Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRIMLJ)

Drug Name
BX-795 Drug Info
Synonyms BX795; BX 795
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10077147
ChEBI ID
CHEBI:91439
CAS Number
CAS 702675-74-9
TTD Drug ID
DMRIMLJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Approved Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Phosphoinositide dependent protein kinase-1 (PDPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AR-12 DM4RK6P Lymphoma 2A80-2A86 Phase 1 [5]
L-serine-O-phosphate DMTJ1NH Discovery agent N.A. Investigative [6]
PMID20005102C1 DMMESBW Discovery agent N.A. Investigative [7]
BX-912 DMZA45C Discovery agent N.A. Investigative [2]
PHT-427 DMI96Y3 Discovery agent N.A. Investigative [8]
PF-5177624 DMUOFT0 Solid tumour/cancer 2A00-2F9Z Investigative [9]
GSK-2334470 DM3BI7R Solid tumour/cancer 2A00-2F9Z Investigative [10]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Targeting Checkpoint kinase-1 (CHK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LY2603618 DMCXRZF Pancreatic cancer 2C10 Phase 2 [11]
UCN-01 DMUNJZB Non-small-cell lung cancer 2C25.Y Phase 2 [12]
SCH-900776 DM67EMK Solid tumour/cancer 2A00-2F9Z Phase 2 [13]
LY2606368 DM4XMF7 Ovarian cancer 2C73 Phase 2 [14]
LY2880070 DMADEHZ Solid tumour/cancer 2A00-2F9Z Phase 1/2 [15]
RG7741 DMK6P9J Lymphoma 2A80-2A86 Phase 1 [16]
GDC-0425 DMDZ26X Lymphoma 2A80-2A86 Phase 1 [17]
AZD7762 DM1FW0C Solid tumour/cancer 2A00-2F9Z Phase 1 [18]
MK-8776 DMAS1RB Hodgkin lymphoma 2B30 Phase 1 [19]
Diamidothiazole derivative 1 DM02V5Q N. A. N. A. Patented [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
R-roscovitine DMSH108 Non-small-cell lung cancer 2C25.Y Phase 2 [21]
Ro 31-7453 DM83QCL Solid tumour/cancer 2A00-2F9Z Phase 2 [22]
PHA848125 DMS2Q9G Thymic cancer 2C27 Phase 2 [23]
TG02 DMZFIGQ Anaplastic astrocytoma 2A00.0 Phase 1/2 [24]
NUV-422 DMQJQNT Malignant glioma 2A00.0 Phase 1/2 [25]
RGB-286638 DMEGOQP Haematological malignancy 2B33.Y Phase 1 [26]
FN-1501 DM7BMD6 Solid tumour/cancer 2A00-2F9Z Phase 1 [27]
AG-024322 DMY4WVK Solid tumour/cancer 2A00-2F9Z Phase 1 [21]
PHA-793887 DM2Y4FG Solid tumour/cancer 2A00-2F9Z Phase 1 [28]
SNS-032 DMEITAS Solid tumour/cancer 2A00-2F9Z Phase 1 [29]
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Drug(s) Targeting Glycogen synthase kinase-3 beta (GSK-3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AMO-02 DMJRU3A Myotonic dystrophy 8C71.0 Phase 2/3 [30]
LY2090314 DMTBFE4 Acute myeloid leukaemia 2A60 Phase 2 [31]
Lithium DMZ3OU6 Bipolar disorder 6A60 Phase 2 [32]
Tideglusib DME4LA1 Alzheimer disease 8A20 Phase 2 [33]
9-ING-41 DM57TY3 Myelofibrosis 2A20.2 Phase 2 [34]
Neu-120 DMXKOUC Parkinson disease 8A00.0 Phase 1/2 [35]
KENPAULLONE DMAGVXW Discovery agent N.A. Patented [36]
CHIR-99021 DMB8MNU Allergic inflammation 4A80-4A85 Patented [37]
TDZD-8 DMG6Q45 Malignant glioma 2A00.0 Patented [38]
AR-A014418 DMUPN01 Ovarian cancer 2C73 Patented [39]
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Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [40]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [41]
Regorafenib DMHSY1I Gastrointestinal stromal tumour 2B5B Approved [42]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [43]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [44]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [22]
Pazopanib HCl DM6U9CQ Renal cell carcinoma 2C90 Approved [45]
Fruquintinib DMHOSCQ Colorectal cancer 2B91.Z Approved [46]
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [47]
Tivozanib DMUKC5L Renal cell carcinoma 2C90 Approved [48]
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Drug(s) Targeting Fungal Protein kinase A (Fung ypkA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BALANOL DMDLN9E N. A. N. A. Terminated [49]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X Discovery agent N.A. Investigative [50]
Ro-4396686 DM5DMCH Discovery agent N.A. Investigative [51]
PMID20005102C1 DMMESBW Discovery agent N.A. Investigative [7]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [52]
PMID19364658C33 DMSE1C3 Discovery agent N.A. Investigative [53]
BX-912 DMZA45C Discovery agent N.A. Investigative [2]
chelerythrine DMCP1G9 Discovery agent N.A. Investigative [54]
PMID21742770C1 DME3JMH Discovery agent N.A. Investigative [55]
Rp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Rp-cAMPS) DM1JWGH Discovery agent N.A. Investigative [56]
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Drug(s) Affected By 3-phosphoinositide-dependent protein kinase 1 (PDPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [60]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [61]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [62]
Amiloride DMRTSGP Congestive heart failure BD10 Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [64]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [61]
Paclitaxel DMLB81S Breast carcinoma Approved [65]
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Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [66]
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [68]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [70]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [70]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [68]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [71]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [72]
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Drug(s) Affected By Serine/threonine-protein kinase TBK1 (TBK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [4]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [60]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [76]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [77]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [78]
Flavonoid derivative 1 DMCQP0B N. A. N. A. Patented [74]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Checkpoint kinase-1 (CHK1) TTTU902 CHK1_HUMAN Inhibitor [2]
Cyclin-dependent kinase 2 (CDK2) TT7HF4W CDK2_HUMAN Inhibitor [2]
Fungal Protein kinase A (Fung ypkA) TTYVI76 Q56921_YEREN Inhibitor [2]
Glycogen synthase kinase-3 beta (GSK-3B) TTRSMW9 GSK3B_HUMAN Inhibitor [2]
Phosphoinositide dependent protein kinase-1 (PDPK1) TT9QBI6 PDPK1_HUMAN Inhibitor [2]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-phosphoinositide-dependent protein kinase 1 (PDPK1) OTT09ZVP PDPK1_HUMAN Gene/Protein Processing [3]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) OT5VYOSM IKKE_HUMAN Gene/Protein Processing [4]
Serine/threonine-protein kinase TBK1 (TBK1) OT1P06NV TBK1_HUMAN Gene/Protein Processing [4]

References

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