Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQIBZD)

Drug Name
Silmitasertib Drug Info
Synonyms CX-4945; CX4945; CX-4945 (Silmitasertib); CX 4945; UNII-C6RWP0N0L2; W-204393
Indication
Disease Entry ICD 11 Status REF
Cholangiocarcinoma 2C12.10 Phase 1/2 [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
24748573
ChEBI ID
CHEMBL1230165
CAS Number
CAS 1009820-21-6
TTD Drug ID
DMQIBZD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [5]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [6]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Gefitinib DM15F0X Colon adenocarcinoma Approved [8]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [9]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [10]
Etretinate DM2CZFA Keratosis ED56 Approved [11]
Prednisone DM2HG4X Acute asthma CA23 Approved [12]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [13]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor JunB (JUNB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [15]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [16]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [20]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [21]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [22]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [23]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [24]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [29]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [31]
Gefitinib DM15F0X Colon adenocarcinoma Approved [32]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [35]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [36]
Paclitaxel DMLB81S Breast carcinoma Approved [37]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [38]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [39]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [43]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [46]
Testosterone DM7HUNW Hot flushes GA30 Approved [47]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [48]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [51]
Selenium DM25CGV N. A. N. A. Approved [52]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [53]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [54]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [61]
Selenium DM25CGV N. A. N. A. Approved [52]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [64]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [67]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HUMAN casein kinase II (CSK2) TTDT8RP CSK21_HUMAN; CSK22_HUMAN; CSK23_HUMAN; CSK2B_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Post-Translational Modifications [4]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Post-Translational Modifications [3]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Gene/Protein Processing [3]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Post-Translational Modifications [3]

References

1 ClinicalTrials.gov (NCT02128282) Study of CX-4945 in Combination With Gemcitabine and Cisplatin for Frontline Treatment of Cholangiocarcinoma. U.S. National Institutes of Health.
2 News report, company report or official report of Senhwa Biosciences, Inc. Senhwa Biosciences Silmitasertib Named as Potential COVID-19 Therapy. 2020 March 31.
3 MEK inhibitor PD-0325901 overcomes resistance to CK2 inhibitor CX-4945 and exhibits anti-tumor activity in head and neck cancer. Int J Biol Sci. 2015 Feb 23;11(4):411-22. doi: 10.7150/ijbs.10745. eCollection 2015.
4 Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. J Med Chem. 2011 Jan 27;54(2):635-54.
5 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
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7 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
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16 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
17 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
18 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
19 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
20 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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26 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
27 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
28 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
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34 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
35 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
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53 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
54 Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
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