7.73 1.0949 4.5988
SCC-25 GDSC1 4.4248 6.3395 1.7125 0.9697
BB49-HNC GDSC1 4.4422 6.7508 1.5581 1.689
KON GDSC1 4.5263 6.2559 1.7859 0.6055
SCC-15 GDSC1 4.5617 6.7166 1.6259 1.2294
HSC-4 GDSC1 4.5734 6.1086 1.8574 0.3581
SAT [Human HNSCC] GDSC1 4.6356 7.9129 1.1687 3.6411
KOSC-2 GDSC1 4.6631 7.4808 1.3653 2.4495
JHU-011 GDSC1 4.6655 9.5008 0.4757 8.0053
PE/CA-PJ15 GDSC1 4.6984 7.9582 1.1822 3.4597
PCI-15A GDSC1 4.7048 6.8443 1.6385 1.0446
SCC-4 GDSC1 4.7188 6.9156 1.6171 1.1239
BICR 10 GDSC1 4.7426 6.4776 1.7898 0.4692
Ca9-22 GDSC1 4.7893 7.1754 1.5471 1.3717
HO-1-u-1 GDSC1 4.9509 7.023 1.6728 0.7293
JHU-022 GDSC1 4.999 7.5231 1.5037 1.3698
SKN-3 GDSC1 5.0405 7.0501 1.6982 0.5918
PCI-04B GDSC1 5.0628 9.5765 0.6741 5.9531
PCI-06A GDSC1 5.1399 8.0518 1.3588 1.9079
NCI-H3118 GDSC1 5.1689 10.8378 0.1669 8.8618
LB771-HNC GDSC1 5.2262 7.2035 1.714 0.4542
CAL-33 GDSC1 5.3182 7.5402 1.6285 0.658
BICR 31 GDSC1 5.356 7.6038 1.6202 0.6633
DOK GDSC1 5.3609 7.3472 1.7134 0.3997
SCC-9 GDSC1 6.0472 15.864 -1.625 16.3395
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC1 3.7171 5.138 1.8696 0.9297
639V GDSC1 4.0939 5.6998 1.8164 0.8104
UM-UC-3 GDSC1 4.0949 6.2681 1.5888 1.9659
RT-4 GDSC1 4.1041 7.3656 1.1146 4.9563
CAL-29 GDSC1 4.2019 5.9003 1.7857 0.8488
HT-1197 GDSC1 4.2648 5.5893 1.9257 0.3111
647V GDSC1 4.3859 5.7933 1.8989 0.3297
BFTC-905 GDSC1 4.4091 5.8437 1.8897 0.3443
SW780 GDSC1 4.7009 6.4762 1.7742 0.5399
RT-112 GDSC1 4.8164 12.6475 -0.9116 15.8
TCCSUP GDSC1 4.9261 6.2858 1.9224 0.1206
HT-1376 GDSC1 5.0534 7.1053 1.6832 0.6323
5637 GDSC1 5.0561 7.0995 1.6863 0.6207
T24 GDSC1 5.2298 12.8701 -0.7421 13.9121
SW1710 GDSC1 5.2474 7.0156 1.7874 0.273
J82 GDSC1 5.371 6.9301 1.8592 0.1258
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ACC-OV7 GDSC1 1.8225 3.0264 1.5143 8.8644
SKN GDSC1 3.3997 7.8968 0.4001 11.7271
HeLa GDSC1 3.4956 4.7826 1.9097 0.9781
OVCA433 GDSC1 3.674 6.17 1.4034 3.8676
OVCA420 GDSC1 3.8379 5.5877 1.7445 1.4393
SiHa GDSC1 3.8686 5.077 1.9576 0.4261
SKG-IIIa GDSC1 4.0159 5.9359 1.6874 1.5233
MS751 GDSC1 4.0878 5.6518 1.8322 0.7488
SW756 GDSC1 4.0951 5.7677 1.7907 0.9229
OMC-1 [Human cervical carcinoma] GDSC1 4.0999 6.2757 1.5881 1.9628
KGN GDSC1 4.1461 6.8089 1.3851 3.1106
SW954 GDSC1 4.1632 6.0437 1.7126 1.2224
PA-1 GDSC1 4.1918 7.582 1.0681 5.0911
NEC8 GDSC1 4.1952 5.8404 1.8057 0.77
JHOS-3 GDSC1 4.1968 8.3348 0.7261 7.3925
HEC-1 GDSC1 4.2124 5.7192 1.8583 0.554
BPH-1 GDSC1 4.2307 11.6344 -0.8288 16.8981
JEG-3 GDSC1 4.2825 6.1866 1.7098 1.1137
C-4-I GDSC1 4.3618 6.1326 1.7647 0.8036
DSH1 GDSC1 4.3994 6.3453 1.6992 1.0505
C-33 A GDSC1 4.4613 6.3673 1.7174 0.9177
PEO1 GDSC1 4.4651 6.8923 1.5115 1.9069
SW962 GDSC1 4.4744 6.731 1.581 1.5357
NCC-IT GDSC1 4.5443 6.3717 1.7503 0.7228
Ca Ski GDSC1 4.5924 9.565 0.4012 8.647
CAL-39 GDSC1 4.6111 6.4557 1.7461 0.6918
HEY GDSC1 4.6272 7.7939 1.2153 3.3726
DoTc2 4510 GDSC1 4.6484 6.7773 1.6401 1.0865
OVMIU GDSC1 4.7068 8.6964 0.8644 5.4209
SiSo GDSC1 4.7129 7.6655 1.3131 2.6744
NT2-D1 GDSC1 4.7184 6.3262 1.8346 0.3555
JAR GDSC1 4.7411 6.5036 1.7799 0.5001
UWB1.289 GDSC1 4.9336 7.2172 1.5931 1.0443
HT-3 GDSC1 5.081 7.233 1.6474 0.7351
ME-180 GDSC1 5.2328 10.12 0.5285 6.5323
LB831-BLC GDSC1 5.2752 7.0699 1.7786 0.2824
OV17R GDSC1 5.5231 13.9593 -1.0659 14.8941
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Alectinib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Increased risk of hepatotoxicity by the combination of Alectinib and Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [7]
Pexidartinib DMS2J0Z Major Increased risk of hepatotoxicity by the combination of Alectinib and Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [8]
Calaspargase pegol DMQZBXI Moderate Increased risk of hepatotoxicity by the combination of Alectinib and Calaspargase pegol. Malignant haematopoietic neoplasm [2B33] [9]
Siponimod DM2R86O Major Increased risk of bradycardia by the combination of Alectinib and Siponimod. Multiple sclerosis [8A40] [7]
Ozanimod DMT6AM2 Moderate Increased risk of bradycardia by the combination of Alectinib and Ozanimod. Multiple sclerosis [8A40] [10]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
FD&C blue no. 2 E00446 2723854 Colorant
Glyceryl monooleate E00473 5283468 Bioadhesive material; Emollient; Emulsifying agent; Emulsion stabilizing agent; Gelling agent; Modified-release agent; Surfactant
Potassium chloride E00074 4873 Tonicity agent
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Carboxymethylcellulose sodium E00621 Not Available Adsorbent; Binding agent; Disintegrant; Emulsifying agent; Suspending agent; Viscosity-controlling agent
Eisenoxyd E00585 56841934 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Hydroxypropyl cellulose E00632 Not Available Binding agent; Coating agent; Emulsifying agent; Film/Membrane-forming agent; Modified-release agent; Suspending agent; Viscosity-controlling agent
Hypromellose E00634 Not Available Coating agent
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Haematite red E00236 14833 Colorant
Carrageenan E00714 Not Available Emulsion stabilizing agent; Gelling agent; Microencapsulating agent; Modified-release agent; Suspending agent; Viscosity-controlling agent
Pregelatinized starch E00674 Not Available Binding agent; Diluent; Disintegrant
Shellac E00695 Not Available Coating agent; Film/membrane-forming agent; Microencapsulating agent; Modified-release agent
⏷ Show the Full List of 16 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Alectinib 150 mg capsule 150 mg Oral Capsule Oral
Alectinib Hydrochloride eq 150mg base capsule eq 150mg base Capsule Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Alectinib versus crizotinib in patients with ALK-positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial. Lancet. 2017 Jul 1;390(10089):29-39.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7739).
3 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
4 CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011 May 17;19(5):679-90.
5 In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes. Xenobiotica. 2018 Jun;48(6):546-554.
6 Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.
7 Cerner Multum, Inc. "Australian Product Information.".
8 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
9 Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
10 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.